Bacterial Infections and Cancer: Exploring This Association And Its Implications for Cancer Patients

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 3110 - 3110

Published: Feb. 4, 2023

Bacterial infections are common in the etiology of human diseases owing to ubiquity bacteria. Such promote development periodontal disease, bacterial pneumonia, typhoid, acute gastroenteritis, and diarrhea susceptible hosts. These may be resolved using antibiotics/antimicrobial therapy some However, other hosts unable eliminate bacteria, allowing them persist for long durations significantly increasing carrier's risk developing cancer over time. Indeed, infectious pathogens modifiable factors, through this comprehensive review, we highlight complex relationship between several types. For searches were performed on PubMed, Embase, Web Science databases encompassing entirety 2022. Based our investigation, found critical associations, which causative: Porphyromonas gingivalis Fusobacterium nucleatum associated with Salmonella spp., Clostridium perfringens, Escherichia coli, Campylobacter Shigella gastroenteritis. Helicobacter pylori infection is implicated gastric cancer, persistent Chlamydia present a factor cervical carcinoma, especially patients papillomavirus (HPV) coinfection. typhi linked gallbladder pneumoniae lung etc. This knowledge helps identify adaptation strategies used by bacteria evade antibiotic/antimicrobial therapy. The article also sheds light role antibiotics treatment, consequences their use, limiting antibiotic resistance. Finally, dual as well briefly discussed, an area that help facilitate novel microbe-based therapeutics means securing improved outcomes.

Language: Английский

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The Promising Role of Antioxidant Phytochemicals in the Prevention and Treatment of Periodontal Disease via the Inhibition of Oxidative Stress Pathways: Updated Insights

Antioxidants, Journal Year: 2020, Volume and Issue: 9(12), P. 1211 - 1211

Published: Dec. 1, 2020

There is growing evidence on the involvement of oxidative stress, which simply described as imbalance between oxidants and antioxidants in favor former, development periodontal disease that most common inflammatory oral cavity. Thus, potential antioxidant phytochemicals adjunctively preventive therapeutic agents against initiation progression a topic great interest. The current review firstly aims to provide updated insights about immuno-inflammatory pathway regulated by stress pathology. Then, this work further presents systemic knowledge phytochemicals, particularly pharmacological activities, can be utilized prevention treatment disease. Additionally, challenges future prospects regarding such scope are figured out.

Language: Английский

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Diabetes and Oral Health: Summary of Current Scientific Evidence for Why Transdisciplinary Collaboration Is Needed

Frontiers in Dental Medicine, Journal Year: 2021, Volume and Issue: 2

Published: July 29, 2021

This Perspective provides a brief summary of the scientific evidence for often two-way links between hyperglycemia, including manifest diabetes mellitus (DM), and oral health. It delivers in nutshell examples current following manifestations along with any available effect opposite direction: periodontal diseases, caries/periapical periodontitis, tooth loss, peri-implantitis, dry mouth (xerostomia/hyposalivation), dysbiosis microbiome, candidiasis, taste disturbances, burning syndrome, cancer, traumatic ulcers, infections wounds, delayed wound healing, melanin pigmentation, fissured tongue, benign migratory glossitis (geographic tongue), temporomandibular disorders, osteonecrosis jaw. Evidence effects on quality life will also be reported. condensed overview rationale sets stage urgent need delivery general health care patient-centered transdisciplinary collaboration early detection management both hyperglycemia diseases to improve life.

