Applied Sciences,
Journal Year:
2024,
Volume and Issue:
14(3), P. 1132 - 1132
Published: Jan. 29, 2024
Magnetite-based
nanoparticles
are
of
constant
interest
in
the
scientific
community
as
potential
systems
for
biomedical
applications.
Over
years,
ability
to
synthesize
diverse
based
on
iron
(II,
III)
oxide
has
been
mastered
maximize
their
effectiveness
targeted
delivery
active
substances
cancer
therapy.
The
present
review
explores
recent
literature
findings
that
detail
various
magnetic
nanosystems.
These
encompass
straightforward
designs
featuring
a
polymer
coating
core
and
more
intricate
matrices
delivering
chemotherapeutic
drugs.
This
paper
emphasizes
novel
synthetic
approaches
impact
efficacy
progress
anticancer
investigations,
specifically
targeting
particular
type.
research
also
delves
into
combinations
with
alternative
treatment
methods
diagnostic
approaches.
Additionally,
it
highlights
critical
aspect—the
interaction
cells—identifying
least
developed
aspect
current
these
systems.
Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
27, P. 101110 - 101110
Published: June 4, 2024
Cellular
alignment
plays
a
pivotal
role
in
several
human
tissues,
including
skeletal
muscle,
spinal
cord
and
tendon.
Various
techniques
have
been
developed
to
control
cellular
using
3D
biomaterials.
However,
the
majority
of
3D-aligned
scaffolds
require
invasive
surgery
for
implantation.
In
contrast,
injectable
hydrogels
provide
non-invasive
delivery
method,
gaining
considerable
attention
treatment
diverse
conditions,
osteochondral
lesions,
volumetric
muscle
loss,
traumatic
brain
injury.
We
engineered
biomimetic
hydrogel
with
magnetic
responsiveness
by
combining
gellan
gum,
hyaluronic
acid,
collagen,
nanoparticles
(MNPs).
Collagen
type
I
was
paired
MNPs
form
collagen
bundles
(MCollB),
allowing
orientation
these
within
matrix
through
application
remote
low-intensity
field.
This
resulted
creation
an
anisotropic
architecture.
The
mechanical
properties
were
comparable
those
soft
such
as
proof
aligned
concept
demonstrated.
vitro
findings
confirmed
absence
toxicity
pro-inflammatory
effects.
Notably,
increased
fibroblast
cell
proliferation
pro-regenerative
activation
macrophages
observed.
in-vivo
study
further
validated
biocompatibility
demonstrated
feasibility
injection
rapid
situ
gelation.
Consequently,
this
magnetically
controlled
exhibits
significant
promise
minimally
invasive,
gelling
effective
regenerating
various
tissues.
Nanomaterials,
Journal Year:
2024,
Volume and Issue:
14(15), P. 1311 - 1311
Published: Aug. 3, 2024
Antimicrobial
resistance
(AMR)
is
growing
into
a
major
public
health
crisis
worldwide.
The
reducing
alternatives
to
conventional
agents
starve
for
novel
antimicrobial
agents.
Due
their
unique
magnetic
properties
and
excellent
biocompatibility,
iron
oxide
nanoparticles
(IONPs)
are
the
most
preferable
nanomaterials
in
biomedicine,
including
antibacterial
therapy,
primarily
through
reactive
oxygen
species
(ROS)
production.
IONP
characteristics,
size,
shape,
surface
charge,
superparamagnetism,
influence
biodistribution
activity.
External
fields,
foreign
metal
doping,
surface,
shape
modification
improve
effect
of
IONPs.
Despite
few
disadvantages,
IONPs
expected
be
promising
new
generation.
Chemistry Africa,
Journal Year:
2024,
Volume and Issue:
7(8), P. 4581 - 4591
Published: Aug. 27, 2024
Abstract
Iron
oxide
nanoparticles
are
inexpensive
materials
that
environmentally
friendly
and
have
properties
render
them
suitable
for
wide
range
of
applications.
A
facile
time-effective
coprecipitation
method
was
used
to
prepare
iron
in
a
1:1
molar
ratio
Fe
2+
3+
ions
solution.
obtained
at
18
60
°C
yielded
spherical
magnetite
with
particle
sizes
7.63
8.5
nm
respectively
while
comprising
mixture
hematite
nanorods,
mean
width
9.5
length
75
were
90
°C.
synthesized
energy
band
gap
4.16
eV
those
the
same
4.66
eV.
Precursor
concentrations
0.042,
0.08
0.0126
M
7.94,
size
increased
increasing
concentration.
Magnetite
0.126
optical
gaps
4.65,
4.88
5.19
respectively.
The
crystalline
phase
produced
regardless
concentration
temperatures
temperature
phases.
showed
direct
proportionality
an
inert
environment.
