Inflammatory Processes Affecting Bone Health and Repair

Current Osteoporosis Reports, Journal Year: 2023, Volume and Issue: 21(6), P. 842 - 853

Published: Sept. 28, 2023

Language: Английский

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Frailty phenotype as mediator between systemic inflammation and osteoporosis and fracture risks: A prospective study

Journal of Cachexia Sarcopenia and Muscle, Journal Year: 2024, Volume and Issue: 15(3), P. 897 - 906

Published: March 11, 2024

Abstract Background Systemic inflammation and frailty have been implicated in osteoporosis (OP) fracture risks; however, existing evidence remains limited inconclusive. This study aimed to assess the associations of systemic phenotype with incident OP evaluate mediating role phenotype. Methods The present analysed data from UK Biobank, a comprehensive representative dataset encompassing over 500 000 individuals general population. Baseline peripheral blood cell counts were employed calculate markers, including neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte (PLR) immune‐inflammation index (SII). Frailty was assessed using five criteria, defined as frail (≥3 items met), pre‐frail (1–2 met) non‐frail (0 met). events confirmed through participants' health‐related records. Multivariable linear Cox regression models utilized, along mediation analysis. Results Increased associated increased risks fracture. corresponding hazard ratios 95% confidence intervals (CIs) for risk per standard deviation increase log‐transformed NLR, PLR SII 1.113 (1.093–1.132), 1.098 (1.079–1.118) 1.092 (1.073–1.111), risk, they 1.066 (1.051–1.082), 1.059 (1.044–1.075) 1.073 (1.058–1.089), respectively. Compared individuals, ones showed an elevated by 21.2% (95% CI: 16.5–26.2%) 111.0% 98.1–124.8%), respectively, 6.1% 2.8–9.5%) 38.2% 30.7–46.2%), level demonstrated positive association frailty, β CI) 0.034 (0.031–0.037), 0.026 (0.023–0.029) 0.008 (0.005–0.011) response increment SII, NLR PLR, mediated between OP/fracture risk. Subgroup sensitivity analyses robustness these findings. Conclusions are independently linked partially mediates osteoporotic traits. These results highlight significance interventions targeting prevention management.

Language: Английский

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Targeting different phenotypes of macrophages: A potential strategy for natural products to treat inflammatory bone and joint diseases

Phytomedicine, Journal Year: 2023, Volume and Issue: 118, P. 154952 - 154952

Published: July 12, 2023

Language: Английский

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A review of mathematical modeling of bone remodeling from a systems biology perspective

Frontiers in Systems Biology, Journal Year: 2024, Volume and Issue: 4

Published: April 9, 2024

Bone remodeling is an essential, delicately balanced physiological process of coordinated activity bone cells that remove and deposit new tissue in the adult skeleton. Due to complex nature this process, many mathematical models have been developed. Each these has unique features, but they underlying patterns. In review, authors highlight important aspects frequently found for discuss how why are included when considering physiology basic multicellular unit, which term used collection responsible remodeling. The review also emphasizes view from a systems biology perspective. Understanding systemic mechanisms involved will help provide information on pathology associated with aging, endocrine disorders, cancers, inflammatory conditions enhance pharmacology. Furthermore, some features cycle interactions other organ not yet modeled mathematically discussed as promising future directions field.

Language: Английский

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Resveratrol-loaded nanoplatform RSV@DTPF promote alveolar bone regeneration in OVX rat through remodeling bone-immune microenvironment

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 476, P. 146615 - 146615

Published: Oct. 18, 2023

The reconstruction of alveolar bone defect is essential for periodontal regenerative therapy or subsequent prosthetic/implant therapy, particularly in individuals with systemic diseases, such as osteoporosis. ROS accumulation, coupled aberrant macrophage polarization, pivotal the pathogenesis osteoporosis and contributes to disequilibrium between immune system. Consequently, therapeutic strategies targeting microenvironment present a promising approach treatment situ regeneration osteoporotic condition. Herein, we represented novel nano platform denoted RSV@DTPF, designed target facilitate controllable release resveratrol ROS-responsive behavior. This aims modulate tampered microenvironment. conjugated folate moiety selectively interacts receptors expressed on surface, thereby augmenting cellular uptake. while thioketal bond would break down when sensing high level intracellular encapsulated RSV. In vitro experiments suggested that designated nanoparticles could scavenge effectively restore M1/M2 ratio lipopolysaccharide(LPS)-stimulated inflammation environment; co-culture experiment provided evidence substantiating adeptness modified milieu fostering osteoblast differentiation, concurrently impeding osteoclast maturation. Furthermore, through comprehensive imaging histopathological evaluations, elucidate potential RSV@DTPF promoting osteogenesis within model utilizing ovariectomized (OVX) rats. vivo study substantiates advantageous impact nanoplatform its associated immunomodulatory effects. To sum up, exhibited capacity orchestrate microenvironmental shifts enhance generation ability also be expected applied other biomedical fields redox metabolism imbalance.

