Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity

Signal Transduction and Targeted Therapy, Journal Year: 2021, Volume and Issue: 6(1)

Published: Dec. 16, 2021

Hydrogel is a type of versatile platform with various biomedical applications after rational structure and functional design that leverages on material engineering to modulate its physicochemical properties (e.g., stiffness, pore size, viscoelasticity, microarchitecture, degradability, ligand presentation, stimulus-responsive properties, etc.) influence cell signaling cascades fate. In the past few decades, plethora pioneering studies have been implemented explore cell-hydrogel matrix interactions figure out underlying mechanisms, paving way lab-to-clinic translation hydrogel-based therapies. this review, we first introduced hydrogels their fabrication approaches concisely. Subsequently, comprehensive description deep discussion were elucidated, wherein influences different behaviors cellular events highlighted. These or included integrin clustering, focal adhesion (FA) complex accumulation activation, cytoskeleton rearrangement, protein cyto-nuclei shuttling activation Yes-associated (YAP), catenin, etc.), compartment reorganization, gene expression, further biology modulation spreading, migration, proliferation, lineage commitment, etc.). Based them, current in vitro vivo hydrogel mainly covered diseases models, delivery protocols for tissue regeneration disease therapy, smart drug carrier, bioimaging, biosensor, conductive wearable/implantable biodevices, etc. summarized discussed. More significantly, clinical potential trials presented, accompanied which remaining challenges future perspectives field emphasized. Collectively, insights review will shed light principles new understand processes, are available providing significant indications serving broad range applications.

Language: Английский

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Natural Fiber-Reinforced Polycaprolactone Green and Hybrid Biocomposites for Various Advanced Applications

Polymers, Journal Year: 2022, Volume and Issue: 14(1), P. 182 - 182

Published: Jan. 3, 2022

Recent developments within the topic of biomaterials has taken hold researchers due to mounting concern current environmental pollution as well scarcity resources. Amongst all compatible biomaterials, polycaprolactone (PCL) is deemed be a great potential biomaterial, especially tissue engineering sector, its advantages, including biocompatibility and low bioactivity exhibition. The commercialization PCL infant technology despite advantages. This contributed disadvantages PCL, expensive, toxic, complex. Therefore, shift towards utilization an alternative biomaterial in development biocomposites been exponentially increased recent years. PCL-based are unique versatile equipped with several importance features. In addition, understanding on properties blend vital it influenced by application biocomposites. superior characteristics green hybrid expanded their applications, such biomedical field, medical implants. Thus, this review aimed critically discuss biocomposites, which cover each mechanical thermal applications. emergence nanomaterials reinforcement agent was also tackled issue review. On whole, applications reviewed.

Language: Английский

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Degradable Polymeric Bio(nano)materials and Their Biomedical Applications: A Comprehensive Overview and Recent Updates

Polymers, Journal Year: 2024, Volume and Issue: 16(2), P. 206 - 206

Published: Jan. 10, 2024

Degradable polymers (both biomacromolecules and several synthetic polymers) for biomedical applications have been promising very much in the recent past due to their low cost, biocompatibility, flexibility, minimal side effects. Here, we present an overview with updated information on natural degradable where a brief account different polysaccharides, proteins, viz. polyesters/polyamino acids/polyanhydrides/polyphosphazenes/polyurethanes relevant has provided. The various approaches transformation of these by physical/chemical means cross-linking, as polyblends, nanocomposites/hybrid composites, interpenetrating complexes, interpolymer/polyion functionalization, polymer conjugates, block graft copolymers, are described. degradation mechanism, drug loading profiles, toxicological aspects polymeric nanoparticles formed also defined. Biomedical polymer-based biomaterials wound dressing/healing, biosensors, delivery systems, tissue engineering, regenerative medicine, etc., highlighted. In addition, use such nano systems solve current problems is briefly reviewed.

Language: Английский

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Bringing innovative wound care polymer materials to the market: Challenges, developments, and new trends

Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 207, P. 115217 - 115217

Published: Feb. 27, 2024

Language: Английский

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Bone Tissue Engineering through 3D Bioprinting of Bioceramic Scaffolds: A Review and Update

