Emerging variants of canine enteric coronavirus associated with seasonal outbreaks of severe canine gastroenteric disease DOI Creative Commons
Edward Cunningham-Oakes, Jack Pilgrim, Alistair C. Darby

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: Oct. 4, 2022

Abstract Canine enteric coronavirus (CECoV) variants have an emerging role in severe outbreaks of canine gastroenteritis. Here we used syndromic health data from a sentinel network UK veterinary practices to identify outbreak Affected dogs frequently presented with vomiting, diarrhoea and inappetence. Data diagnostic laboratories showed similar seasonal increases CECoV diagnosis. Membrane glycoprotein (M) gene sequence analysis implied wide geographical circulation new variant. Whole genome sequencing suggested the main circulating 2022 variant was most closely related one previously identified 2020 additional spike recombination; all were unrelated CECoV-like viruses recently associated human respiratory disease. Identifying factors that drive population-level evolution, its implications for host protection virulence, will be important understand health, may act as model population adaptation more widely.

Language: Английский

The Huanan Seafood Wholesale Market in Wuhan was the early epicenter of the COVID-19 pandemic DOI Creative Commons
Michael Worobey, Joshua I. Levy, Lorena M. Malpica Serrano

et al.

Science, Journal Year: 2022, Volume and Issue: 377(6609), P. 951 - 959

Published: July 26, 2022

Understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in 2019 is critical to preventing future zoonotic outbreaks before they become the next pandemic. The Huanan Seafood Wholesale Market Wuhan, China, was identified as a likely source of cases early reports, but later this conclusion became controversial. We show here that earliest known COVID-19 from December 2019, including those without reported direct links, were geographically centered on market. report live SARS-CoV-2–susceptible mammals sold at market late and within market, SARS-CoV-2–positive environmental samples spatially associated with vendors selling mammals. Although there insufficient evidence define upstream events, exact circumstances remain obscure, our analyses indicate emergence SARS-CoV-2 occurred through wildlife trade China epicenter

Language: Английский

Citations

338
The Emergence and Evolution of SARS-CoV-2 DOI
Edward C. Holmes

Annual Review of Virology, Journal Year: 2024, Volume and Issue: 11(1), P. 21 - 42

Published: April 18, 2024

The origin of SARS-CoV-2 has evoked heated debate and strong accusations, yet seemingly little resolution. I review the scientific evidence on its subsequent spread through human population. available data clearly point to a natural zoonotic emergence within, or closely linked to, Huanan Seafood Wholesale Market in Wuhan. There is no direct linking laboratory work conducted at Wuhan Institute Virology. global was characterized by gradual adaptation humans, with dual increases transmissibility virulence until Omicron variant. Of note been frequent transmission from humans other animals, marking it as strongly host generalist virus. Unless lessons are learned, inevitable that more events leading epidemics pandemics will plague populations.

Language: Английский

Citations

32
Genetic tracing of market wildlife and viruses at the epicenter of the COVID-19 pandemic DOI

Alexander Crits‐Christoph,

Joshua I. Levy, Jonathan E. Pekar

et al.

Cell, Journal Year: 2024, Volume and Issue: 187(19), P. 5468 - 5482.e11

Published: Sept. 1, 2024

Language: Английский

Citations

29
Wildlife trade is likely the source of SARS-CoV-2 DOI Open Access
Xiaowei Jiang, Ruoqi Wang

Science, Journal Year: 2022, Volume and Issue: 377(6609), P. 925 - 926

Published: Aug. 25, 2022

Multiple transmissions from wildlife at a market in Wuhan probably led to SARS-CoV-2 emergence

Language: Английский

Citations

23
Mitochondria in COVID-19: from cellular and molecular perspective DOI Creative Commons
Michał Rurek

Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15

Published: June 21, 2024

The rapid development of the COVID-19 pandemic resulted in a closer analysis cell functioning during β-coronavirus infection. This review will describe evidence for as syndrome with strong, albeit still underestimated, mitochondrial component. Due to sensitivity host mitochondria coronavirus infection, SARS-CoV-2 affects signaling, modulates immune response, modifies cellular energy metabolism, induces apoptosis and ageing, worsening symptoms which can sometimes be fatal. Various aberrations across human systems tissues their relationships were reported. In this review, particular attention is given characterization multiple alterations gene expression pattern metabolism COVID-19; complexity interactions between proteins presented. participation mitogenome fragments signaling occurrence subgenomic RNA within membranous compartments, including widely discussed. As severely quality system mitochondria, background dynamics additionally characterized. Finally, perspectives on mitigation by affecting biogenesis numerous compounds therapeutic treatments are briefly outlined.

