Clinical Nutrition ESPEN, Journal Year: 2024, Volume and Issue: 60, P. 116 - 121
Published: Jan. 21, 2024
Language: Английский
Journal of Cachexia Sarcopenia and Muscle, Journal Year: 2022, Volume and Issue: 14(1), P. 57 - 70
Published: Dec. 13, 2022
Muscle ultrasound is an emerging tool for diagnosing sarcopenia. This review aims to summarize the current knowledge on diagnostic test accuracy of diagnosis We collected data from Ovid Medline, Embase and Cochrane Central Register Controlled Trials. Diagnostic studies using muscle detect sarcopenia were included. Bivariate random-effects models based sensitivity specificity pairs used calculate pooled estimates sensitivity, area under curves (AUCs) summary receiver operating characteristic (SROC), if possible. screened 7332 publications included 17 with 2143 participants (mean age range: 52.6-82.8 years). All had a high risk bias. The study populations, reference standards measurement methods varied across studies. Lower extremity muscles commonly studied, whereas thickness (MT) was most widely measured parameter, followed by cross-sectional (CSA). MTs gastrocnemius, rectus femoris, tibialis anterior, soleus, abdominis geniohyoid showed moderate (SROC-AUC 0.83, 8 studies; SROC-AUC 0.78, 5 AUC 0.82, 1 study; 0.76-0.78, 2 0.76, 0.79, study, respectively), vastus intermedius, quadriceps femoris transversus low (AUC 0.67-0.71, 3 0.64, 4 0.68, respectively). CSA biceps brachii gastrocnemius fascicle length also 0.70-0.90, 0.81, 0.78-0.80, echo intensity (EI) 0.52-0.67, 0.48-0.50, 0.43-0.49, 0.69, combination EI or better than either alone shows low-to-moderate depending different parameters, muscles, populations. quality indicators (e.g., EI) quantity MT) might provide accuracy.
Language: Английский
Citations
62
Published: Aug. 12, 2024
The triad of vascular impairment, muscle atrophy, and cognitive decline represents critical age-related conditions that significantly impact health. Vascular impairment disrupts blood flow, precipitating mass reduction seen in sarcopenia the neuronal functions characteristic neurodegeneration. Our limited understanding intricate relationships within this hinders accurate diagnosis effective treatment strategies. This review ana-lyzes interrelated mechanisms contribute to these conditions, with a specific focus on ox-idative stress, chronic inflammation, impaired nutrient delivery. aim is understand common pathways involved suggest comprehensive therapeutic approaches. dysfunctions hinder circulation transportation nutrients, resulting sar-copenia characterized by atrophy weakness. dysfunction have negative physical function quality life. Neurodegenerative diseases exhibit comparable pathophysiological affect motor functions. Preventive approaches encompass lifestyle adjustments, addressing oxidative in-flammation, integrated therapies improving muscular well-being. Better links can refine strategies yield better patient out-comes. study emphasizes complex interplay between dysfunction, de-generation, decline, highlighting necessity for multidisciplinary ap-proaches. Advances domain promise improved diagnostic accuracy, more thera-peutic options, enhanced preventive measures, all contributing higher life elderly population.
Language: Английский
Citations
10
Klinische Pädiatrie, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 16, 2025
Abstract Obesity is one of the most common chronic diseases seen in children and adolescents. This study aims to examine impact obesity on body composition, assessed by sonographic anthropometric measurements, health-related quality life (HRQoL) Anthropometric measurements subcutaneous fat, quadriceps muscle, Achilles tendon thickness, HRQoL were performed between 12–18 years age. Comparisons adolescents with normal mass index (BMI) examined. A total 300 similar physical activity levels, 28.7% obesity, enrolled. The thickness mid-forearm/mid-thigh fat tissue muscle was significantly higher participants (p≤0.001). Moderate-to-strong correlation BMI waist circumference observed (r>0.40, p<0.01). Participants longer duration had thicker irrespective severity or presence metabolic syndrome. did not differ groups. lower indicated a negative moderate functioning (r<− 0.50, An important relationship demonstrated Ultrasound seems have role evaluation composition beyond what captured overall BMI. Significantly increased coupled its relation implies potential temporal association excess weight adaptation muscle.
Language: Английский
Citations
1
Discover Oncology, Journal Year: 2022, Volume and Issue: 13(1)
Published: Oct. 28, 2022
Abstract Background Lung cancer is the leading cause of cancer-related mortality worldwide. Sarcopenia, defined as loss muscle mass and function, known to adverse health outcomes. The purpose this umbrella review was integrate published systematic reviews meta-analyses exploring sarcopenia lung provide comprehensive knowledge on their relationship. Methods Eligible studies were searched from scientific databases until June 28, 2022. Critical appraisal performed using A Measurement Tool Assess Systematic Reviews (AMSTAR) 2. impact pathophysiology, prevalence, prognosis summarized at level or meta-analyses. Results Fourteen conducted. methodological quality high for one review, low nine, critically four. most common standard diagnosing in population computed tomography (CT) measure skeletal index third lumbar vertebra (L3). Sarcopenia highly prevalent among patients with cancer, a pooled prevalence ranging 42.8% 45.0%. association between increased postoperative complications decreased disease control rates immune checkpoint inhibitors has been demonstrated. Mortality significantly higher sarcopenic than non-sarcopenic regardless stage type treatment. Conclusions poor prognostic factor cancer. Future are necessary clarify pathophysiology develop effective interventions
Language: Английский
Citations
32
Annals of Medicine, Journal Year: 2022, Volume and Issue: 55(1), P. 190 - 197
Published: Dec. 20, 2022
Technological advances of hand-held ultrasound devices and educational programmes for their use, such as point-of-care ultrasonography (POCUS) training, have contributed to the increasing application these in clinical practice. With greater impact frailty sarcopenia aging societies, attention is being focused on use skeletal muscle assessment. In this narrative review, we discuss how can be applied assessment, especially that quadriceps muscle, Muscle thickness by has been shown good reliability validity evaluation size, echo intensity used evaluate quality. not only useful diagnose various settings, but also validated predict health-related outcomes death functional disability. Recommended methods was published recently, results future studies are expected comparable. Although several challenging issues with remain, if it could incorporated into POCUS more clinicians may able assessment future.KEY MESSAGESThe evolution enables physicians perform at bedside part regular medical examinations.Muscle considered an effective tool evaluating size quality, studied settings.More development future.
