The Role of Interleukin 6 in Periodontitis and Its Complications

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2146 - 2146

Published: Feb. 10, 2024

Interleukin 6 (IL-6) is a pleomorphic pro-inflammatory cytokine that strongly associated with local as well systemic inflammatory processes. Its role in physiological and pathogenic processes throughout the human body has been subject of numerous studies recent years. Measurements IL-6 levels gingival crevicular fluid (GFC), serum, can be important diagnostic prognostic factors periodontal diseases (PD) assessing their impact on range related diseases. This narrative review explores significant patients periodontitis its association other widespread pathologies.

Language: Английский

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Mitochondrial Dysfunction in Diabetic Periodontitis: Mechanisms and Therapeutic Potential

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 115 - 126

Published: Jan. 1, 2025

Abstract: Diabetic periodontitis is a common oral complication of diabetes characterized by progressive destruction periodontal tissues. Recent evidence suggests that mitochondrial dysfunction plays crucial role in the pathogenesis and progression this condition. This review aims to systematically summarize potential mechanisms diabetic periodontitis. We first explore relationship between dysfunction, then analyze specific manifestations periodontitis, including morphological changes, energy metabolism disorders, increased oxidative stress, enhanced apoptosis. further delve into connections pathogenic such as exacerbated inflammatory responses, decreased tissue repair capacity, autophagy dysregulation. Finally, we discuss therapeutic targets based on function, antioxidant strategies, mitochondria-targeted drugs, regulators. also propose future research directions, emphasizing need for in-depth exploration molecular mechanisms, development new diagnostic markers personalized treatment approaches. provides insights understanding offers theoretical basis developing targeted prevention strategies improve health patients. Keywords: inflammation,

Language: Английский

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Connection between oral health and chronic diseases

MedComm, Journal Year: 2025, Volume and Issue: 6(1)

Published: Jan. 1, 2025

Chronic diseases have emerged as a paramount global health burden, accounting for 74% of mortality and causing substantial economic losses. The oral cavity serves critical indicator overall is inextricably linked to chronic disorders. Neglecting can exacerbate localized pathologies accelerate the progression conditions, whereas effective management has potential reduce their incidence mortality. Nevertheless, limited resources lack awareness often impede timely dental intervention, delaying optimal therapeutic measures. This review provides comprehensive analysis impact prevalent diseases-such diabetes mellitus, rheumatoid arthritis, cardiovascular disorders, respiratory diseases-on health, along with an exploration how changes in affect these conditions through both deterioration intervention mechanisms. Additionally, novel insights into underlying pathophysiological mechanisms governing relationships are presented. By synthesizing advancements, this aims illuminate complex interrelationship between while emphasizing urgent need greater collaboration practitioners general healthcare providers improve outcomes.

Language: Английский

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Vitamin B6 status, type 2 diabetes mellitus, and periodontitis: evidence from the NHANES database 2009–2010

BMC Oral Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 24, 2025

Periodontitis is a chronic inflammatory disease that seriously affects the quality of patients' life. Diabetes mellitus (DM) independent risk factor periodontitis. The association between vitamin B6 with several diseases have been reported in previous studies. However, effect on T2DM and periodontitis remains unclear. This study aimed to explore [evaluated by serum pyridoxal 5'-phosphate (PLP)] American population. Data this cross-sectional were extracted from National Health Nutrients Examination Survey (NHANES) 2009–2010. Serum PLP level was indicator status vivo measured enzymatic assay. Covariates included demographic information, physical examination, lifestyle characteristics, laboratory parameters complications. weighted univariate multivariate logistics regression models conducted PLP, periodontitis, odds ratios (ORs) 95% confidence intervals (CIs). Subgroup analyses further performed these associations based age, body mass index (BMI), cardiovascular (CVD) dental decay. Finally, 3,491 eligible adults information measurement, diagnosis detection included. Among them, 1,999 (57.26%) had After adjusted confounders, we found high (OR = 1.45, 95%CI: 1.04–2.02); while no significant observed. Adults low (< 67.20 nmol/L) combined 1.82, 1.29–2.55), (≥ nmol/L). These results suggested levels may modulatory robust subgroup analysis, especially aged ≥ 60 years 4.54, 2.15–9.62), obese 3.06, 1.31–7.18), without history CVD 2.25, 1.06–4.79) decay 2.93, 1.51–5.68) (all P < 0.05). Our plays association. patients maintaining higher intake potential benefits reducing risk.