Language: Английский

Citations

4
Lack of detection of SARS-CoV-2 in British wildlife 2020–21 and first description of a stoat (Mustela erminea) Minacovirus DOI
Ternenge Apaa, Amy J. Withers, Laura MacKenzie

et al.

Journal of General Virology, Journal Year: 2023, Volume and Issue: 104(12)

Published: Dec. 7, 2023

Repeat spillover of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into new hosts has highlighted the critical role cross-species transmission coronaviruses and establishment reservoirs virus in pandemic epizootic spread coronaviruses. Species particularly susceptible to SARS-CoV-2 include Mustelidae (mink, ferrets related animals), cricetid rodents (hamsters felids (domestic cats animals) white-tailed deer. These predispositions led us screen British wildlife with sarbecovirus-specific quantitative PCR pan assays for using samples collected during human establish if widespread was occurring. Fourteen species (

Language: Английский

Citations

11
An outbreak of canine coronavirus type 2 in captive snow leopards (Panthera uncia) demonstrates a possible role for felids as mixing vessels for alphacoronaviruses DOI Creative Commons
Ximena A. Olarte‐Castillo,

Abigail B. Schlecht,

Paul P. Calle

et al.

IJID One Health, Journal Year: 2025, Volume and Issue: unknown, P. 100057 - 100057

Published: March 1, 2025

Language: Английский

Citations

0
Genetic diversity of canine coronavirus identified in dogs in Yulin city, southern China DOI

Chun-Yang Lian,

Xin-Yan Yao,

Zhi-Hang Lv

et al.

Virology, Journal Year: 2025, Volume and Issue: unknown, P. 110528 - 110528

Published: April 1, 2025

Language: Английский

Citations

0
Emergence of Canine Parvovirus Type 2a and Canine Enteric Coronavirus in Diarrheal Outbreaks Among Farmed Raccoon Dogs in China DOI Creative Commons

Rongguang Lu,

Haixu Cao,

Wei Yang

et al.

Transboundary and Emerging Diseases, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Canine parvovirus (CPV) and canine enteric coronavirus (CCoV) are primary viral pathogens responsible for causing diarrhea in carnivores. CCoV infection generally induces mild enteritis, whereas infections solely by CPV or coinfections involving both frequently result severe can lead to fatal outcomes affected animals. This study investigated raccoon dogs farmed China between 2018 2023. Among the 133 small intestine tissue samples from with diarrhea, 107 of (80.5%) were nucleic acid positive, CPV‐2 CPV‐2a subtypes. The amplicons maintained I418T, S927A, T27S. Moreover, subtype possessed G300S, N562V, Y573F mutations compared dog‐ori CPV‐2a. 30 (22.6%) positive CCoV, containing CCoV‐IIa CCoV‐IIb Of these, 25 (83.3%) coinfected CCoV. In alone, inflammatory infiltration was observed lamina propria intestine. Immunohistochemical staining revealed that antigens mainly detected crypts Furthermore, coronavirus‐like particles samples. Next, we analyzed detailed binding model dog‐origin (RD‐ori) host aminopeptidase N (APN). receptor‐binding domain (RBD) RD‐ori showed robust dog APN but not human APN. Our results demonstrated emerging northern China. Further investigations should be performed monitor potential evolution recombination events CCoVs.

Language: Английский

Citations

0
Discovery and identification of a novel canine coronavirus causing a diarrhea outbreak in Vulpes DOI Creative Commons
Yuting Liu,

Yao Deng,

Sheng Niu

et al.

Science Bulletin, Journal Year: 2023, Volume and Issue: 68(21), P. 2598 - 2606

Published: Sept. 12, 2023

Cross-species transmission of viruses from wildlife animal reservoirs, such as bats, poses a threat to human and domestic health. Previous studies have shown that animals important roles intermediate hosts, enabling the genetically diverse coronaviruses natural hosts humans. Here, we report identification characterization novel canine coronavirus (VuCCoV), which caused an epidemic acute diarrhea in Vulpes (foxes) Shenyang, China. The started on November 8, 2019, more than 39,600 deaths by January 1, 2022. Full-length viral genomic sequences were obtained 15 foxes with at early stage this outbreak. VuCCoV genome shared 90% nucleotide identity (CCoV) for three four structural genes, S gene showing larger amount divergence. In addition, 67% (10/15) genomes contained open reading frame (ORF3) gene, was previously only detected CCoV-I genomes. Notably, had two amino acid differences partial RNA-dependent RNA polymerase (RdRp) level bat CoV, suggesting close genetic relationship. Therefore, these represent unsampled lineage CCoVs. We also show spike protein binds fox aminopeptidase N (APN), may allow serve entry receptor. cell lines identified are sensitive using pseudovirus system. These data highlight importance identifying diversity distribution animals, could mitigate future outbreaks threaten livestock, public health, economic growth.

Language: Английский

Citations

8