Small Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 11, 2025
Microrobots
engineered
from
self‐propelling
active
particles
extend
the
reach
of
robotic
operations
to
submillimeter
dimensions
and
are
becoming
increasingly
relevant
for
various
tasks,
such
as
manipulation
micro/nanoscale
cargo,
particularly
targeted
drug
delivery.
However,
achieving
deep‐tissue
penetration
delivery
remains
a
challenge.
This
work
develops
novel
biohybrid
microrobot
consisting
jellyfish‐stinging
capsules,
which
act
natural
nanoinjectors
efficient
delivery,
assembled
onto
an
Janus
particle
(JP).
While
transport
navigation
is
externally
controlled
by
magnetic
field‐induced
rolling,
capsule
loading
JP
surface
electric
field.
Following
precise
microrobots
vicinity
target
tissues,
capsules
activated
specific
enzyme
introduced
solution,
then
triggers
tubule
ejection
release
preloaded
molecules.
Use
drug/toxin
cancer
spheroids
live
Caenorhabditis
elegans
demonstrated
in
vitro.
The
findings
offer
insights
future
development
bioinspired
capable
deep
Future
directions
may
involve
encapsulation
drugs
within
different
types
enhanced
versatility.
study
also
inspire
vivo
applications
involving
tissue
Nanoscale Advances,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Safe
implementation
of
nanotechnology-based
products
in
biomedical
applications
necessitates
an
extensive
understanding
the
(bio)transformations
that
nanoparticles
undergo
living
organisms.
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
unknown, P. 101699 - 101699
Published: March 1, 2025
Nowadays,
tendon
injuries
represent
a
global
health
issue
that
annually
affects
millions
of
individuals.
An
innovative
approach
for
their
treatment
is
represented
by
the
development
tissue
engineered
scaffolds
able
to
support
host
cells
adhesion,
differentiation,
and
proliferation.
However,
scaffold
alone
could
be
insufficient
guarantee
an
improvement
healing
control.
Magnetite
nanoparticles
(Fe3O4
NPs)
are
gaining
interest
due
unique
properties.
In
particular,
when
combined
with
bio-mimetic
scaffolds,
they
should
lead
mechano-stimulation,
improving
tenogenic
differentiation
allowing
deeper
reparation.
The
aim
this
work
study
based
on
polyhydroxybutyrate
gelatin
doped
Fe3O4
NPs.
characterized
aligned
fibrous
shape
mimic
fascicles.
Moreover,
possess
superparamagnetic
behavior
slow
degradation
rate
structural
during
regeneration.
magnetic
promote
cell
proliferation
alignment
onto
matrix,
in
particular
application
external
field.
Also,
differentiate
produce
collagen
I
extracellular
matrix.
Finally,
vivo
promotes
complete
after
1
week
stimulation.
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 1, 2025
Abstract
Background
Uncovering
the
genomic
basis
of
traits
has
advanced
rapidly
in
evolutionary
biology
and
neuroscience,
largely
through
phenotypic
with
adaptive
value
been
advancing
biology,
behavior,
due
to
research
using
non-traditional
model
systems.
Direct
gene
editing
adult
brain
represents
a
crucial
next
step
linking
genotype
phenotype,
avoiding
confounding
effects
that
arise
from
modifications
during
development.
However,
implementing
these
technologies
beyond
traditional
laboratory
models
remains
challenging
delivery
limitations.
Methods
We
developed
an
intracranial
microinjection
protocol
for
guppies
(Poecilia
reticulata)
deliver
gene-editing
elements
cells.
designed
magnetic
nanoparticles
functionalized
novel
translocating
agent,
non-viral
carrier
capable
transporting
linearized
nucleic
acids
across
cellular
nuclear
membranes.
comprehensively
assessed
nanoparticle
uptake,
colocalization,
potential
health
impacts
histological
analysis,
liver
enzyme
activity
assays,
behavioral
assessments.
Results
Our
successfully
entered
cells
colocalized
nuclei
at
rates
exceeding
50%
after
two
weeks,
demonstrating
their
efficient
in
vivo
editing.
Health
assessments
showed
no
significant
cell
death
(>
80%
viability),
toxicity
(normal
ALT,
AST,
ALP
levels),
alterations
individual
social
behaviors,
confirming
nanoparticles’
biocompatibility
systemic
safety.
Conclusions
results,
combined
previous
vitro
work
our
are
effective
system
editing,
show
they
can
be
used
safe
interventions
P.
reticulata.
This
overcomes
major
technical
barrier
acid-carrying
vehicle
brain.
approach
provides
versatile
platform
studying
genetic
mechanisms
underlying
behavior
small
freshwater
fish
while
helping
overcome
limitations
conducting
functional
studies
on
non-model
organisms.
