[Retracted] Periodontitis Exacerbates Benign Prostatic Hyperplasia through Regulation of Oxidative Stress and Inflammation DOI Creative Commons
Cheng Fang, Lan Wu,

Ming-Juan Zhao

et al.

Oxidative Medicine and Cellular Longevity, Journal Year: 2021, Volume and Issue: 2021(1)

Published: Jan. 1, 2021

Epidemiological studies demonstrate that men with periodontitis are also susceptible to benign prostatic hyperplasia (BPH) and periodontal treatment can improve the symptom. However, molecular links of this relationship largely unknown. The goal current study was elucidate effects experimental on prostate whether oxidative stress inflammation participated in process. For purpose, ligature‐induced periodontitis, testosterone‐induced BPH, composite models rats were established. Four weeks later, all sacrificed following items measured: alveolar bone loss histological examination tissues taken assess establishment model, index test BPH inflammatory cytokines plasma assessed, Bax/Bcl‐2 proteins related cell apoptosis analyzed via western blot analysis. To further investigate participates aggravation vitro conducted measure production intracellular reactive oxygen species (ROS) hydrogen peroxide (H 2 O ) concentration. We found simultaneous synergistically aggravated changes, significantly increased Ki67 proliferation, reduced rat tissues. Also, our results showed ligation induced Bcl‐2 protein expression, whereas Bax expression decreased than normal rats. Compared control group, both enhanced cytokine levels TNF‐ α , IL‐6, IL‐1 β CRP. Furthermore, Porphyromonas gingivalis lipopolysaccharide generation ROS H BPH‐1 cells. Our evidence demonstrated might promote development through regulation process, thus providing new strategies for prevention BPH.

Language: Английский

Role of oxidative stress in the relationship between periodontitis and systemic diseases DOI Creative Commons

Jiaxin Shang,

Haifeng Liu, Youli Zheng

et al.

Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14

Published: July 12, 2023

Periodontitis is a common inflammatory disease. It characterized by destruction of the supporting structures teeth and could lead to tooth loss systemic inflammation. Bacteria in inflamed gingival tissue virulence factors are capable entering bloodstream induce response, thus influencing pathological process many diseases, such as cardiovascular diabetes, chronic kidney disease, well liver injury. An increasing body evidence show complex interplay between oxidative stress inflammation disease pathogenesis. When periodontitis occurs, increased reactive oxygen species accumulation leads stress. Oxidative contributes major cellular components damage, including DNA, proteins, lipids. In this article, focus will be on periodontal relationship inflammation, impact therapy parameters.

Language: Английский

Citations

41
Epigallocatechin gallate-based nanoparticles with reactive oxygen species scavenging property for effective chronic periodontitis treatment DOI
Mi Tian, Guangcan Chen, Jingchen Xu

et al.

Chemical Engineering Journal, Journal Year: 2021, Volume and Issue: 433, P. 132197 - 132197

Published: Sept. 4, 2021

Language: Английский

Citations

81
Polyphenols as Antioxidants for Extending Food Shelf-Life and in the Prevention of Health Diseases: Encapsulation and Interfacial Phenomena DOI Creative Commons
Marlene Costa, Zerrin Sezgin Bayındır, Sonia Losada‐Barreiro

et al.

Biomedicines, Journal Year: 2021, Volume and Issue: 9(12), P. 1909 - 1909

Published: Dec. 14, 2021

Toxicity caused by the exposure to human-made chemicals and environmental conditions has become a major health concern because they may significantly increase formation of reactive oxygen species (ROS), negatively affecting endogenous antioxidant defense. Living systems have evolved complex mechanisms protect cells from oxidative conditions. Although stress contributes various pathologies, intake molecules such as polyphenols, obtained natural sources, limit their effects antimicrobial properties against lipid peroxidation broad range foodborne pathogens. Ingestion polyphenol-rich foods, fruits vegetables, help reduce harmful ROS, but use supramolecular nanomaterials delivery emerged an efficient method improve pharmacological therapeutic effects. Suitable exogenous polyphenolic antioxidants should be readily absorbed delivered sites where pathological damage take place, for instance, intracellular locations. Many potential poor bioavailability, can encapsulated ideal solubility permeability profile. Development effective strategies requires creation new nanoscale drug stress. In this review we provide overview process, highlight some discuss role polyphenols bioactives in controlling overproduction ROS bacterial fungal growth, paying special attention encapsulation suitable location colloidal interfaces play crucial role.

