Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 181, P. 19 - 45
Published: May 8, 2024
Language: Английский
Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13
Published: June 30, 2022
Different stimuli can polarize macrophages into two basic types, M1 and M2. Tumor-associated (TAMs) in the tumor microenvironment (TME) are composed of heterogeneous subpopulations, which include anti-tumor M2 pro-tumor phenotypes. TAMs predominantly play a M2-like tumor-promoting role TME regulate various malignant effects, such as angiogenesis, immune suppression, metastasis; hence, have emerged hot topic research cancer therapy. This review focuses on three main aspects TAMs. First, we summarize macrophage polarization along with effects TME. Second, recent advances challenges treatment checkpoint blockade CAR-T cell therapy emphasized. Finally, factors, signaling pathways, associated TAM potential strategies for targeting repolarization to pro-inflammatory phenotype discussed.
Language: Английский
Citations
269
Materials Today Bio, Journal Year: 2022, Volume and Issue: 18, P. 100522 - 100522
Published: Dec. 21, 2022
Extracellular vesicles (EVs) are a collective term for nanoscale or microscale secreted by cells that play important biological roles. Mesenchymal stem class of with the potential self-healing and multidirectional differentiation. In recent years, numerous studies have shown EVs, especially those mesenchymal cells, can promote repair regeneration various tissues and, thus, significant in regenerative medicine. However, due to rapid clearance capacity circulatory system, EVs barely able act persistently at specific sites target tissues. Hydrogels good biocompatibility loose porous structural properties allow them serve as EV carriers, thereby prolonging retention certain areas slowing release EVs. When needed function sites, EV-loaded hydrogels stand an excellent approach. this review, we first introduce sources, roles, extraction characterization methods describe their current application status. We then review different types discuss factors influencing abilities carry summarize several strategies loading into characterizing hydrogels. Furthermore, applications tissue repair. This article concludes summary state research on outlook future directions, which hope will provide promising ideas researchers.
Language: Английский
Citations
259
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Jan. 12, 2024
Abstract Although stem cell-based therapy has demonstrated considerable potential to manage certain diseases more successfully than conventional surgery, it nevertheless comes with inescapable drawbacks that might limit its clinical translation. Compared cells, cell-derived exosomes possess numerous advantages, such as non-immunogenicity, non-infusion toxicity, easy access, effortless preservation, and freedom from tumorigenic ethical issues. Exosomes can inherit similar therapeutic effects their parental cells embryonic adult through vertical delivery of pluripotency or multipotency. After a thorough search meticulous dissection relevant literature the last five years, we present this comprehensive, up-to-date, specialty-specific disease-oriented review highlight surgical application exosomes. derived (e.g., embryonic, induced pluripotent, hematopoietic, mesenchymal, neural, endothelial cells) are capable treating encountered in orthopedic neurosurgery, plastic general cardiothoracic urology, head neck ophthalmology, obstetrics gynecology. The diverse cells-derived hierarchical translation tissue-specific responses, cell-specific molecular signaling pathways. In review, viable potent alternative managing various conditions. We recommend future research combines wisdoms surgeons, nanomedicine practitioners, cell researchers intriguing area.
Language: Английский
Citations
216
Molecular Therapy, Journal Year: 2022, Volume and Issue: 30(10), P. 3133 - 3154
Published: April 9, 2022
