Advances in Nanotechnology for Biofilm Inhibition

ACS Omega, Journal Year: 2023, Volume and Issue: 8(24), P. 21391 - 21409

Published: June 7, 2023

Biofilm-associated infections have emerged as a significant public health challenge due to their persistent nature and increased resistance conventional treatment methods. The indiscriminate usage of antibiotics has made us susceptible range multidrug-resistant pathogens. These pathogens show reduced susceptibility intracellular survival. However, current methods for treating biofilms, such smart materials targeted drug delivery systems, not been found effective in preventing biofilm formation. To address this challenge, nanotechnology provided innovative solutions formation by clinically relevant Recent advances nanotechnological strategies, including metallic nanoparticles, functionalized dendrimers, polymeric cyclodextrin-based delivery, solid lipid polymer conjugates, liposomes, may provide valuable technological against infectious diseases. Therefore, it is imperative conduct comprehensive review summarize the recent advancements limitations advanced nanotechnologies. present Review encompasses summary agents, mechanisms that lead formation, impact on human health. In nutshell, offers survey managing infections. A detailed presentation how these strategies improve control prevent key objective mechanisms, applications, prospects nanotechnologies better understanding

Language: Английский

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Staphylococcus aureus biofilm: Formulation, regulatory, and emerging natural products-derived therapeutics

Biofilm, Journal Year: 2024, Volume and Issue: 7, P. 100175 - 100175

Published: Jan. 1, 2024

Staphylococcus aureus can readily form biofilm which enhances the drug-resistance, resulting in life-threatening infections involving different organs. Biofilm formation occurs due to a series of developmental events including bacterial adhesion, aggregation, maturation, and dispersion, are controlled by multiple regulatory systems. Rapidly increasing research development outcomes on natural products targeting S. and/or regulation led an emergent application active phytochemicals combinations. This review aimed at providing in-depth understanding mechanisms for aureus, outlining most important antibiofilm strategies potential targets products, summarizing latest progress combating with plant-derived products. These findings provided further evidence novel drugs clinical therapies.

Language: Английский

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Molecular Aspects of the Functioning of Pathogenic Bacteria Biofilm Based on Quorum Sensing (QS) Signal-Response System and Innovative Non-Antibiotic Strategies for Their Elimination

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2655 - 2655

Published: Feb. 24, 2024

One of the key mechanisms enabling bacterial cells to create biofilms and regulate crucial life functions in a global highly synchronized way is communication system called quorum sensing (QS). QS cell-to-cell process that depends on population density mediated by small signalling molecules autoinducers (AIs). In bacteria, controls biofilm formation through regulation gene expression involved extracellular polymeric matrix (EPS) synthesis, virulence factor production, stress tolerance metabolic adaptation. Forming one antimicrobial resistance (AMR). A common feature human pathogens ability form biofilm, which poses serious medical issue due their high susceptibility traditional antibiotics. Because associated with formation, there belief inhibition activity quenching (QQ) may provide alternative therapeutic methods for treating microbial infections. This review summarises recent progress research, focusing biofilms, especially those formed pathogenic become resistant antibiotic treatment. Subsequently, potential approach highlighting innovative non-antibiotic strategies control AMR bacteria has been discussed.

Language: Английский

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Efflux pumps and microbial biofilm formation

Infection Genetics and Evolution, Journal Year: 2023, Volume and Issue: 112, P. 105459 - 105459

Published: June 2, 2023

Biofilm-related infections are resistant forms of pathogens that regarded as a medical problem, particularly due to the spread multiple drug resistance. One factors associated with biofilm resistance is presence various types efflux pumps in bacteria. Efflux also play role formation by influencing Physical-chemical interactions, mobility, gene regulation, quorum sensing (QS), extracellular polymeric substances (EPS), and toxic compound extrusion. According findings studies based on pump expression analysis, their anatomical position within will differ depending stage, encoding level, type concentration substrate. In some cases, function can overlap each other, so it seems necessary accurate identify biofilm-forming bacteria along this process. Such help choose treatment strategy, at least combination antibiotics. Furthermore, if goal an manipulation, we should not limit inhibition.