Language: Английский

Citations

57
The role of mitochondrial dysfunction in periodontitis: From mechanisms to therapeutic strategy DOI
Wentao Jiang, Yujing Wang, Zelin Cao

et al.

Journal of Periodontal Research, Journal Year: 2023, Volume and Issue: 58(5), P. 853 - 863

Published: June 18, 2023

Periodontitis is an inflammatory and destructive disease of tooth-supporting tissue has become the leading cause adult tooth loss. The most central pathological features periodontitis are damage reaction. As energy metabolism center eukaryotic cells, mitochondrion plays a notable role in various processes, such as cell function response. When intracellular homeostasis disrupted, it can lead to mitochondrial dysfunction inability generate adequate maintain basic cellular biochemical reactions. Recent studies have revealed that closely related initiation development periodontitis. excessive production reactive oxygen species, imbalance biogenesis dynamics, mitophagy DNA all affect progression Thus, targeted therapy potentially promising treatment. In this review, we summarize above mechanism pathogenesis discuss some potential approaches exert therapeutic effects on by modulating activity. understanding summary might provide new research directions for intervention or treatment

Language: Английский

Citations

29
Role of medicinal herbs in periodontal therapy: A systematic review DOI
Mohan Kumar Pasupuleti,

Raghavendra R Nagate,

Saad M Alqahtani

et al.

Journal of International Society of Preventive and Community Dentistry, Journal Year: 2023, Volume and Issue: 13(1), P. 9 - 16

Published: Jan. 1, 2023

A bstract Aims and Objectives: The use of medicinal herbs to prevent gingival periodontal diseases has become increasingly popular due their anti-inflammatory antioxidant properties. This systematic review aims provide the current literature validate traditional in management diseases. Materials Methods: An online search was conducted identify research papers published from 2010 2022 three major scientific databases, PubMed, Scopus, Web Science, June 2022. Original studies, case reports, reviews on plants’ application oral health care were selected be included this review. Only high-quality articles identified quality assessment for evidence synthesis. Results: Initial keyword yielded 726 free-text between Of these, 14 (8 6 reviews) review’s findings indicate that antibacterial property plants is alkaline nature prevents plaque calculus formation by maintaining acid–alkali balance saliva. Various parts help maintain health. Glycyrrhiza glabra , Ficus religiosa Plantago effectively inhibit primary colonizers pathogens. Medicago sativa Aloe barbadensis Miller, Trifolium pratense have excellent applications treating Mangifera indica Pongamia pinnata husk Cocos nucifera root G. Curcuma longa leaves Psidium guajava Azadirachta fruits Citrus medica Punica granatum Ocimum Moringa oleifera extract, pomegranate peel extract can serve as a promising alternative managing chronic gingivitis. Conclusion: anti-inflammatory, antioxidant, antibacterial, astringent action extracts obtained various make them effective reducing Herbal medicine may viable contemporary pharmaceuticals an adjuvant scaling planning procedures.

