Regenerative Therapy, Journal Year: 2024, Volume and Issue: 26, P. 1037 - 1047
Published: June 1, 2024
Language: Английский
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(4), P. 567 - 567
Published: April 21, 2024
Extracellular vesicles (EVs), acting as inherent nanocarriers adept at transporting a range of different biological molecules such proteins, lipids, and genetic material, exhibit diverse functions within the gastroenteric tract. In states normal health, they participate in upkeep systemic organ homeostasis. Conversely, pathological conditions, significantly contribute to pathogenesis gastrointestinal diseases (GIDs). Isolating EVs from patients' biofluids facilitates discovery new biomarkers that have potential offer rapid, cost-effective, non-invasive method for diagnosing prognosing specific GIDs. Furthermore, demonstrate considerable therapeutic naturally targeted physiological carriers intercellular delivery cargo or nanoscale tools engineered specifically regulate physio-pathological conditions disease progression. Their attributes including safety, high permeability, stability, biocompatibility, low immunogenicity, homing/tropism capabilities their promising clinical applications. This review will delve into various examples serving context GIDs, highlighting both functional structural conditions. The versatile advantageous properties position them candidates innovative strategies advancing personalized medicine approaches tailored tract, addressing
Language: Английский
Citations
5
Clinical and Translational Medicine, Journal Year: 2024, Volume and Issue: 14(8)
Published: Aug. 1, 2024
The liver possesses a distinctive capacity for regeneration within the human body. Under normal circumstances, cells replicate themselves to maintain function. Compensatory replication of healthy hepatocytes is sufficient after acute injuries. In late stage chronic damage, large number die and hepatocyte blocked. Liver has more complex mechanisms, such as transdifferentiation between cell types or hepatic progenitor mediated. Dysregulation causes severe disease. Gaining comprehensive understanding mechanisms would facilitate advancement efficient therapeutic approaches. This review provides an overview signalling pathways linked different aspects in various diseases. Moreover, new knowledge on cellular interactions during regenerative process also presented. Finally, this paper explores potential applications technologies, nanotechnology, stem transplantation organoids, injury, offering fresh perspectives treating
Language: Английский
Citations
5
Published: Jan. 15, 2025
Liver inflammation, injury, and hepatic cell death are caused by external agents (viruses, bacteria, drugs, alcohol, etc.) along with the genetic susceptibility of an individual. Persistent activation fibrogenic response in cells leads to liver fibrosis which turn progresses cirrhosis cancer. The dysregulation immune system generates reactive oxygen species induce necrosis hepatocytes. This process activates stellate myofibroblasts produce a huge quantity collagens, alpha-smooth muscle actin, extracellular matrix deposition parenchyma. Due multifactorial nature this disease, conventional therapies increasingly attempted combinatorial therapy or polytherapy target multiple mechanistic sites order prevent entry into further complicated irreversible stages. Despite advancements therapy, several cases aggravate (grade 3 4) cirrhosis. inconsistency treatment outcomes limited organ donors for transplantation have led ever-increasing challenging demand alternative therapies. In review, we analyze mechanism causative factors diseases, mode, therapeutic options. central diseases dysregulation, hence bioactive immunomodulatory properties should be searched exploited meet needs. Mesenchymal stem (MSCs) their specialized anti-inflammatory could utilized as effective candidate treating inflammatory diseases. MSC-derived exosome provides additional option that work tandem MSC synergistic form. series, reviewed preconditioned genetically edited MSCs augment homing, proliferation, differentiation. Importantly, all clinical challenges noted addressed before cytotherapy considered safe patients Published literature indicated has potential substitute options high-grade
Language: Английский
Citations
0
Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107618 - 107618
Published: Jan. 1, 2025
Language: Английский
Citations
0
Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 9041 - 9058
Published: Nov. 1, 2024
Lung diseases are associated with high morbidity and mortality rates, thereby jeopardizing human health imposing a great burden on society. Currently, lung mainly treated medications, oxygen therapy mechanical ventilation, but these approaches unable to effectively reduce the rate. Therefore, transplantation remains ultimate treatment for various chronic diseases, this is also hindered by limited availability of sources, immature technology low survival rate after transplantation. With constant changes in environment, pathogens, type amount harmful substances prevalence respiratory there an urgent need identify alternative methods. Research stem cell has been very successful recent years, mesenchymal cells (MSCs), together their secretory bodies, play significant therapeutic role. Extracellular vesicles MSCs (MSC-EVs) major components paracrine secretion MSCs, including exosomes, microvesicles, apoptotic among which exosomes most typical. MSC-EVs believed be present tissues body where they can carry proteins, DNA, RNA biologically active factors, just name few. They transmit biological signals participate different activities, maintenance homeostasis within tissue. Several studies have further demonstrated that generated extracellular important role diseases. In paper, origin, properties roles reviewed, mechanisms limitations current options Chronic Obstructive Pulmonary Disease, asthma, infectious disease, cancer, pulmonary fibrosis, arterial hypertension, acute injury/ distress syndrome discussed (Figure 1). addition, possible future research directions view providing new ideas