Life, Journal Year: 2022, Volume and Issue: 12(6), P. 903 - 903

Published: June 16, 2022

Trauma and bone loss from infections, tumors, congenital diseases make repair regeneration the greatest challenges in orthopedic, craniofacial, plastic surgeries. The shortage of donors, intrinsic limitations, complications transplantation have led to more focus interest regenerative medicine. Structures that closely mimic tissue can be produced by this unique technology. steady development three-dimensional (3D)-printed engineering scaffold therapy has played an important role achieving desired goal. Bioceramic scaffolds are widely studied appear most promising solution. In addition, 3D printing technology simulate mechanical biological surface properties print with high precision complex internal external structures match their functional properties. Inkjet, extrusion, light-based among rapidly advancing bioprinting technologies. Furthermore, stem cell recently shown field, although large defects difficult fill injection alone. combination 3D-printed cells very results. Therefore, biocompatible artificial living is key element required for clinical applications where there a demand defect repair. emergence various advanced manufacturing technologies made form biomaterials functions, composition, structure diversified, manifold. importance article lies it aims briefly review main principles characteristics currently available methods orthopedic prepare bioceramic scaffolds, finally discuss prospects vital field.

Language: Английский

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A Review on Production, Characterization and Application of Bacterial Cellulose and Its Biocomposites

Journal of Polymers and the Environment, Journal Year: 2021, Volume and Issue: 29(9), P. 2738 - 2755

Published: Feb. 20, 2021

Language: Английский

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Collagen Stimulators in Body Applications: A Review Focused on Poly-L-Lactic Acid (PLLA)

Clinical Cosmetic and Investigational Dermatology, Journal Year: 2022, Volume and Issue: Volume 15, P. 997 - 1019

Published: June 1, 2022

Abstract: The number of aesthetic procedures performed worldwide continues to grow together with an increase in the population seeking restoration or preservation a youthful appearance. Requests for non-surgical body rejuvenation are increasing. Patients looking safe and effective minimally invasive procedures. Soft-tissue dermal fillers can meet these expectations. Based on beneficial outcomes treatments many facial areas, new trend is developing target areas. Different available include collagen stimulators initially developed restore volume. Furthermore, they associated long-lasting efficiency, high level patient satisfaction good safety profile, mainly minor adverse events reported. In appropriate conditions use, now used clinical practice. Their use expanding allows addressing various issues including volume loss, skin laxity, cellulite, striae distensae wrinkles. This review focuses poly-L-lactic acid (PLLA), first stimulator one most investigated off-facial applications. published data, although still limited, presented by area, neck chest, buttocks, abdomen, upper arms, thighs, knees, hands. Key features concerned zones main signs affecting part as well injection modalities provided along results. represents state art which base further developments necessary optimal treatment PLLA-based others this class rejuvenation. Keywords: acid, PLLA, augmentation, contouring, filler, stimulator, rejuvenation, quality

Language: Английский

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Strategies for improving the 3D printability of decellularized extracellular matrix bioink

Theranostics, Journal Year: 2023, Volume and Issue: 13(8), P. 2562 - 2587

Published: Jan. 1, 2023

3D bioprinting is a revolutionary technology capable of replicating native tissue and organ microenvironments by precisely placing cells into structures using bioinks.However, acquiring the ideal bioink to manufacture biomimetic constructs challenging.A natural extracellular matrix (ECM) an organ-specific material that provides physical, chemical, biological, mechanical cues are hard mimic small number components.Organ-derived decellularized ECM (dECM) has optimal properties.However, dECM always "non-printable" owing its poor properties.Recent studies have focused on strategies improve printability bioink.In this review, we highlight decellularization methods procedures used produce these bioinks, effective their printability, recent advances in regeneration dECM-based bioinks.Finally, discuss challenges associated with manufacturing bioinks potential large-scale applications.

Language: Английский

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Current State and Opportunities with Long-acting Injectables: Industry Perspectives from the Innovation and Quality Consortium “Long-Acting Injectables” Working Group

Pharmaceutical Research, Journal Year: 2023, Volume and Issue: 40(7), P. 1601 - 1631

Published: Feb. 22, 2023

Language: Английский

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Recent advances in biomaterials for tissue-engineered constructs: Essential factors and engineering techniques

Materials Today Chemistry, Journal Year: 2024, Volume and Issue: 37, P. 102016 - 102016

Published: April 1, 2024

Tissue-engineered constructs can replicate the structural and physiological properties of natural tissues. The be designed to address transplantation issues affected by shortage donor tissues organs. One major concerns in tissue engineering is design development structures that improve interaction between materials cells provide an ideal platform for form functional tissue. Several contributing factors need considered fabricate constructs, including biomaterials, biological, topographical, biophysical, morphological either alone or combination. Here, we review application, advancement, future directions these essential designing developing regeneration. In particular, focus on original approaches tools construct parameters engineering.

Language: Английский

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