Targeting Cancer Stem Cells as the Key Driver of Carcinogenesis and Therapeutic Resistance DOI Open Access
Refaat A. Eid, Muhammad Alaa Eldeen,

Eslam M. Shedid

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(2), P. 1786 - 1786

Published: Jan. 16, 2023

The emerging concept of cancer stem cells (CSCs) as the key driver behind carcinogenesis, progression, and diversity has displaced prior model a tumor composed with similar subsequently acquired mutations an equivalent capacity for renewal, invasion, metastasis. This significant change shifted research focus toward targeting CSCs to eradicate cancer. may be characterized using cell surface markers. They are defined by their self-renew differentiate, resist conventional therapies, generate new tumors following repeated transplantation in xenografted mice. CSCs' functional capabilities governed various intracellular extracellular variables such pluripotency-related transcription factors, internal signaling pathways, external stimuli. Numerous natural compounds synthetic chemicals have been investigated ability disrupt these regulatory components inhibit stemness terminal differentiation CSCs, hence achieving clinical implications. However, no treatment focuses on biological consequences drugs functions established. article provides biomedical discussion at time along overview origin, features, characterization, isolation techniques, novel targeted therapeutic approaches. Additionally, we highlighted factors endorsed controlling or helping promote CSCs. Our objective was encourage future studies prospective treatments develop framework application single combined therapeutics forms

Language: Английский

Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy DOI Creative Commons
Tuying Yong,

Xiaoqiong Zhang,

Nana Bie

et al.

Nature Communications, Journal Year: 2019, Volume and Issue: 10(1)

Published: Aug. 23, 2019

Developing biomimetic nanoparticles without loss of the integrity proteins remains a major challenge in cancer chemotherapy. Here, we develop biocompatible tumor-cell-exocytosed exosome-biomimetic porous silicon (PSiNPs) as drug carrier for targeted Exosome-sheathed doxorubicin-loaded PSiNPs (DOX@E-PSiNPs), generated by exocytosis endocytosed DOX-loaded from tumor cells, exhibit enhanced accumulation, extravasation blood vessels and penetration into deep parenchyma following intravenous administration. In addition, DOX@E-PSiNPs, regardless their origin, possess significant cellular uptake cytotoxicity both bulk cells stem (CSCs). These properties endow DOX@E-PSiNPs with great vivo enrichment total side population features CSCs, resulting anticancer activity CSCs reduction subcutaneous, orthotopic metastatic models. results provide proof-of-concept use exocytosed promising efficient

Language: Английский

Citations

666
Ligand‐Installed Nanocarriers toward Precision Therapy DOI
Peng Mi, Horacio Cabral, Kazunori Kataoka

et al.

Advanced Materials, Journal Year: 2019, Volume and Issue: 32(13)

Published: July 28, 2019

Development of drug-delivery systems that selectively target neoplastic cells has been a major goal nanomedicine. One strategy for achieving this milestone is to install ligands on the surface nanocarriers enhance delivery tissues, as well internalization by cells, which improves accuracy, efficacy, and ultimately enhances patient outcomes. Herein, recent advances regarding development ligand-installed are introduced effect their design biological performance discussed. Besides academic achievements, progress in clinical trials presented, along with challenges faced these formulations. Lastly, future perspectives discussed, particular emphasis potential emerging precision therapies.

Language: Английский

Citations

302
Recent advances in drug delivery systems for targeting cancer stem cells DOI Creative Commons
Hongxia Duan, Yanhong Liu, Zhonggao Gao

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2020, Volume and Issue: 11(1), P. 55 - 70

Published: Oct. 2, 2020

Cancer stem cells (CSCs) are a subpopulation of cancer with functions similar to those normal cells. Although few in number, they capable self-renewal, unlimited proliferation, and multi-directional differentiation potential. In addition, CSCs have the ability escape immune surveillance. Thus, play an important role occurrence development tumors, closely related tumor invasion, metastasis, drug resistance, recurrence after treatment. Therefore, specific targeting may improve efficiency therapy. A series corresponding promising therapeutic strategies based on CSC targeting, such as niche, signaling pathways, mitochondria, currently under development. Given rapid progression this field nanotechnology, delivery systems (DDSs) for increasingly being developed. review, we summarize advances CSC-targeted DDSs. Furthermore, highlight latest developmental trends through main line process; some considerations about rationale, advantages, limitations different DDSs therapies were discussed.

Language: Английский

Citations

198
Nanodiamonds for In Vivo Applications DOI

KiranJ. van der Laan,

Masoumeh Hasani, Tingting Zheng

et al.

Small, Journal Year: 2018, Volume and Issue: 14(19)

Published: Feb. 9, 2018

Abstract Due to their unique optical properties, diamonds are the most valued gemstones. However, beyond sparkle, have a number of properties. Their extreme hardness gives them outstanding performance as abrasives and cutting tools. Similar many materials, nanometer‐sized form has yet other Nanodiamonds very inert but still can be functionalized on surface. Additionally, they made in small sizes narrow size distribution. also host stable fluorescent defects. Since protected crystal lattice, never bleach. These defects utilized for nanoscale sensing since change example, based temperature or magnetic fields surroundings. In this Review, vivo applications focused upon. To end, how different diamond materials affects properties discussed first. Next, biocompatibility studies reviewed. Finally, reader is introduced diamonds. include drug delivery, aiding radiology, labeling, use cosmetics. The field critically reviewed perspective future developments provided.

