The influence of the ultrasonic treatment of working fluids on electrospun amorphous solid dispersions DOI Creative Commons
Haibin Wang, Yingying Lü, Haisong Yang

et al.

Frontiers in Molecular Biosciences, Journal Year: 2023, Volume and Issue: 10

Published: May 10, 2023

Based on a working fluid consisting of poorly water-soluble drug and pharmaceutical polymer in an organic solvent, electrospinning has been widely exploited to create variety amorphous solid dispersions However, there have very few reports about how prepare the reasonable manner. In this study, investigation was conducted determine influences ultrasonic pretreatment quality resultant ASDs fabricated from fluids. SEM results demonstrated that nanofiber-based treated fluids exhibited better than traditional nanofibers untreated following aspects: 1) straighter linear morphology; 2) smooth surface; 3) more evener diameter distribution. The fabrication mechanism associated with treatments nanofibers’ is suggested. Although XRD ATR–FTIR experiments clearly verified ketoprofen homogeneously distributed all over TASDs state regardless treatments, vitro dissolution tests had sustained release performance terms initial rate time periods.

Language: Английский

Progress of Electrospun Nanofibrous Carriers for Modifications to Drug Release Profiles DOI Creative Commons
Ying Wang, Deng‐Guang Yu, Yang Liu

et al.

Journal of Functional Biomaterials, Journal Year: 2022, Volume and Issue: 13(4), P. 289 - 289

Published: Dec. 9, 2022

Electrospinning is an advanced technology for the preparation of drug-carrying nanofibers that has demonstrated great advantages in biomedical field. Electrospun nanofiber membranes are widely used field drug administration due to their such as large specific surface area and similarity extracellular matrix. Different electrospinning technologies can be prepare different structures, those with a monolithic structure, core–shell Janus or porous structure. It also possible controlled-release functions, sustained release, delayed biphasic targeted release. This paper elaborates on drug-loaded using various concludes mechanisms behind controlled release drugs.

Language: Английский

Citations

103

The Applications of Ferulic-Acid-Loaded Fibrous Films for Fruit Preservation DOI Open Access
Xinyi Huang,

Wenlai Jiang,

Jianfeng Zhou

et al.

Polymers, Journal Year: 2022, Volume and Issue: 14(22), P. 4947 - 4947

Published: Nov. 16, 2022

The aim of this study was to develop a novel ultrathin fibrous membrane with core-sheath structure as an antioxidant food packaging membrane. prepared by coaxial electrospinning, and the release active substances regulated its special structure. Ferulic acid (FA) incorporated into electrospun zein/polyethylene oxide fibers ensure their synergistic properties. We found that had good morphology smooth surface. internal stable, three materials we used were compatible. For different loading positions, it observed core layer ferulic-acid-loaded sustained action, while sheath pre-burst action. Finally, apples selected for using membranes simulate practical applications. effective in reducing water loss apple quality loss, well extending shelf life. According these experiments, FA-loaded zein/PEO electrospinning fiber can be will also undergo more improvements future.

Language: Английский

Citations

100

Processes of Electrospun Polyvinylidene Fluoride-Based Nanofibers, Their Piezoelectric Properties, and Several Fantastic Applications DOI Open Access

Yubin Bai,

Yanan Liu, He Lv

et al.

Polymers, Journal Year: 2022, Volume and Issue: 14(20), P. 4311 - 4311

Published: Oct. 13, 2022

Since the third scientific and technological revolution, electronic information technology has developed rapidly, piezoelectric materials that can convert mechanical energy into electrical have become a research hotspot. Among them, polymers are widely used in various fields such as water treatment, biomedicine, flexible sensors due to their good flexibility weak toxicity. However, compared with ceramic materials, properties of poor, so it is very important improve polymers. Electrospinning by adjusting electrospinning parameters control piezoelectrically active phase transition In addition, prepared nanofibrous membrane also substrate for supporting functional particles, which effectively doping particles. This paper reviews electrospun polymer membranes, especially polyvinylidene fluoride (PVDF)-based membranes (NFs). Additionally, this introduces methods increasing from perspective structure species. Finally, applications NFs biology, energy, photocatalysis discussed, future directions development prospected.

Language: Английский

Citations

92

Electrospun Porous Nanofibers: Pore−Forming Mechanisms and Applications for Photocatalytic Degradation of Organic Pollutants in Wastewater DOI Open Access

Xianyang Cao,

Wei Chen, Ping Zhao

et al.

Polymers, Journal Year: 2022, Volume and Issue: 14(19), P. 3990 - 3990

Published: Sept. 23, 2022

Electrospun porous nanofibers have large specific surface areas and abundant active centers, which can effectively improve the properties of nanofibers. In field photocatalysis, electrospun increase contact area loaded photocatalytic particles with light, shorten electron transfer path, activity. this paper, main pore−forming mechanisms nanofiber are summarized as breath figures, phase separation (vapor−induced separation, non−solvent−induced thermally induced separation) post−processing (selective removal). Then, application loading in degradation pollutants (such organic, inorganic, bacteria) water is introduced, its future development prospected. Although structures beneficial improving performance nanofibers, they reduce their mechanical properties. Therefore, strategies for also briefly discussed.

