The Added Value of Bronchoalveolar Lavage for Pulmonary Tuberculosis Diagnosis in High-Risk Hospitalized Patients with Negative Sputum Samples DOI Creative Commons
Ophir Freund,

Yitzhac Hadad,

Tomer Lagziel

et al.

Advances in respiratory medicine, Journal Year: 2023, Volume and Issue: 92(1), P. 15 - 24

Published: Dec. 21, 2023

Hospitalized patients with a high suspicion of pulmonary tuberculosis (HS-PTB) are isolated until definite diagnosis can be determined. If doubt remains after negative sputum samples, bronchoscopy bronchoalveolar lavage (BAL) is often sought. Still, evidence the added value BAL in this patient population scarce. To address issue, we included consecutive HS-PTB samples who underwent between 2017 and 2018. Chest X-rays (CXR) CT scans were evaluated by chest radiologist blind to final diagnosis. Independent predictors for PTB assessed multivariate regression, using all positive 2019 (by or BAL) as control group (n = 41). Overall, 42 (mean age 51 ± 9, 36% female). was viable diagnostic three (7%) cases other clinically relevant pathogens six (14%). ≥2 sub-acute symptoms (adjusted OR 3.18, 95% CI 1.04–9.8), CXR upper-lobe consolidation (AOR 8.70, 2.5–29), centrilobular nodules 3.96, 1.20–13.0, p 0.02). In conclusion, hospitalized had 7% samples. Our findings highlight specific that could used future controlled studies personalize evaluation.

Language: Английский

Smoking and Respiratory Diseases in Patients with Coronary Microvascular Dysfunction DOI
Ophir Freund, Aviel Shetrit, Amir Bar‐Shai

et al.

The American Journal of Medicine, Journal Year: 2024, Volume and Issue: 137(6), P. 538 - 544.e1

Published: March 12, 2024

Language: Английский

Citations

6
Nanotechnology safety in biomedical industry DOI

Abdulhammed K. Hamzat,

Md Shafinur Murad, Eylem Asmatulu

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 97 - 113

Published: Jan. 1, 2025

Language: Английский

Citations

0
A tale as old as time – the importance of accelerated lung aging in chronic obstructive pulmonary disease DOI
Carolyn Wang, Janice M. Leung, Don D. Sin

et al.

Expert Review of Respiratory Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 13, 2025

Chronic obstructive pulmonary disease (COPD) is progressive in nature and predominantly affects older individuals. Lung function decline a typical part of the aging process, characterized by gradual loss lung mechanics, airway remodeling, persistent low-grade inflammation airways, compromised epithelial barrier function, impaired immune responses over time. The pathology senile advanced patients with COPD, whereby genomic damages contribute to structural defects cellular dysfunction. Primary, antagonistic integrative hallmarks are accelerated potentiated cumulative injury sustained from repeated environmental exposures interaction comorbidities. Identification epigenetic profiles COPD indicates how processes advancement biological age. Epigenetic abnormalities unique subpopulations occur individuals who immunodeficient, often experience early onset increased severity COPD. Accelerated indicated other biomarkers may be promising avenue for detection, prevention, subsequent management Understanding risk factors contributing implementation mitigation strategies such as cessation smoking, repurposing existing pharmacotherapeutics development novel therapies slow age-related pathologies

Language: Английский

Citations

0
The gut-lung axis: Mendelian randomization identifies a causal association between inflammatory bowel disease and interstitial lung disease DOI
Qinghua Luo, Ping Zhou,

Shuangqing Chang

et al.

Heart & Lung, Journal Year: 2023, Volume and Issue: 61, P. 120 - 126

Published: May 27, 2023

Language: Английский

Citations

7
The Role of Congestion Biomarkers in Heart Failure with Reduced Ejection Fraction DOI Open Access
Michele Correale, Francesco Fioretti, Lucia Tricarico

et al.

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(11), P. 3834 - 3834

Published: June 3, 2023

In heart failure with reduced ejection fraction, edema and congestion are related to cardiac function. Edema further aggravated by chronic kidney pulmonary abnormalities. Furthermore, together edema/congestion, sodium/water retention is an important sign of the progression failure. Edema/congestion often anticipates clinical symptoms, such as dyspnea hospitalization; it associated a quality life major risk mortality. It very for clinicians predict signs biomarkers and, mainly, understand pathophysiological findings that underlie edema. Not all congestions secondary failure, in nephrotic syndrome. This review summarizes principal evidence on possible roles old new HFrEF patients (diagnostic, prognostic, therapeutic roles). we provide description conditions other than increased biomarkers, order aid reaching differential diagnosis. To conclude, focuses how may be affected HF drugs (gliflozins, vericiguat, etc.) approved HFrEF.