Exosomes have a crucial role in intercellular communication and mediate interactions between tumor cells tumor-associated macrophages (TAMs). Exosome-encapsulated non-coding RNAs (ncRNAs) are involved various physiological processes. Tumor-derived exosomal ncRNAs induce M2 macrophage polarization through signaling pathway activation, signal transduction, transcriptional post-transcriptional regulation. Conversely, TAM-derived promote proliferation, metastasis, angiogenesis, chemoresistance, immunosuppression. MicroRNAs gene silencing by directly targeting mRNAs, whereas lncRNAs circRNAs act as miRNA sponges to indirectly regulate protein expressions. The of tumor-host is ubiquitous. Current research increasingly focused on the microenvironment. On basis "cancer-immunity cycle" hypothesis, we discuss effects immune T cell exhaustion, overexpression programmed death ligands, create immunosuppressive Furthermore, potential applications prospects clinical biomarkers drug delivery systems. Non-coding do not encode proteins but control expression function.1Hombach S. Kretz M. RNAs: classification, biology functioning.Adv. Exp. Med. Biol. 2016; 937: 3-17Crossref PubMed Scopus (346) Google Scholar, 2Chan J.J. Tay Y. Noncoding RNA:RNA regulatory networks cancer.Int. J. Mol. Sci. 2018; 19: 1310Crossref (608) 3Guil Esteller RNA-RNA regulation: coding noncoding players.Trends Biochem. 2015; 40: 248-256Abstract Full Text PDF Scholar Several types ncRNAs, including microRNAs (miRNAs), long (lncRNAs), circular (circRNAs), affect growth, metabolism multiple mechanisms.3Guil 4Anastasiadou E. Jacob L.S. Slack F.J. RNA cancer.Nat. Rev. Cancer. 18: 5-18Crossref (900) 5Goodall G.J. Wickramasinghe V.O. 2021; 21: 22-36Crossref (337) miRNAs 20–25 nucleotide that at level binding 3′ untranslated region (3′ UTR) target thus regulating other cellular processes.6Ha Kim V.N. Regulation microRNA biogenesis.Nat. Cell 2014; 15: 509-524Crossref (3372) Scholar,7Dong H. Lei Ding L. Wen Ju Zhang X. MicroRNA: function, detection, bioanalysis.Chem. 2013; 113: 6207-6233Crossref (823) longer than 200 nucleotides regulation nucleus cytoplasm.8Chen L.L. Linking localization function.Trends 41: 761-772Abstract (592) Scholar,9Quinn Chang H.Y. Unique features biogenesis function.Nat. Genet. 17: 47-62Crossref (2150) modulate stability, translation, translocation mRNAs.9Quinn Scholar,10Statello Guo C.J. Chen Huarte Gene its biological functions.Nat. 22: 96-118Crossref (817) increase mRNA expressions sponging competitive endogenous (ceRNAs), secreted either alone or bound proteins.11Tay Rinn Pandolfi P.P. multilayered complexity ceRNA crosstalk competition.Nature. 505: 344-352Crossref (2450) Scholar,12Lin C. Yang Long cancer: wiring circuitry.Trends 28: 287-301Abstract (330) characterized covalently closed-loop structure without 5′ cap poly(A) tail.13Yu C.Y. Kuo H.C. emerging roles functions their generation.J. Biomed. 2019; 26: 29Crossref (167) Scholar,14Kristensen Andersen M.S. Stagsted L.V.W. Ebbesen K.K. Hansen T.B. Kjems biogenesis, characterization RNAs.Nat. 20: 675-691Crossref (1539) These implicated spongings, interactions, nuclear transcription pre-mRNA splicing.15Wang R. Li N. Jia Pan Liang CircNT5E acts sponge miR-422a glioblastoma tumorigenesis.Cancer Res. 78: 4812-4825Crossref (199) Scholar,16Qian Yu Z. Meng Huang Wang P. significance human cancers.Biochim. Biophys. Acta 1870: 247-260Crossref (0) 40–150 nm extracellular vesicles pathological processes mediating communication.17Hessvik N.P. Llorente A. knowledge exosome release.Cell Life 75: 193-208Crossref (1112) Scholar,18Pegtel D.M. Gould S.J. Exosomes.Annu. 88: 487-514Crossref (793) content exosomes released donor protected from enzymatic hydrolysis.19Abels E.R. Breakefield X.O. Introduction vesicles: cargo selection, content, release, uptake.Cell. Neurobiol. 36: 301-312Crossref (713) 20Mathieu Martin-Jaular Lavieu G. Théry Specificities secretion uptake for cell-to-cell communication.Nat. 9-17Crossref (1420) 21Mashouri Yousefi Aref A.R. Ahadi A.M. Molaei F. Alahari S.K. Exosomes: composition, mechanisms cancer metastasis resistance.Mol. 75Crossref (410) fundamental resistance.21Mashouri 22van Niel D'Angelo Raposo Shedding light vesicles.Nat. 213-228Crossref (2898) 23Zhang D. development, immunity.Biochim. 1871: 455-468Crossref (215) Tumoral secrete microenvironment (TIME).23Zhang Scholar,24Kalluri function cancer.J. Clin. Invest. 