Language: Английский

Citations

169
Actively targeted nanomedicines for precision cancer therapy: Concept, construction, challenges and clinical translation DOI

Wenxing Gu,

Fenghua Meng, Rainer Haag

et al.

Journal of Controlled Release, Journal Year: 2020, Volume and Issue: 329, P. 676 - 695

Published: Oct. 3, 2020

Language: Английский

Citations

152
Nanoparticle drug delivery systems and their applications as targeted therapies for triple negative breast cancer DOI
Xiangyi Kong, Yihang Qi,

Xiangyu Wang

et al.

Progress in Materials Science, Journal Year: 2023, Volume and Issue: 134, P. 101070 - 101070

Published: Jan. 16, 2023

Language: Английский

Citations

86
Doxorubicin conjugated functionalizable carbon dots for nucleus targeted delivery and enhanced therapeutic efficacy DOI
Lei Yang,

Zheran Wang,

Ju Wang

et al.

Nanoscale, Journal Year: 2016, Volume and Issue: 8(12), P. 6801 - 6809

Published: Jan. 1, 2016

Carbon dots (CDs) have shown great potential in imaging and drug/gene delivery applications. In this work, CDs functionalized with a nuclear localization signal peptide (NLS-CDs) were employed to transport doxorubicin (DOX) into cancer cells for enhanced antitumor activity. DOX was coupled NLS-CDs (DOX-CDs) through an acid-labile hydrazone bond, which cleavable the weakly acidic intracellular compartments. The cytotoxicity of DOX-CD complexes evaluated by MTT assay cellular uptake monitored using flow cytometry confocal laser scanning microscopy. Cell confirmed that DOX-CDs mainly located nucleus. Furthermore, could efficiently induce apoptosis human lung adenocarcinoma A549 cells. vivo therapeutic efficacy investigated xenograft nude mice model exhibited ability inhibit tumor growth compared free DOX. Thus, conjugates may be exploited as promising drug vehicles therapy.

Language: Английский

Citations

163
Rational Design of Nanoparticles with Deep Tumor Penetration for Effective Treatment of Tumor Metastasis DOI
Zhiwen Zhang, Hong Wang, Tao Tan

et al.

Advanced Functional Materials, Journal Year: 2018, Volume and Issue: 28(40)

Published: Aug. 6, 2018

Abstract The limited penetration of nanoparticles in primary tumors and metastases remains a great challenge for effective treatment tumor metastasis. This review outlines the current approaches summarizes rational design with deep capacity anti‐metastasis treatment. There are two ways to achieve better penetration; through regulation physicochemical properties remodeling microenvironment, including vasculature stromal environment. Moreover, biomimetic strategies that integrate advantages metastasis‐homing molecules during cancer cell metastasis discussed. These efforts have led promising results facilitating intratumoral permeation various enhance antitumor effects. considerations some feasible future directions proposed improve therapies.

Language: Английский

Citations

150
Cancer stem cells-emanated therapy resistance: Implications for liposomal drug delivery systems DOI
Hassan Dianat‐Moghadam, Maryam Heidarifard, Rana Jahanban‐Esfahlan

et al.

Journal of Controlled Release, Journal Year: 2018, Volume and Issue: 288, P. 62 - 83

Published: Sept. 2, 2018

Language: Английский

Citations

126
EGFR and CD44 Dual-Targeted Multifunctional Hyaluronic Acid Nanogels Boost Protein Delivery to Ovarian and Breast Cancers In Vitro and In Vivo DOI
Jing Chen, Jia Ouyang, Qijun Chen

et al.

ACS Applied Materials & Interfaces, Journal Year: 2017, Volume and Issue: 9(28), P. 24140 - 24147

Published: July 4, 2017

Protein drugs with intracellular targets like Granzyme B (GrB) have demonstrated great proliferative inhibition activity in cancer cells. Their clinical translation, however, relies on the development of safe, efficient, and selective protein-delivery vehicles. Here, we report that epidermal growth factor receptor (EGFR) CD44 dual-targeted multifunctional hyaluronic acid nanogels (EGFR/CD44-NGs) boost protein delivery to ovarian breast cancers vitro vivo. EGFR/CD44-NGs obtained via nanoprecipitation photoclick chemistry from derivatives tetrazole, GE11 peptide/tetrazole, cystamine methacrylate groups had nearly quantitative loading therapeutic proteins cytochrome C (CC) GrB, a small size ca. 165 nm, excellent stability serum, fast release under reductive condition. Flow cytometry assays showed exhibited over 6-fold better uptake EGFR-positive SKOV-3 cells than CD44-NGs. In accordance, GrB-loaded (GrB-EGFR/CD44-NGs) displayed enhanced caspase as compared CD44-NGs (GrB-CD44-NGs) control. Intriguingly, studies human carcinoma MDA-MB-231 tumor xenografted nude mice revealed GrB-EGFR/CD44-NGs at low dose 3.85 nmol GrB equiv/kg induced complete suppression both tumors, which was obviously more effective GrB-CD44-NGs, without causing any adverse effects. EGFR appeared safe efficacious platform for therapy.

Language: Английский

Citations

112