Advances in the Repurposing and Blood–Brain Barrier Penetrance of Drugs in Pediatric Brain Tumors

Cancers, Journal Year: 2025, Volume and Issue: 17(3), P. 439 - 439

Published: Jan. 27, 2025

Central nervous system (CNS) tumors are the leading cause of cancer-related mortality in children, with prognosis remaining dismal for some these malignancies. Though past two decades have seen advancements surgery, radiation, and targeted therapy, major unresolved hurdles continue to undermine therapeutic efficacy. These include challenges suboptimal drug delivery through blood–brain barrier (BBB), marked intra-tumoral molecular heterogeneity, elusive tumor microenvironment. Drug repurposing or re-tasking FDA-approved drugs evidence penetration into CNS, using newer methods intracranial facilitating optimal exposure, has been an area intense research. This could be a valuable tool, as most agents already gone lengthy process development evaluation safety risks pharmacokinetic profile. They can now used tested clinics accelerated different approach. Conclusions: The next-generation strategy should prioritize oncologic non-oncologic that other indication, demonstrated robust preclinical activity against pediatric brain tumors. In combination novel techniques, hold significant promise neurooncology.

Language: Английский

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Exosomes as Therapeutic and Diagnostic Tools: Advances, Challenges, and Future Directions

Cell Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Language: Английский

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Evidence-Based Clinical Practice Guidelines on Regenerative Medicine Treatment for Chronic Pain: A Consensus Report from a Multispecialty Working Group

Journal of Pain Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 2951 - 3001

Published: Sept. 1, 2024

Injectable biologics have not only been described and developed to treat dermal wounds, cardiovascular disease, cancer, but also reported chronic pain conditions. Despite emerging evidence supporting regenerative medicine therapy for pain, many aspects remain controversial.

Language: Английский

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Engineered extracellular vesicles for TGF-β encapsulation as a therapeutic strategy against LPS-induced systemic inflammation

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 148, P. 114109 - 114109

Published: Jan. 24, 2025

Language: Английский

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Endocytosis at the maternal-fetal interface: balancing nutrient transport and pathogen defense

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: June 18, 2024

Endocytosis represents a category of regulated active transport mechanisms. These encompass clathrin-dependent and -independent mechanisms, as well fluid phase micropinocytosis macropinocytosis, each demonstrating varying degrees specificity capacity. Collectively, these mechanisms facilitate the internalization cargo into cellular vesicles. Pregnancy is one such physiological state during which endocytosis may play critical roles. A successful pregnancy necessitates ongoing communication between maternal fetal cells at maternal-fetal interface to ensure immunologic tolerance for semi-allogenic fetus whilst providing adequate protection against infection from pathogens, viruses bacteria. It also requires nutrients across interface, but restriction potentially harmful chemicals drugs allow development. In this context, trogocytosis, specific form endocytosis, plays crucial role in immunological prevention. thought significant nutrient toxin handling though its remain less understood. comprehensive understanding not only enhances our knowledge interactions essential identifying pathogenesis pathologies new avenues therapeutic intervention.

Language: Английский

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Emerging insights into macrophage extracellular traps in bacterial infections

The FASEB Journal, Journal Year: 2024, Volume and Issue: 38(13)

Published: June 25, 2024

Abstract Macrophages possess a diverse range of well‐defined capabilities and roles as phagocytes, encompassing the regulation inflammation, facilitation wound healing, maintenance tissue homeostasis, serving crucial element in innate immune response against microbial pathogens. The emergence extracellular traps is novel strategy defense that has been observed several types cells. In to infection, macrophages are stimulated produce macrophage (METs), which take form net‐like structures, filled with strands DNA adorned histones other cellular proteins. METs not only capture eliminate microorganisms but also play role development certain diseases such inflammation autoimmune disorders. primary objective this study examine latest advancements for tackling bacterial infections. We delve into current knowledge tactics utilized by bacteria elude or endure effects METs. Through investigation, we hope shed light on intricate interactions between host's system, particularly context microbicidal effector mechanisms continued exploration their impact host various pathogens opens up new avenues understanding potentially manipulating system's

