Curcumin and its anti‐colorectal cancer potential: From mechanisms of action to autophagy DOI Creative Commons
Aranka Brockmueller, Vicenç Ruiz de Porras, Mehdi Shakibaei

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(7), P. 3525 - 3551

Published: May 3, 2024

Abstract Colorectal cancer (CRC) development and progression, one of the most common cancers globally, is supported by specific mechanisms to escape cell death despite chemotherapy, including cellular autophagy. Autophagy an evolutionarily highly conserved degradation pathway involved in a variety processes, such as maintenance homeostasis clearance foreign bodies, its imbalance associated with many diseases. However, role autophagy CRC progression remains controversial, it has dual function, affecting either or survival, senescence tumor therapy. Indeed, numerous data have been presented that serves alternative apoptosis when latter ineffective apoptosis‐resistant cells, which why also referred programmed type II. Curcumin, active constituents Curcuma longa , great potential combat influencing various signaling pathways epigenetic regulation safe cost‐effective approach. This review discusses efficacy curcumin against vitro vivo, particularly modulation pathways. While clinical studies assessed prevention treatment, none specifically examined Nonetheless, we offer overview correlations support use this polyphenol prophylactic co‐therapeutic agent CRC.

Language: Английский

Cancer stem cells as key drivers of tumour progression DOI Creative Commons

Ain Zubaidah Ayob,

Thamil Selvee Ramasamy

Journal of Biomedical Science, Journal Year: 2018, Volume and Issue: 25(1)

Published: March 6, 2018

Cancer stem cells (CSCs) are subpopulations of cancer sharing similar characteristics as normal or progenitor such self-renewal ability and multi-lineage differentiation to drive tumour growth heterogeneity. Throughout the progression, CSC can further be induced from differentiated via adaptation cross-talks with microenvironment well a response therapeutic pressures, therefore contributes their heterogeneous phenotypes. Challengingly, conventional treatments target bulk unable CSCs due highly resistance nature, leading metastasis recurrence.

Language: Английский

Citations

759
Targeting cancer stem cells and signaling pathways by phytochemicals: Novel approach for breast cancer therapy DOI
Prasad Dandawate, Dharmalingam Subramaniam, Roy A. Jensen

et al.

Seminars in Cancer Biology, Journal Year: 2016, Volume and Issue: 40-41, P. 192 - 208

Published: Sept. 9, 2016

Language: Английский

Citations

278
Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs DOI Creative Commons
James A. McCubrey,

Kvin Lertpiriyapong,

Linda S. Steelman

et al.

Aging, Journal Year: 2017, Volume and Issue: 9(6), P. 1477 - 1536

Published: June 12, 2017

Aging | doi:10.18632/aging.101250. James A. McCubrey, Kvin Lertpiriyapong, Linda S. Steelman, Steve L. Abrams, Li V. Yang, Ramiro M. Murata, Pedro Rosalen, Aurora Scalisi, Luca Neri, Lucio Cocco, Stefano Ratti, Alberto Martelli, Piotr Laidler, Joanna Dulińska-Litewka, Dariusz Rakus, Agnieszka Gizak, Paolo Lombardi, Ferdinando Nicoletti, Saverio Candido, Massimo Libra, Giuseppe Montalto, Melchiorre Cervello

Language: Английский

Citations

224
Curcumin and colorectal cancer: An update and current perspective on this natural medicine DOI

Wenhao Weng,

Ajay Goel

Seminars in Cancer Biology, Journal Year: 2020, Volume and Issue: 80, P. 73 - 86

Published: Feb. 21, 2020

Language: Английский

Citations

223
Anticancer Activity of Curcumin and Its Analogues: Preclinical and Clinical Studies DOI
Alessandro Allegra, Vanessa Innao,

Sabina Russo

et al.

Cancer Investigation, Journal Year: 2016, Volume and Issue: 35(1), P. 1 - 22

Published: Dec. 20, 2016

Curcumin has been shown to have a wide variety of therapeutic effects, ranging from anti-inflammatory, chemopreventive, anti-proliferative, and anti-metastatic. This review provides an overview the recent research conducted overcome problems with bioavailability curcumin, preclinical clinical studies that reported success in combinatorial strategies coupling curcumin other treatments. Research on signaling pathways treatment targets shows it potently acts major intracellular components involved key processes such as genomic modulations, cell invasion death pathways. is promising molecule for prevention cancer.

Language: Английский

Citations

213
New insights into therapeutic activity and anticancer properties of curcumin DOI Creative Commons
Abir K. Panda, Dwaipayan Chakraborty, Irene Sarkar

et al.

