Dopamine in the Regulation of Glucose Homeostasis, Pathogenesis of Type 2 Diabetes, and Chronic Conditions of Impaired Dopamine Activity/Metabolism: Implication for Pathophysiological and Therapeutic Purposes DOI Creative Commons
Giuseppe Lisco, Anna De Tullio,

Michele Iovino

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(11), P. 2993 - 2993

Published: Nov. 7, 2023

Dopamine regulates several functions, such as voluntary movements, spatial memory, motivation, sleep, arousal, feeding, immune function, maternal behaviors, and lactation. Less clear is the role of dopamine in pathophysiology type 2 diabetes mellitus (T2D) chronic complications conditions frequently associated with it. This review summarizes recent evidence on regulating insular metabolism activity, traditional T2D, pathophysiological interconnection between T2D neurological psychiatric disorders characterized by impaired activity/metabolism, therapeutic implications. Reinforcing signaling especially patients dopamine-related disorders, Parkinson’s Huntington’s diseases, addictions, attention-deficit/hyperactivity disorder. On other hand, although specific trials are probably needed, certain medications approved for (e.g., metformin, pioglitazone, incretin-based therapy, gliflozins) may have a due to anti-inflammatory anti-oxidative effects, improvement insulin signaling, neuroinflammation, mitochondrial dysfunction, autophagy, apoptosis, restoration striatal synthesis, modulation reward hedonic eating. Last, targeting could potential diagnostic purposes diabetes-related complications, diabetic retinopathy.

Language: Английский

Diagnosis and Management of Prediabetes DOI
Justin B. Echouffo‐Tcheugui, Leigh Perreault, Linong Ji

et al.

JAMA, Journal Year: 2023, Volume and Issue: 329(14), P. 1206 - 1206

Published: April 11, 2023

Importance Prediabetes, an intermediate stage between normal glucose regulation and diabetes, affects 1 in 3 adults the US approximately 720 million individuals worldwide. Observations Prediabetes is defined by a fasting level of 100 to 125 mg/dL, 140 199 mg/dL measured 2 hours after 75-g oral load, or glycated hemoglobin (HbA 1C ) 5.7% 6.4% 6.0% 6.4%. In US, 10% people with prediabetes progress having diabetes each year. A meta-analysis found that at baseline was associated increased mortality cardiovascular event rates (excess absolute risk, 7.36 per 10 000 person-years for 8.75 disease during 6.6 years). Intensive lifestyle modification, consisting calorie restriction, physical activity (≥150 min/wk), self-monitoring, motivational support, decreased incidence 6.2 cases 3-year period. Metformin risk among 3.2 years. most effective women prior gestational younger than 60 years body mass index 35 greater, plasma 110 higher, HbA 1c higher. Conclusions Relevance events, mortality. First-line therapy modification includes weight loss exercise metformin. Lifestyle larger benefit

Language: Английский

Citations

219
Social isolation, loneliness, and incident type 2 diabetes mellitus: results from two large prospective cohorts in Europe and East Asia and Mendelian randomization DOI
Yanjun Song, Chen Zhu, Boqun Shi

et al.

EClinicalMedicine, Journal Year: 2023, Volume and Issue: 64, P. 102236 - 102236

Published: Sept. 21, 2023

Language: Английский

Citations

61
Pharmacological Approaches to Nonalcoholic Fatty Liver Disease: Current and Future Therapies DOI Creative Commons
Idoia Genua, Kenneth Cusi

Diabetes Spectrum, Journal Year: 2024, Volume and Issue: 37(1), P. 48 - 58

Published: Feb. 1, 2024

Nonalcoholic fatty liver disease (NAFLD) and its more severe form, nonalcoholic steatohepatitis (NASH), can promote the development of cirrhosis, hepatocellular carcinoma, cardiovascular disease, type 2 diabetes. Similarly, diabetes confers greatest risk for NASH, especially when associated with obesity. Although lifestyle changes are critical to success, early implementation pharmacological treatments obesity essential treat NASH avoid progression. This article reviews current guidance regarding use agents such as pioglitazone, glucagon-like peptide 1 receptor agonists, sodium-glucose cotransporter inhibitors in setting NAFLD NASH. It also latest information on new drugs currently being investigated treatment

Language: Английский

Citations

29
Efficacy and safety of once-weekly semaglutide 2·4 mg versus placebo in people with obesity and prediabetes (STEP 10): a randomised, double-blind, placebo-controlled, multicentre phase 3 trial DOI
Barbara McGowan, Jens Meldgaard Bruun,

Matt Capehorn

et al.