Language: Английский

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Exploring Cytokines Dynamics: Uncovering Therapeutic Concepts for Metabolic Disorders in Postmenopausal Women- Diabetes, Metabolic Bone Diseases, and Non-Alcohol Fatty Liver Disease

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102505 - 102505

Published: Sept. 1, 2024

Language: Английский

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Effects of Metabolic Dysfunction-Associated Steatotic Liver Disease on Bone Density and Fragility Fractures: Associations and Mechanisms

Journal of Obesity & Metabolic Syndrome, Journal Year: 2024, Volume and Issue: 33(2), P. 108 - 120

Published: May 14, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) has profound adverse effects on bone health and homeostasis. MASLD appears to be associated with changes in mineral density (BMD) fracture rate. However, the data are ambiguous conflicting. Although several studies have shown that children adolescents decreased BMD, prevalence of fragility fractures among scarce. In adults, increasing evidence suggests decreases BMD increases risk fractures, which due deterioration architecture addition a decrease BMD. Effects may also age- race-specific. does not seem increase but elderly men, especially those Asian origin. From mechanistic perspective, remodeling is continuous process between osteoblasts (bone-forming) osteoclasts (bone-resorbing), any imbalance resulting metabolic disease. individuals MASLD, loss anabolic insulin receptor signaling (insulin resistance) increased activator nuclear factor κB (RANK)/RANK ligand (proinflammatory cytokines) swings pendulum toward accelerated loss. These processes further complicated by concomitant presence obesity, type 2 diabetes mellitus, or sarcopenia MASLD. This study reviews current literature children/adolescents adults. review discusses pathomechanisms link fractures.

Language: Английский

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Network Pharmacology and Experimental Validation of the Therapeutic Effect of Baji Capsule on LPS-Induced Osteoporosis

Orthopedic Research and Reviews, Journal Year: 2025, Volume and Issue: Volume 17, P. 61 - 81

Published: Feb. 1, 2025

Purpose: Osteoporosis is a common skeletal disease characterized by impaired bone microarchitecture, decreased mineral density and increased fragility, leading to heavy physical economic burden due its greatly risk of fracture. Baji capsule proprietary medicine that can treat menstrual disorders postmenopausal osteoporosis. However, the efficacy has not been reported for osteoporosis caused oxidative stress inflammation. Therefore, aim this study was evaluate whether therapeutic effect on lipopolysaccharide (LPS)-induced inflammatory explore underlying mechanisms through network pharmacology. Patients Methods: model in ICR mice induced with LPS. Mice were treated vitamin E (100mg/kg), PBS, high-dose (810mg/kg) low-dose (90mg/kg), respectively. The evaluated high-resolution micro-computed tomography (Micro-CT) tissue section staining, serum factor levels assessed ELISA, stress-related marker determined kits, finally mechanism explored pharmacology then verified immunohistochemistry. Results: Micro-CT results showed attenuated LPS-induced loss.Baji also reduced oxygen free radical production. Target screening yielded total 236 active ingredients capsule, as well 278 targets after taking intersection ingredient disease-related targets. Conclusion: reducing inflammation stress. effects shown be multi-targeted multi-pathway In future, anti-inflammatory antioxidant properties utilized further diseases, prospective clinical treatment Keywords: inflammatory, stress, osteoporosis, traditional Chinese medicine,

Language: Английский

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Exercise alleviates osteoporosis by regulating the secretion of the Senescent Associated Secretory Phenotype

Bone, Journal Year: 2025, Volume and Issue: unknown, P. 117485 - 117485

Published: April 1, 2025

Language: Английский

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Systemic Inflammatory Regulators Associated with Osteoporosis: A Bidirectional Mendelian Randomization Study

Calcified Tissue International, Journal Year: 2024, Volume and Issue: 114(5), P. 490 - 501

Published: March 25, 2024

Language: Английский

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