Abstract
Early
tumor
recurrence
in
hepatocellular
carcinoma
(HCC)
remains
a
challenging
area,
as
the
mechanisms
involved
are
not
fully
understood.
While
microvascular
invasion
is
linked
to
early
recurrence,
established
biomarkers
for
diagnosis
and
prognostication
lacking.
In
this
study,
our
objective
was
identify
DNA
methylation
sites
that
can
predict
outcomes
of
liver
cancer
patients
elucidate
molecular
driving
HCC
aggressiveness.
Using
methylome
data
from
patient
samples
CGRC
TCGA
databases,
we
pinpointed
hypermethylated
CpG
HCC.
Our
analysis
revealed
cg02746869
acts
crucial
regulatory
site
VIM-AS1
(vimentin
antisense
RNA1),
1.8
kb
long
noncoding
RNA.
RNA
sequencing
cells
with
manipulated
expression
EPHA3
pathogenic
target
,
which
performs
an
oncogenic
function
Hypermethylation-induced
suppression
significantly
impacted
cell
dynamics,
particularly
impairing
motility
invasiveness.
Mechanistically,
reduced
stabilized
mRNA
by
enhancing
binding
IGF2BP1
mRNA,
leading
increased
promotion
progression.
vivo
experiments
further
confirmed
VIM-AS1‒EPHA3
axis
controlled
growth
microenvironment
These
findings
suggest
downregulation
due
hypermethylation
at
via
m6A-dependent
mechanism
increase
Cells,
Journal Year:
2023,
Volume and Issue:
12(18), P. 2272 - 2272
Published: Sept. 14, 2023
With
recent
advancements
in
biological
research,
long
non-coding
RNAs
(lncRNAs)
with
lengths
exceeding
200
nucleotides
have
emerged
as
pivotal
regulators
of
gene
expression
and
cellular
phenotypic
modulation.
Despite
initial
skepticism
due
to
their
low
sequence
conservation
levels,
significance
various
processes
has
become
increasingly
apparent.
We
provided
an
overview
lncRNAs
discussed
defining
features
modes
operation.
then
explored
crucial
function
the
hepatocarcinogenesis
process,
elucidating
complex
involvement
hepatocellular
carcinoma
(HCC).
The
influential
role
within
HCC
tumor
microenvironment
is
emphasized,
illustrating
potential
key
modulators
disease
dynamics.
also
investigated
significant
influence
N6-methyladenosine
(m6A)
modification
on
lncRNA
HCC,
enhancing
our
understanding
both
roles
upstream
regulators.
Additionally,
promising
biomarkers
was
liver
cancer
diagnosis,
suggesting
a
novel
avenue
for
future
research
clinical
application.
Finally,
work
underscored
dual
contributors
pathogenesis
innovative
tools
its
diagnosis.
Existing
challenges
prospective
trajectories
are
discussed,
emphasizing
advancing
research.
Carcinogenesis,
Journal Year:
2024,
Volume and Issue:
45(6), P. 363 - 377
Published: March 6, 2024
Long
non-coding
RNAs
(lncRNAs)
have
been
established
as
pivotal
players
in
various
cellular
processes,
encompassing
the
regulation
of
transcription,
translation
and
post-translational
modulation
proteins,
thereby
influencing
functions.
Notably,
lncRNAs
exert
a
regulatory
influence
on
diverse
biological
particularly
context
tumor
development.
Tumor-associated
macrophages
(TAMs)
exhibit
M2
phenotype,
exerting
significant
impact
crucial
processes
such
initiation,
angiogenesis,
metastasis
immune
evasion.
Elevated
infiltration
TAMs
into
microenvironment
(TME)
is
closely
associated
with
poor
prognosis
cancers.
LncRNAs
within
play
direct
role
regulating
processes.
Functioning
integral
components
tumor-derived
exosomes,
prompt
M2-like
polarization
macrophages.
Concurrently,
reports
indicate
that
cells
contribute
to
expression
release
molecules
modulate
TME.
These
actions
induce
recruitment,
TAMs,
providing
critical
support
for
In
this
review,
we
survey
recent
studies
elucidating
macrophage
function
across
different
types
Frontiers in Cell and Developmental Biology,
Journal Year:
2025,
Volume and Issue:
12
Published: March 13, 2025
LncRNAs
are
RNA
molecules
of
more
than
200
nucleotides
in
length
and
participate
cellular
metabolism
responses
through
their
diverse
interactomedespite
having
no
protein-coding
capabilities.
Such
significant
interactions
also
implicate
the
presence
lncRNAs
complex
pathobiological
pathways
various
diseases,
affecting
survival
by
modulating
autophagy,
inflammation
apoptosis.