Language: Английский

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The prevalence of periodontitis in an Iraqi population using the 2017 classification

Journal of Baghdad College of Dentistry, Journal Year: 2024, Volume and Issue: 36(2), P. 1 - 10

Published: June 15, 2024

Background: To determine the prevalence and severity of periodontitis in an Iraqi population using 2017 classification. Methods: Data on periodontal status patients were retrospectively collected from healthcare records. The information included demographics, clinical parameters including bleeding probing (BOP), pocket depth (PPD), attachment loss (CAL). Descriptive inferential statistical analyses performed SPSS (version 26, IBM, USA) software. Results: Out 1578 records, health, gingivitis, represented 26.4%, 37.1%, 36.5%, respectively with males more affected by disease compared females. Periodontitis cases dominated stage 3 4 which combined accounted for 77.3%, followed 2 (21.3%), 1 (1.4%). When looking at grade levels stability, localized pattern, Grade C, unstable most prevalent domains. Regression analysis suggested age, BOP, male, positive family history as predictors increasing extent CAL both health disease. Conclusion: (periodontitis, gingivitis) was almost equally expressed. Severe dominant group whilst milder forms least prevalent. data indicated that demographic variables could predict loss.

Language: Английский

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Malocclusions, pathologic tooth migration, and the need for orthodontic treatment in subjects with stage III–IV periodontitis. A cross-sectional study

European Journal of Orthodontics, Journal Year: 2023, Volume and Issue: 45(4), P. 418 - 429

Published: March 4, 2023

Summary Background Literature is scarce on malocclusion prevalence and orthodontic treatment need (OTN) in subjects with stage III–IV periodontitis. Study aims were to assess of primary secondary malocclusions periodontitis OTN based pathologic tooth migration (PTM) occlusal trauma anterior teeth (AT). Subjects methods One hundred twenty-one examined. A comprehensive periodontal–orthodontic examination was performed. Exclusion criteria: age <30 years, removable prosthetics, uncontrolled diabetes, pregnancy/lactation, oncologic disease. Results Class II found 49.6% (Class div 1—20.7%, 2—9.9%, subdivision II—19.0%), I—31.4%, III—10.7%, no malocclusion—8.3% subjects. PTM observed 74.4% maxillary 60.3% mandibular AT. Spacing extrusion the main types Odds ratio for AT 9.3 cases >30% sites clinical attachment loss ≥5 mm (P = 0.001). influenced by periodontitis, III malocclusion, lost teeth. Tongue habit had impact spacing Dental Health Component Index Orthodontic Treatment Need yielded that >50% due PTM, impaired function 66.1% Conclusions The most prevalent II. more than half study highlights preventive measures

Language: Английский

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Periodontitis, coronary heart disease and myocardial infarction: treat one, benefit all

Blood Coagulation & Fibrinolysis, Journal Year: 2020, Volume and Issue: 31(6), P. 339 - 345

Published: July 18, 2020

Periodontal disease is conventionally defined as an inflammatory condition affecting the tissues surrounding and supporting teeth (i.e. gum periodontium). Recent statistics show that prevalence of this continuously growing worldwide, thus raising severe healthcare concerns, not only for local problems emerging from poor oral health, but also potential risk developing systemic complications. Therefore, article aims to provide update on intriguing association between periodontitis, coronary heart (CHD) and/or myocardial infarction (MI). Taken together, available published information seems support existence a significant periodontitis CHD, whilst acute ischemic cardiac events appears magnified in patients with preexisting artery disease. This epidemiological link supported by reliable biological evidence, showing periodontal may unfavourably modulate cardiovascular risk, whereby have increased frequency overweight, hypertension, endothelial dysfunction, dyslipidaemia, platelet hyper-reactivity, be characterized prothrombotic state. Apart these critical atherogenic factors, translocation microorganisms into bloodstream, their further accumulation within atherosclerotic plaques, would contribute enhance plaque instability events. Interesting evidence or statins administration could beneficial safeguarding enlightening relationship existing CHD periodontitis.

Language: Английский

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Oral health in patients with cleft lip and palate: a systematic literature review and meta-analysis of periodontal and dental disease and oral microbiota (part 1)

BMC Oral Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 29, 2025

Orofacial cleft impacts jawbone and dental development function, often with consequences for oral health. The first in this two-part systematic review of the literature on health persons lip and/or palate focuses periodontal parameters composition bacterial flora, while second analyzes data caries. Four databases (PubMed, Cochrane, Scopus, Web Science) were searched studies that compared parameters, caries index, microbiota between healthy controls. Newcastle-Ottawa scale Joanna Briggs Institute checklist applied to evaluate study quality. A total 24 underwent review, 18 which entered meta-analysis. Twenty included a control group, four only orofacial cleft. part (18 studies) microbiota. Meta-analysis (plaque gingival bleeding probing pocket depth, clinical attachment level) revealed an association greater risk poor disease. Good relies correct home hygiene regular visits dentist starting at early age.

