Sleep, Health, and Society

Sleep Medicine Clinics, Journal Year: 2016, Volume and Issue: 12(1), P. 1 - 22

Published: Dec. 20, 2016

Language: Английский

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Role of sleep deprivation in immune-related disease risk and outcomes

Communications Biology, Journal Year: 2021, Volume and Issue: 4(1)

Published: Nov. 18, 2021

Modern societies are experiencing an increasing trend of reduced sleep duration, with nocturnal sleeping time below the recommended ranges for health. Epidemiological and laboratory studies have demonstrated detrimental effects deprivation on Sleep exerts immune-supportive function, promoting host defense against infection inflammatory insults. has been associated alterations innate adaptive immune parameters, leading to a chronic state increased risk infectious/inflammatory pathologies, including cardiometabolic, neoplastic, autoimmune neurodegenerative diseases. Here, we review recent advancements responses as evidenced by experimental epidemiological studies, pathophysiology, role deprivation-induced changes in Gaps knowledge methodological pitfalls still remain. Further understanding causal relationship between deregulation would help identify individuals at disease prevent adverse health outcomes.

Language: Английский

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Sleep duration, cardiovascular disease, and proinflammatory biomarkers

Nature and Science of Sleep, Journal Year: 2013, Volume and Issue: unknown, P. 93 - 93

Published: July 1, 2013

Sleep duration, cardiovascular disease, and proinflammatory biomarkers Michael A Grandner,1,2 Megan R Sands-Lincoln,3 Victoria M Pak,2,4 Sheila N Garland1,5 1Behavioral Medicine Program, Department of Psychiatry, Perelman School Medicine, University Pennsylvania, PA, USA; 2Center for Circadian Neurobiology, 3Center Evidence Based Elsevier Inc, Philadelphia, 4Division 5Department Family Community Health, USA Abstract: Habitual sleep duration has been associated with cardiometabolic via several mechanistic pathways, but few have thoroughly explored. One hypothesis is that short and/or long a state, which could increase risk metabolic diseases. This largely explored in the context experimental deprivation studies attempted to demonstrate changes markers following acute loss laboratory. Despite controlled environment available these studies, samples tend lack generalization population at large may not be perfect analog sleep. To address limitations, based associations between habitual duration. review summarizes what known from cross-sectional about association biomarkers. First, both morbidity mortality, focus on reviewed. Then, brief potential role disease presented. The majority this details specific findings related molecules, including tumor necrosis factor-α, interleukins-1, -6, -17, C-reactive protein, coagulation cellular adhesion visfatin. Finally, discussion limitations current future directions provided. Keywords: inflammation, cytokines

Language: Английский

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What keeps low-SES children from sleeping well: the role of presleep worries and sleep environment

Sleep Medicine, Journal Year: 2014, Volume and Issue: 16(4), P. 496 - 502

Published: Dec. 16, 2014

Language: Английский

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The relationship between sleep quality, stress, and academic performance among medical students

Journal of Family and Community Medicine, Journal Year: 2020, Volume and Issue: 27(1), P. 23 - 23

Published: Jan. 1, 2020

Sleep is essential for the body, mind, memory, and learning. However, relationship between sleep quality, stress, academic performance has not been sufficiently addressed in literature. The aim of this study was to assess quality psychological stress among medical students investigate performance.This cross-sectional targeted all their preclinical years at a Saudi college 2019. All were asked complete an electronic self-administered questionnaire comprising Pittsburgh Quality Index (PSQI), Kessler Psychological Distress Scale (K10), questions on students' current overall grade point average, other demographic lifestyle factors. associations categorical variables analyzed using Pearson's Chi-squared test 0.05 significance level.The mean PSQI score 8.13 ± 3.46; 77% participants reported poor 63.5% some level (mean K10 score: 23.72 8.55). Poor significantly associated with elevated mental levels (P < 0.001) daytime naps = 0.035). Stepwise logistic regression model showed that nap quality. Whereas, or did show any significant association performance.Poor strees. they statistically performance.

Language: Английский

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Determinants of sleep quality in college students: A literature review

EXPLORE, Journal Year: 2020, Volume and Issue: 17(2), P. 170 - 177

Published: Nov. 17, 2020

To review the various determinants of sleep quality among college students.The PubMed, Web Science and Cochrane Library databases were searched with search string "sleep quality" AND "college students" for articles published between January 2007 October 2017. Articles excluded if they (1) examined as a risk factor other outcomes or (2) involved inpatients participants under medical care.The 112 identified studies classified into categories according to investigated their effect on quality. Physical activity healthy social relations improved quality, while caffeine intake, stress irregular sleep-wake patterns decreased Less consistent results reported regarding eating habits knowledge, proper napping during day might improve overall quality.College students are vulnerable different factors When designing interventions students, main need be taken consideration.

