Recent Advances and Mechanisms of Phage-Based Therapies in Cancer Treatment

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 9938 - 9938

Published: Sept. 14, 2024

The increasing interest in bacteriophage technology has prompted its novel applications to treat different medical conditions, most interestingly cancer. Due their high specificity, manipulability, nontoxicity, and nanosize nature, phages are promising carriers targeted therapy cancer immunotherapy. This approach is particularly timely, as current challenges research include damage healthy cells, inefficiency targeting, obstruction by biological barriers, drug resistance. Some cancers being kept at the forefront of phage research, such colorectal HCC, while others like lymphoma, cervical cancer, myeloma have not been retouched a decade. Common mechanisms immunogenic antigen display on coats use transporters carry drugs, genes, other molecules. To date, popular treatments tested gene phage-based vaccines using M13 λ phage, with some having advanced human clinical trials. results from these studies promising, but limitations therapies reticuloendothelial system clearance or diffusion must be addressed. Before for can successfully used oncology practice, more in-depth support local governments required.

Language: Английский

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Superior Electrochemical Sensor Application of Co₃O₄/C Heterostructure in Rapid Analysis of Anticancer Drug Palbociclib in Pharmaceutical Formulations and Biological Fluids

Langmuir, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 28, 2024

In this work, we report a study examining how different salt concentrations affect the structure and electrochemical performance of two Co

Language: Английский

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Advances in Cancer Gene Therapy: Strategies, Delivery Methods, and Challenges

Methods in pharmacology and toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 105 - 123

Published: Jan. 1, 2025

Language: Английский

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Gene editing techniques in cancer research

Methods in cell biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Cytokines Meet Phages: A Revolutionary Pathway to Modulating Immunity and Microbial Balance

Biomedicines, Journal Year: 2025, Volume and Issue: 13(5), P. 1202 - 1202

Published: May 15, 2025

Bacteriophages are a unique and fascinating group of viruses, known for their highly specific ability to infect replicate within bacterial cells. While potential as antibacterial agents has been recognized decades, recent research revealed complex interactions between phages the human immune system, offering new insights into role in modulation. New evidence reveals dynamic intricate relationship cytokines, suggesting regulate inflammation, tolerance, host-pathogen interaction. Herein, we review how affect production cytokines behavior cells indirectly by lysis bacterium or directly on mammalian Phages have shown induce both pro- anti-inflammatory responses recently, they explored personalized immunotherapy, cancer microbiome modulation, which focus this review. Several challenges remain despite significant progress, including practical obstructions related endotoxins along with host variability regulatory issues. Nevertheless, bacteriophages modulate makes them attractive candidates future precision medicine.

Language: Английский

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Breaking the Silence: AI-Enhanced Multi-Omics biosensors for liquid Biopsy-Based early diagnosis of pancreatic cancer

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 114118 - 114118

Published: June 1, 2025

Language: Английский

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