26th International Conference on Optical Fiber Sensors, Journal Year: 2023, Volume and Issue: unknown, P. Th5.1 - Th5.1
Published: Jan. 1, 2023
The paper provides an overall picture of the technological roadmap aimed to develop Lab on fiber (LOF) assisted needles for in-vivo liquid and tissue biopsy support light localized therapies precision medicine.
Language: Английский
Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 104, P. 106520 - 106520
Published: Dec. 20, 2024
Language: Английский
Citations
2
Journal of Hepatocellular Carcinoma, Journal Year: 2024, Volume and Issue: Volume 11, P. 1265 - 1278
Published: July 1, 2024
Abstract: Ferroptosis is a type of cell death that relies on iron and distinguished by the occurrence lipid peroxidation buildup reactive oxygen species. has been demonstrated to have significant impact advancement resistance treatment hepatocellular carcinoma (HCC), thereby highlighting its potential as viable therapeutic target. was observed in HCC tissues contrast normal liver tissue. The inhibition ferroptosis found increase viability cells decrease their susceptibility various anticancer therapies, including chemotherapy, radiotherapy, immune checkpoint blockade. administration drugs directly modulate regulators or induce excessive production lipid-reactive species enhance responsiveness drug-resistant treatment. However, precise mechanism underlying this phenomenon remains ambiguous. This review presents comprehensive overview crucial role played enhancing efficacy for (HCC). main aim study examine feasibility utilizing approach improve overcome drug resistance. Keywords: ferroptosis, carcinoma, tyrosine kinase inhibitor, immunosuppressive therapy, radiotherapy
Language: Английский
Citations
1
Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101270 - 101270
Published: Sept. 24, 2024
Language: Английский
Citations
1
Clinics and Research in Hepatology and Gastroenterology, Journal Year: 2024, Volume and Issue: unknown, P. 102508 - 102508
Published: Nov. 1, 2024
Language: Английский
Citations
1
Nanomaterials, Journal Year: 2023, Volume and Issue: 14(1), P. 47 - 47
Published: Dec. 23, 2023
To develop a potential cancer treatment, we formulated novel drug delivery platform made of poly(lactic-co-glycolic) acid (PLGA) and used combination an emerging siRNA technology extracted natural substance called catechins. The synthesized materials were characterized to determine their properties, including morphology, hydrodynamic size, charge, particle stability, release profile. therapeutic effect AFP-siRNA epigallocatechin gallate (EGCG) was revealed have remarkable cytotoxicity towards HepG2 when in soluble formulation. Notably, the killing enhanced by co-treatment AFP-siRNA-loaded PLGA EGCG. Cell viability significantly dropped 59.73 ± 6.95% after treatment with 12.50 μg/mL EGCG AFP-siRNA-PLGA. Meanwhile, 80% viable cells observed monotherapy. reduction survival is clear indication complementary action both active PLGA. corresponding cell death involved apoptosis, as evidenced increased caspase-3/7 activity. combined exhibited 2.5-fold increase Moreover, nanoparticles internalized time-dependent manner, indicating appropriate use carrier. Accordingly, system effective strategy.
Language: Английский
Citations
3
Published: Dec. 19, 2023
This study was to designed develop sorafenib-loaded polymeric nanoparticles, surface-modified with pluronic F-127 for the effective treatment of hepatocellular (HCC) and renal cell carcinomas (RCC). Poly lactic coglycolic acid (PLGA) used encapsulate different concentrations sorafenib by a simple modified solvent evaporation method applying as surfactant coating agent. The preformulation characterization studies were conducted evaluate incompatibilities among sorafenib, PLGA F-127, physicochemical properties formulations, respectively. sizes coated plain nanoparticles ~140 ± 14.7 nm ~ 120 10.1 nm, It has been confirmed from in vitro release that sustained avoiding initial burst release, while vivo demonstared have greater affinity target aorgans than free drug keeping dose constant (20 mg/kg body weight). delivery into tissues their pharmacokinetic parameters improved significantly compared reported formulations.
Language: Английский
Citations
2
International Journal of Applied Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 135 - 141
Published: July 7, 2024
Objective: The purpose of this study was to develop, characterize, and optimize sorafenib-loaded Poly (lactic-co-glycolic acid) PLGA polymeric nanoparticles for prolonged delivery sorafenib improved hepatic cancer treatment Methods: drug-excipient interaction explored by molecular docking studies within silico tools. drug-loaded were prepared single emulsion solvent evaporation method using box-bhenkan design characterized particle size, zeta potential, entrapment efficiency. Shape surface morphology analysed Transmission Electron Microscopy (TEM). In vitro drug release performed a diffusion membrane. Results: analysis inferred that the has interacted well with PF-68, which could prevent crystal formation. optimized had size 175 nm, Entrapment Efficiency (EE) 85.1% potential of-23.8mV found be 95% CI predicted value, is acceptable. TEM showed formed smooth, spherical in shape uniform size. formulation extended sorafenib. Conclusion: Based on computational studies, developed Sorafenib loaded promising oral liver cancer.
Language: Английский
Citations
0
Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 113(11), P. 3145 - 3172
Published: Aug. 15, 2024
Language: Английский
Citations
0
Open Life Sciences, Journal Year: 2024, Volume and Issue: 19(1)
Published: Jan. 1, 2024
Abstract Hepatocellular carcinoma (HCC) is among the most common malignant liver tumors. Despite progress in anticancer drugs and surgical approaches, early detection of HCC remains challenging, often leading to late-stage diagnosis where rapid disease progression precludes intervention, leaving chemotherapy as only option. However, systemic toxicity, low bioavailability, significant adverse effects lead resistance, rendering treatments ineffective for many patients. This article outlines how nanoparticles, following functional modification, offer high sensitivity, reduced drug extended duration action, enabling precise targeting tissues. Combined with other therapeutic modalities imaging techniques, this significantly enhances diagnosis, treatment, long-term prognosis HCC. The advent nanomedicine provides new methodologies strategies integrated treatment
Language: Английский
Citations
0
26th International Conference on Optical Fiber Sensors, Journal Year: 2023, Volume and Issue: unknown, P. Th5.1 - Th5.1
Published: Jan. 1, 2023
The paper provides an overall picture of the technological roadmap aimed to develop Lab on fiber (LOF) assisted needles for in-vivo liquid and tissue biopsy support light localized therapies precision medicine.
Language: Английский
Citations
0