Language: Английский

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Microbial Biofilms: Applications, Clinical Consequences, and Alternative Therapies

Microorganisms, Journal Year: 2023, Volume and Issue: 11(8), P. 1934 - 1934

Published: July 29, 2023

Biofilms are complex communities of microorganisms that grow on surfaces and embedded in a matrix extracellular polymeric substances. These prevalent various natural man-made environments, ranging from industrial settings to medical devices, where they can have both positive negative impacts. This review explores the diverse applications microbial biofilms, their clinical consequences, alternative therapies targeting these resilient structures. We discussed beneficial including role wastewater treatment, bioremediation, food industries, agriculture, biotechnology. Additionally, we highlighted mechanisms biofilm formation consequences biofilms context human health. also focused association with antibiotic resistance, chronic infections, device-related infections. To overcome challenges, therapeutic strategies explored. The examines potential antimicrobial agents, such as peptides, quorum-sensing inhibitors, phytoextracts, nanoparticles, biofilms. Furthermore, highlight future directions for research this area phytotherapy prevention treatment biofilm-related infections settings.

Language: Английский

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Multifunctional nanocomposites integrated green synthesized amphiphilic chitosan/thyme extract/nanosilver for antimicrobial and anti-biofilm applications

Reactive and Functional Polymers, Journal Year: 2023, Volume and Issue: 194, P. 105791 - 105791

Published: Nov. 20, 2023

Language: Английский

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The Antimicrobial Potency of Mesoporous Silica Nanoparticles Loaded with Melissa officinalis Extract

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(4), P. 525 - 525

Published: April 10, 2024

Melissa officinalis is an important medicinal plant that used and studied intensively due to its numerous pharmacological effects. This has active compounds with biomedical potential; some are volatile, while others sensitive heat or oxygen. Therefore, increase stability prolong biological activities, the natural extract can be loaded into various nanostructured systems. In this study, different loading systems were obtained from mesoporous silica, like Mobile Composition of Matter family (MCM) a hexagonal (MCM-41) cubic (MCM-48) pore structure, simple functionalized amino groups (using 3-aminopropyl) such as triethoxysilane (APTES). Thus, four materials characterized morphological structural points view by scanning electron microscopy, BET analysis adsorption–desorption isotherms, Fourier-transform infrared spectroscopy (FTIR) thermogravimetric coupled differential calorimetry. Natural was concentrated analyzed High-Performance Liquid Chromatography identify polyphenolic compounds. The tested against Gram-negative bacteria yeasts both reference strains clinical belonging Gram-positive previously isolated intra-hospital infections. highest antimicrobial efficiency found fungal strains. Good activity also recorded methicillin-resistant S. aureus, inhibiting production virulence factors.

Language: Английский

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A hope for ineffective antibiotics to return to treatment: investigating the anti-biofilm potential of melittin alone and in combination with penicillin and oxacillin against multidrug resistant-MRSA and -VRSA

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Feb. 1, 2024

The emergence and rapid spread of multi-drug resistant (MDR) bacterial strains, such as methicillin-resistant

Language: Английский

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Applications of Antimicrobial Photodynamic Therapy in Aquaculture: Effect on Fish Pathogenic Bacteria

Fishes, Journal Year: 2024, Volume and Issue: 9(3), P. 99 - 99

Published: March 5, 2024

Increased infectious diseases and the reduced effectiveness of antibiotics due to antimicrobial resistance pose global challenges affecting aquaculture industry. As bacteria increasingly develop antibiotic resistance, research scientists are shifting their focus technologies such as photodynamic therapy (aPDT), which show potential for treating controlling fish infections without promoting development resistant bacteria. Various photosensitizers (PSs), both natural synthetic, under investigation application in aPDT within This shift is crucial sustainability industry, plays a significant role achieving several United Nations (UN) Sustainable Development Goals (SDGs). review highlights against pathogens industry types PSs utilized. It also explores this technique infections, along with advantages limitations its use production systems. Finally, conclusion future perspectives provided.

Language: Английский

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Application of metal–organic framework materials in regenerative medicine

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(35), P. 8543 - 8576

Published: Jan. 1, 2024

Applications of nano-MOFs in bone tissue engineering, wound healing, and others, including periodontitis, tendon repair, nerve cardiovascular disease. Created with BioRender.com.

Language: Английский

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