Published: Jan. 1, 2024
Language: Английский
Health and Quality of Life Outcomes, Journal Year: 2023, Volume and Issue: 21(1)
Published: Jan. 28, 2023
The Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog) evaluates perceived cognitive functioning and their impact on quality life. This study was designed to evaluate the factors associated with in a sample women breast cancer (BC) Lebanon. We also sought explore psychometric properties FACT-Cog Arabic version.A cross-sectional carried out between March August 2020 among BC. Socio-demographic clinical characteristics were collected. In addition, patients asked complete version as well European Organization for Research Treatment Quality Life Core Questionnaire 30, Patient Health (PHQ-9), Generalized Anxiety Disorder (GAD-7). internal consistency tool evaluated using Cronbach's alpha. Content, convergent, known group validity evaluated. All statistical analyses performed SPSS 23.0.A 134 BC Internal consistencies FACT-cog total scale its subscales high (Cronbach's α 0.83 0.95). convergent supported by positive correlation EORTC-cognitive subscale. Moreover, negative correlations found fatigue, pain, anxiety, depression. Known-group statistically significant mean differences early (I &II) late (III & IV) stages. Unmarried those having higher depressive symptoms lower life be at risk impairment.The Lebanese is valid reliable assessing women. Higher level depression impaired decline functioning.
Language: Английский
Citations
7
Cancer, Journal Year: 2024, Volume and Issue: 130(16), P. 2834 - 2847
Published: April 27, 2024
Abstract Background Cancer‐related cognitive impairment (CRCI) and anxiety co‐occur in patients with cancer. Little is known about mechanisms for the co‐occurrence of these two symptoms. The purposes this secondary analysis were to evaluate perturbed pathways associated self‐reported CRCI low versus high levels symptoms identify potential using biological processes common across any neurodegenerative disease pathways. Methods Patients completed Attentional Function Index Spielberger State‐Trait Anxiety Inventory six times over cycles chemotherapy. Based on findings from a previous latent profile analysis, grouped into none both Gene expression was quantified, pathway impact analyses performed. Signaling evaluation defined Kyoto Encyclopedia Genes Genomes database. Results A total 451 had data available analysis. Approximately 85.0% class 15.0% class. Pathway identified five related diseases (i.e., amyotrophic lateral sclerosis, Huntington disease, Parkinson prion neurodegeneration–multiple diseases). Apoptosis, mitochondrial dysfunction, oxidative stress, endoplasmic reticulum stress Conclusions This study first describe perturbations receiving These provide new insights targets development mechanistically based interventions.
Language: Английский
Citations
2
Nursing Research, Journal Year: 2023, Volume and Issue: unknown
Published: April 24, 2023
Up to 45% of patients report cancer-related cognitive impairment (CRCI). A variety characteristics are associated with the occurrence and/or severity CRCI. However, an important gap in knowledge risk factors for CRCI is relative contribution each factor. The multifactorial model (MMCRCI) a conceptual that can be used evaluate strength relationships between various and
Language: Английский
Citations
6
Cancers, Journal Year: 2022, Volume and Issue: 14(13), P. 3281 - 3281
Published: July 5, 2022
Cancer related cognitive impairment (CRCI) is a common and persistent symptom in breast cancer patients. The Attentional Function Index (AFI) self-report measure that assesses CRCI. AFI includes three subscales, namely effective action, attentional lapses, interpersonal effectiveness, are based on working memory, inhibitory control, flexibility. Previously, we identified classes of patients with distinct CRCI profiles using the total scores. purpose this study was to expand our previous work latent class growth analysis (LCGA), identify for each subscales same sample (i.e., 397 women who were assessed seven times from prior through 6 months following surgery). For subscale, parametric non-parametric statistics used determine differences demographic, clinical, pre-surgical psychological physical symptoms among subgroups. Three-, four-, two-classes effectiveness respectively. Across all lower functional status, higher levels anxiety, depression, fatigue, sleep disturbance, worse decrements energy associated performance. These other modifiable characteristics may be potential targets personalized interventions
Language: Английский
Citations
9
Sensors, Journal Year: 2023, Volume and Issue: 23(19), P. 8017 - 8017
Published: Sept. 22, 2023
