Effects of Taekwondo training on thigh muscle cross-sectional area, health-related physical fitness, HbA1c, and GLP-1 in sedentary older women DOI Creative Commons
Jae‐Hyun Park, Bong‐Jo Kim, Minki Jeong

et al.

Frontiers in Sports and Active Living, Journal Year: 2025, Volume and Issue: 7

Published: April 3, 2025

Background Sedentary lifestyles in older individuals are associated with reduced physical function and an increased risk of metabolic diseases such as type 2 diabetes. Physical exercise can enhance muscle mass, insulin sensitivity, health. Taekwondo, a martial art that integrates both aerobic resistance components, may improve strength, balance, health individuals. This study investigated the effect long-term Taekwondo training on thigh cross-sectional area, related fitness, indicators sedentary women. Methods Seventeen participants (aged 65 years older, time 8 h more per day) were randomly assigned to group ( n = 9) control 8). Outcomes, including health-related Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), Glucagon-like peptide-1 (GLP-1) measured before after program. The underwent 60 min training, three times week 12 weeks. Variable changes over between groups analyzed using two-way repeated measures ANOVA performed significant interactions. Results exhibited reduction body weight, mass index, fat, mean arterial blood pressure p < 0.05), well lean lower limb 0.05). Improvements balance gait speed, stride observed indicating fall enhanced mobility. Laboratory analyses revealed triglyceride free fatty acids elevated HDL-cholesterol GLP-1 levels Increased area was inversely correlated fasting glucose, insulin, HOMA-IR, suggesting improved sensitivity glucose regulation. Conclusion Long-term fitness markers women, providing evidence its use effective intervention promote this population.

Language: Английский

Impaired skeletal muscle regeneration in diabetes: From cellular and molecular mechanisms to novel treatments DOI Creative Commons
Ever Espino‐Gonzalez, Emilie Dalbram, Rémi Mounier

et al.

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(6), P. 1204 - 1236

Published: March 14, 2024

Diabetes represents a major public health concern with considerable impact on human life and healthcare expenditures. It is now well established that diabetes characterized by severe skeletal muscle pathology limits functional capacity quality of life. Increasing evidence indicates also one the most prevalent disorders impaired regeneration, yet underlying mechanisms therapeutic treatments remain poorly established. In this review, we describe cellular molecular alterations currently known to occur during regeneration in people animal models diabetes, including its associated comorbidities, e.g., obesity, hyperinsulinemia, insulin resistance. We role myogenic non-myogenic cell types conditions or without diabetes. Therapies for gaps our knowledge are discussed, while proposing future directions field.

Language: Английский

Citations

24
The Vicious Cycle of Type 2 Diabetes Mellitus and Skeletal Muscle Atrophy: Clinical, Biochemical, and Nutritional Bases DOI Open Access
José M. López-Pedrosa,

María Camprubí-Robles,

Germán Guzmán-Rolo

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(1), P. 172 - 172

Published: Jan. 4, 2024

Today, type 2 diabetes mellitus (T2DM) and skeletal muscle atrophy (SMA) have become increasingly common occurrences. Whether the onset of T2DM increases risk SMA or vice versa has long been under investigation. Both conditions are associated with negative changes in health, which can, turn, lead to impaired physical function, a lowered quality life, an increased mortality. Poor nutrition can exacerbate both SMA. linked by vicious cycle events that reinforce worsen each other. Muscle insulin resistance appears be pathophysiological link between To explore this association, our review (i) compiles evidence on clinical association SMA, (ii) reviews mechanisms underlying biochemical muscles people at (iii) examines how nutritional therapy activity as muscle-targeted treatments benefit population. Based evidence, we conclude effective treatment patients T2DM-SMA depends restoration maintenance mass. We thus propose regular intake key functional nutrients, along guidance for activity, help maintain euglycemia improve status all

Language: Английский

Citations

20
The growing range of complications of diabetes mellitus DOI
Peter Shane Hamblin, Anthony Russell, Stella Talic

et al.

Trends in Endocrinology and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

2
Role of Cognitive Frailty in Older Adults With Cardiovascular Disease DOI Creative Commons

Naila Ijaz,

Yasser Jamil, Charles H. Brown

et al.