Language: Английский
Citations
2
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7235 - 7235
Published: June 30, 2024
Mesenchymal stem cells (MSCs) have shown great potential for the treatment of liver injuries, and therapeutic efficacy greatly depends on their homing to site injury. In present study, we detected significant upregulation hepatocyte growth factor (HGF) in serum mice with acute or chronic vitro study revealed that miR-9-5p miR-221-3p promoted migration human MSCs (hMSCs) toward HGF. Moreover, overexpression hMSC injured resulted significantly higher engraftment upon peripheral infusion. hMSCs reduced hepatic necrosis inflammatory infiltration but showed little effect extracellular matrix (ECM) deposition. By contrast, overexpressing not only less centrilobular venous congestion also a reduction ECM deposition, leading obvious improvement morphology alleviation fibrosis around central vein portal triads. Further studies inhibited activation stellate (HSCs) could decrease expression TIMP-1 injury MCP-1 injury, while led further inactivation HSCs downregulation all three fibrogenic proinflammatory factors TGF-β, MCP-1, both injuries. Overexpression downregulated α-SMA Col-1α1 activated cell line LX-2, suggesting may partially contribute by preventing HSC collagen expression, shedding light improving via microRNA modification.
Language: Английский
Citations
1
Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1849 - 1849
Published: Aug. 14, 2024
Hepatic fibrosis, arising from prolonged liver injury, entails the activation of hepatic stellate cells (HSCs) into myofibroblast-like expressing alpha-smooth muscle actin (α-SMA), thereby driving extracellular matrix deposition and fibrosis progression. Strategies targeting activated HSC reversal hepatocyte regeneration show promise for management. Previous studies suggest that vesicles (EVs) mesenchymal stromal (MSCs) can suppress activation, but ensuring EV purity is essential clinical use. This study investigated effects MSC-derived EVs cultured in chemically defined conditions on spheroids HSCs. Umbilical cord- bone marrow-derived MSCs were expanded media, isolated using filtration differential ultracentrifugation. The impact MSC-EVs was evaluated generated Sphericalplate 5D™ human HSCs, both by transforming growth factor beta 1 (TGF-β1). effectively reduced expression profibrotic markers HSCs induced TGF-β1 stimulation. These results highlight potential collected under to mitigate phenotype spheroids, suggesting as a promising treatment fibrosis.
Language: Английский
Citations
1
Pharmacological Research, Journal Year: 2024, Volume and Issue: 209, P. 107471 - 107471
Published: Oct. 18, 2024
Language: Английский
Citations
1
Deleted Journal, Journal Year: 2024, Volume and Issue: 2, P. 100016 - 100016
Published: March 1, 2024
Liver damage resulting from the administration of various allopathic drugs and their associated toxicity has become a major health problem, leading to hepatic fibrosis, cirrhosis, metabolic disorders. This epidemic condition liver disease represents global cause death morbidity. Although orthotopic transplantation remains vital treatment option for fibrotic conditions, its efficacy is limited by organ scarcity risk immunological rejection. Consequently, alternative therapeutic approaches are urgently needed. Cell-based therapy utilizing mesenchymal stem cells (MSCs) garnered considerable interest as promising modality. MSCs exhibit immunomodulatory properties can differentiate into hepatocytes, thus facilitating regeneration damaged hepatocytes increasing residual hepatocyte proliferation while inhibiting activation or apoptosis stellate cells. However, despite potential benefits, transplanted often low survival rates due inadequate oxidative inflammatory stress resistance. Plants harbor diverse array bioactive compounds known possess hepatoprotective antioxidant properties. Nanomaterials play crucial role in regenerative medicine providing targeted delivery agents scaffolds tissue engineering. In treating liver, nanomaterials help mitigate fibrosis progression promote through controlled release anti-fibrotic growth factors. review highlights synergistic cell-based therapy, natural antioxidants, differentiation factors, nanotechnology combating advancing medicine. These combined offer avenues effectively conditions promoting regeneration.
Language: Английский
Citations
0
Regenerative Therapy, Journal Year: 2024, Volume and Issue: 26, P. 1037 - 1047
Published: June 1, 2024
Language: Английский
Citations
0