Serum vitamin D insufficiency is correlated with quadriceps neuromuscular functions in patients with anterior cruciate ligament injury: A preliminary study

Asia-Pacific Journal of Sports Medicine Arthroscopy Rehabilitation and Technology, Journal Year: 2024, Volume and Issue: 35, P. 76 - 80

Published: Jan. 1, 2024

This study aimed to investigate the correlations of serum vitamin D insufficiency with quadriceps neuromuscular function in patients anterior cruciate ligament (ACL) injury. A cross-sectional was conducted. Eighteen a primary, unilateral ACL injury who had insufficient concentrations (<30 ng/ml) were recruited for study. Bilateral function, including maximal strength, speed rapid contraction, and inhibition, measured on an isokinetic dynamometer hip knee joint flexion at 90° 45°, respectively. Quadriceps strength by voluntary isometric contractions (MVIC); contraction quantified rate torque development (RTD), which divided into early (RTD0-50) late phase (RTD100-200); inhibition central activation ratio (CAR). Serum concentration quantitatively determined 25(OH)D ELISA kit. The Spearman rank correlation analysis used examine between bilateral MVIC, RTD0-50, RTD100-200, CAR, results analyses showed that significantly correlated MVIC (injured: r = 0.574, p 0.013; uninjured: 0.650, 0.003) RTD0-50 (r 0.651, 0.003), CAR 0.662, uninjured limb. However, no significant found other outcomes. correlates insufficiency.

Language: Английский

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Complex interplay of neurodevelopmental disorders (NDDs), fractures, and osteoporosis: a mendelian randomization study

BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)

Published: March 27, 2024

Abstract Background Neurodevelopmental disorders (NDDs), such as Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum (ASD), and Tourette Syndrome (TS), have been extensively studied for their multifaceted impacts on social emotional well-being. Recently, there has growing interest in potential relationship with fracture risks adulthood. This study aims to explore the associations between these rates, order facilitate better prevention treatment. Methods Employing a novel approach, this utilized Mendelian randomization (MR) analysis investigate complex interplay ADHD, ASD, TS, fractures. The MR framework, leveraging extensive genomic datasets, facilitated systematic examination of causal relationships genetic predispositions. Results findings unveil intriguing bidirectional links specific types Notably, ADHD is identified risk factor fractures, pronounced various anatomical regions, including skull, trunk, lower limbs. Conversely, individuals notably those affecting femur lumbar spine, exhibit an increased predisposition ASD. In research, no correlation was found TS or osteoporosis.These results provide perspective NDDs emphasizing importance early diagnosis, intervention, holistic approach healthcare. Conclusion research sheds new light intricate connections offering valuable insights into factors links. fractures highlight need comprehensive clinical approaches that consider both physical

Language: Английский

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Evaluation of the Effect of Vitamin D Treatment on Cardiac Function in Non-Obese Female Adolescents with Vitamin D Deficiency in Türkiye: A Cross-Sectional Study

Nigerian Journal of Clinical Practice, Journal Year: 2024, Volume and Issue: 27(2), P. 194 - 201

Published: Feb. 1, 2024

A BSTRACT Background: Vitamin D deficiency may cause adverse effects on the cardiovascular system as well many other systems. The risk of vitamin increases during adolescence, when growth rate is high, due to reasons such limited sun exposure, inadequate dietary calcium, and intake. Aim: To evaluate effect daily 2000 IU supplementation for 12 weeks cardiac function in non-obese adolescent girls with deficiency. Methods: This cross-sectional study was carried out between September 2021 June 2022. total 108 having 25-hydroxyvitamin [25(OH)D] levels below ng/mL were given orally weeks. Serum 25(OH)D, alkaline phosphatase, parathormone, phosphate, determined before after treatment. Results: After treatment, 25(OH)D above 20 90.8% adolescents. parathormone phosphatase decreased, while phosphate increased. Echocardiographic tissue Doppler studies showed positive changes some systolic diastolic indicators. In addition, myocardial performance index decreased from 0.42 ± 0.03 0.40 ( P < 0.001) left ventricle, 0.43 0.38 right 0.41 0.04 0.02 interventricular septum treatment compared pretreatment. Conclusion: It observed that administration a period contributed positively function.

