Systemic impacts of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) on heart, muscle, and kidney related diseases

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: July 16, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty (NAFLD), is the most common disorder worldwide, with an estimated global prevalence of more than 31%. steatohepatitis (MASH), formerly (NASH), a progressive form MASLD characterized by hepatic steatosis, inflammation, and fibrosis. This review aims to provide comprehensive analysis extrahepatic manifestations MASH, focusing on chronic diseases related cardiovascular, muscular, renal systems. A systematic published studies literature was conducted summarize findings systemic impacts MASH. The focused association MASH metabolic comorbidities, cardiovascular mortality, sarcopenia, kidney disease. Mechanistic insights into concept lipotoxic inflammatory "spill over" from MASH-affected were also explored. are highly associated (50%-80%) other comorbidities such impaired insulin response, type 2 diabetes, dyslipidemia, hypertriglyceridemia, hypertension. Furthermore, 90% obese patients diabetes have Data suggest that in middle-aged individuals (especially those aged 45-54), independent risk factor for plays crucial role mediating pathological effects observed. Understanding multifaceted impact heart, muscle, early detection stratification. knowledge timely implementing management strategies addressing multi-organ involvement pathogenesis.

Language: Английский

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Adipokines: masterminds of metabolic inflammation

Nature reviews. Immunology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

Language: Английский

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An overview of obesity‐related complications: The epidemiological evidence linking body weight and other markers of obesity to adverse health outcomes

Diabetes Obesity and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Abstract Obesity is a highly prevalent chronic multisystem disease associated with shortened life expectancy due to number of adverse health outcomes. Epidemiological data link body weight and parameters central fat distribution an increasing risk for type 2 diabetes, hypertension, fatty liver diseases, cardiovascular diseases including myocardial infarction, heart failure, atrial fibrillation, stroke, obstructive sleep apnoea, osteoarthritis, mental disorders some types cancer. However, the individual develop cardiometabolic other obesity‐related cannot entirely be explained by increased mass. Rather than excess accumulation, dysfunction adipose tissue may represent mechanistic between obesity There are people living who seem protected against premature development diseases. On hand, normal typical upon predominantly visceral distribution. The mechanisms linking impaired function in include adipocyte hypertrophy, altered cellular composition, limited expandability safe subcutaneous stores, ectopic deposition depots, organs, hypoxia, variety stresses, inflammatory processes, release pro‐inflammatory, diabetogenic atherogenic signals. Genetic environmental factors might contribute either alone or via interaction intrinsic biological variation function. still many open questions regarding how causes whether these pathologies could reversed. Evidence‐based loss interventions using behaviour change, pharmacological surgical approaches have clarified beneficial effects realistic sustained on complications as hard This review focusses recent advances understanding epidemiological trends Plain Language Summary complex progressive characterized excessive that impair quality life. Worldwide, adults has more doubled since 1990. lead reduced expectancy, because it increases (e.g., high blood pressure, stroke), musculoskeletal respiratory depression certain not every person develops For better prevention treatment, important understand mass related It become clear explain higher complications. People can low developing Compared those abdominal region, average bigger cells, immune cells signals released from directly affect brain, liver, vasculature organs. Both inherited environment cause abnormalities through changes lower calorie intake, physical activity), medications surgery improve health, reduce

Language: Английский

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Inter-organ metabolic interaction networks in non-alcoholic fatty liver disease

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 9, 2025

Non-alcoholic fatty liver disease (NAFLD) is a multisystem metabolic disorder, marked by abnormal lipid accumulation and intricate inter-organ interactions, which contribute to systemic imbalances. NAFLD may progress through several stages, including simple steatosis (NAFL), non-alcoholic steatohepatitis (NASH), cirrhosis, potentially cancer. This closely associated with disorders driven overnutrition, key pathological processes dysregulation, impaired autophagy, mitochondrial dysfunction, endoplasmic reticulum (ER) stress, local inflammation. While hepatic metabolism in well-documented, further research into communication mechanisms crucial for deeper understanding of progression. review delves intrahepatic networks tissue-specific signaling mediators involved pathogenesis, emphasizing their impact on distal organs.

Language: Английский

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Mechanisms by which obesity regulates inflammation and anti-tumor immunity in cancer

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 733, P. 150437 - 150437

Published: July 23, 2024

Language: Английский

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Fish Oil Supplementation Mitigates High-Fat Diet-Induced Obesity: Exploring Epigenetic Modulation and Genes Associated with Adipose Tissue Dysfunction in Mice

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(7), P. 861 - 861

Published: July 1, 2024

This study investigated the effects of fish oil (FO) treatment, particularly enriched with eicosapentaenoic acid (EPA), on obesity induced by a high-fat diet (HFD) in mice. The investigation focused elucidating impact FO epigenetic modifications white adipose tissue (WAT) and involvement adipose-derived stem cells (ASCs). C57BL/6j mice were divided into two groups: control HFD for 16 weeks. In last 8 weeks, group was subdivided + (treated FO). WAT removed RNA protein extraction, while ASCs isolated, cultured, treated leptin. All samples analyzed using functional genomics tools, including PCR-array, RT-PCR, Western Blot assays. Mice receiving an displayed increased body mass, fat accumulation, altered gene expression associated inflammation dysfunction. supplementation attenuated these effects, potential protective role against HFD-induced obesity. Analysis H3K27 revealed changes histone, which partially reversed treatment. further explored leptin signaling ASCs, suggesting mechanism ASC dysfunction obesity-rich environment WAT. Overall, demonstrated efficacy mitigating obesity, influencing molecular pathways, shedding light

