Revisiting the role of Akkermansia muciniphila as a therapeutic bacterium

Gut Microbes, Journal Year: 2022, Volume and Issue: 14(1)

Published: May 25, 2022

Despite a short history since its first isolation, Akkermansia muciniphila has been extensively studied in relation to effects on human metabolism. A recent intervention study also demonstrated that the bacterium is safe use for therapeutic purposes. The best-known of A. health and disease relate ability strengthen gut integrity, modulate insulin resistance, protect host from metabolic inflammation. further molecular mechanism, induction GLP-1 secretion through ICAM-2 receptor, was recently discovered with identification new bacterial protein produced by muciniphila. However, other studies have suggested detrimental role specific immune settings. Here, we evaluate molecular, mechanistic suggest some missing links be connected before organism should considered as next-generation biotherapeutic agent.

Language: Английский

---

Role of Akkermansia in Human Diseases: From Causation to Therapeutic Properties

Nutrients, Journal Year: 2023, Volume and Issue: 15(8), P. 1815 - 1815

Published: April 8, 2023

The gut microbiota plays a critical role in the modulation of host metabolism and immune response, its impairment has been implicated many gastrointestinal extraintestinal diseases. Current evidence shows well-documented A. muciniphila maintaining integrity intestinal barrier, modulating improving several metabolic pathways, making it key element pathogenesis human In this scenario, is most promising next-generation probiotic one first microbial species suitable for specific clinical use when compared with traditional probiotics. Further studies are needed to provide more accurate insight into mechanisms action better elucidate properties major areas, paving way integrated personalized therapeutic approach that finally makes our knowledge microbiota.

Language: Английский

---

Diet-driven differential response of Akkermansia muciniphila modulates pathogen susceptibility

Molecular Systems Biology, Journal Year: 2024, Volume and Issue: 20(6), P. 596 - 625

Published: May 14, 2024

Language: Английский

---

Bacterial extracellular vesicles-based therapeutic strategies for bone and soft tissue tumors therapy

Theranostics, Journal Year: 2022, Volume and Issue: 12(15), P. 6576 - 6594

Published: Jan. 1, 2022

Bone and soft tissue tumors are complex mesenchymal neoplasms that seriously endanger human health. Over the past decade, relationship between microorganisms health diseases is getting more attention. The extracellular vesicles derived from bacteria have been shown to regulate bacterial-host cell communication by transferring their contents, including nucleic acids, proteins, metabolites, lipopolysaccharides, peptidoglycans. Bacteria (BEVs) promising lipid-bilayer nanocarriers for treatment of many due low toxicity, drug loading capacity, ease modification industrialization. Specially, BEVs-based cancer therapy has attracted much attention because ability effectively stimulate immune responses. In this review, we provide an overview biogenesis, composition, isolation, classification, internalization BEVs. We then comprehensively summarize sources BEVs in BEVs-related strategies. further highlight great potential bone tumors. Finally, conclude major advantages challenges therapy. believe comprehensive understanding field will generate innovative solutions achieve clinical applications.

Language: Английский

---

The metabolic, protective, and immune functions of Akkermansia muciniphila

Microbiological Research, Journal Year: 2022, Volume and Issue: 266, P. 127245 - 127245

Published: Oct. 28, 2022

Numerous studies have almost proven the beneficial effects of gut microbiota in various aspects human health, and even is known as a new forgotten organ. Akkermansia muciniphila, member microbiota, considered bacterium with probiotic properties; consequently, it has remarkable position microbiome research. This accounts for about 1-4 % total fecal population also health marker. The accumulated evidence shown significant association between A. muciniphila several disorders diseases, such obesity, fatty liver disease, diabetes, behavioral disorders. On other hand, different shown, protective role against pathogenic agents, antitumor properties, tight junctions' improvement, reduction inflammation, permeability, boosting adaptive immune responses. In this review, based on available latest research, we comprehensively evaluated impact host from three points view: metabolic, protective, functions, well possible mechanisms each process.

