Ameliorating role of Tetrastigma hemsleyanum polysaccharides in antibiotic-induced intestinal mucosal barrier dysfunction in mice based on microbiome and metabolome analyses

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 241, P. 124419 - 124419

Published: April 18, 2023

Language: Английский

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Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections and gut microbiota composition: what do we know?

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 6, 2025

Post-streptococcal autoimmune neuropsychiatric disorders (PANDAS) are a group of pathological condition characterized by sudden-onset obsessive-compulsive and tic following beta-hemolytic Streptococcus A (GAS) infection, hypothesized to be caused mechanisms targeting the basal ganglia. Scant literature is available regarding microbiota composition in children with PANDAS, however few studies support hypothesis that streptococcal infections may alter gut these patients, leading chronic inflammation impact brain function behavior. Notable changes include reduced microbial diversity shifts bacterial populations, which affect metabolic functions crucial for neuroinflammation. Elevated serum levels sNOX2-dp isoprostanes indicate oxidative stress, while presence lipopolysaccharides (LPS) contribute The aim this narrative review explore link between PANDAS composition. potential connection symptoms might suggest importance dietary interventions, such as promoting Mediterranean diet fiber intake, reduce inflammatory state patients therefore improve their outcome.

Language: Английский

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Glycerol Monolaurate Complex Improved Antioxidant, Anti-Inflammation, and Gut Microbiota Composition of Offspring in a Sow–Piglet Model

Veterinary Sciences, Journal Year: 2025, Volume and Issue: 12(1), P. 24 - 24

Published: Jan. 7, 2025

This study aimed to investigate the effects of maternal glycerol monolaurate complex (GML) and antibiotic (acetylisovaleryltylosin tartrate, ATLL) supplementation during late gestation lactation on reproductive performance sows growth piglets. In total, 64 pregnant were randomly divided into control, antibiotic, 0.1% GML, 0.2% GML groups. The shortened their delivery interval farrowing duration. ATLL increased level malondialdehyde (MDA) in piglets enhanced glutathione peroxidase (GSH-Px) piglets, while reducing tumor necrosis factor-α (TNF-α) sows. tended increase milk protein colostrum decreased TNF-α at lactation. Meanwhile, serum total superoxide dismutase (T-SOD) activity interleukin-6 weaned Furthermore, microbial diversity sows, group had an relative abundance Bacteroidota Peptostreptococcales-Tissierellales, Proteobacteria, harmful bacteria Romboutsia Compared with group, reduced Interestingly, both Peptostreptococcaceae Correlation analysis also found positive anti-inflammatory antioxidant aspects. conclusion, by improving status maintaining intestinal flora balance, making it a promising alternative future applications.

Language: Английский

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Comparison of short-term and long-term effects of peroral L-carnitine intake: clinical implications of elevated TMAO levels in cardiovascular complications

Published: Feb. 10, 2025

L-Carnitine (LC) is integral to energy production and fatty acid metabolism, facilitating the transport of long-chain acids into mitochondria for β-oxidation. It modulates metabolic pathways, including pyruvate dehydrogenase activity, proteolysis, protein synthesis, while also having anti-inflammatory antioxidant characteristics. LC can be commonly applied win battle against HIV cancer cachexia. Also, it recruited with aim improving physical cognitive functions in athletes elderly. Despite these benefits, long-term administration has been associated cardiovascular risks due its conversion trimethylamine-N-oxide (TMAO) by gut microbiota. Elevated TMAO levels are linked atherosclerosis, oxidative stress, an increased risk disease, diabetes, chronic kidney disease. Managing using dietary treatments microbiota-targeting techniques, such as probiotics, may reduce risks. This comprehensive review presents state-of-the-art information on LC’s dual role, emphasizing balance between therapeutic potential prolonged supplementation. aims guide clinicians researchers optimizing benefits addressing long term safety concerns.

Language: Английский

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Doxycycline degradation by Enterobacter cloacae HS-08: A comparative analysis of biodegradation and bio-electrodegradation approaches with toxicity implications

Journal of Environmental Management, Journal Year: 2025, Volume and Issue: 381, P. 125212 - 125212

Published: April 7, 2025

Language: Английский

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Ceftriaxone alters the gut microbiome composition and reduces alcohol intake in male and female Sprague–Dawley rats

Alcohol, Journal Year: 2024, Volume and Issue: 120, P. 169 - 178

Published: Jan. 28, 2024

Language: Английский

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Restrictive Versus Permissive Use of Broad-spectrum Antibiotics in Patients Receiving Allogeneic Stem Cell Transplantation and With Early Fever Due to Cytokine Release Syndrome: Evidence for Beneficial Microbiota Protection Without Increase in Infectious Complications