Language: Английский

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The Non-conventional Effects of Hypovitaminosis D: A Pandemic Even in Sunlight-Rich Countries

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: April 29, 2024

The synthesis and absorption of Vitamin D play crucial roles in numerous bodily functions, yet deficiencies persist due to factors like insufficient sunlight exposure dietary inadequacy. Research underscores the significance lifestyle elements such as diet, sun exposure, physical activity maintaining optimal levels. Strategies aimed at tackling emphasize supplementation alongside adjustments, especially regions with abundant Middle East North Africa (MENA). Despite abundance sunshine Arab world, there remains a prevalent issue deficiency. This problem arises from various factors, including cultural practices traditional clothing covering most skin areas, which limit environmental air pollution that reduce UV penetration. Dietary habits choices also contribute this Dealing ongoing pandemic requires focused effort enhance awareness. While some individuals may recognize common diseases caused by deficiency, rickets osteomalacia, many remain unaware broader health risks associated condition, non-skeletal manifestations. Additionally, is lack understanding regarding hidden benefits hormone. Therefore, prioritizing educational initiatives delve into these aspects essential effectively combat current crisis. literature review aims report both skeletal extraskeletal consequences hypovitaminosis briefly discuss cause paradoxical vitamin deficiency sunny MENA. was done reviewing pertinent articles published between January 2000 2024, sourced databases PubMed, UpToDate, Scopus, CINAHL, focusing exclusively on English language using keywords "Vitamin deficiency" "Extraskeletal manifestations."

Language: Английский

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Relationship between Vitamin D Insufficiency, Lipid Profile and Atherogenic Indices in Healthy Women Aged 18–50 Years.

Published: June 11, 2024

Although vitamin D deficiency has been correlated with an increased risk of cardiovascular disease (CVD), there are few data on the association between 25-hydroxyvitamin (25(OH) D) and atherogenic indices predictive CVD. This study aimed to investigate relationship status lipid profile in adult women Morocco. Three hundred healthy women, aged 18 50 years, from Meknes were included. Fasting 25(OH) concentrations determined using a one-step electrochemiluminescence-based immunoassay enzymatic method, respectively. Atherogenic (Atherogenic index plasma (AIP), non-HDL cholesterol (Non-HDL-C), coefficient (AC), Castelli I II (CRI-I II), CHOLIndex (CI)) calculated conventional parameters. Logistic regression models operating characteristic curve (ROC) analysis used assess variables estimate threshold levels associated high indices. below 20 ng/ml was significantly enhanced hypertriglyceridemia elevated values AIP, AC, Non-HDL-C, CRI-I OR (95% CI) 4.904 (1.856-12.959); 3.637(2.149-6.158); 3.589(1.673-7.700); 2.074(1.215-3.540), 2.481(1.481-4.123), According ROC analysis, likelihood 25(OH)D thresholds ≤15.15 ng/ml, ≤ 17.5 19.8 20.1 19.5 respectively, all p &amp;lt; 0.01. Based indices, this indicates that may increase women. Additional health efforts needed raise awareness among healthcare providers preventing controlling factors.

Language: Английский

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Relationship between Vitamin D Insufficiency, Lipid Profile and Atherogenic Indices in Healthy Women Aged 18–50 Years

European Journal of Investigation in Health Psychology and Education, Journal Year: 2024, Volume and Issue: 14(8), P. 2337 - 2357

