ACS Nano,
Journal Year:
2024,
Volume and Issue:
19(2), P. 2591 - 2614
Published: Dec. 26, 2024
Neural
stem
cell
(NSCs)
transplantation
is
a
promising
therapeutic
strategy
for
spinal
cord
injury
(SCI),
but
its
efficacy
greatly
limited
by
the
local
inhibitory
microenvironment.
In
this
study,
based
on
l-arginine
(l-Arg)-loaded
mesoporous
hollow
cerium
oxide
(AhCeO2)
nanospheres,
we
constructed
an
injectable
composite
hydrogel
(AhCeO2-Gel)
with
microenvironment
modulation
capability.
AhCeO2-Gel
protected
NSCs
from
oxidative
damage
eliminating
excess
reactive
oxygen
species
while
continuously
delivering
Nitric
Oxide
to
lesion
of
SCI
in
pathological
microenvironment,
latter
which
effectively
promoted
neural
differentiation
NSCs.
The
process
was
confirmed
be
closely
related
up-regulation
cAMP-PKA
pathway
after
NO-induced
calcium
ion
influx.
addition,
significantly
polarization
microglia
toward
M2
subtype
as
well
enhanced
regeneration
nerves
and
myelinated
axons.
prepared
bioactive
system
also
efficiently
facilitated
integration
transplanted
host
circuits,
replenished
damaged
neurons,
alleviated
neuroinflammation,
inhibited
glial
scar
formation,
thus
accelerating
recovery
motor
function
rats.
Therefore,
synergized
has
great
potential
integrated
treat
comprehensively
reversing
Gels,
Journal Year:
2025,
Volume and Issue:
11(4), P. 293 - 293
Published: April 15, 2025
As
an
intelligent
polymer
material,
pH-sensitive
hydrogels
exhibit
the
capability
to
dynamically
sense
alterations
in
ambient
pH
levels
and
subsequently
initiate
corresponding
physical
or
chemical
responses,
including
swelling,
contraction,
degradation,
ion
exchange.
Given
significant
variations
inherent
human
pathophysiological
microenvironments,
particularly
tumor
tissues,
inflammatory
lesions,
gastrointestinal
system,
these
smart
materials
demonstrate
remarkable
application
potential
across
diverse
domains
such
as
targeted
drug
delivery
systems,
regenerative
medicine
engineering,
biosensing,
disease
diagnostics.
Recent
breakthroughs
nanotechnology
precision
have
substantially
propelled
advancements
design
of
pH-responsive
hydrogels.
This
review
systematically
elaborates
on
current
research
progress
future
challenges
regarding
biomedical
applications,
with
particular
emphasis
their
stimulus–response
mechanisms,
fabrication
methodologies,
multifunctional
integration
strategies,
scenarios.
In
lower
vertebrates,
retinal
Müller
glia
(MG)
exhibit
a
life-long
capacity
of
cell-cycle
re-entry
to
regenerate
neurons
following
the
injury.
However,
mechanism
driving
such
injury-induced
MG
remains
incompletely
understood.
Combining
single-cell
transcriptomic
analysis
and
in-vivo
clonal
analysis,
we
identified
previously
undescribed
cxcl18b
-defined
transitional
states
as
essential
routes
towards
proliferation
green/red
cone
(G/R
cone)
ablation.
Microglial
inflammation
was
necessary
for
triggering
these
states,
which
expressed
gene
modules
shared
by
cells
ciliary
marginal
zone
(CMZ)
where
adult
neurogenesis
takes
place.
Functional
studies
redox
properties
further
demonstrated
regulatory
role
nitric
oxide
(NO)
produced
Nos2b
in
proliferation.
Finally,
developed
viral-based
strategy
specifically
disrupt
nos2b
revealed
effect
state-specific
NO
signaling.
Our
findings
elucidate
redox-related
underlying
re-entry,
providing
insights
into
species-specific
mechanisms
vertebrate
retina
regeneration.
In
lower
vertebrates,
retinal
Müller
glia
(MG)
exhibit
a
life-long
capacity
of
cell-cycle
re-entry
to
regenerate
neurons
following
the
injury.
However,
mechanism
driving
such
injury-induced
MG
remains
incompletely
understood.
Combining
single-cell
transcriptomic
analysis
and
in-vivo
clonal
analysis,
we
identified
previously
undescribed
cxcl18b
-defined
transitional
states
as
essential
routes
towards
proliferation
green/red
cone
(G/R
cone)
ablation.
Microglial
inflammation
was
necessary
for
triggering
these
states,
which
expressed
gene
modules
shared
by
cells
ciliary
marginal
zone
(CMZ)
where
adult
neurogenesis
takes
place.
Functional
studies
redox
properties
further
demonstrated
regulatory
role
nitric
oxide
(NO)
produced
Nos2b
in
proliferation.
Finally,
developed
viral-based
strategy
specifically
disrupt
nos2b
revealed
effect
state-specific
NO
signaling.
Our
findings
elucidate
redox-related
underlying
re-entry,
providing
insights
into
species-specific
mechanisms
vertebrate
retina
regeneration.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: June 27, 2024
Severe
spinal
cord
injuries
(SCI)
lead
to
loss
of
functional
activity
the
body
below
injury
site,
affect
a
person’s
ability
self-care
and
have
direct
impact
on
performance.