Journal of the American Heart Association, Journal Year: 2024, Volume and Issue: 13(4)

Published: Feb. 14, 2024

As the older adult population expands, an increasing number of patients affected by geriatric syndromes are seen cardiovascular clinicians. One such syndrome that has been associated with poor outcomes is cognitive frailty: simultaneous presence impairment, without evidence dementia, and physical frailty, which results in decreased reserve. Driven common pathophysiologic underpinnings (eg, inflammation neurohormonal dysregulation), disease, frailty also share following risk factors: hypertension, diabetes, obesity, sedentary behavior, tobacco use. Cardiovascular disease onset progression may be reversible early stages, making it essential for clinicians to diagnose condition a timely manner prescribe appropriate interventions. Additional research required elucidate mechanisms underlying development establish preventive therapeutic strategies address needs at ultimately facilitate targeted intervention studies.

Language: Английский

Citations

12
Mitochondrial involvement in sarcopenia DOI Creative Commons
Charles Affourtit, Jane E. Carré

Acta Physiologica, Journal Year: 2024, Volume and Issue: 240(3)

Published: Feb. 2, 2024

Abstract Sarcopenia lowers the quality‐of‐life for millions of people across world, as accelerated loss skeletal muscle mass and function contributes to both age‐ disease‐related frailty. Physical activity remains only proven therapy sarcopenia date, but alternatives are much sought after manage this progressive disorder in individuals who unable exercise. Mitochondria have been widely implicated etiology increasingly suggested attractive therapeutic targets help restore perturbed balance between protein synthesis breakdown that underpins atrophy. Reviewing current literature, we note mitochondrial bioenergetic changes generally interpreted intrinsic dysfunction renders cells incapable making sufficient ATP fuel synthesis. Based on reported effects interventions, however, argue observed may instead reflect an adaptation pathologically decreased energy expenditure sarcopenic muscle. Discrimination these mechanistic possibilities will be crucial improving management sarcopenia.

Language: Английский

Citations

10
Mitochondrial bioenergetics, metabolism, and beyond in pancreatic β-cells and diabetes DOI Creative Commons

Alejandra María Rivera Nieves,

Brian Michael Wauford,

Accalia Fu

et al.

Frontiers in Molecular Biosciences, Journal Year: 2024, Volume and Issue: 11

Published: Feb. 9, 2024

In Type 1 and 2 diabetes, pancreatic β-cell survival function are impaired. Additional etiologies of diabetes include dysfunction in insulin-sensing hepatic, muscle, adipose tissues as well immune cells. An important determinant metabolic health across these various is mitochondria structure. This review focuses on the role pathogenesis, with a specific emphasis β-cells. These dynamic organelles obligate for survival, function, replication, insulin production, control over release. Therefore, it not surprising that severely defective diabetic contexts. Mitochondrial poses challenges to assess cause-effect studies, prompting us assemble deliberate evidence cause or consequence diabetes. Understanding precise molecular mechanisms underlying mitochondrial identifying therapeutic strategies restore homeostasis enhance active expanding areas research. summary, this examines multidimensional focusing β-cells highlighting significance metabolism, bioenergetics, calcium, dynamics, mitophagy pathophysiology We describe effects diabetes-related gluco/lipotoxic, oxidative inflammation stress mitochondria, played by pathologic outcomes paradigms. By examining aspects, we provide updated insights highlight where further research required deeper understanding

Language: Английский

Citations

9
Role of Medical Nutrition Therapy as Treatment of Sarcopenia in Older People with Type 2 Diabetes DOI Open Access
Alessia Gaglio, Valeria Grancini, Federico Giacchetti