Language: Английский

Citations

7
Circadian rhythm and variability of large and small airway spirometric variables in healthy individuals DOI Creative Commons
Yingying Zhang, Yiting Wu, Xue Zhang

et al.

Digital Health, Journal Year: 2024, Volume and Issue: 10

Published: Jan. 1, 2024

To assess the diurnal rhythm and variability of lung function in healthy individuals, encompassing both large small airways.

Language: Английский

Citations

1
Sobrerol: New Perspectives to Manage Patients with Frequent Respiratory Infections DOI Creative Commons
Giorgio Ciprandi,

Attilio Varriccchio

Children, Journal Year: 2023, Volume and Issue: 10(7), P. 1210 - 1210

Published: July 12, 2023

Respiratory tract infections (RTIs) are usually characterized by mucus hypersecretion. This condition may worsen and prolong symptoms signs. For this reason, reducing production improving removal represent relevant aspects of managing patients with RTIs. In regard, mucoactive drugs be effective. Mucoactive agents constitute a large class compounds different mechanisms action. Sobrerol is monoterpene able to fluidify mucus, increase mucociliary clearance, exert antioxidant activity. available in various formulations (granules, syrup, nebulized, suppository). has been on the market for over 50 years. Therefore, present article revised evidence concerning compound proposed new possible strategies. The literature analysis showed that several studies investigated efficacy safety sobrerol acute chronic RTIs hyperproduction. Seven pediatric have conducted favorable outcomes. However, regulatory agencies recently reduced treatment duration three days. future study will test hypothesis combination oral topical could benefit children adults frequent respiratory infections. rationale approach based concept accumulation risk factor increased susceptibility

Language: Английский

Citations

2
Monocyte to eosinophil ratio as a diagnostic biomarker for overlap syndrome and predictor of disease exacerbation DOI Creative Commons
Asmaa Ali, Ahmed Samir Abdelhafiz, Mai M. Saleh

et al.

International Journal of Immunopathology and Pharmacology, Journal Year: 2023, Volume and Issue: 37

Published: Jan. 1, 2023

Objectives: Chronic Obstructive Pulmonary Disease (COPD) is one of the most common pulmonary diseases. The concomitant association Sleep Apnea (OSA) and COPD known as Overlap Syndrome (OS). This study aimed to identify markers for predicting OS, among routine laboratory tests, including differential blood counts.Methods: One hundred twenty-five patients with exacerbated were enrolled in screened OSA using Epworth Sleepiness Scale (ESS). Those a positive ESS score underwent polysomnography (PSG) confirmation. All followed 90 days monitor subsequent exacerbations.Results: Out 125 COPD, 25 confirmed have OSA. OS had significantly higher body mass index (BMI) (p < 0.001). monocyte eosinophil ratio (MER) was group, while neutrophil (NMR) platelets (PMR) lower. Younger age, male sex, all associated OS. During 90-day follow-up period after hospital discharge, 60% re-admitted due acute exacerbations. hazard second exacerbation increased by two-fold every one-unit increase MER. MER demonstrated excellent utility exacerbation, an area under curve (AUC) 83% p-value .005.Conclusion: independent predictors very good prognostic next episodes. Long term follow up recommended evaluate severity exacerbations effect complications on morbidity mortality these patients.

Language: Английский

Citations

2
The Added Value of Bronchoalveolar Lavage for Pulmonary Tuberculosis Diagnosis in High-Risk Hospitalized Patients with Negative Sputum Samples DOI Creative Commons
Ophir Freund,

Yitzhac Hadad,

Tomer Lagziel

et al.

Advances in respiratory medicine, Journal Year: 2023, Volume and Issue: 92(1), P. 15 - 24

Published: Dec. 21, 2023

Hospitalized patients with a high suspicion of pulmonary tuberculosis (HS-PTB) are isolated until definite diagnosis can be determined. If doubt remains after negative sputum samples, bronchoscopy bronchoalveolar lavage (BAL) is often sought. Still, evidence the added value BAL in this patient population scarce. To address issue, we included consecutive HS-PTB samples who underwent between 2017 and 2018. Chest X-rays (CXR) CT scans were evaluated by chest radiologist blind to final diagnosis. Independent predictors for PTB assessed multivariate regression, using all positive 2019 (by or BAL) as control group (n = 41). Overall, 42 (mean age 51 ± 9, 36% female). was viable diagnostic three (7%) cases other clinically relevant pathogens six (14%). ≥2 sub-acute symptoms (adjusted OR 3.18, 95% CI 1.04–9.8), CXR upper-lobe consolidation (AOR 8.70, 2.5–29), centrilobular nodules 3.96, 1.20–13.0, p 0.02). In conclusion, hospitalized had 7% samples. Our findings highlight specific that could used future controlled studies personalize evaluation.

Language: Английский

Citations

2