Nanotechnology-Enhanced Controlled Release Systems in Topical Therapeutics DOI Creative Commons

Yohannes Teklehaimanot

Precision Nanomedicine, Journal Year: 2024, Volume and Issue: 7(4)

Published: Dec. 11, 2024

<img src=” https://s3.amazonaws.com/production.scholastica/article/127336/large/prnano_1672024ga.jpg?1733950699”> Topical and transdermal drug delivery are alternative routes for medications facing challenges like solubility, stability, first-pass metabolism. However, conventional immediate-release dosage forms delivered topically have drawbacks, including poor penetration high side ef-fects. Controlled-release nanoparticles offer a promising solution, improving permeation providing controlled release. This review examines recent advances, challenges, prospects of controlled-release topical delivery. Various types nanoparticles, lipid nanoemulsions, nanoemulgels, cubosome liposomes, poly-meric solid-lipid lipid-polymer hybrid nanostructured carriers, carbon nanotubes, nanocomposites, protein been explored their ability to encapsulate drugs, prolong release, enhance skin as well improve therapeutic outcomes. Studies demonstrated the effectiveness these in sustained wide range poorly soluble, low degree penetration, drugs with bioavailability biological products. Despite potential benefits, such scalability, reproducibility, safety concerns remain. Future research should ad-dress explore novel strategies efficacy by converging microneedles 3D nanoparticles. Ultimately, revolutionize dermatological delivery, leading improved outcomes patient care.

Language: Английский

Current advance of nanotechnology in diagnosis and treatment for malignant tumors DOI Creative Commons

Bilan Wang,

Shiqi Hu, Yan Teng

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Aug. 12, 2024

Cancer remains a significant risk to human health. Nanomedicine is new multidisciplinary field that garnering lot of interest and investigation. shows great potential for cancer diagnosis treatment. Specifically engineered nanoparticles can be employed as contrast agents in diagnostics enable high sensitivity high-resolution tumor detection by imaging examinations. Novel approaches labeling are also made possible the use nanoprobes nanobiosensors. The achievement targeted medication delivery therapy accomplished through rational design manufacture nanodrug carriers. Nanoparticles have capability effectively transport medications or gene fragments tissues via passive active targeting processes, thus enhancing treatment outcomes while minimizing harm healthy tissues. Simultaneously, context radiation sensitization photothermal enhance therapeutic efficacy malignant tumors. This review presents literature overview summary how nanotechnology used According oncological diseases originating from different systems body combining pathophysiological features cancers at sites, we most recent developments applications. Finally, briefly discuss prospects challenges cancer.

Language: Английский

Citations

99
Advances in pharmaceutical and biomedical applications of plant–based nano-biopolymers with special emphasis on vaginal drug delivery systems: A review DOI Creative Commons

Rafia Noor-ul-Ain,

Noshin Ilyas,

Maimona Saeed

et al.

Industrial Crops and Products, Journal Year: 2025, Volume and Issue: 225, P. 120592 - 120592

Published: Jan. 25, 2025

Language: Английский

Citations

1
Revolutionizing Cancer Immunotherapy: Emerging Nanotechnology-Driven Drug Delivery Systems for Enhanced Therapeutic Efficacy DOI Creative Commons
Theivendren Panneerselvam, Selvaraj Kunjiappan, Parasuraman Pavadai

et al.

ACS Measurement Science Au, Journal Year: 2024, Volume and Issue: 5(1), P. 31 - 55

Published: Nov. 15, 2024

Cancer immunotherapy is an innovative way of treating cancer by stimulating individual cells to overcome cancer. Widespread biomedical studies were carried out with the aim exploring therapeutics, and this review spotlights some mechanisms in which it was developed, namely immune checkpoint inhibitors (E.G PD-1/PD-L1, CTLA-4), adoptive cell therapy (e.g., CAR T-cell therapy), vaccines. Although has shown clinical benefit a number types, including melanoma non-small-cell lung cancer, several challenges have dampened enthusiasm for approach, from differing patient response rates toxicities. Nanotechnology drug delivery systems must play role overcoming same. enables increased specificity controlled release, improved solubility bioavailability, can treat tumor specifically, localized at disease site decreases systemic toxicity. The also features advances construction lipid-based, polymeric, inorganic nanoparticles that improve stability allow cotherapeutic agents. Nanotechnology-based be used alone or combination assist improving response, gaining access microenvironment, biological barriers. Thus, nano-DDS both safe effective preclinical studies, ongoing trials they are capable increasing therapeutic index anticancer drugs. Lastly, discusses current regulatory issues advancing these technologies highlights importance further research devise appropriate methodology efficient functionalization nanotechnology individualized solutions treatment.

