Overview of Cancer Stem Cells (CSCs) and Mechanisms of Their Regulation: Implications for Cancer Therapy

Current Protocols in Pharmacology, Journal Year: 2013, Volume and Issue: 61(1)

Published: June 1, 2013

Abstract The identification of small subpopulations cancer stem cells (CSCs) from blood mononuclear in human acute myeloid leukemia (AML) 1997 was a landmark observation that recognized the potential role CSCs tumor aggressiveness. Two critical properties contribute to functional establishment and recurrence cancerous tumors: their capacity for self‐renewal differentiate into unlimited heterogeneous populations cells. These findings suggest may represent novel therapeutic targets treatment and/or prevention progression, since they appear be involved cell migration, invasion, metastasis, resistance–all which lead poor clinical outcomes. CSC‐specific markers, isolation characterization malignant tissues, targeting strategies destruction provide opportunity research. This overview describes implications several common CSC markers are restricted diseases, e.g., leukemia, breast, prostate, pancreatic, lung cancers. microRNAs (miRNAs) regulation function is also discussed, as methods commonly used antidiabetic drug metformin– has been shown have effects on CSCs, known an antitumor agent–is discussed example this new class chemotherapeutics. Curr. Protoc. Pharmacol . 61:14.25.1‐14.25.14 © 2013 by John Wiley & Sons, Inc.

Language: Английский

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Chemotherapy: a double-edged sword in cancer treatment

Cancer Immunology Immunotherapy, Journal Year: 2021, Volume and Issue: 71(3), P. 507 - 526

Published: Aug. 5, 2021

Language: Английский

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Emerging role of tumor cell plasticity in modifying therapeutic response

Signal Transduction and Targeted Therapy, Journal Year: 2020, Volume and Issue: 5(1)

Published: Oct. 7, 2020

Abstract Resistance to cancer therapy is a major barrier management. Conventional views have proposed that acquisition of resistance may result from genetic mutations. However, accumulating evidence implicates key role non-mutational mechanisms underlying drug tolerance, the latter which focus will be discussed here. Such processes are largely driven by tumor cell plasticity, renders cells insusceptible drug-targeted pathway, thereby facilitating survival and growth. The concept plasticity highlights significance re-activation developmental programs closely correlated with epithelial–mesenchymal transition, properties stem cells, trans-differentiation potential during exposure. From observations in various cancers, this provides an opportunity for investigating nature anticancer resistance. Over years, our understanding emerging phenotype switching modifying therapeutic response has considerably increased. This expanded knowledge contributes developing novel strategies or combination regimens using available drugs, likely improve patient outcomes clinical practice.

Language: Английский

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Tumor-associated macrophages: an effective player of the tumor microenvironment

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 16, 2023

Cancer progression is primarily caused by interactions between transformed cells and the components of tumor microenvironment (TME). TAMs (tumor-associated macrophages) make up majority invading immune components, which are further categorized as anti-tumor M1 pro-tumor M2 subtypes. While known to have anti-cancer properties, recognized extend a protective role tumor. As result, manipulates TME in such way that it induces macrophage infiltration switching bias secure its survival. This M2-TAM promotes cancer cell proliferation, neoangiogenesis, lymphangiogenesis, epithelial-to-mesenchymal transition, matrix remodeling for metastatic support, manipulation an immunosuppressive state. additionally promote emergence stem (CSCs), their ability originate, metastasize, relapse into tumors. CSCs also help revealing escape survival strategies during initiation phases. review describes reasons immunotherapy failure and, thereby, devises better impair tumor-TAM crosstalk. study will shed light on understudied TAM-mediated address much-needed holistic approach therapy, encompasses targeting cells, CSCs, all at same time.

