How metformin affects various malignancies by means of microRNAs: a brief review DOI Creative Commons
Nahid Alimoradi, Negar Firouzabadi,

Reihaneh Fatehi

et al.

Cancer Cell International, Journal Year: 2021, Volume and Issue: 21(1)

Published: April 13, 2021

Abstract Metformin known as the first-line orally prescribed drug for lowering blood glucose in type II diabetes (T2DM) has recently found various therapeutic applications including cancer. been studied its influences prevention and treatment of cancer through multiple mechanisms such microRNA (miR) regulation. Alteration expression miRs by metformin may play an important role cancers. MiRs are single-stranded RNAs that involved gene By binding to 3′UTR target mRNAs, influence protein levels. Irregularities control oncogenes tumor suppressor genes associated with onset progression possess effect on modifying miR downstream pathways. Here, we summarize different types regulating molecules.

Language: Английский

The long and short non-coding RNAs modulating EZH2 signaling in cancer DOI Creative Commons
Sepideh Mirzaei, Mohammad Gholami, Kiavash Hushmandi

et al.

Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)

Published: March 2, 2022

Non-coding RNAs (ncRNAs) are a large family of RNA molecules with no capability in encoding proteins. However, they participate developmental and biological processes their abnormal expression affects cancer progression. These can function as upstream mediators different signaling pathways enhancer zeste homolog 2 (EZH2) is among them. Briefly, EZH2 belongs to PRCs exert functional roles cells due its methyltransferase activity. gene via inducing H3K27me3. In the present review, our aim provide mechanistic discussion ncRNAs role regulating cancers. MiRNAs dually induce/inhibit affect downstream targets such Wnt, STAT3 EMT. Furthermore, miRNAs regulate therapy response affecting signaling. It noteworthy that reduce miRNA by binding promoter exerting Small-interfering (siRNA) short-hairpin (shRNA) synthetic, short capable reducing suppressing LncRNAs mainly targeting miRNAs. lncRNAs induce modulating expression. Circular (CircRNAs), like lncRNAs, areas discussed review focus on molecular leading clinical translation.

Language: Английский

Citations

138
Exosomal lncRNA NEAT1 from cancer-associated fibroblasts facilitates endometrial cancer progression via miR-26a/b-5p-mediated STAT3/YKL-40 signaling pathway DOI Creative Commons
Jiangtao Fan,

Zhao‐Yu Zhou,

Yan‐Lu Luo

et al.

Neoplasia, Journal Year: 2021, Volume and Issue: 23(7), P. 692 - 703

Published: June 18, 2021

Cancer-associated fibroblasts cells (CAFs) confer a rapid growth and metastasis ability of endometrial cancer (EC) via exosomes-mediated cellular communication. Long non-coding RNA nuclear enriched abundant transcript 1 (lncRNA NEAT1) drives the malignant phenotypes EC cells. However, role exosomal NEAT1 from CAFs in progression remains ambiguous, which needs to be investigated. In our study, YKL-40 were up-regulated, while miR-26a/b-5p was down-regulated tissues. Moreover, expression increased CAF-exosomes compared with that NF-exosomes. addition, derived could transfer promote expression. Further exploration showed enhanced regulating miR-26a/b-5p-STAT3 axis More importantly, accelerated vivo tumor miR-26a/b-5p-STAT3-YKL-40 axis. Taken together, study reveals contributes miR-26a/b-5p-mediated STAT3/YKL-40 pathway, indicates therapeutic potential for treating EC.

Language: Английский

Citations

72
NEAT1 as a competing endogenous RNA in tumorigenesis of various cancers: Role, mechanism and therapeutic potential DOI Creative Commons
Kun Li,

Tongyue Yao,

Yu Zhang

et al.

International Journal of Biological Sciences, Journal Year: 2021, Volume and Issue: 17(13), P. 3428 - 3440

Published: Jan. 1, 2021

The nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA (lncRNA) that upregulated in variety of human cancer types.Increasing evidence has shown the elevation NEAT1 cells promotes cell growth, migration, and invasion inhibits apoptosis.It also known lncRNAs act as competing endogenous (ceRNA) by sponging microRNAs (miRNAs) to alter expression levels their target genes development cancers.Therefore, it important understand molecular mechanisms underlying this observation.In review, specific emphasis was placed on NEAT1's role tumor development.We summarize discuss feedback roles NEAT1/miRNA/target network progression various cancers.As our understanding during tumorigenesis improves, its therapeutic potential biomarker and/or for becomes clearer.

Language: Английский

Citations

66
Noncoding RNAs link metabolic reprogramming to immune microenvironment in cancers DOI Creative Commons
Yiyin Zhang, Qijiang Mao,

Qiming Xia

et al.

Journal of Hematology & Oncology, Journal Year: 2021, Volume and Issue: 14(1)

Published: Oct. 15, 2021

Abstract Altered metabolic patterns in tumor cells not only meet their own growth requirements but also shape an immunosuppressive microenvironment through multiple mechanisms. Noncoding RNAs constitute approximately 60% of the transcriptional output human and have been shown to regulate numerous cellular processes under developmental pathological conditions. Given extensive action mechanisms based on motif recognition patterns, noncoding may serve as hinges bridging activity immune responses. Indeed, recent studies that microRNAs, long circRNAs are widely involved rewiring, cell infiltration function. Hence, we summarized existing knowledge role remodeling metabolism microenvironment, notably, established TIMELnc manual, which is a free public manual for researchers identify pivotal lncRNAs simultaneously correlated with bioinformatic approach.