Clinical Infectious Diseases, Journal Year: 2023, Volume and Issue: 77(10), P. 1432 - 1439

Published: June 30, 2023

Abstract Background Intestinal microbiome contributes to the pathophysiology of acute gastrointestinal (GI) graft-versus-host disease (GvHD) and loss diversity influences outcome patients after allogeneic stem cell transplantation (SCT). Systemic broad-spectrum antibiotics have been identified as a major cause early intestinal dysbiosis. Methods In 2017, our transplant unit at university hospital in Regensburg changed antibiotic strategy from permissive way with initiation all neutropenic fever independent underlying risk restrictive use cases high likelihood cytokine release syndrome (eg, anti-thymocyte globulin [ATG] therapy). We analyzed clinical data parameters obtained 7 days SCT 188 ATG therapy transplanted 2015/2016 (permissive cohort, n = 101) 2918/2019 (restrictive 87). Results Restrictive treatment postponed beginning administration 1.4 ± 7.6 prior 1.7 5.5 (P .01) significantly reduced duration by 5.8 < .001) without increase infectious complications. Furthermore, we observed beneficial effects compared on (urinary 3-indoxylsulfate, P .01; Shannon Simpson indices, species abundance post-transplant well positive trend toward incidence severe GI GvHD .1). Conclusions Our indicate that microbiota protection can be achieved more careful selection qualifying for during increased

Language: Английский

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Oral Administration of Lactobacillus acidophilus LA5 Prevents Alveolar Bone Loss and Alters Oral and Gut Microbiomes in a Murine Periodontitis Experimental Model

Microorganisms, Journal Year: 2024, Volume and Issue: 12(6), P. 1057 - 1057

Published: May 24, 2024

Periodontitis is a destructive inflammatory response triggered by dysbiosis. Lactobacillus acidophilus LA5 (LA5) may impair microbial colonization and alter the host. Thus, we evaluated effect of on alveolar bone loss in periodontitis murine model investigated its oral gut microbiomes. Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum, Streptococcus gordonii were inoculated C57BL/6 mice (P+), with (L+). SHAM infected controls (P- and/or L- groups) also evaluated. After 45 days, maxilla microbiomes determined. The administration controlled consortium-induced loss. Periodontopathogens infection resulted shifts consistent dysbiosis, reshaped these changes. microbiome P+L- group showed increased abundance Enterococaccea, Streptoccocaceae, Staphylococcaceae, Moraxellaceae, Pseudomonadaceae, which attenuated to (P+L+). otherwise non-infected superphylum Patescibacteria family Saccharamonadaceae gut. These data indicate L. as candidate probiotic for control periodontitis.

Language: Английский

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Alterations in gut microbiota and inflammatory cytokines after administration of antibiotics in mice

Microbiology Spectrum, Journal Year: 2024, Volume and Issue: 12(8)

Published: June 20, 2024

ABSTRACT Antibiotics are widely used to treat bacterial infection and reduce the mortality rate, while antibiotic overuse can cause gut microbiota dysbiosis. The impact of antibiotics on is not fully understood. In our study, four commonly (ceftazidime, cefoperazone-sulbactam, imipenem-cilastatin, moxifloxacin) were given subcutaneously mice, their impacts composition serum cytokine levels evaluated through 16S rRNA analysis a multiplex immunoassay. Antibiotic treatment markedly reduced diversity changed composition. significantly increased decreased abundance Firmicutes Bacteroidota, respectively. treatments opportunistic pathogens such as Enterococcus that Lachnospiraceae Muribaculaceae . For moxifloxacin, high Klebsiella was observed after 14 21 days treatment. However, relatively low found imipenem-cilastatin Additionally, various pro-inflammatory cytokines, IL-1β, IL-12 (p70), IL-17, treatments. Overall, these results provide guide for rational use in clinical settings: short-term moxifloxacin recommended with regard health, 14-day may have less severe than other antibiotics. IMPORTANCE directly associated changes effective against both beneficial bacteria. Gut dysbiosis induced by could increase risk some diseases. Therefore, an adequate understanding crucial. this we investigated effects continuous microbiota, intestinal inflammatory response. Our suggest recommended, effect health cefoperazone-sulbactam. These useful guidance health.

Language: Английский

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Long-term effects on liver metabolism induced by ceftriaxone sodium pretreatment

Environmental Pollution, Journal Year: 2023, Volume and Issue: 335, P. 122238 - 122238

Published: July 26, 2023

Language: Английский

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