Language: Английский

---

Extracellular Vesicles of Probiotics: Shedding Light on the Biological Activity and Future Applications

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 522 - 522

Published: Feb. 4, 2023

For many decades, the proper functioning of human body has become a leading scientific topic. In course numerous experiments, striking impact probiotics on been documented, including maintaining physiological balance endogenous microorganisms, regulating immune system, enhancing digestive properties host, and preventing or alleviating diseases. Recent research, especially from last decade, shows that this health-benefiting activity is largely conditioned by production extracellular vesicles. Although importance vesicles in virulence live-threatening pathogens widely described literature, much less known with respect to health-promoting effect secreted non-pathogenic probiotics. Based this, current review article, we decided collect latest literature data health-inducing The characteristics probiotics’ will be extended description their physicochemical proteome connection biological activities exhibited these structures.

Language: Английский

---

Prostate cancer-derived small extracellular vesicle proteins: the hope in diagnosis, prognosis, and therapeutics

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Dec. 14, 2023

Current diagnostic tools for prostate cancer (PCa) diagnosis and risk stratification are insufficient. The hidden onset poor efficacy of traditional therapies against metastatic PCa make this disease a heavy burden in global men's health. Prostate cancer-derived extracellular vesicles (PCDEVs) have garnered attention recent years due to their important role communications tumor microenvironment. Recent advancements demonstrated PCDEVs proteins play an invasion, progression, metastasis, therapeutic resistance, immune escape. In review, we briefly discuss the applications sEV prognosis liquid biopsy, focus on roles PCa-derived small EVs (sEVs) microenvironment associated with explore potential applied future therapy.

Language: Английский

---

Bacteria-based immunotherapy for cancer: a systematic review of preclinical studies

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 3, 2023

Immunotherapy has been emerging as a powerful strategy for cancer management. Recently, accumulating evidence demonstrated that bacteria-based immunotherapy including naive bacteria, bacterial components, and derivatives, can modulate immune response via various cellular molecular pathways. The key mechanisms of antitumor immunity include inducing cells to kill tumor directly or reverse the immunosuppressive microenvironment. Currently, antigens synthesized vaccine candidates by bioengineering technology are novel immunotherapy. Especially combination therapy with conventional therapies may further achieve enhanced therapeutic benefits against cancers. However, clinical translation is limited biosafety concerns non-uniform production standards. In this review, we aim summarize strategies based on advanced therapeutics discuss their potential management, will also propose approaches optimizing facilitating translation.

Language: Английский

---

Health and Disease: Akkermansia muciniphila , the Shining Star of the Gut Flora

Research, Journal Year: 2023, Volume and Issue: 6

Published: Jan. 1, 2023

(

---

Akkermansia muciniphila: A potential target and pending issues for oncotherapy

Pharmacological Research, Journal Year: 2023, Volume and Issue: 196, P. 106916 - 106916

Published: Sept. 9, 2023

In the wake of development metagenomic, metabolomic, and metatranscriptomic approaches, intricate interactions between host various microbes are now being progressively understood. Numerous studies have demonstrated evident changes in gut microbiota during process a variety diseases, such as diabetes, obesity, aging, cancers. Notably, is viewed potential source novel therapeutics. Currently, Next-generation probiotics (NGPs) gaining popularity therapeutic agents that alter affect cancer development. Akkermansia muciniphila (A. muciniphila), representative commensal bacterium, has received substantial attention over past decade promising NGP. The components metabolites A. can directly or indirectly tumorigenesis, particular through its effects on antitumor immunosurveillance, including stimulation pattern recognition receptors (PRRs), which also leads to better outcomes situations, prevention curation this article, we systematically summarize role tumorigenesis (involving gastrointestinal non-gastrointestinal cancers) tumor therapy. particular, carefully discuss some critical scientific issues need be solved for future using beneficial bacterium treatment, might provide bright clues assistance application drugs targeting clinical oncotherapy.

Language: Английский

---