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(1), P. 172 - 172

Published: Jan. 2, 2025

Background: Globally, the progressive increase in aging population has led to social and health problems associated with age-related chronic diseases, such as type 2 diabetes mellitus (T2DM) sarcopenia. Recent studies have highlighted that sarcopenia a bidirectional relationship. Nutritional therapy is key element treatment of both diabetes. To date, there are no nutritional guidelines for management T2DM. The aim this study was evaluate efficacy muscle-targeted intervention older people based on Italian nutrition guidelines. Methods: A total 211 subjects (117 M 94 F) affected by T2DM mean age 74 ± 6.0 years were screened sarcopenia, using EWGSOP2 diagnosis criteria, enrolled receive personalized dietary plans two main targets: daily energy intake 25–30 kcal/kg body weight protein at least 1.1–1.2 g/kg weight. Results: In total, 34 (24 10 sarcopenic prevalence 16%, which higher men. After six months treatment, handgrip strength increased 0.83 kg (19.57 5.70 vs. 20.40 6.10 kg, p = 0.649), improved (0.91 0.28 1.03 0.40 weight, 0.115), glycated hemoglobin decreased (7.39 0.49% 6.82 0.98%, 0.010). Seven younger had an improvement decrease HbA1c (7.50 0.59% 6.91 0.79, 0.19). difference over time consumption saturated fatty acids (OR 0.6, 95% CI 0.33–1.09, 0.096) simple sugars 0.91, 0.80–1.01, 0.090) appeared be status. 177 did not meet criteria 148 assessed. (26.22 9.36 26.18 9.24 p0.974) (7.21 1.07 7.27 0.735) remained stable time, while (0.81 0.29 0.91 0.024). Four diagnosed follow-up, lower test result. These worse glycemic control (HbA1c + 0.5%). Conclusions: Lifestyle modification important prevent or reverse development disease. therefore aimed meeting all needs promoting better control, terms hemoglobin, order reduce Although promising, requires validation larger groups.

Language: Английский

Citations

1
Respiratory sarcopenia: A scoping review of the current literature DOI
Raju Vaishya, Anoop Misra, Mahmoud Nassar

et al.

International Journal of Diabetes in Developing Countries, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Language: Английский

Citations

1
The efficacy of resistance exercise training on metabolic health, body composition, and muscle strength in older adults with type 2 diabetes: A systematic review and Meta-Analysis DOI
Miaolin Feng,

Luyan Gu,

Yan Zeng

et al.

Diabetes Research and Clinical Practice, Journal Year: 2025, Volume and Issue: unknown, P. 112079 - 112079

Published: March 1, 2025

Language: Английский

Citations

1
Optimizing Nutritional Care with Machine Learning: Identifying Sarcopenia Risk Through Body Composition Parameters in Cancer Patients—Insights from the NUTritional and Sarcopenia RIsk SCREENing Project (NUTRISCREEN) DOI Open Access
Giuseppe Porciello,

Teresa Di Lauro,

Assunta Luongo

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1376 - 1376

Published: April 18, 2025

Background/Objectives: Cancer and related treatments can impair body composition (BC), increasing the risk of malnutrition sarcopenia, poor prognosis, Health-Related Quality Life (HRQoL). To enhance BC parameter interpretation through Bioelectrical Impedance Analysis (BIA), we developed a predictive model based on unsupervised approaches including Principal Component (PCA) k-means clustering for sarcopenia in cancer patients at Istituto Nazionale Tumori IRCCS “Fondazione G. Pascale” (Naples). Methods: Sarcopenia risks were assessed using NRS-2002 SARC-F questionnaires, anthropometric measurements, BIA. HRQoL was evaluated with EORTC QLQ-C30 questionnaire. PCA analysis performed to identify different profiles. Results: Data from 879 (mean age: 63 ± 12.5 years) collected: 117 (13%) 128 (15%) respectively. identified three main components, determined clusters, namely HMP (High Muscle Profile), MMP (Moderate LMP (Low Profile). Patients older, higher prevalence comorbidities, malnutrition, sarcopenia. In multivariable analysis, age, lung site, diabetes, significantly associated an increased sarcopenia; among had (+62%, p = 0.006). Conclusions: The NUTRISCREEN project, part ONCOCAMP study (ClinicalTrials.gov ID: NCT06270602), provides personalized nutritional pathway early screening Using approach, provide distinct profiles valuable insights into factors risk. This approach clinical practice could help define categories, ensure most appropriate strategies, improve patient outcomes by providing data-driven care.

Language: Английский

Citations

1