A Journey of Challenges and Victories: A Bibliometric Worldview of Nanomedicine since the 21st Century

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(15)

Published: Jan. 17, 2024

Abstract Nanotechnology profoundly affects the advancement of medicine. Limitations in diagnosing and treating cancer chronic diseases promote growth nanomedicine. However, there are very few analytical descriptive studies regarding trajectory nanomedicine, key research powers, present landscape, focal investigative points, future outlooks. Herein, articles reviews published Science Citation Index Expanded Web Core Collection from first January 2000 to 18th July 2023 analyzed. a bibliometric visualization publication trends, countries/regions, institutions, journals, categories, themes, references, keywords is produced elaborated. Nanomedicine‐related academic output increasing since COVID‐19 pandemic, solidifying uneven global distribution performance. While China leads terms quantity has numerous highly productive USA advantages impact, commercialization, industrial value. Nanomedicine integrates with other disciplines, establishing interdisciplinary platforms, which drug delivery nanoparticles remain points. Current focuses on integrating nanomedicine cell ferroptosis induction immunotherapy. The keyword “burst testing” identifies promising directions, including immunogenic death, chemodynamic therapy, tumor microenvironment, immunotherapy, extracellular vesicles. prospects, major challenges, barriers addressing these directions discussed.

Language: Английский

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Fine-Tuned Graphene Oxide Nanocomposite: Harnessing Copper(II)–Imidazole Complex for Enhanced Biological Responses and Balanced Photocatalytic Functionality

Materials, Journal Year: 2024, Volume and Issue: 17(4), P. 892 - 892

Published: Feb. 15, 2024

In this study, the synthesis of biologically active copper(II) complex [Cu(im)2]Cl2 was achieved using a reported method. Subsequently, strategically grafted onto graphene oxide, resulting in formation nanocomposite denoted as copper(II)-complex-grafted oxide (Cu-GO). The comprehensive characterization Cu-GO conducted through various techniques, including X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR), UV-visible spectroscopy, emission spectra analysis, photoelectron (XPS), and Copper K-edge Absorption Near Edge Structure (XANES) spectroscopy. antibacterial efficacy compounds assessed disk diffusion microbroth dilution methods. Notably, copper exhibited highest effectiveness, showcasing Minimal Inhibitory Concentration (MIC) value 500 µL against Klebsiella bacteria. activities all were systematically screened, revealing superior performance compared to standalone compounds. Expanding scope investigation, we explored antioxidant anti-obesity complexes organisms. results underscore promising directions for further exploration diverse health-related applications these Moreover, photocatalytic evaluated under sunlight irradiation. Cu-GO, terms percentage inhibition at concentration 200 mg/mL, values 41% 45%, respectively. Additionally, composite exceptional efficacy, achieving degradation efficiency 74% RhB irradiation, surpassing both graphite GO. These findings not only demonstrate enhanced biological activity, but also highlight notable level moderate performance. Such dual functionality underscores potential versatility nanocomposites across applications, blending heightened with controlled photocatalysis. Our study offers valuable insights into multifunctional attributes nanocomposites, thereby paving way their broader utilization fields.

Language: Английский

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Potential of graphene-based nanomaterials for cardiac tissue engineering

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(31), P. 7280 - 7299

Published: Jan. 1, 2023

Graphene and its derivatives have many desirable characteristics that make them suitable for use in cardiac tissue engineering.

Language: Английский

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Fluorescent nanomaterials for the detection of chronic kidney disease

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 173, P. 117572 - 117572

Published: Feb. 9, 2024

Language: Английский

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Graphene Quantum Dots from Natural Carbon Sources for Drug and Gene Delivery in Cancer Treatment

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10539 - 10539

Published: Sept. 30, 2024

Cancer therapy is constantly evolving, with a growing emphasis on targeted and efficient treatment options. In this context, graphene quantum dots (GQDs) have emerged as promising agents for precise drug gene delivery due to their unique attributes, such high surface area, photoluminescence, up-conversion biocompatibility. GQDs can damage cancer cells exhibit intrinsic photothermal conversion singlet oxygen generation efficiency under specific light irradiation, enhancing effectiveness. They serve direct therapeutic versatile platforms capable of being easily functionalized various targeting molecules agents. However, challenges achieving uniform size morphology, bandgap engineering, scalability, along minimizing cytotoxicity the environmental impact production, must be addressed. Additionally, there need more comprehensive understanding cellular mechanisms release processes, well improved purification methods. Integrating into existing systems enhances efficacy traditional treatments, offering less invasive options patients. This review highlights transformative potential in while acknowledging that researchers overcome broader application.