Published: Aug. 9, 2024

Although vitamin D insufficiency has been correlated with an increased risk of cardiovascular disease (CVD), there are few data on the association between 25-hydroxyvitamin (25(OH)D) and atherogenic indices predictive CVD. This study investigated relationship status lipid profile in adult women Morocco. Three hundred aged 18 to 50 years from Meknes were included. Fasting 25(OH)D concentrations assayed by a one-step electrochemiluminescence-based immunoassay enzymatic method, respectively. Atherogenic (atherogenic index plasma (AIP), coefficient (AC), non-HDL cholesterol (non-HDL-C), Castelli I II (CRI-I II), CHOLIndex (CI)) calculated using conventional parameters. Logistic regression models operating characteristic curve (ROC) analysis used assess variables estimate threshold levels associated high indices. 25(OH) below 20 ng/mL was significantly enhanced hypertriglyceridemia elevated values AIP, AC, non-HDL-C, CRI-I OR (95% CI) 4.904 (1.856–12.959), 3.637 (2.149–6.158), 3.589 (1.673–7.700), 2.074 (1.215–3.540), 2.481 (1.481–4.123), According ROC analysis, likelihood thresholds ≤15.15 ng/mL, ≤17.5 ≤19.8 ≤20.1 ≤19.5 respectively, all p < 0.01. Based indices, this indicates that may increase women. Additional health measures essential raise awareness among professionals preventing controlling factors, particularly young individuals.

Language: Английский

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Editorial: The role of vitamin D in metabolic and cardiovascular health

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: April 24, 2023

EDITORIAL article Front. Nutr., 24 April 2023Sec. Nutrition and Metabolism Volume 10 - 2023 | https://doi.org/10.3389/fnut.2023.1193758

Language: Английский

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The Role of Vitamin D in COVID-19 Survival and Prevention: A Meta-analysis

Sudan Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: March 29, 2024

Background: COVID-19 is still ongoing with frequently discovered new strains, although vaccines are highly effective for prevention. Literature on vitamin D supplementation in prevention and its effect survival scarce. This meta-analysis assessed the role of survival. Methods: Four databases (Web Science, SCOPUS, PubMed, MEDLINE, first 100 articles Google Scholar) were searched published up to September 2023. The keywords used COVID-19, mortality, supplementation, calcitriol, cholecalciferol, Calcifediol, survival, death, Six hundred seven studies retrieved, four three remained after duplication removal; them eighty-three full texts screened, them, only sixteen (prospective, randomized controlled trials, retrospective studies) included final meta-analysis. Results: Sixteen observational including 5905,109 patients 186,500 events included. Vitamin reduced mortality among patients, odd ratio, 2.31, 95% CI, 1.49–3.58; addition, was prevention, 1.92, 1.01–3.64. Conclusion: prevented increased admitted moderate/severe COVID-19.

Language: Английский

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Long-term ultraviolet B irradiation at 297 nm with light-emitting diode improves bone health via vitamin D regulation

Biomedical Optics Express, Journal Year: 2024, Volume and Issue: 15(7), P. 4081 - 4081

Published: May 16, 2024

Ultraviolet radiation is the primary determinant for vitamin D synthesis. Sunlight inefficient and poses a risk, particularly long-term exposure. In this study, we screened most favorable wavelength synthesis among four types of narrowband light-emitting diodes (LEDs) then irradiated osteoporosis rats with optimal 3–12 months. The 297 nm LED was efficient. Long-term increased levels in all osteoporotic improved bone health. No skin damage observed during irradiation. Our findings provide an efficient safe method supplementation.

Language: Английский

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Vitamin D status in children in the South Marmara Region in Turkey

Journal of Contemporary Medicine, Journal Year: 2024, Volume and Issue: 14(4), P. 160 - 167

Published: May 20, 2024

Aim: The aim of our study was to investigate the age, gender and seasonal differences in vitamin D levels children determine prevalence deficiency. Materials Methods: Between January 2022 December 2023, records aged 0-17 years who underwent serum 25-hydroxyvitaminD (25 (OH) D) pediatric outpatient clinics hospital were retrospectively reviewed. Children divided into four groups according age (0-1, 2-5, 6-11 12-17 years); three 25 (vitamin deficiency (below 12 ng/mL), insufficiency (between 12-20 ng/mL) sufficiency (above 20 ng/mL)); seasons. Results: 25(OH)D 41899 children, 19738 (47.1%) boys 22161 (52.9%) girls, 18.6 ng/mL (3-145); lower girls than (16.8 (3-136) 20.3 (3-145) p

Language: Английский

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