126: 1208-1215Crossref (967) (TEXs) immunological activities, polarization, regulation, inhibition natural killer (NK) activity.25Whiteside T.L. progression.Adv. Chem. 74: 103-141Crossref (402) 26Kok V.C. C.C. Cancer-derived exosomes: biomarker development.Int. Nanomed. 2020; 8019-8036Crossref (50) 27Greening D.W. Gopal Xu Simpson R.J. W. cancer.Semin. Dev. 72-81Crossref (401) TEXs also malignancy, suggesting key tumoral cells.28Xie Zhou Fang Su Tu Extracellular immunotherapy.Adv. 6: 1901779Crossref (103) 29Veerman R.E. Güçlüler Akpinar Eldh Gabrielsson Immune cell-derived - therapeutic applications.Trends 25: 382-394Abstract (110) 30Yan Jiang cancer-immunity cycle.Trends 506-517Abstract (46) development immunosuppression attracted increasing attention.31Sun Shi K. Liu Q. Song Yuan Effect applications.Mol. 147Crossref 32Cheng Zhu Peng Exosomal Glioma: 66Crossref (131) 33Xie Dang Yue Zhai Yan Lu cancer.Mol. 37Crossref (134) can be used because high encapsulation efficiency ability transport anti-cancer drugs, agents, nucleic acids, gene-editing systems such CRISPR-Cas9.34Pullan J.E. Confeld M.I. Osborn J.K. Sarkar Mallik carriers therapy.Mol. Pharm. 16: 1789-1798Crossref (76) 35Liu Cheng Delivery strategies CRISPR-Cas9 system applications.J. Control. Release. 2017; 266: 17-26Crossref (257) 36Ghaemi Bagheri Abnous Taghdisi S.M. Ramezani Alibolandi CRISPR-cas9 genome editing targeted therapy.Life 267: 118969Crossref (7) Macrophages phagocytic cells, phenotypes influenced cytokines factors TIME.37Belgiovine D'Incalci Allavena Frapolli Tumor-associated anti-tumor therapies: complex links.Cell. 73: 2411-2424Crossref assume classically activated pro-inflammatory (M1) phenotype an alternatively anti-inflammatory (M2) phenotype.38Orecchioni Ghosheh Pramod A.B. Ley Macrophage polarization: different signatures M1(LPS+) vs. Classically M2(LPS-) Alternatively macrophages.Front. Immunol. 10: 1084Crossref (541) (TAMs) M1 early stages cancer.37Belgiovine In later stage, growth mediators, IL-4, IL-10, TGF-β, expressed TIME, inducing polarization.37Belgiovine M1-M2 highly dynamic reversible. TAMs produce inhibit activity TIME.39Yin Han Zheng B. Zhao SALL4-mediated upregulation miR-146a-5p drives T-cell exhaustion HCC.Oncoimmunology. 8: 1601479Crossref (3) TAM infiltration solid tumors underscores these progression immunosuppression.39Yin 40Ruffell Coussens L.M. resistance cancer.Cancer Cell. 27: 462-472Abstract (800) 41Sica Erreni Porta pathology.Cell. 72: 4111-4126Crossref (352) divided into M2a, M2b, M2c, M2d.42Rőszer T. Understanding mysterious activation markers effector mechanisms.Mediators Inflamm. 2015: 816460Crossref M2a subgroup IL-4 IL-13 produces CD163, CD206, IL1Ra.42Rőszer M2b stimulated complexes bacterial lipopolysaccharide CD86, IL-6, TNF-α.42Rőszer M2c induced glucocorticoids, TGF-β TGF-β; addition, this active against apoptotic cells.42Rőszer M2d subgroup, IL-6 adenosine, secretes (high levels IL-10 low IL-12) vascular endothelial factor (VEGF) angiogenesis.42Rőszer Some pathways switch.41Sica Scholar,43Shapouri-Moghaddam Mohammadian Vazini Taghadosi Esmaeili S.A. Mardani Seifi Mohammadi Afshari J.T. Sahebkar plasticity, health disease.J. Physiol. 233: 6425-6440Crossref (1441) Pro-inflammatory malignant behavior, promotes tumorigenesis evasion.41Sica Therefore, fine-tuned TIME. Tumor tissues may contain mixed populations with spectrum states. However, review, assumed phenotype, described literature.37Belgiovine Increased attention has been given TAMs. polarized support forming cycle which (Figure 1). This review discusses during initiation controlled influence formation TIME based model, application diagnostic prognostic targets. involves networks.38Orecchioni phosphatidylinositol 3-kinase (PI3K)/AKT JAK/STAT factors, transducer activator (STAT) family, peroxisome proliferator-activated receptor-γ (PPARγ), interferon polarization.44Czimmerer Daniel Horvath Rückerl Nagy Kiss Peloquin Budai M.M. Cuaranta-Monroy I. Simandi et al.The STAT6 mediates direct repression inflammatory enhancers limits macrophages.Immunity. 