Language: Английский

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Sleep Deprivation and Neurological Disorders

BioMed Research International, Journal Year: 2020, Volume and Issue: 2020, P. 1 - 19

Published: Nov. 23, 2020

Sleep plays an important role in maintaining neuronal circuitry, signalling and helps maintain overall health wellbeing. deprivation (SD) disturbs the circadian physiology exerts a negative impact on brain behavioural functions. SD impairs cellular clearance of misfolded neurotoxin proteins like α-synuclein, amyloid-β, tau which are involved major neurodegenerative diseases Alzheimer's disease Parkinson's disease. In addition, is also shown to affect glymphatic system, glial-dependent metabolic waste pathway, causing accumulation faulty synaptic compartments resulting cognitive decline. Also, affects immunological redox system neuroinflammation oxidative stress. Hence, it understand molecular biochemical alterations that causative factors leading these pathophysiological effects system. This review attempt this direction. It provides up-to-date information key processes, pathways, negatively affected by become reasons for neurological disorders over prolonged period time, if left unattended.

Language: Английский

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Circadian rhythms and cancers: the intrinsic links and therapeutic potentials

Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)

Published: March 4, 2022

The circadian rhythm is an evolutionarily conserved time-keeping system that comprises a wide variety of processes including sleep-wake cycles, eating-fasting and activity-rest coordinating the behavior physiology all organs for whole-body homeostasis. Acute disruption may lead to transient discomfort, whereas long-term irregular will result in dysfunction organism, therefore increasing risks numerous diseases especially cancers. Indeed, both epidemiological experimental evidence has demonstrated intrinsic link between dysregulated cancer. Accordingly, rapidly understanding molecular mechanisms rhythms opening new options cancer therapy, possibly by modulating clock. In this review, we first describe general regulators their functions on addition, provide insights into underlying how several types (including sleep-wake, eating-fasting, activity-rest) can drive progression, which expand our development from clock perspective. Moreover, also summarize potential applications treatment, optional therapeutic strategy patients.

Language: Английский

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Mediterranean Diet on Sleep: A Health Alliance

Nutrients, Journal Year: 2022, Volume and Issue: 14(14), P. 2998 - 2998

Published: July 21, 2022

The Mediterranean diet is a plant-based, antioxidant-rich, unsaturated fat dietary pattern that has been consistently associated with lower rates of noncommunicable diseases and total mortality, so it considered one the healthiest patterns. Clinical trials mechanistic studies have demonstrated its peculiar foods nutrients exert beneficial effects against inflammation, oxidative stress, dysmetabolism, vascular dysfunction, adiposity, senescence, cognitive decline, neurodegeneration, tumorigenesis, thus preventing age-associated chronic improving wellbeing health. Nocturnal sleep an essential physiological function, whose alteration health outcomes diseases. Scientific evidence suggests are related in bidirectional relationship, understanding this association important given their role disease prevention. In review, we surveyed literature concerning current state from epidemiological on impact nighttime quantity quality. available indicate greater adherence to adequate duration several indicators better Potential mechanisms mediating effect described, gap-in-knowledge new research agenda corroborate findings discussed.

Language: Английский

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Adherence to Healthy Lifestyle Prior to Infection and Risk of Post–COVID-19 Condition

JAMA Internal Medicine, Journal Year: 2023, Volume and Issue: 183(3), P. 232 - 232

Published: Feb. 6, 2023

Few modifiable risk factors for post-COVID-19 condition (PCC) have been identified.To investigate the association between healthy lifestyle prior to SARS-CoV-2 infection and of PCC.In this prospective cohort study, 32 249 women in Nurses' Health Study II reported preinfection habits 2015 2017. Healthy included body mass index (BMI, 18.5-24.9; calculated as weight kilograms divided by height meters squared), never smoking, at least 150 minutes per week moderate vigorous physical activity, alcohol intake (5 15 g/d), high diet quality (upper 40% Alternate Eating Index-2010 score), adequate sleep (7 9 h/d).SARS-CoV-2 (confirmed test) PCC (at 4 weeks symptoms) were self-reported on 7 periodic surveys administered from April 2020 November 2021. Among participants with infection, relative (RR) number (0 6) was estimated using Poisson regression adjusting demographic comorbidities.A total 1981 a positive test over 19 months follow-up documented. those participants, mean age 64.7 years (SD, 4.6; range, 55-75); 97.4% (n = 1929) White; 42.8% 848) active health care workers. these, 871 (44.0%) developed PCC. associated lower dose-dependent manner. Compared without any factors, 5 6 had 49% (RR, 0.51; 95% CI, 0.33-0.78) In model mutually adjusted all BMI independently 18.5-24.9 vs others, RR, 0.85; 0.73-1.00, P .046; sleep, 7-9 h/d 0.83; 0.72-0.95, .008). If these associations causal, 36.0% cases would prevented if (population attributable percentage, 36.0%; 14.1%-52.7%). Results comparable when defined symptoms 2-month duration or having ongoing time assessment.In pre-infection substantially Future research should whether interventions may reduce developing mitigate among individuals possibly other postinfection syndromes.

Language: Английский

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