Language: Английский

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Research trends in lung cancer and the tumor microenvironment: a bibliometric analysis of studies published from 2014 to 2023

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: July 31, 2024

Background Lung cancer (LC) is one of the most common malignant tumors in world and leading cause cancer-related deaths, which seriously threatens human life health as well brings a heavy burden to society. In recent years, tumor microenvironment (TME) has become an emerging research field hotspot affecting pathogenesis therapeutic approaches. However, date, there been no bibliometric analysis lung from 2014 2023.This study aims comprehensively summarize current situation development trends perspective. Methods The publications about 2023 were extracted Web Science Core Collection (WoSCC). Microsoft Excel, Origin, R-bibliometrix, CiteSpace, VOSviewer software are used scientifically analyze data. Results Totally, 763 identified this study. A rapid increase number was observed after 2018. More than 400 organizations published these 36 countries or regions. China United States have significant influence field. Zhou, CC Frontiers Immunology productive authors journals respectively. Besides, frequently cited references those on pathogenesis, clinical trials, treatment modalities. It suggests that novel models mainly based TME components, such cancer-associated fibroblasts (CAFs) may lead future trends. Conclusions still beginning stages. Gene expression, molecular pathways, modalities, detection technologies widely studied by researchers. This first trend regarding over last decade. result our provides updated perspective for scholars understand key information cutting-edge hotspots field, identify directions.

Language: Английский

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Engineering Macrophage‐Derived Exosome to Deliver Pirfenidone: A Novel Approach to Combat Silicotic Pulmonary Fibrosis

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 14(4)

Published: Oct. 9, 2024

Silicosis is a severe lung disease characterized by diffuse pulmonary fibrosis, for which there currently no effective treatment. Pirfenidone (PFD) shows great antifibrotic potential but clinically hindered low bioavailability and gastrointestinal side effects. To address these limitations, this study develops PFD delivery system (PFD-Exo) using J774A.1 macrophage-derived exosomes. Firstly, loaded via sonication, then PFD-Exo Raman spectral imaging UV absorption spectroscopy. Finally, in vitro vivo silicosis models are established to evaluate its Results show that outperforms free inhibiting TGF-β1-induced transdifferentiation of primary fibroblasts vitro. In mouse model silicosis, found be accumulated the lungs following intratracheal administration significantly ameliorates inflammation fibrosis while minimizing Mechanistic studies reveal modulates TGF-β signaling pathway downregulating SMAD3 upregulating SMAD7 NOGGIN. conclusion, provides first evidence exosomes as an treatment offers promising strategy other refractory diseases.

Language: Английский

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Therapeutic Properties of M2 Macrophages in Chronic Wounds: An Innovative Area of Biomaterial-Assisted M2 Macrophage Targeted Therapy

Stem Cell Reviews and Reports, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

Language: Английский

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Novel insights into the pathological features of COPD: Focus on oxidative stress and mitophagy

Clinical and Translational Discovery, Journal Year: 2024, Volume and Issue: 4(4)

Published: July 19, 2024

Abstract Chronic airway obstructive pulmonary disease (COPD) is a preventable and curable characterised by persistent airflow limitation. It chronic bronchitis and/or emphysema, its aetiology related to various factors such as smoking infectious factors, so forth. The pathogenesis complex prone frequent exacerbations, the prognosis of acute exacerbations COPD often poor. As crucial component innate immune system, lung macrophages significantly influence onset progression COPD. When macrophage mitochondria become dysfunctional, many functions (e.g., phagocytosis, cytokine secretion, chemotaxis, etc.) change. aim this paper describe three major pathological features (oxidative stress imbalance, polarisation mitochondrial membrane potential [MMP] production autophagy), in detail mechanism autophagy pathway association with oxidative emphasise role reactive oxygen species (mROS) COPD, providing ideas directions for subsequent studies.

Language: Английский

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