Language: Английский

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Clinical Efficacy of Extracellular Vesicle Therapy in Periodontitis: Reduced Inflammation and Enhanced Regeneration

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5753 - 5753

Published: May 25, 2024

Periodontitis, a prevalent inflammatory condition, affects the supporting structures of teeth, leading to significant oral health challenges. Traditional treatments have primarily focused on mechanical debridement, antimicrobial therapy, and surgery, which often fail restore lost periodontal structures. Emerging as novel approach in regenerative medicine, extracellular vesicle (EV) including exosomes, leverages nano-sized vesicles known for facilitating intercellular communication modulating physiological pathological processes. This study is proof-of-concept type that evaluates clinical efficacy EV therapy non-surgical treatment stage I–III periodontitis, focusing its anti-inflammatory potential. The research involved seven patients undergoing healthy individuals. Clinical parameters, plaque index, bleeding probing, probing depth, attachment level, were assessed alongside cytokine levels gingival crevicular fluid. found improvements marked reduction pro-inflammatory cytokines post-treatment, matching subjects, underscoring therapy’s ability not only attenuate inflammation enhance tissue regeneration, but also highlighting potential restoring health. investigation illuminates promising role treatment, advocating shift towards therapies halt disease progression promote structural functional restoration tissues.

Language: Английский

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Mitochondria-targeted drug delivery system based on tetrahedral framework nucleic acids for bone regeneration under oxidative stress

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 496, P. 153723 - 153723

Published: July 4, 2024

Language: Английский

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Integrated analyses revealed the potential role and immune link of mitochondrial dysfunction between periodontitis and type 2 diabetes mellitus

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 130, P. 111796 - 111796

Published: March 1, 2024

Language: Английский

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Periodontitis: An often-neglected complication of diabetes

World Journal of Diabetes, Journal Year: 2024, Volume and Issue: 15(3), P. 318 - 325

Published: March 15, 2024

The bidirectional association between type 2 diabetes mellitus (T2DM) and periodontitis is now well established, resulting in periodontal disease being considered as the 6th major complication of (DM) after car-diovascular disease, eye neuropathy, nephropathy, peripheral vascular disease. DM can worsen virulence invasiveness pathogenic oral microbial flora aggravating local inflammation infection those with On other hand, chemical immunological mediators released into circulation part systemic insulin resistance worsening T2DM. Periodontitis if undiagnosed or left untreated also result eventual tooth loss. A study by Xu et al World Journal Diabetes examined predictive factors associated Chinese patients prevalence was found to be 75.7% this study. Based on logistic regression analysis, for higher risk were low brushing frequency [odds ratio (OR) = 4.3], high triglycerides (TG; OR 3.31), total cholesterol (TC; 2.87), glycated hemoglobin (HbA1c; 2.55), age (OR 1.05) while education level protective 0.53). However, most influential variables HbA1c followed age, TC, TG, level, frequency, sex random forest model (this showed sensitivity predicting risk). good understanding predictors T2DM important prevention, early detection susceptible patients, intervention improve health enable long-term glycaemic control observed .

Language: Английский

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Effect of non-surgical treatment in diabetes-associated periodontitis on immune/inflammatory and oxidative stress biomarkers: A pilot study

Journal of Diabetes and its Complications, Journal Year: 2025, Volume and Issue: 39(4), P. 108999 - 108999

Published: March 7, 2025

Language: Английский

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Mitochondrial dysfunction as a key player in aggravating periodontitis among diabetic patients: review of the current scope of knowledge

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Language: Английский

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