Language: Английский

Citations

24
Bioactivity and Bioavailability of Carotenoids Applied in Human Health: Technological Advances and Innovation DOI Open Access
Tomás Gabriel Bas

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7603 - 7603

Published: July 11, 2024

This article presents a groundbreaking perspective on carotenoids, focusing their innovative applications and transformative potential in human health medicine. Research jointly delves deeper into the bioactivity bioavailability of revealing therapeutic uses technological advances that have to revolutionize medical treatments. We explore pioneering which carotenoids are used treat chronic diseases such as cancer, cardiovascular disease, age-related macular degeneration, offering novel protective mechanisms benefits. Our study also shows cutting-edge innovations carotenoid extraction bioavailability, including development supramolecular carriers advanced nanotechnology, dramatically improve absorption efficacy these compounds. These not only ensure consistent quality but tailor therapies each patient's needs, paving way for personalized By integrating latest scientific discoveries techniques, this research provides prospective clinical establishing new benchmark future studies field. findings underscore importance optimizing extraction, administration, bioactivity, methods develop more effective, targeted, treatments, thus visionary insight modern practices.

Language: Английский

Citations

12
The immune landscape in apical periodontitis: From mechanism to therapy DOI Open Access
Yuan‐Hao Wen,

Yuxiu Lin,

Lu Zhou

et al.

International Endodontic Journal, Journal Year: 2024, Volume and Issue: 57(11), P. 1526 - 1545

Published: Aug. 1, 2024

Apical periodontitis (AP) is featured by a persistent inflammatory response and alveolar bone resorption initiated microorganisms, posing risks to both dental systemic health. Nonsurgical endodontic treatment the recommended plan for AP with high success rate, but in some cases, periapical lesions may persist despite standard treatment. Better comprehension of microenvironment can help develop adjunct therapies improve outcome This review presents an overview immune landscape AP, elucidating how microbial invasion triggers host activation shapes microenvironment, ultimately impacting homeostasis. The destructive effect excessive on tissues emphasized. aimed systematically discuss immunological basis cell network thereby providing insights into potential immunotherapeutic strategies such as targeted therapy, antioxidant adoptive therapy cytokine mitigate AP-associated tissue destruction.

Language: Английский

Citations

8
Humic acid from vermicompost effectively regulates the redox status and mitigates the progression of experimental periodontitis DOI

Hugo Giordano Tavares,

Patrícia Ribeiro Orlando,

Ramona Ramalho de Souza Pereira

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Language: Английский

Citations

1
The role of Nrf2 in periodontal disease by regulating lipid peroxidation, inflammation and apoptosis DOI Creative Commons

Fengyu Ma,

Shangdie Luo,

Chunting Lu

et al.

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: Nov. 22, 2022

Nuclear factor E2-related 2(Nrf2) is a transcription that mainly regulates oxidative stress in the body. It initiates expression of several downstream antioxidants, anti-inflammatory proteins and detoxification enzymes through Kelch-like ECH-associating protein 1 (Keap1) -nuclear -antioxidant response element (ARE) signaling pathway. Its anti-apoptosis, anti-oxidative effects have gradually become focus periodontal disease research recent years. In this paper, structure function Nrf2 pathway its mechanism action treatment periodontitis years were analyzed summarized, so as to further clarify relationship between occurrence development periodontitis, provide ideas for new drugs targeting

Language: Английский

Citations

28
Oxidative Stress and Natural Products in Orthodontic Treatment: A Systematic Review DOI Open Access
Francesco Inchingolo, Angelo Michele Inchingolo, G Latini

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 16(1), P. 113 - 113

Published: Dec. 28, 2023

In recent years, orthodontics, a specialized branch of dentistry, has evolved considerably in terms both techniques and materials used. Aimed at correcting dental malocclusions craniofacial anomalies, it improves the functionality aesthetics face oral cavity. However, orthodontic treatment, its developmental stages, may induce oxidative stress (O.S.) phenomena, with an increase production reactive oxygen species (ROS), damaging periodontal tissues involved, affecting short-, medium- long-term results. Studies on antioxidant effects natural products (e.g., resveratrol, green tea, turmeric, etc.) medical field have aroused considerable interest years. A systematic literature review was conducted PubMed, Scopus, Web Science databases using (N.P.s), O.S., as keywords. The study aims to consider determinants ROS occurring during treatment possibility being able control neutralize biochemical phenomena by restoring physiological process which balance between ability body’s system them is favor latter.

Language: Английский

Citations

21