Advanced Composites and Hybrid Materials, Journal Year: 2025, Volume and Issue: 8(2)
Published: April 1, 2025
Language: Английский
Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 209, P. 115304 - 115304
Published: April 9, 2024
Language: Английский
Citations
20
Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(9), P. 3876 - 3900
Published: June 22, 2024
Despite the promising prospects of nanoparticles in oral drug delivery, process administration involves a complex transportation pathway that includes cellular uptake, intracellular trafficking, and exocytosis by intestinal epithelial cells, which are necessary steps for to enter bloodstream exert therapeutic effects. Current researchers have identified several crucial factors regulate interaction between including surface properties such as ligand modification, charge, hydrophilicity/hydrophobicity, protein corona formation, well holistic like particle size, shape, rigidity. Understanding these is essential enhancing transepithelial transport efficiency designing effective delivery systems. Therefore, this review provides comprehensive overview influence nanoparticles, elucidating underlying principles governing their impact on transport. The also outlines chosen parameters be considered subsequent design
Language: Английский
Citations
20
Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: unknown, P. 121926 - 121926
Published: Feb. 1, 2024
Language: Английский
Citations
18
Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(11), P. 4683 - 4716
Published: Sept. 2, 2024
About 40% of approved drugs and nearly 90% drug candidates are poorly water-soluble drugs. Low solubility reduces the drugability. Effectively improving bioavailability is a critical issue that needs to be urgently addressed in development application. This review briefly introduces conventional solubilization techniques such as solubilizers, hydrotropes, cosolvents, prodrugs, salt modification, micronization, cyclodextrin inclusion, solid dispersions, details crystallization strategies, ionic liquids, polymer-based, lipid-based, inorganic-based carriers bioavailability. Some most commonly used carrier materials for presented. Several using summarized. Furthermore, this summarizes mechanism each technique, reviews latest research advances challenges, evaluates potential clinical translation. could guide selection approach, dosage form, administration route Moreover, we discuss several promising attracting increasing attention worldwide.
Language: Английский
Citations
14
Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 231 - 231
Published: Feb. 8, 2025
Colorectal cancer (CRC) represents one of the most serious health issues and third commonly diagnosed worldwide. However, treatment options for CRC are associated with adverse reactions, in some cases, resistance can develop. Flavonoids have emerged as promising alternatives prevention therapy due to their multitude biological properties ability target distinct processes involved pathogenesis. Their innate disadvantageous (e.g., low solubility stability, reduced bioavailability, lack tumor specificity) delayed potential inclusion flavonoids regimens but hastened design nanopharmaceuticals comprising a flavonoid agent entrapped nanosized delivery platform that not only counteract these inconveniences also provide an augmented therapeutic effect elevated safety profile by conferring targeted action. Starting brief presentation pathological features overview classes, present study comprehensively reviews anti-CRC activity different from mechanistic perspective while portraying latest discoveries made area flavonoid-containing nanocarriers proved efficient management. This review concludes showcasing future perspectives advancement flavonoid-based research.
Language: Английский
Citations
1
Asian Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 19(5), P. 100951 - 100951
Published: Aug. 23, 2024
Metal-organic frameworks (MOFs) offer innovative solutions to the limitations of traditional oral drug delivery systems through their unique combination metal ions and organic ligands. This review systematically examines structural properties principles MOFs, setting stage for application in delivery. It discusses various classes including those based on zirconium, iron, zinc, copper, titanium, aluminum, potassium, magnesium, assessing drug-loading capacities, biocompatibility, controlled release mechanisms. The effectiveness MOFs is illustrated case studies that highlight capabilities enhancing solubility, providing protection against harsh gastrointestinal environment, enabling precise release. addresses potential challenges, particularly toxicity concerns associated with calls further research into biocompatibility interactions biological systems. concludes by emphasizing revolutionizing delivery, highlighting critical need comprehensive harness full clinical applications.
Language: Английский
Citations
8
Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 94, P. 105473 - 105473
Published: Feb. 23, 2024
Language: Английский
Citations
7
Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: unknown
Published: April 24, 2024
Language: Английский
Citations
5
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 1967 - 1983
Published: Feb. 1, 2024
Purpose: Kaempferia parviflora extracellular vesicles (KPEVs) have been reported as promising nanovesicles for drug delivery. This study aimed to load clarithromycin (CLA) into KPEVs (KPEVS-CLA) and determine the physical properties, drug-releasing efficiency, gastric cell uptake, anti- H. pylori activities, anti-inflammatory responses in comparison with free CLA KPEVs. Methods: The size surface charge of KPEVs-CLA were evaluated using dynamic light scattering visualized a transmission electron microscope. encapsulation efficiency (EE%), loading capacity (LC%), release examined HPLC. Anti- growth anti-adhesion evaluated. IL-8 gene expression, NF-κB signaling proteins, profiles qRT-PCR, Western blotting, Bio-Plex immunoassay, respectively. Anti-chemotaxis was then Transwell assay. Results: intact showed negative similar that However, slightly enlarged observed. successfully loaded EE 93.45% ± 2.43%, LC 9.3% 3.02%. PBS mimic buffer Fickian diffusion ( n ≤ 0.43) according Korsmeyer-Peppas kinetic model (R 2 =0.98). localized cells' cytoplasm perinuclear region. adhesion compared those no cytotoxicity adenocarcinoma cells. significantly reduced IL-8, G-CSF, MIP-1α, MIP-1β levels. Moreover, superior effect over reducing phosphorylation monocyte chemotactic activities. Conclusion: serve potential carriers CLA. They exhibited higher inhibiting inflammation mediated by infection than establishment nanodrug delivery treatment could be applied other plant or cancer drugs treatment. Keywords: vesicle, clarithromycin, , Helicobacter
Language: Английский
Citations
4
Nanoscale, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
MOMIPP-SEDDS increased the relative bioavailability by 19.98-fold and achieved favorable tumor inhibition. Clear evidence of methuosis in tissue following treatment was revealed TEM imaging.
Language: Английский
Citations
0