Language: Английский

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Influence of Graphene, Hydroxyapatite, and Hydroxyapatite‐Niobium Pentoxide Nanoparticles on Polycaprolactone Electrospun Fibers Mats Properties

Journal of Applied Polymer Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

ABSTRACT Polycaprolactone (PCL) electrospun fiber mats containing varying concentrations of graphene flakes (GF), hydroxyapatite (HAp), and with niobium pentoxide (HAp5Nb) were successfully prepared by electrospinning. These composites exhibit great potential in biomedical applications, particularly as scaffolds for bone tissue engineering. The addition GF enhances the rheological properties PCL solution due to intrinsic resulting from their interactions. Additionally, incorporating HAp HAp5Nb nanoparticles increases viscosity PCL‐based solutions, leading formation thinner diameters. GF, HAp, characterized using transmission electron microscopy (TEM) x‐ray diffractometry (XRD), while degree disorder heterogeneity was assessed Raman spectroscopy. physical chemical also scanning (SEM), XRD, fourier‐transform infrared spectroscopy (FTIR), contact angle measurements. cytotoxicity evaluated mouse fibroblasts. Results showed that cell viability 100% extract higher than pure or Dulbecco's modified Eagle's medium DMEM control, indicating samples non‐toxic promoted growth. This highlights

Language: Английский

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Chasing Graphene-Based Anticancer Drugs: Where are We Now on the Biomedical Graphene Roadmap?

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 3973 - 3989

Published: May 1, 2024

Graphene and graphene-based materials have attracted growing interest for potential applications in medicine because of their good biocompatibility, cargo capability possible surface functionalizations.In parallel, prototypic devices been developed to diagnose, imaging track tumor growth cancer patients.There is a number reports on the use graphene its functionalized derivatives design innovative drugs delivery systems, photothermal photodynamic therapy, as platform combine multiple therapies.The aim this review introduce latest scientific achievements field composite potentially applied therapy.The "Technology Innovation Roadmap" published Flagship indicates, that first anti-cancer using graphenederived will appeared market by 2030.However, it necessary broaden understanding material interactions with cellular metabolism signaling at functional level, well toxicity.The main aspects further research should elucidate how treatment methods (e.g., combination therapy) physicochemical properties influence ability modulate autophagy kill cells.Interestingly, recent also prove nanocomposites cell death inducing precise dysfunctions caused lysosome damage.It turns out developing oncological treatments, be taken into account near-infrared-II radiation (1000-1500 nm) better option than NIR-I (750-1000 can penetrate deeper tissues due less scattering longer wavelengths radiation.

Language: Английский

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Nanotechnology in Neuro-Oncology: Evaluating the Potential of Graphene and Boron Nitride Nanostructures

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Language: Английский

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Intrathecal Immunoselective Nanopheresis for Alzheimer’s Disease: What and How? Why and When?

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10632 - 10632

Published: Oct. 2, 2024

Nanotechnology is transforming therapeutics for brain disorders, especially in developing drug delivery systems. Intrathecal immunoselective nanopheresis with soluble monoclonal antibodies represents an innovative approach the realm of systems Central Nervous System conditions, targeting beta-amyloid Alzheimer’s disease. This review delves into concept intrathecal nanopheresis. It provides overall description devices to perform this technique while discussing nanotechnology behind its mechanism action, potential advantages, and clinical implications. By exploring current research advancements, we aim provide a comprehensive understanding novel method, addressing critical questions what it is, how works, why needed, when should be applied. Special attention given patient selection optimal timing therapy initiation Alzheimer’s, coinciding peak accumulation amyloid oligomers early stages. Potential limitations alternative targets beyond future perspectives are also described.

Language: Английский

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Nanomedicine in cancer treatment - an overview

Advances in Natural Sciences Nanoscience and Nanotechnology, Journal Year: 2024, Volume and Issue: 16(1), P. 013001 - 013001

Published: Dec. 31, 2024

Abstract Cancer remains a formidable global health challenge, with millions of lives lost annually and projected increase in cases, particularly regions like South Central Asia, Europe, Eastern etc, Traditional cancer treatments, including chemotherapy, radiotherapy, surgery, face limitations effectively managing the complex tumor microenvironment addressing diverse characteristics cells. Nano-oncology has emerged as promising frontier therapy, utilizing nanoscale materials to deliver therapeutic agents precision efficacy. The benefits nanoparticle-based drug delivery systems are ability target cells while minimizing adverse effects overcoming multidrug resistance. Advancements hybrid nanoparticle development have further enhanced stability performance systems, offering new avenues for treatment. Moreover, therapies hold potential modulate immunosuppressive improve outcomes immunotherapy. review provides comprehensive overview nanotherapeutic products currently various preclinical clinical study stages, focusing on their success rates lung breast cancers compared conventional chemotherapeutic drugs. By elucidating landscape nano-oncology evaluating its efficacy specific types, this aims shed light transformative approaches treatment diagnosis. They exploring promises pave way innovative strategies combating improving patient globally.

Language: Английский

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