Language: Английский

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Targeting the facilitative glucose transporter GLUT1 inhibits the self-renewal and tumor-initiating capacity of cancer stem cells

Oncotarget, Journal Year: 2014, Volume and Issue: 6(2), P. 651 - 661

Published: Nov. 26, 2014

// Keita Shibuya 1,2,3,* , Masashi Okada 1,* Shuhei Suzuki 1,4 Manabu Seino 1,5 Shizuka 1,2,3,6 Hiroyuki Takeda and Chifumi Kitanaka 1 Department of Molecular Cancer Science, Yamagata University School Medicine, Yamagata, Japan 2 Oncology Research Center, Institute for Advanced Epidemiology, University, 3 Global COE program Medical Sciences, Society Promotion Tokyo, 4 Clinical Oncology, 5 Obstetrics Gynecology, 6 * These authors contributed equally to this work Correspondence: Kitanaka, email: Keywords : cancer initiating cell, glioma, tumorigenicity, xenograft analysis Received August 11, 2014 Accepted November 25, Published 26, Abstract Increased glucose metabolism is now recognized as an emerging hallmark cancer. Recent studies have shown that even more active in stem cells (CSCs), a rare population with the capacity self-renew initiate tumors, CSCs are dependent on glycolysis their survival/growth. However, role control self-renewal tumor-initiating per se still remains obscure. Moreover, much unknown which numerous molecules involved suitable target CSCs. Here we demonstrate facilitative transporter GLUT1 essential maintenance pancreatic, ovarian, glioblastoma Notably, found WZB117, specific inhibitor, could inhibit without compromising proliferative potential vitro . In vivo systemic WZB117 administration inhibited tumor initiation after implantation causing significant adverse events host animals. Our findings indicate GLUT1-dependent has pivotal not only growth survival but also stemness suggest promising CSC-directed therapy.

Language: Английский

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Pathways to Breast Cancer Recurrence

ISRN Oncology, Journal Year: 2013, Volume and Issue: 2013, P. 1 - 16

Published: Feb. 28, 2013

Breast cancer remains a deadly disease, even with all the recent technological advancements. Early intervention has made an impact, but overwhelmingly large number of breast patients still live under fear “recurrent” disease. recurrence is clinically huge problem and one that largely not well understood. Over years, factors have been studied overarching aim being able to prognose recurrent This paper attempts provide overview our current knowledge its associated challenges. Through survey literature on stem cells (CSCs), epithelial-mesenchymal transition (EMT), various signaling pathways such as Notch/Wnt/hedgehog, microRNAs (miRNAs), we also examine hypotheses are currently investigation for prevention recurrence.

Language: Английский

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Nanomedicine-mediated cancer stem cell therapy

Biomaterials, Journal Year: 2015, Volume and Issue: 74, P. 1 - 18

Published: Sept. 29, 2015

Language: Английский

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Sulforaphane enhances the anticancer activity of taxanes against triple negative breast cancer by killing cancer stem cells

Cancer Letters, Journal Year: 2017, Volume and Issue: 394, P. 52 - 64

Published: Feb. 28, 2017

Language: Английский

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Targeting colorectal cancer stem cells using curcumin and curcumin analogues: insights into the mechanism of the therapeutic efficacy

Cancer Cell International, Journal Year: 2015, Volume and Issue: 15(1)

Published: Oct. 9, 2015

Colorectal cancer is one of the commonest cancers in world and it also a common cause cancer-related death worldwide. Despite advanced treatment strategies, disease rarely cured completely due to recurrence. Evidence shows that this small population cells, called stem cells (CSCs), tumour mass have self-renewal differentiation potential give rise new population. Many pre-clinical clinical studies used curcumin its analogues as anti-cancer agents various types cancer, including colorectal cancer. Intriguingly, recently been shown be effective lowering recurrence by targeting CSC population, hence inhibiting growth. In review, we highlight efficacy underlying molecular mechanism involved. Curcumin, presence or absence other agents, has reduce size growth both vivo vitro affecting many intracellular events are associated with progression formation. An insight into unraveled mode action via which could affect key regulators CSC, importantly; (1) signaling pathways, Wnt/β-catenin, Sonic Hedgehog, Notch PI3K/Akt/mTOR, (2) microRNA (3) epithelial-mesenchymal transition at multiple levels. Therefore, play role chemosensitiser whereby CSCs now sensitised towards therapy, therefore, combination therapy using agent much more than single agent. This modality can further developed employing an delivery system nanotechnology based approach treat

Language: Английский

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CD133+ cells contribute to radioresistance via altered regulation of DNA repair genes in human lung cancer cells

Radiotherapy and Oncology, Journal Year: 2014, Volume and Issue: 110(3), P. 538 - 545

Published: Jan. 16, 2014

Language: Английский

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