Language: Английский

Citations

7
Nanohydrogel mediated approaches for wound healing DOI
Ashkan Farazin, Fatemeh Rajabi

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 131 - 138

Published: Jan. 1, 2025

Language: Английский

Citations

0
Nanotechnology-based natural remedies: Advancing inflammatory bowel disease treatment through targeted drug delivery DOI
Luqing Zhao,

Dan Dou,

Di Zhang

et al.

Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 111262 - 111262

Published: April 1, 2025

Language: Английский

Citations

0
Enhanced Quercetin Encapsulation through Charge Density and Amphiphilicity Tuning in Cationic Triblock Micelles DOI
Ridouan El Yousfi, Leonard Ionuț Atanase,

Abderrahman Makaoui

et al.

ACS Applied Polymer Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Language: Английский

Citations

0
Advances on Delivery System of Active Ingredients of Dried Toad Skin and Toad Venom DOI Creative Commons
Dan Zhang,

Bingtao Zhai,

Jing Sun

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 7273 - 7305

Published: July 1, 2024

Abstract: Dried toad skin (TS) and venom (TV) are the dried of Bufo bufo gargarizans Cantor melanostictus Schneider , which remove internal organs white secretions retroauricular glands. Since 2005, cinobufacini preparations have been approved by State Food Drug Administration for use as adjuvant therapies in treatment various advanced cancers. Meanwhile, bufalenolides has identified main component TS/TV, exhibiting antitumor activity, inducing apoptosis cancer cells inhibiting cell proliferation or metastasis through a variety signaling pathways. However, clinical agents frequently face limitations such inherent toxicity at high concentrations insufficient tumor targeting. Additionally, development utilization these active ingredients hindered poor water solubility, low bioavailability, rapid clearance from bloodstream. To address challenges, design targeted drug delivery system (TDDS) aims to enhance improve targeting within body, increase efficacy, reduce adverse reactions. This article reviews TDDS their components, including passive, active, stimuli-responsive TDDS, provide reference advancing use. Keywords: skin, venom, system, passive targeted,

Language: Английский

Citations

2
Nanotechnology-Enhanced Controlled Release Systems in Topical Therapeutics DOI Creative Commons

Yohannes Teklehaimanot

Precision Nanomedicine, Journal Year: 2024, Volume and Issue: 7(4)

Published: Dec. 11, 2024

<img src=” https://s3.amazonaws.com/production.scholastica/article/127336/large/prnano_1672024ga.jpg?1733950699”> Topical and transdermal drug delivery are alternative routes for medications facing challenges like solubility, stability, first-pass metabolism. However, conventional immediate-release dosage forms delivered topically have drawbacks, including poor penetration high side ef-fects. Controlled-release nanoparticles offer a promising solution, improving permeation providing controlled release. This review examines recent advances, challenges, prospects of controlled-release topical delivery. Various types nanoparticles, lipid nanoemulsions, nanoemulgels, cubosome liposomes, poly-meric solid-lipid lipid-polymer hybrid nanostructured carriers, carbon nanotubes, nanocomposites, protein been explored their ability to encapsulate drugs, prolong release, enhance skin as well improve therapeutic outcomes. Studies demonstrated the effectiveness these in sustained wide range poorly soluble, low degree penetration, drugs with bioavailability biological products. Despite potential benefits, such scalability, reproducibility, safety concerns remain. Future research should ad-dress explore novel strategies efficacy by converging microneedles 3D nanoparticles. Ultimately, revolutionize dermatological delivery, leading improved outcomes patient care.

Language: Английский

Citations

0