This pilot feasibility study aimed to evaluate the effects of transcranial magnetic stimulation (TMS) on chemotherapy-related cognitive impairment (CRCI), and we report here first patient. Background: Deleterious changes due chemotherapy or CRCI are commonly referred as “chemo brain”. With increasing survival cancer patients, this poorly understood inadequately treated condition will likewise have an toll individuals society. Since there is no approved treatment for chemo brain, initiated a therapeutic trial using (TMS), non-invasive brain technique in many countries neurologic psychiatric conditions like migraine depression. Case presentation: A 58-year-old woman, diagnosed 7 years prior with left breast cancer, underwent partial mastectomy sentinel lymph node biopsy. She then received four cycles adjuvant followed by radiation therapy. Afterwards, she was tamoxifen 4 switched aromatase inhibitors. The patient’s started during severely impaired her quality life additional two years. In third year after chemotherapy, partially cleared stabilize level at time presentation trial. patient continues memory difficulties decreased concentration, which makes multi-tasking very difficult impossible. reliant aids work home. participant 10 consecutive sessions TMS weekdays 2 weeks. Stimulation directed dorsolateral prefrontal cortex. After TMS, significantly improved function neuropsychological testing. While reported subjective differences concentration memory, did improvement sleep. Functional resonance imaging before showed increased resting-state functional connectivity between site several regions. Remarkably, 6 remaining same position inability concentrate multi-task, applied promotion 5–6 months treatments. Conclusions: phase 1 clinical testing brain” provided important lessons insights into mechanisms potential benefit.
Language: Английский
Citations
4
Seminars in Oncology Nursing, Journal Year: 2024, Volume and Issue: 40(5), P. 151724 - 151724
Published: Aug. 24, 2024
Language: Английский
Citations
1
Journal of Clinical Medicine, Journal Year: 2022, Volume and Issue: 11(5), P. 1215 - 1215
Published: Feb. 24, 2022
Damage of the central nervous system (CNS), manifested by cognitive impairment, occurs in 80% women with breast cancer (BC) as a complication surgical treatment and radiochemotherapy. In this study, levels ICAM-1, PECAM-1, NSE, anti-NR-2 antibodies which are associated damage CNS endothelium were measured blood ELISA potential biomarkers that might reflect pathogenetic mechanisms these patients. A total 102 patients enrolled single-center trial divided into four groups: (1) 26 after treatment, (2) 21 chronic brain ischemia (CBI) asymptomatic carotid stenosis (ICA stenosis) (CBI + ICA stenosis), (3) 35 CBI but without stenosis, (4) 20 healthy female volunteers (control group). Intergroup analysis demonstrated group following BC there was significant increase ICAM-1 (mean difference: −368.56, 95% CI −450.30 to −286.69, p < 0.001) PECAM-1 −47.75, −68.73 −26.77, molecules, compared volunteers. Additionally, decrease 0.89, 0.41 1.48, detected. The intergroup comparison revealed comparable −33.58, −58.10 125.26, = 0.76), −5.03, −29.93 19.87, 0.95), well −0.05, −0.26 0.16, 0.93) stenosis. NSE level significantly higher than −43.64, 3.31 −83.99, 0.03). Comparable also detected −21.28, −111.03 68.48, 0.92). molecules −13.68, −35.51 8.15, 0.35). conclusion, among other mechanisms, endothelial dysfunction play role survivors.
Language: Английский
Citations
6
Surgical Clinics of North America, Journal Year: 2022, Volume and Issue: 103(1), P. 155 - 167
Published: Nov. 18, 2022
Language: Английский
Citations
6
International Journal of Nursing Practice, Journal Year: 2023, Volume and Issue: 29(4)
Published: Feb. 9, 2023
The purpose of this study was to identify risk factors for cognitive impairment in advanced cancer patients and develop predictive models based on these factors.Cancer-related seriously affects the quality life patients. However, neural network with have not yet been identified.A cross-sectional design used.This collected 494 questionnaires between January June 2022. Statistically significant clinical indicators were selected by univariate analysis, artificial model logistic regression used multivariate analysis. predicted value estimated using area under subject's working characteristic curve.The suggested that course, anxiety age major All indexes constructed are better than those model.The can predict cancer. Better prediction will enable nurses other healthcare professionals provide targeted timely support.
Language: Английский
Citations
3
EXPLORE, Journal Year: 2021, Volume and Issue: 18(6), P. 657 - 662
Published: Nov. 10, 2021
Language: Английский
Citations
4