Language: Английский

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New Mediators in the Crosstalk between Different Adipose Tissues

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4659 - 4659

Published: April 25, 2024

Adipose tissue is a multifunctional organ that regulates many physiological processes such as energy homeostasis, nutrition, the regulation of insulin sensitivity, body temperature, and immune response. In this review, we highlight relevance different mediators control adipose activity through systematic review main players present in white brown tissues. Among them, inflammatory secreted by tissue, classical adipokines more recent ones, elements system infiltrated into (certain cell types interleukins), well role intestinal microbiota derived metabolites, have been reviewed. Furthermore, anti-obesity promote activation beige e.g., myokines, thyroid hormones, amino acids, both long micro RNAs, are exhaustively examined. Finally, also analyze therapeutic strategies based on those described to date. conclusion, novel regulators obesity, microRNAs or microbiota, being characterized promising tools treat obesity future.

Language: Английский

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Adipose ZFP36 protects against diet-induced obesity and insulin resistance

Metabolism, Journal Year: 2025, Volume and Issue: 164, P. 156131 - 156131

Published: Jan. 4, 2025

Highlights•ZFP36 downregulation in adipose tissues of humans and mice is linked to obesity metabolic disorders.•Adipose ZFP36 deficiency exacerbates diet-induced syndrome mice.•The expansion adipocytes contributes tissue hypoxia, leading dysfunction obesity.•ZFP36 attenuates hypertrophy white via RNF128/Sirt1/lipolysis signaling.AbstractAimsObesity, as a worldwide healthcare problem, has become more prevalent. well-known RNA-binding protein involved the posttranscriptional regulation many physiological processes. Whether plays role insulin resistance remains unclear.MethodsThe expression levels were analyzed obese patients, mice, ob/ob db/db mice. To determine whether protects against obesity, we generated adipose-specific knockout (ZFP36AKO) which subjected high-fat-diet (HFD) for 16 weeks. explore specific molecular mechanisms regulating disorders, used gene array assay control ZFP36-deficient tissue, assessed pathways vitro vivo.ResultsWestern blotting RT-PCR performed downregulating level Relative ZFP36AKO susceptible HFD-induced along with resistance, glucose tolerance, increased disorders. The was attributed decreased Perilipin1 (PLIN1), triglyceride lipase (ATGL), hormone-sensitive (HSL). We discovered that oppositely regulated RNF128 by repressing mRNA stability translation RNF128, negative regulator SIRT1 expression.ConclusionsThis study suggests an important identifies novel signaling pathway ZFP36/RNF128/Sirt1 obesity.Graphical abstract

Language: Английский

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The value of sex hormones and sex hormone-binding globulin in metabolic dysfunction-associated fatty liver disease among boys with obesity

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 6, 2025

This study aims to investigate the relationship between metabolic dysfunction-associated fatty liver disease (MAFLD) and sex hormones hormone-binding globulin (SHBG) in boys with obesity. Retrospective analysis of indicators hormone levels obesity who sought medical attention at First People's Hospital Lianyungang City from January 2020 December 2023. Based on abdominal ultrasound results, they were categorized into a simple group MAFLD group, differences two groups compared. Utilizing logistic regression explore risk factors for developing MAFLD, through construction Receiver Operating Characteristic (ROC) curves, conducting preliminary assessment diagnostic value MAFLD. A total 155 male children included study, mean age 11.07 ± 1.53 years. Children had higher height[(159.49 12.73)cm vs.(155.55 10.50)cm], weight[(82.32 18.75)kg vs.(68.28 15.00)kg], BMI[(32.08 4.49)kg/m2 vs.(27.85 4.21)kg/m2],fasting insulin[33.42(24.07,43.93)uIU/ml vs.23.91(15.72,31.52)uIU/ml],HOMA-IR[7.27(5.26,10.71) vs.4.87(3.27,6.86)],fastingC-peptide[1409.00(1175.00,1668.00)pmol/L vs.1020.00(849.05,1303.00)pmol/L], WBC[(7.85 1.80)×109/L vs.(7.15 1.42)×109/L], HbA1c[5.40(5.30,5.70)% vs.(5.30(5.20,5.60)%],ALT[48.00(27.00,80.00)U/L vs.19.00(15.00,26.50)U/L], AST[31.00(24.00,60.00)U/L vs.21.00(18.50, 26.00)U/L] compared (P<0.05). lower HDL[(1.05 0.21)mmol/L vs.(1.16 0.26)mmol/L], testosterone [42.41(30.33,143.28)ng/dl vs.125.41(23.41,221.57)ng/dl], SHBG[13.20(9.10,17.30)nmol/l vs.19.60(13.50,29.85)nmol/l] Logistic showed that BMI, testosterone, SHBG independent boys, ROC curve indicated their potential early diagnosis are occurrence To control it is essential address root cause high growth rate The roles merit further research.

Language: Английский

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Special Issue “Adipose Tissue Diseases: Physiopathology, Molecular Mechanism, Diagnosis, and Treatment”

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2068 - 2068

Published: Feb. 27, 2025

Adipose tissue (AT) is now considered an organ in all respects; therefore, it customary to refer as adipose [...].

Language: Английский

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