Language: Английский

Citations

77

Recent Progress of the Preparation and Application of Electrospun Porous Nanofibers DOI Open Access
Pu Wang, He Lv,

Xianyang Cao

et al.

Polymers, Journal Year: 2023, Volume and Issue: 15(4), P. 921 - 921

Published: Feb. 12, 2023

Electrospun porous nanofibers have gained a lot of interest recently in various fields because their adjustable structure, high specific surface area, and large number active sites, which can further enhance the performance materials. This paper provides an overview common polymers, preparation, applications electrospun nanofibers. Firstly, polymers commonly used to construct structures main pore-forming methods by electrospinning, namely template method phase separation method, are introduced. Secondly, recent air purification, water treatment, energy storage, biomedicine, food packaging, sensor, sound wave absorption, flame retardant, heat insulation reviewed. Finally, challenges possible research directions for future study discussed.

Language: Английский

Citations

76

Recent Progress of Electrospun Herbal Medicine Nanofibers DOI Creative Commons
Hang Liu,

Yubin Bai,

Chang Huang

et al.

Biomolecules, Journal Year: 2023, Volume and Issue: 13(1), P. 184 - 184

Published: Jan. 16, 2023

Herbal medicine has a long history of medical efficacy with low toxicity, side effects and good biocompatibility. However, the bioavailability extract raw herbs bioactive compounds is poor because their water solubility. In order to overcome solubility issues, electrospinning technology can offer delivery alternative resolve them. The electrospun fibers have advantages high specific surface area, porosity, excellent mechanical strength flexible structures. At same time, various natural synthetic polymer-bound mimic extracellular matrix applications in different fields. this paper, development polymers used for incorporating herbal into nanofibers are reviewed. Finally, recent progress these biomedical (drug delivery, wound dressing, tissue engineering) food fields along future prospects discussed.

Language: Английский

Citations

59

How can Electrospinning Further Service Well for Pharmaceutical Researches? DOI
Deng‐Guang Yu, Jianfeng Zhou

Journal of Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: 112(11), P. 2719 - 2723

Published: Aug. 27, 2023

Language: Английский

Citations

51

Electrospun fibers with blank surface and inner drug gradient for improving sustained release DOI
Menglong Wang, Ruiliang Ge, Feiyang Zhang

et al.

Biomaterials Advances, Journal Year: 2023, Volume and Issue: 150, P. 213404 - 213404

Published: March 31, 2023

Language: Английский

Citations

44

Advanced Technique-Based Combination of Innovation Education and Safety Education in Higher Education DOI
Deng‐Guang Yu, Qiang Li, Wenliang Song

et al.

Journal of Chemical Education, Journal Year: 2023, Volume and Issue: 100(2), P. 507 - 516

Published: Jan. 5, 2023

The essence of higher education is to cultivate innovative talents for the society. Hence, institutions (HEIs), on one hand, need respond social needs and government policies. On other they keep pace with times improve details teaching effectiveness education. In this paper, several combination examples in HEIs about safety innovation are shown encourage students realize innovations technique during their laboratory experiments electrospinning. To obtain professional knowledge traditional skills, taught implement electrospinning, an advanced treating polymers, research laboratory. Safety also taught, which encouraged play subjective roles ponder how apply safe, effective, implementation. a series small technological spinneret, most part electrospinning system. They can modify spinneret safer, more energy-saving, convenient operations single-fluid blending, coaxial, triaxial, side-by-side processes. Moreover, deepen stimulate enjoyment innovations. be powerful tool promoting increasing awareness related issues. reported protocols paper show new way conducting combined techniques.

Language: Английский

Citations

43

Enhancing diabetic wound healing: advances in electrospun scaffolds from pathogenesis to therapeutic applications DOI Creative Commons

Xuewen Jiang,

Yue Zeng, Chaofei Li

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Feb. 5, 2024

Diabetic wounds are a significant subset of chronic characterized by elevated levels inflammatory cytokines, matrix metalloproteinases (MMPs), and reactive oxygen species (ROS). They also associated with impaired angiogenesis, persistent infection, high likelihood hospitalization, leading to substantial economic burden for patients. In severe cases, amputation or even mortality may occur. foot ulcers (DFUs) common complication diabetes, up 25% diabetic patients being at risk developing over their lifetime, more than 70% ultimately requiring amputation. Electrospun scaffolds exhibit structural similarity the extracellular (ECM), promoting adhesion, growth, migration fibroblasts, thereby facilitating formation new skin tissue wound site. The composition size electrospun can be easily adjusted, enabling controlled drug release through fiber structure modifications. porous nature these facilitates gas exchange absorption exudate. Furthermore, surface readily modified impart specific functionalities, making electrospinning nanofiber highly promising treatment wounds. This article provides concise overview healing process in normal pathological mechanisms underlying wounds, including complications such as ulcers. It explores advantages treatment. Additionally, it summarizes findings from various studies on use different types reviews methods loading onto scaffolds. These advancements broaden horizon effectively treating

Language: Английский

Citations

36