Sustainability,
Journal Year:
2023,
Volume and Issue:
15(2), P. 892 - 892
Published: Jan. 4, 2023
Since
the
World
Health
Organization
(WHO)
declared
outbreak
of
severe
acute
respiratory
syndrome
COVID-19
virus
2
(COVID-19)
disease
(SARS-CoV-2)
on
9
January
2020,
entire
world
has
been
exceptionally
interested
in
examining
impact
this
pandemic
people
and
environment.
The
led
to
unprecedented
measures
halt
air
traffic
close
factories
due
lockdowns,
economic
closures,
stopping
transportation
all
kinds.
decline
use
coal
by
power
plants,
oil
refining,
steel
manufacturing
had
a
beneficial
effect
pollution
caused
decrease
carbon
dioxide
emissions.
Moreover,
concept
sustainability
become
more
prevalent,
reflecting
increasing
awareness
responsibility
placed
every
member
society.
Sustainability
is
quality
quantity
change
that
meets
our
needs
without
destroying
giving
planet,
which
hope
for
survival
future
generations.
We
summarized
discussed
studies
research
documenting
these
effects
environment
health
worldwide
come
up
with
objective
conclusions,
draw
some
recommendations
concepts
about
importance
sustainability.
significance
article
lies
it
aims
briefly
review
positive
negative
impacts
observed
reported
during
SARS-CoV-2
planet’s
duration
April
2020–October
2022,
finally
discuss
challenges
prospects
endorse
planet
While
many
recovery,
there
were
also
profound
itself.
Government
policymakers
must
take
prevent
environmental
healing
process
from
being
transient.
Journal of the European Ceramic Society,
Journal Year:
2023,
Volume and Issue:
44(1), P. 23 - 42
Published: Sept. 9, 2023
Bone
healing
is
an
impressive
ability
of
the
human
body,
but
critical-sized
bone
defects
require
external
intervention.
Bioceramic
scaffolds
with
excellent
biocompatibility
and
bioactivity
have
been
developed
to
treat
non-healing
because
their
unique
features
for
repair.
Meanwhile,
mechanical
properties
material
continue
be
disadvantageous.
This
review
focuses
on
(i)
essential
factors
in
affecting
improving
bioceramic-based
scaffolds'
properties,
including
porosity,
pore
size,
methods,
composition,
(ii)
summarizing
previous
studies
highlighting
strategies
fabricate
improved
such
as
using
nano-particles,
a
combination
bioceramics
polymers,
modifying
scaffold
surfaces.
Further
research
necessary
improve
bioceramic
repair
applications.
Acta Biomaterialia,
Journal Year:
2023,
Volume and Issue:
168, P. 1 - 21
Published: July 15, 2023
3D-printed
composite
scaffolds
have
emerged
as
an
alternative
to
deal
with
existing
limitations
when
facing
bone
reconstruction.
The
aim
of
the
study
was
systematically
review
feasibility
using
PLA/bioceramic
manufactured
by
3D-printing
technologies
grafting
materials
in
preclinical
vivo
studies.
Electronic
databases
were
searched
specific
search
terms,
and
thirteen
manuscripts
selected
after
screening.
synthesis
carried
out
mainly
extrusion-based
techniques.
Likewise,
hydroxyapatite
most
used
bioceramic
for
synthesizing
composites
a
PLA
matrix.
Among
studies,
seven
conducted
rats
six
rabbits,
but
high
variability
that
exists
regarding
experimental
process
made
it
difficult
compare
them.
Regarding
results,
PLA/Bioceramic
shown
be
biocompatible
mechanically
resistant.
Preclinical
studies
elucidated
ability
grafts,
allowing
growing
without
adverse
reactions.
In
conclusion,
PLA/Bioceramics
been
demonstrated
promising
treating
defects.