Language: Английский
Citations
29
Cancers, Journal Year: 2024, Volume and Issue: 16(5), P. 1061 - 1061
Published: March 5, 2024
The objective of this study was to explore the possible association between low skeletal muscle mass (SMM)—assessed by computed tomography (CT) and ultrasound (US)—and hematologic toxicity in cancer patients. A prospective cohort conducted patients who received anthracycline-based chemotherapy 2018 2020 had baseline abdominal CT including L3 level for measuring SMM. Regional measurements were carried out using US. total 65 (14 males, 51 females) included. ROC (receiver operating characteristic) analysis identified threshold values 18.0 mm [AUC (area under curve) = 0.765] females 20.0 (AUC 0.813) predicting severe neutropenia. Using these cut-offs, with rectus femoris (RF) thickness (<18.0 mm) a significantly higher incidence grade ≥3 neutropenia (50.0% vs. 10.8%, p 0.005), males RF (<20.0 (80.0% 22.2%, 0.063). regression analysis, irrespective age, gender, body index, revealed that only increased risk 3–4 9.210 times (95% CI 2.401–35.326, 0.001). Utilizing US measure aids identifying at an elevated developing Needless say, can serve as convenient easily accessible tool assessing SMM, providing repeat point-of-care evaluations clinical practice.
Language: Английский
Citations
7
Journal of Ultrasound, Journal Year: 2024, Volume and Issue: 27(4), P. 769 - 779
Published: June 21, 2024
Abstract Previously regarded as a movement and posture control agent, the skeletal muscle is now recognized an endocrine organ that may affect systemic inflammation metabolic health. The discovery of myokines such IL-6, released from in response to physical exercise, one most recent insights. Myokines are mediators balance between pro-inflammatory anti-inflammatory responses. This underscores function determinant good health prevention diseases. Advances ultrasound technology improved evaluation thickness, composition, determining fat distribution. Combining imaging with molecular biology, researchers discovered complicated interplay function, cytokine production general effects.The exercise showcasing adaptability muscles high-stress conditions contributing metabolism regulation. These findings have significant implications order provide improvement inflammatory
Language: Английский
Citations
6
Life, Journal Year: 2021, Volume and Issue: 12(1), P. 9 - 9
Published: Dec. 22, 2021
There is an increasing number of reviews investigating the value ultrasound (US) in assessment aging-related muscle loss. The present umbrella review aimed to systematically investigate evidence US imaging diagnosis and evaluation sarcopenia. PubMed, Medline, Embase Web Science were searched from their inceptions 31 October 2021. Systematic using a systematic strategy for literature search enrolled. extracted data narrated at level meta-analyses. This included four articles pertaining 125 original studies yielded several important findings. First, reliable valid tool skeletal mass. Second, among all parameters B-mode, thickness most commonly used one, which has good correlation with other standard measurements. Third, although sonoelastography contrast-enhanced are promising modalities, clinical utility still limited current stage. Finally, future warranted analyze how different ultrasonographic diagnostic criteria influence prevalence sarcopenia as well its adverse health outcomes.
Language: Английский
Citations
39
American Journal of Physical Medicine & Rehabilitation, Journal Year: 2022, Volume and Issue: unknown
Published: May 12, 2022
The aims of the study were to investigate relationship between sarcopenia and renin-angiotensin system-related disorders explore effects angiotensin-converting enzyme inhibitors angiotensin II receptor blockers on muscle mass/function physical performance.This multicenter, cross-sectional was performed using ISarcoPRM algorithm for diagnosis sarcopenia.Of 2613 participants (mean age = 61.0 ± 9.5 yrs), 1775 (67.9%) hypertensive. All sarcopenia-related parameters (except chair stand test in males) worse hypertensive group than normotensive (all P < 0.05). When clinical/potential confounders adjusted, hypertension found be an independent predictor males (odds ratio 2.403 [95% confidence interval 1.514-3.813]) females 1.906 1.328-2.734], both 0.001). After adjusting confounding factors, we that all grip strength independently/negatively related In females, users had higher performance values but lower anterior thigh thickness gait speed values, as compared with those 0.05).Hypertension associated increased risk at least 2 times. Among antihypertensives, while function mass only females.
Language: Английский
Citations
24
Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 91, P. 102043 - 102043
Published: Aug. 28, 2023
Language: Английский
Citations
15