Language: Английский

Citations

63
Towards Personalized Medicine: Non-Coding RNAs and Endometrial Cancer DOI Open Access
Anna Franca Cavaliere, Federica Perelli, Simona Zaami

et al.

Healthcare, Journal Year: 2021, Volume and Issue: 9(8), P. 965 - 965

Published: July 30, 2021

Endometrial cancer (EC) is the most frequent female associated with excellent prognosis if diagnosed at an early stage. The risk factors on which clinical staging based are constantly updated and genetic epigenetic characteristics have recently been emerging as prognostic markers. evidence shows that non-coding RNAs (ncRNAs) play a fundamental role in various biological processes pathogenesis of EC many them also prediction function, remarkable importance defining therapeutic surveillance path patients. Personalized medicine focuses continuous updating identifiable during to tailor treatments This review aims show summary current classification systems encourage integration factors, introducing RNAs, avoid aggressive therapies where not necessary treat strictly monitor subjects greater relapse.

Language: Английский

Citations

57
LncRNA–miRNA–mRNA regulatory axes in endometrial cancer: a comprehensive overview DOI
Abhishek Shetty, Thejaswini Venkatesh,

Shama Prasada Kabbekodu

et al.

Archives of Gynecology and Obstetrics, Journal Year: 2022, Volume and Issue: 306(5), P. 1431 - 1447

Published: Feb. 18, 2022

Language: Английский

Citations

41
MicroRNAs and Their Influence on the ZEB Family: Mechanistic Aspects and Therapeutic Applications in Cancer Therapy DOI Creative Commons
Milad Ashrafizadeh,

Hui Li Ang,

Ebrahim Rahmani Moghadam

et al.

Biomolecules, Journal Year: 2020, Volume and Issue: 10(7), P. 1040 - 1040

Published: July 12, 2020

Molecular signaling pathways involved in cancer have been intensively studied due to their crucial role cell growth and dissemination. Among them, zinc finger E-box binding homeobox-1 (ZEB1) -2 (ZEB2) are molecules that play vital roles ensure the survival of tumor cells, particularly through enhancing proliferation, promoting migration invasion, triggering drug resistance. Importantly, ZEB proteins regulated by microRNAs (miRs). In this review, we demonstrate impact miRs on therapy, targeting proteins. MiRs able act as onco-suppressor factors inhibit malignancy cells ZEB1/2 down-regulation. This can lead an inhibition epithelial-mesenchymal transition (EMT) mechanism, therefore reducing metastasis. Additionally, ZEB1/2-mediated resistance immunosuppression. explore upstream modulators such long non-coding RNAs (lncRNAs) circular (circRNAs), these regulators influence inhibitory effect progression.

Language: Английский

Citations

68
Exploring the Roles of lncRNAs in GBM Pathophysiology and Their Therapeutic Potential DOI Creative Commons
Christian T. Stackhouse, G. Yancey Gillespie, Christopher D. Willey

et al.

Cells, Journal Year: 2020, Volume and Issue: 9(11), P. 2369 - 2369

Published: Oct. 28, 2020

Glioblastoma (GBM) remains the most devastating primary central nervous system malignancy with a median survival of around 15 months. The past decades research have not yielded significant advancements in treatment GBM. In that same time, novel class molecules, long non-coding RNAs (lncRNAs), has been found to play multitude roles cancer and normal biology. increased accessibility next generation sequencing technologies advent lncRNA-specific microarrays facilitated study lncRNA etiology. Molecular computational methods can be applied predict function. LncRNAs serve as molecular decoys, scaffolds, super-enhancers, or repressors. These molecules phenotypic switches for GBM cells at expression and/or epigenetic levels. affect stemness/differentiation, proliferation, invasion, survival, DNA damage response, chromatin dynamics. Aberrant these transcripts may facilitate therapy resistance, leading tumor recurrence. could theragnostic prognostic biomarkers other cancers. RNA-based therapeutics also employed target lncRNAs route recurrent this review, we explore pathophysiology posit their therapeutic potential

Language: Английский

Citations

55
Non-Coding RNAs as Prognostic Markers for Endometrial Cancer DOI Open Access
Roberto Piergentili, Simona Zaami, Anna Franca Cavaliere

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(6), P. 3151 - 3151

Published: March 19, 2021

Endometrial cancer (EC) has been classified over the years, for prognostic and therapeutic purposes. In recent classification systems have emerging not only based on EC clinical pathological characteristics but also its genetic epigenetic features. Noncoding RNAs (ncRNAs) are as promising markers in several types, including EC, which their value is currently under investigation will likely integrate present tools protein coding genes. This review aims to underline importance of events tumorigenesis, by expounding upon role ncRNAs.

Language: Английский

Citations

54
Molecular Interactions of the Long Noncoding RNA NEAT1 in Cancer DOI Open Access
Jingtao Gu, Bo Zhang, Rui An

et al.

Cancers, Journal Year: 2022, Volume and Issue: 14(16), P. 4009 - 4009

Published: Aug. 19, 2022

As one of the best-studied long noncoding RNAs, nuclear paraspeckle assembly transcript 1 (NEAT1) plays a pivotal role in progression cancers. NEAT1, especially its isoform NEAT1-1, facilitates growth and metastasis various cancers, excluding acute promyelocytic leukemia. NEAT1 can be elevated via transcriptional activation or stability alteration cancers changing aggressive phenotype cancer cells. also secreted from other cells delivered to through exosomes. Hence, elucidating molecular interaction may shed light on future treatment cancer. Herein, we review function progression, explain how interacts with proteins, DNA promoter regions upregulate tumorigenic factors.

Language: Английский

Citations

28