Nevertheless,
more
care
should
taken
designing
performing
trials,
since
lack
standardization
processes,
which
prevents
comparison
results
reduces
quality
information.
polylactic
acid/bioceramic
Since
animal
models
represent
mandatory
step
clinical
translation,
present
manuscript
analyzed
discussed
not
only
those
aspects
related
selection
material,
implants
their
characterization.
But
provides
new
approach
understand
how
design
perform
well
analysis
methods,
may
affect
obtained
covering
authors'
knowledgebase
from
veterinary
medicine
biomaterial
science.
Thus,
this
aims
trials.
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
31, P. 101531 - 101531
Published: Feb. 5, 2025
Three-dimensional
(3D)
printing
technology
has
shown
significant
promise
in
the
medical
field,
particularly
orthopedics,
prosthetics,
tissue
engineering,
and
pharmaceutical
preparations.
This
review
focuses
on
innovative
application
of
3D
addressing
challenges
osteonecrosis
femoral
head
(ONFH).
Unlike
traditional
hip
replacement
surgery,
which
is
often
suboptimal
for
younger
patients,
offers
precise
localization
necrotic
areas
ability
to
create
personalized
implants.
By
integrating
advanced
biomaterials,
this
a
promising
strategy
approach
early
hip-preserving
treatments.
Additionally,
3D-printed
bone
engineering
scaffolds
can
mimic
natural
environment,
promoting
regeneration
vascularization.
In
future,
potential
extends
combining
with
artificial
intelligence
optimizing
treatment
plans,
developing
materials
enhanced
bioactivity
compatibility,
translating
these
innovations
from
laboratory
clinical
practice.
demonstrates
how
uniquely
addresses
critical
ONFH
treatment,
including
insufficient
vascularization,
poor
mechanical
stability,
limited
long-term
success
conventional
therapies.
introducing
gradient
porous
scaffolds,
bioactive
material
coatings,
AI-assisted
design,
work
outlines
novel
strategies
improve
interventions.
These
advancements
not
only
enhance
efficacy
but
also
pave
way
findings
into
applications.
Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(2), P. 325 - 325
Published: Jan. 24, 2023
Bone
generally
displays
a
high
intrinsic
capacity
to
regenerate.
Nonetheless,
large
osseous
defects
sometimes
fail
heal.
The
treatment
of
such
segmental
still
represents
considerable
clinical
challenge.
regeneration
bone
often
proves
difficult,
since
it
relies
on
the
formation
amounts
within
an
environment
impedimental
osteogenesis,
characterized
by
soft
tissue
damage
and
hampered
vascularization.
Consequently,
research
efforts
have
concentrated
engineering
regenerative
medical
strategies
resolve
this
multifaceted
In
review,
we
summarize,
critically
evaluate,
discuss
present
approaches
in
light
their
relevance;
also
future
advanced
techniques
for
engineering,
outlining
steps
realize
translation
from
bench
bedside.
discussion
includes
physiology
healing,
requirements
properties
natural
synthetic
biomaterials
reconstruction,
use
conjunction
with
cellular
components
suitable
growth
factors,
improve
vascularization
these
concepts
vivo
applications.
We
conclude
that
ideal
all-purpose
material
scaffold-guided
is
currently
not
available.
It
seems
variety
different
solutions
will
be
employed,
according
necessary.
Journal of Advanced Ceramics,
Journal Year:
2023,
Volume and Issue:
12(9), P. 1671 - 1684
Published: July 17, 2023
In
bone
tissue
engineering,
scaffolds
with
excellent
mechanical
and
bioactive
properties
play
prominent
roles
in
space
maintaining
regeneration,
attracting
increasingly
interests
clinical
practice.
this
study,
strontium-incorporated
β-tricalcium
phosphate
(β-TCP),
named
Sr-TCP,
bioceramic
triply
periodic
minimal
surface
(TPMS)
structured
were
successfully
fabricated
by
digital
light
processing
(DLP)
based
3D
printing
technique,
achieving
high
porosity,
enhanced
strength
bioactivity.
The
Sr-TCP
first
characterized
element
distribution,
macro-
microstructure,
properties.