48: 75-90.e76Abstract (112) Scholar,45Vergadi Ieronymaki Lyroni Vaporidi Tsatsanis Akt M1/M2 polarization.J. 198: 1006-1014Crossref (398) Tumors controlling factors. For instance, HPV+ head neck squamous carcinoma (HNSCC), miR-9 was enriched transported macrophages, downregulating PPARδ.46Tong Mao Xie Sun Wei HPV + HNSCC-derived induces increases radiosensitivity.Cancer Lett. 478: 34-44Crossref (23) miR-451/miR-21 were detected primary multiforme (GBM) taken up brain mice, decreasing c-Myc levels. miR-21 miR-451 increased microglia co-cultured GBM heparin reduced effect.47van der Vos K.E. Abels Lai Carrizosa Oakley Prabhakar Mardini O. Crommentuijn M.H. Skog al.Directly visualized glioblastoma-derived transfer microglia/macrophages brain.Neuro Oncol. 58-69Crossref (207) prostate (PCa), let-7a-5p let7-b, -g, -i downregulated integrin-β3, causing PCa migration.48Ferguson Lee Deci Nguyen phenotypic distinct sources: comparative study composition.AAPS 67Crossref lncRNA TUC339 hepatocellular (HCC) promoted leading cytokine production, compromised phagocytosis, decreased co-stimulatory molecule macrophages.49Kogure I.K. Lin W.L. Patel vesicle-mediated novel TUC339: mechanism cancer.Genes 4: 261-272Crossref (239) Scholar,50Li Wu HCC-derived TUC339.Int. 2958Crossref (36) receptor CXCR chemokine pathways, explain underlying regulation.50Li miR-21-5p colorectal (CRC) cells.51Shao Shen al.Colorectal cancer-derived small establish premetastatic niche liver metastasis.Carcinogenesis. 39: 1368-1379Crossref (6) CRC lines SW480, SW620, LoVo injected nude mice significantly macrophages. via TLR7 pre-metastatic survival colonization, ultimately metastasis.51Shao metabolic enzymes. melanoma miR-125b-5p lysosomal acid lipase A switching survival.52Gerloff Lützkendorf Moritz R.K.C. Wersig Mäder Müller L.P. Sunderkötter Melanoma-derived educates associated (LIPA).Cancers. 12: 464Crossref BMP-7, PI3K/AKT pathway.45Vergadi Scholar,53Covarrubias A.J. Aksoylar H.I. Horng Control mTOR signaling.Semin. 286-296Crossref (189) Scholar,54Zhao Kong F.Q. Jie A.D. Y.Q. D.D. Z.Q. al.Macrophage MSR1 BMSC osteogenic differentiation M2-like activating PI3K/AKT/GSK3β/β-catenin pathway.Theranostics. 17-35Crossref (37) Phosphatase tension homolog deleted chromosome ten (PTEN) inhibits AKT dephosphorylating PIP3.45Vergadi Scholar,55Lu PTEN/PI3k/AKT regulates emphysematous mice.Scand. 85: 395-405Crossref (38) bladder regulated inhibiting PTEN enhanced STAT3 expression, promoting migration invasion.56Lin Yin H.B. X.Y. G.M. He W.Y. Gou Bladder cell-secreted activates progression.Int. 56: 151-164PubMed miR-130b-3p, miR-425-5p, miR-25-3p pathway. epithelial-mesenchymal transition (EMT) VEGF metastasis.57Wang Si Cui Qu contribute CXCL12/CXCR4-induced enhancing macrophages.Cancer 474: 36-52Crossref (108) Scholar,58Wang Corrigendum "Exosome-encapsulated macrophages" [Canc. 474 (2020) 36-52].Cancer 2022; 525: 200-202Crossref circFARSA upregulated non-small lung (NSCLC) exosomes.59Chen PTEN/PI3K/AKT metastasis.Cancer Treat. Commun. 100412Crossref (11) ubiquitination degradation PTEN, polarization.59Chen RNA-binding eIF4A3 triggered cyclization EMT NSCLC cells.59Chen STAT1/5 STAT 3/6 respectively.60Zhao Bian Y.Y. Y.J. Ma Y.T. Pei Zeng HuoXueTongFu formula alleviates intraperitoneal adhesion SOCS/JAK2/STAT/PPAR-γ signalling pathway.Mediators 2019: 1769374Crossref (14) Scholar,61Hu Ivashkiv L.B. Crosstalk among Jak-STAT, Toll-like receptor, ITAM-dependent activation.J. Leukoc. 2007; 82: 237-243Crossref (157) members suppressor (SOCS) family.60Zhao miR-29a-3p oral SOCS1/STAT6 signaling.62Cai Qiao Gao Oral carcinoma-derived subtype mediated exosome-enclosed miR-29a-3p.Am. 316: C731-C740Crossref co-culture system, miR-223 cervical (CSCC) CSCC creating positive feedback loop.63Zhang Qian STAT3-miR-223-TGFBR3/HMGCS1 axis modulates carcinoma.Mol. 14: 2313-2331Crossref Moreover, repressed TGFBR3 HMGCS1 UTRs, resulting anchorage-independent growth.63Zhang Hypoxia stimulates secretion, hypoxic trigger HIF1α- HIF2α-dependent manner.64Escribese Casas Corbí A.L. Influence oxygen tensions polarization.Immunobiology. 2012; 217: 1233-1240Crossref Scholar,65Díaz-Bulnes Saiz M.L. López-Larrea Rodríguez R.M. hypoxia ER stress res
Language: Английский
Citations
199
Acta Pharmaceutica Sinica B, Journal Year: 2021, Volume and Issue: 12(2), P. 600 - 620
Published: Aug. 12, 2021