Proliferating
cells
harbour
a
microenvironment
that
mainly
stimulate
growth-specific
activities
such
as
DNA
replication,
repair,
protein
synthesis.
They
recognise
damages
at
macromolecular
level,
preventing
them
from
reaching
next-generation.
have
shown
association
with
events
occurring
towards
proliferation,
regulating
key
dividing
cells,
dysregulation
lncRNA
transcriptome
affects
normal
life-cycle,
promoting
development
cancer.
Furthermore,
demonstrated
an
cancer
growth
progression
governing
cell
growth,
epithelial-mesenchymal
transition
metastasis.
This
makes
attractive
target
for
treatment
can
be
used
marker
diagnosis
prognosis
diseases
due
to
differential
expression
diseased
samples.
review
delves
into
correlation
fundamental
signalling
how
this
crosstalk
shapes
complexity
oncogenic
microhabitat.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(7), P. 3101 - 3101
Published: March 27, 2025
Breast
cancer
(BC)
is
a
multifactorial
condition
and
it
primarily
expresses
the
estrogen
receptor
α
(ERα)
that
encoded
by
gene
1
(ESR1),
which
modulates
signaling.
ESR1,
facilitating
overproduction,
plays
an
indispensable
role
in
progression
survival
of
majority
BCs.
To
obtain
molecular
insights
into
these
phenomena,
we
analyzed
The
Cancer
Genome
Atlas
(TCGA)
breast
invasive
carcinoma
(BRCA)
RNA-Seq
datasets
for
expression
ESR1
its
correlation
to
microRNAs
(miRNAs)
long
non-coding
RNAs
(lncRNAs),
along
with
methylation
patterns.
Regulation
was
also
assessed
total
43
cancerous
non-cancerous
cell
lines.
Analyses
both
TCGA
BRCA
line
data
revealed
specific
lncRNAs,
i.e.,
MEG3,
BIK,
MLL,
FAS
are
negatively
correlated
PARP1
demonstrates
positive
association.
Additionally,
miR-30a
miR-145
showed
negative
correlations
expression.
Of
54
loci
analyzed,
them
exhibited
expression,
highlighting
potentially
modifiable
regulatory
mechanism.
These
findings
underscore
complex
events
influencing
interaction
diverse
signaling
pathways,
demonstrating
novel
pathogenesis
potential
therapeutics.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: April 25, 2025
Hepatocellular
carcinoma
(HCC)
represents
a
major
global
health
challenge,
characterized
by
its
complex
immune
microenvironment
that
plays
pivotal
role
in
tumor
progression
and
therapeutic
response.
Long
non-coding
RNAs
(lncRNAs)
have
emerged
as
critical
regulators
of
various
biological
processes,
including
gene
expression
cell
function.
This
review
explores
the
multifaceted
roles
lncRNAs
modulating
HCC.
We
discuss
how
influence
infiltration
activation
cells,
shape
cytokine
profiles,
regulate
checkpoint
molecules,
thereby
affecting
tumor’s
immunogenicity
response
to
immunotherapy.
Furthermore,
we
highlight
specific
implicated
evasion
mechanisms
their
potential
biomarkers
targets.
By
elucidating
intricate
interplay
between
landscape
HCC,
this
aims
provide
insights
into
novel
strategies
for
enhancing
immunotherapeutic
efficacy
improving
patient
outcomes.
International Journal of Oncology,
Journal Year:
2024,
Volume and Issue:
65(4)
Published: Sept. 5, 2024
Hepatocellular
carcinoma
(HCC)
tissue
is
rich
in
dendritic
cells,
T
B
macrophages,
natural
killer
cells
and
cellular
stroma.
Together
they
form
the
tumor
microenvironment
(TME),
which
also
numerous
cytokines.
Tumor‑associated
macrophages
(TAMs)
are
involved
regulation
of
development.
TAMs
HCC
receive
stimuli
different
directions,
polarize
directions
release
cytokines
to
regulate
development
HCC.
mostly
divided
into
two
cell
phenotypes:
M1
M2.
secrete
pro‑inflammatory
mediators,
M2
a
variety
anti‑inflammatory
pro‑tumorigenic
substances.
The
TAM
polarization
tumors
Both
direct
indirect
methods
for
discussed.
indirectly
support
by
promoting
peripheral
angiogenesis
regulating
immune
TME.
In
terms
between
present
review
mainly
focuses
on
molecular
mechanism.
both
proliferation
apoptosis
quantitative
changes
HCC,
stimulate
related
invasive
migratory
ability
stemness
cells.
aims
identify
immunotherapeutic
options
based
mechanisms
TME