Language: Английский

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Differences Between Two Devices With Function of Periopolishing and Piezoelectric Scaler: A Randomized Clinical Trial

International Journal of Dentistry, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Dental procedures often cause anxiety and apprehension in patients due to potential discomfort pain. Understanding patient sensitivity comfort is critical providing effective dental care. The aim of this study was compare operator between two devices with the function periopolishing piezoelectric scaler during guided biofilm therapy (GBT) sessions. A randomized controlled trial conducted involving 20 operators. Primary outcomes, including pain, sensitivity, comfort, were assessed using a visual analog scale (VAS), while periodontal indices served as secondary outcomes. results showed comparable levels devices, higher airflow reported for Mectron Combi Touch ultrasonic handpiece EMS Prophylaxis Master. Both effectively reduced parameters without significant differences. These indicate that both Master offer viable options efficient patient-friendly treatment. provides valuable insights improving experience treatment outcomes office. Considerations device selection based on clinical needs are discussed, well future perspectives advancing preventive This research contributes ongoing topic ensure optimal satisfaction oral health Trial Registration: ClinicalTrials.gov identifier: NCT05263622.

Language: Английский

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The effectiveness of Ocimum sanctum extract application as an Antimicrobial in the Supportive Therapy of Periodontal Disease

Research Journal of Pharmacy and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 177 - 184

Published: Jan. 27, 2025

Background: Periodontal disease is a periodontal tissue disease, including gingivitis to periodontitis in the oral cavity. Gingivitis reversible inflammatory condition of accumulation bacteria cavity with clinical signs, redness, swelling, and bleeding. not treated causes decreases bone density. According Kemenkes (2018) prevalence Indonesia 96.58% Riskesdas (2018), 67.8%. The current supportive treatment for chlorhexidine mouthwash. Chlorhexidine has side effects teeth brown staining burning sensation Therefore, an innovative approach using herbal plants minimal application Ocimum sanctum extract as therapy disease. Objective: To determine effectiveness antimicrobial Literature Review: mouthwash gold standard acts antiseptic that inhibits dental plaque broad spectrum, because it bacteriostatic bactericidal. (kemangi) plant Asia five active components, eugenol, caryophyllene, germacrene-A, clemence caryophyllene-oxide. In tissues, these substances have antibacterial effect. sanctum's immunomodulatory properties boost response host infection by raising interferon, IL-4, T-helper cell levels. plays role early stages progression many illnesses infections such Aggregatibacter actinomycetemcomitans Porphyromonas gingivalis. Conclusion: Application effective

Language: Английский

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Host Transcriptional Regulatory Genes and Microbiome Networks Crosstalk through Immune Receptors Establishing Normal and Tumor Multiomics Metafirm of the Oral-Gut-Lung Axis

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(23), P. 16638 - 16638

Published: Nov. 23, 2023

The microbiome has shown a correlation with the diet and lifestyle of each population in health disease, ability to communicate at cellular level host through innate adaptative immune receptors, therefore an important role modulating inflammatory process related establishment progression cancer. oral cavity is one most interaction windows between human body environment, allowing entry number microorganisms their passage across gastrointestinal tract lungs. In this review, contribution network systemic diseases like cancer analyzed synergistic interactions bidirectional crosstalk oral-gut-lung axis as well its communication cells. Moreover, impact characteristic microbiota formation multiomics molecular metafirm also state-of-the-art sequencing techniques, which allow global study processes involved flow environmental signals cancer-related cells relationship transcription factor responsible for control regulatory tumorigenesis.

Language: Английский

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