Journal of Experimental Pharmacology, Journal Year: 2017, Volume and Issue: Volume 9, P. 31 - 45

Published: March 1, 2017

Natural compounds obtained from plants are capable of garnering considerable attention the scientific community, primarily due to their ability check and prevent onset progress cancer. These natural used nontoxic nature fewer side effects they cause compared chemotherapeutic drugs. Furthermore, such products perform even better when given as an adjuvant along with traditional drugs, thereby enhancing potential chemotherapeutics simultaneously reducing undesired effects. Curcumin, a naturally occurring polyphenol compound found in plant

Language: Английский

Citations

189
Curcumin and Its Derivatives as Potential Therapeutic Agents in Prostate, Colon and Breast Cancers DOI Creative Commons

Zintle Mbese,

Vuyolwethu Khwaza, Blessing A. Aderibigbe

et al.

Molecules, Journal Year: 2019, Volume and Issue: 24(23), P. 4386 - 4386

Published: Nov. 30, 2019

Cancer is a life-threatening disease and the second leading cause of death around world. The increasing threats drug-resistant cancers indicate that there an urgent need for improvement or development more effective anticancer agents. Curcumin, phenolic compound originally derived from turmeric plant (Curcuma longa L. (Zingiberaceae family)) widely known as spice coloring agent food have been reported to possess notable activity by inhibiting proliferation metastasis, enhancing cell cycle arrest apoptosis in various cancer cells. In spite all these benefits, therapeutic application curcumin clinical medicine its bioavailability are still limited due poor absorption rapid metabolism. Structural modification through synthesis curcumin-based derivatives potential approach overcome above limitations. Curcumin can disadvantages while overall efficacy hindering drug resistance. This article reports review published their enhanced activities.

Language: Английский

Citations

154
Aging of mesenchymal stem cell: machinery, markers, and strategies of fighting DOI Creative Commons
Mahmoud Al‐Azab,

Mohammed Safi,

Elina Idiiatullina

et al.

Cellular & Molecular Biology Letters, Journal Year: 2022, Volume and Issue: 27(1)

Published: Aug. 19, 2022

Human mesenchymal stem cells (MSCs) are primary multipotent capable of differentiating into osteocytes, chondrocytes, and adipocytes when stimulated under appropriate conditions. The role MSCs in tissue homeostasis, aging-related diseases, cellular therapy is clinically suggested. As aging a universal problem that has large socioeconomic effects, an improved understanding the concepts can direct public policies reduce its adverse impacts on healthcare system humanity. Several studies have been carried out over several years to understand phenomenon different factors affecting human aging. A reduced ability adult cell populations reproduce regenerate one main contributors process. In this context, senescence major challenge front advancement. Many factors, ranging from genetic metabolic pathways extrinsic through various signaling pathways, involved regulating mechanism MSC senescence. To better reverse senescence, review highlights underlying mechanisms signs discusses strategies combat

Language: Английский

Citations

93
Mechanism of Apoptosis Induced by Curcumin in Colorectal Cancer DOI Open Access

Nor Isnida Ismail,

Iekhsan Othman, Faridah Abas

et al.

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(10), P. 2454 - 2454

Published: May 17, 2019

Colorectal cancer (CRC) is among the top three with higher incident and mortality rate worldwide. It estimated that about over than 1.1 million of death 2.2 new cases by year 2030. The current treatment modalities usage chemo drugs such as FOLFOX FOLFIRI, surgery radiotherapy, which are usually accompanied major side effects, rarely cured along poor survival at recurrence outcome. This trigger needs exploring natural compounds anti-cancer properties possess fewer effects. Curcumin, a common spice used in ancient medicine was found to induce apoptosis targeting various molecules signaling pathways involved CRC. Disruption homeostatic balance between cell proliferation could be one promoting factors colorectal progression. In this review, we describe knowledge regulation curcumin CRC regard molecular targets associated pathways.

Language: Английский

Citations

143
Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1α inhibition DOI Creative Commons
Farid Ahmad Siddiqui, Gopinath Prakasam,

Shilpi Chattopadhyay

et al.

Scientific Reports, Journal Year: 2018, Volume and Issue: 8(1)

Published: May 23, 2018

Abstract Warburg effect is an emerging hallmark of cancer cells with pyruvate kinase M2 (PKM2) as its key regulator. Curcumin extensively-studied anti-cancer compound, however, role in affecting metabolism remains poorly understood. Herein, we show that curcumin inhibits glucose uptake and lactate production (Warburg effect) a variety cell lines by down-regulating PKM2 expression, via inhibition mTOR-HIF1α axis. Stable silencing revealed required for proliferation cells. over-expression abrogated the effects curcumin, demonstrating PKM2-mediated. High expression correlated strongly poor overall survival cancer, suggesting requirement progression. The study unravels novel PKM2-mediated inhibitory on metabolic capacities To best our knowledge, this first linking PKM2-driven glycolysis, thus, providing new perspectives into mechanism anticancer activity.

Language: Английский

Citations

123