The use of small interfering RNAs (siRNAs) has been under investigation for the treatment several unmet medical needs, including acute lung injury/acute respiratory distress syndrome (ALI/ARDS) wherein siRNA may be implemented to modify expression pro-inflammatory cytokines and chemokines at mRNA level. properties such as clear anatomy, accessibility, relatively low enzyme activity make a good target local therapy. However, translation is restricted by inefficient delivery therapeutics cells due naked siRNA. Thus, this review will focus on various systems that can used different barriers need surmounted development stable inhalable formulations human before ALI/ARDS become available in clinic.
Language: Английский
Citations
178
Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 353, P. 1127 - 1149
Published: Dec. 26, 2022
Language: Английский
Citations
168
Nanomaterials, Journal Year: 2021, Volume and Issue: 11(6), P. 1481 - 1481
Published: June 3, 2021
Exosomes as nanosized vesicles are emerging drug delivery systems for therapeutics owing to their natural origin, ability mediate intercellular communication, and potential encapsulate various biological molecules such proteins nucleic acids within the lipid bilayer membrane or in lumen. contain endogenous components (proteins, lipids, RNA) that could be used deliver cargoes target cells, offering an opportunity diagnose treat diseases. Owing travel safely extracellular fluid transport cells with high efficacy, exosomes offer enhanced of vivo. However, several challenges related stabilization exosomes, production sufficient amounts safety efficient loading drugs into clearance from circulation, transition bench scale clinical may limit development use. For use it is important understand molecular mechanisms behind function exosome vesicles. This review exploits techniques isolation characterization enhance therapeutic outcome methods. Further, routes administration, trials, regulatory aspects will discussed this review.
Language: Английский
Citations
144
International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 202, P. 539 - 557
Published: Jan. 21, 2022
Language: Английский
Citations
138
ACS Biomaterials Science & Engineering, Journal Year: 2023, Volume and Issue: 9(2), P. 577 - 594
Published: Jan. 9, 2023
Exosomes are the phospholipid-membrane-bound subpopulation of extracellular vesicles derived from plasma membrane. The main activity exosomes is cellular communication. In cancer, play an important rolefrom two distinct perspectives, one related to carcinogenesis and other as theragnostic drug delivery tools. outer phospholipid membrane Exosome improves targeting efficiency. . Some vital features such biocompatibility, low toxicity, immunogenicity make it a more exciting system. Exosome-based new innovative approach cancer treatment. Exosome-associated biomarker analysis heralded era diagnostics in specific way. This Review focuses on exosome biogenesis, sources, isolation, interrelationship with exosome-related biomarkers, loading methods, exosome-based biomolecule delivery, advances limitations clinical settings studies. understanding will change diagnostic therapeutic future.
Language: Английский
Citations
132
Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)
Published: Aug. 31, 2022
Abstract The rapid advancement of nanomedicine and nanoparticle (NP) materials presents novel solutions potentially capable revolutionizing health care by improving efficacy, bioavailability, drug targeting, safety. NPs are intriguing when considering medical applications because their essential unique qualities, including a significantly higher surface to mass ratio, quantum properties, the potential adsorb transport drugs other compounds. However, must overcome or navigate several biological barriers human body successfully deliver at precise locations. Engineering carrier biointerface can help main optimize delivery in more personalized manner. This review discusses significant heterogeneous how engineering promote carriers prevail over hurdles manner, thus ushering era Precision Medicine. We also summarize nanomedicines' current advantages disadvantages administration, from natural/synthetic sources clinical applications. Additionally, we explore innovative NP designs used both non-personalized customized as well they attain therapeutic strategy.
Language: Английский
Citations
113