The Lancet Diabetes & Endocrinology, Journal Year: 2024, Volume and Issue: 12(9), P. 631 - 642

Published: July 29, 2024

Language: Английский

Citations

26
Vitamin D: Evidence-Based Health Benefits and Recommendations for Population Guidelines DOI Open Access
William B. Grant, Sunil J. Wimalawansa, Paweł Płudowski

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 277 - 277

Published: Jan. 14, 2025

Vitamin D offers numerous under-recognized health benefits beyond its well-known role in musculoskeletal health. It is vital for extra-renal tissues, prenatal health, brain function, immunity, pregnancy, cancer prevention, and cardiovascular Existing guidelines issued by governmental organizations are bone-centric largely overlook the abovementioned extra-skeletal optimal thresholds vitamin D. In addition, they rely on randomized controlled trials (RCTs), which seldom show due to high baseline 25-hydroxyvitamin [25(OH)D] concentrations, moderate supplementation doses, flawed study designs. This review emphasizes findings from prospective cohort studies showing that higher 25(OH)D concentrations reduce risks of major diseases mortality, including pregnancy birth outcomes. Serum > 30 ng/mL (75 nmol/L) significantly lower disease mortality compared <20 ng/mL. With 25% U.S. population 60% Central Europeans having levels ng/mL, should be raised above achievable through daily with 2000 IU/day (50 mcg/day) D3, prevent deaths. Furthermore, a dose between 4000 6000 IU D3 achieve serum 40 70 would provide greater protection against many adverse Future recommendations integrate observational well-designed RCTs improve public personalized care.

Language: Английский

Citations

11
Consuming Pecans as a Snack Improves Lipids/Lipoproteins and Diet Quality Compared to Usual Diet in Adults at Increased Risk for Cardiometabolic Diseases: A Randomized Controlled Trial DOI Creative Commons
Tricia Hart, Penny M. Kris‐Etherton, Kristina Petersen

et al.

American Journal of Clinical Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

2
Mechanisms of weight loss-induced remission in people with prediabetes: a post-hoc analysis of the randomised, controlled, multicentre Prediabetes Lifestyle Intervention Study (PLIS) DOI
Arvid Sandforth, Reiner Jumpertz von Schwartzenberg, Elsa Vazquez Arreola

et al.

The Lancet Diabetes & Endocrinology, Journal Year: 2023, Volume and Issue: 11(11), P. 798 - 810

Published: Sept. 25, 2023

Language: Английский

Citations

39
Insulin resistance drives cognitive impairment in hypertensive pre-diabetic frail elders: the CENTENNIAL study DOI
Pasquale Mone,

Stefano De Gennaro,

Divina Moriello

et al.

European Journal of Preventive Cardiology, Journal Year: 2023, Volume and Issue: 30(12), P. 1283 - 1288

Published: May 17, 2023

Abstract Aims Pre-diabetes is a condition that confers an increased cardiovascular risk. Frailty very common in hypertensive patients, and insulin resistance has been linked to frailty older adults with diabetes. On these grounds, our aim was evaluate the association between cognitive impairment pre-diabetic frail adults. Methods results We studied consecutive elders presenting at Avellino local health authority of Italian Ministry Health (ASL AV) from March 2021 2022. All them fulfilled following inclusion criteria: previous diagnosis hypertension no clinical or laboratory evidence secondary causes, confirmed pre-diabetes, age &gt;65 years, Montreal Cognitive Assessment (MoCA) Score &lt;26, frailty. enrolled 178 which 141 successfully completed study. observed strong inverse correlation (r = −0.807; P &lt; 0.001) MoCA Homeostatic Model for Insulin Resistance (HOMA-IR). The were by linear regression analysis using as dependent variable, after adjusting several potential confounders. Conclusion Taken together, data highlight first time global function pre-diabetes.

Language: Английский

Citations

35
Advances in the management of type 2 diabetes in adults DOI Creative Commons
Rodolfo J. Galindo, Jennifer M. Trujillo, Cecilia C. Low Wang

et al.

BMJ Medicine, Journal Year: 2023, Volume and Issue: 2(1), P. e000372 - e000372

Published: Sept. 1, 2023

Type 2 diabetes is a chronic and progressive cardiometabolic disorder that affects more than 10% of adults worldwide major cause morbidity, mortality, disability, high costs. Over the past decade, pattern management has shifted from predominantly glucose centric approach, focused on lowering levels haemoglobin A

Language: Английский

Citations

30
Association between estimated glucose disposal rate and cardiovascular mortality across the spectrum of glucose tolerance in the US population DOI
Rubing Guo, Jingjing Tong, Yongtong Cao

et al.

Diabetes Obesity and Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 18, 2024

Abstract Aims To determine if estimated glucose disposal rate (eGDR) can predict cardiovascular disease mortality risk at different levels of glycaemic tolerance. Materials and Methods The eGDR 11 656 individuals aged 45–79 years from the National Health Nutrition Examination Survey cycles 1999 to 2010 were analysed. Associations between all‐cause examined using Cox proportional hazards Fine Gray models, respectively. Results After a median follow‐up 12.8 years, total 2852 participants died, with 777 those deaths attributed causes. When comparing values ≤4 mg/kg/min falling within ranges 4–6, 6–8 >8 mg/kg/min, it was found that latter groups exhibited lower hazard ratios for both (0.61 [0.52–0.72], 0.61 [0.52–0.72] 0.46 [0.39–0.55]) (0.44 [0.33–0.57], 0.45 [0.34–0.59] 0.30 [0.23–0.40]). A U‐shaped relationship observed, an inflection point 9.54 mg/kg/min. Conclusions In general population, association reduced independently significant, contributing identification high tolerances.

Language: Английский

Citations

12