Notably,
the
compressive
of
reached
1.44
MPa
a
porosity
80%,
bringing
great
breakthrough
to
porous
scaffolds.
Furthermore,
also
facilitated
osteogenic
differentiation
mouse
osteoblastic
cell
line
(MC3T3-E1)
cells
both
gene
protein
aspects,
verified
alkaline
phosphatase
(ALP)
activity
polymerase
chain
reaction
(PCR)
assays.
Overall,
printed
TPMS
obtained
boosted
superior
bioactivity
at
same
time,
serving
as
promising
approach
for
regeneration.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Feb. 28, 2024
Abstract
The
clinical
standard
therapy
for
large
bone
defects,
typically
addressed
through
autograft
or
allograft
donor
tissue,
faces
significant
limitations.
Tissue
engineering
offers
a
promising
alternative
strategy
the
regeneration
of
substantial
lesions.
In
this
study,
we
harnessed
poly(ethylene
glycol)
(PEG)-based
hydrogels,
optimizing
critical
parameters
including
stiffness,
incorporation
arginine-glycine-aspartic
acid
(RGD)
cell
adhesion
motifs,
degradability,
and
release
BMP2
to
promote
formation.
vitro
demonstrated
that
human
marrow
derived
stromal
(hBMSC)
proliferation
spreading
strongly
correlates
with
hydrogel
stiffness
RGD
peptide
motifs.
Moreover,
osteogenic
growth
factor
into
hydrogels
enabled
sustained
release,
effectively
inducing
in
encapsulated
progenitor
cells.
When
used
vivo
treat
calvarial
defects
rats,
showed
low
intermediate
optimally
facilitated
migration,
proliferation,
differentiation
promoting
efficient
repair
defects.
Our
comprehensive
findings
collectively
suggest
developed
hold
promise
translation
by
delivering
controlled
stimuli
from
active
signaling
molecules.
Biomimetics,
Journal Year:
2024,
Volume and Issue:
9(3), P. 153 - 153
Published: March 1, 2024
The
rehabilitation
of
alveolar
bone
defects
moderate
to
severe
size
is
often
challenging.
Currently,
the
therapeutic
approaches
used
include,
among
others,
guided
regeneration
technique
combined
with
various
grafts.
Although
these
techniques
are
widely
applied,
several
limitations
and
complications
have
been
reported
such
as
morbidity,
suboptimal
graft/membrane
resorption
rate,
low
structural
integrity,
dimensional
stability.
Thus,
development
biomimetic
scaffolds
tailor-made
characteristics
that
can
modulate
cell
tissue
interaction
may
be
a
promising
tool.
This
article
presents
critical
consideration
in
scaffold’s
design
while
also
providing
information
on
fabrication
methods
nanosystems.
Their
utilization
delivery
systems
will
mentioned.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: March 11, 2024
Abstract
Bone
tissue
engineering
scaffolds
may
provide
a
potential
strategy
for
onlay
bone
grafts
oral
implants.
For
determining
the
fate
of
scaffold
biomaterials
and
osteogenesis
effects,
host
immune
response
is
crucial.
In
present
study,
bredigite
(BRT)
bioceramic
with
an
ordered
arrangement
structure
(BRT-O)
random
morphology
(BRT-R)
were
fabricated.
The
physicochemical
properties
first
characterized
by
scanning
electron
microscopy,
mechanical
test
micro-Fourier
transform
infrared
spectroscopy.
addition,
their
osteogenic
immunomodulatory
in
grafting
model
investigated.
vitro,
BRT-O
facilitated
macrophage
polarization
towards
pro-regenerative
M2
phenotype,
which
subsequently
migration
differentiation
marrow-derived
mesenchymal
stem
cells.
vivo,
was
successfully
established
cranium
rabbits.
grafted
on
rabbit
promoted
regeneration
CD68
+
CD206
polarization.
conclusion,
3D-printed
presents
as
promising
biomaterial
regulating
local
microenvironment.
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