Due
structural
features
role
in
body,
consequences
SCI
cannot
be
completely
overcome
at
expense
endogenous
regenerative
potential
and,
developing
over
time,
severe
complications
years
after
injury.
Thus,
primary
task
this
type
treatment
is
create
artificial
conditions
for
growth
damaged
nerve
fibers
through
area
SCI.
Solving
problem
possible
using
tissue
neuroengineering
involving
technology
replacing
natural
environment
with
synthetic
matrices
(for
example,
hydrogels)
combination
stem
cells,
particular,
neural/progenitor
cells
(NSPCs).
This
approach
can
provide
maximum
stimulation
support
axons
neurons
their
myelination.
In
review,
we
consider
currently
available
options
improving
condition
(use
NSC
transplantation
or/and
replacement
matrix,
specifically
hydrogel).
We
emphasise
expediency
effectiveness
hydrogel
matrix
+
NSCs
complex
system
used
reconstruction
Since
such
(a
engineering
cell
therapy),
our
opinion,
allows
not
only
creation
supporting
regeneration
or
mechanical
cord,
but
also
strengthen
regeneration,
prevent
spread
inflammatory
process,
promote
restoration
lost
reflex,
motor
sensory
functions
injured
cord.
Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 10, 2024
Spinal
cord
injury
(SCI)
is
a
severe
clinical
disease
usually
accompanied
by
activated
glial
scar,
neuronal
axon
rupture,
and
disabled
motor
function.
To
mimic
the
microenvironment
of
SCI
site,
hydrogel
system
with
comparable
mechanical
property
to
spinal
desirable.
Therefore,
novel
elastic
bovine
serum
albumin
(BSA)
fabricated
excellent
adhesive,
injectable,
biocompatible
properties.
The
used
deliver
paclitaxel
(PTX)
together
basic
fibroblast
growth
factor
(bFGF)
inhibit
scar
formation
as
well
promote
regeneration
function
for
repair.
Due
specific
interaction
BSA
both
drugs,
bFGF,
PTX
can
be
controllably
released
from
achieve
an
effective
concentration
at
wound
site
during
process.
Moreover,
benefiting
combination
this
bFGF/PTX@BSA
significantly
aided
repair
promoting
elongation
axons
across
reduced
reactive
astrocyte
secretion.
In
addition,
remarkable
anti-apoptosis
nerve
cells
evident
system.
Subsequently,
multi-functionalized
drug
improved
rats
after
SCI.
These
results
reveal
that
ideal
functionalized
material
in
Gels,
Journal Year:
2025,
Volume and Issue:
11(1), P. 52 - 52
Published: Jan. 9, 2025
Carpal
Tunnel
Syndrome
(CTS)
is
a
prevalent
neuropathic
disorder
caused
by
chronic
compression
of
the
median
nerve,
leading
to
sensory
and
motor
impairments.
Conventional
treatments,
such
as
corticosteroid
injections,
wrist
splinting,
surgical
decompression,
often
fail
provide
adequate
outcomes
for
or
recurrent
cases,
emphasizing
need
innovative
therapies.
Hydrogels,
highly
biocompatible
three-dimensional
biomaterials
with
customizable
properties,
hold
significant
potential
CTS
management.
Their
ability
mimic
extracellular
matrix
facilitates
localized
drug
delivery,
anti-adhesion
barrier
formation,
tissue
regeneration.
Advances
in
hydrogel
engineering
have
introduced
stimuli-responsive
systems
tailored
biomechanical
environment
carpal
tunnel,
enabling
sustained
therapeutic
release
improved
integration.
Despite
these
promising
developments,
applications
remain
underexplored.
Key
challenges
include
absence
CTS-specific
preclinical
models
rigorous
clinical
validation.
Addressing
gaps
could
unlock
full
hydrogel-based
interventions,
which
offer
minimally
invasive,
solutions
that
improve
long-term
reduce
recurrence
rates.
This
review
highlights
hydrogels
transformative
approach
therapy,
advocating
continued
research
address
translational
barriers.
These
innovations
redefine
treatment
landscape,
significantly
enhancing
patient
care
quality
life.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2025,
Volume and Issue:
13
Published: April 23, 2025
Spinal
cord
injury
(SCI)
is
a
severe
condition
that
frequently
leads
to
permanent
disabilities
and
neurological
dysfunction.
Its
progression
driven
by
multifaceted
pathophysiology,
encompassing
direct
trauma,
secondary
cascades,
intricate
cellular
molecular
responses.
While
current
therapies
focus
on
alleviating
symptoms
restoring
functionality,
achieving
effective
neural
regeneration
in
the
spinal
continues
be
significant
challenge.
Hydrogels,
recognized
for
their
exceptional
biocompatibility,
conductivity,
injectability,
have
shown
great
potential
as
advanced
scaffolds
support
neuronal
axonal
regeneration.
Recently,
these
materials
attracted
interest
field
of
SCI
rehabilitation
research.
This
review
concludes
recent
progress
hydrogel-based
strategies
rehabilitation,
emphasizing
distinct
properties,
underlying
mechanisms,
integration
with
bioactive
molecules,
stem
cells,
complementary
biomaterials.
Hydrogels
foster
providing
tailored
microenvironment,
while
features
such
self-repair,
electrical
controlled
drug
release
significantly
enhance
therapeutic
experimental
models.
explores
hydrogel
technologies
applications,
underscoring
address
challenges
treatment
paving
way
future
clinical
implementation.
