Assessment of soy leghemoglobin produced from genetically modified Komagataella phaffii, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2019‐162) DOI Creative Commons
Josep Casacuberta, Francisco Barro, Albert Braeuning

et al.

EFSA Journal, Journal Year: 2024, Volume and Issue: 22(11)

Published: Nov. 1, 2024

Abstract Genetically modified Komagataella phaffii strain MXY0541 was developed to produce soy leghemoglobin by introducing the LGB2 coding sequence encoding from soybean (Glycine max). The molecular characterisation data and bioinformatic analyses do not raise any safety concerns. of as a food additive has already been assessed EFSA FAF Panel (EFSA‐Q‐2022‐00031). GMO does identify concerns regarding toxicity allergenicity protein expressed in K. phaffii, finds no evidence that genetic modification would change its overall allergenicity. concludes LegH Prep derived genetically is safe for human consumption with regard effects modification. No environmental impact use this product expected recombinant DNA sequences possibly remaining product. respect potential on health environment at proposed level far concerned. conclusion lead issues.

Language: Английский

Update of the list of qualified presumption of safety (QPS) recommended microbiological agents intentionally added to food or feed as notified to EFSA 19: Suitability of taxonomic units notified to EFSA until September 2023 DOI Creative Commons
Konstantinos Koutsoumanis, Ana Allende, Avelino Álvarez‐Ordóñez

et al.

EFSA Journal, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 1, 2024

The qualified presumption of safety (QPS) process was developed to provide a assessment approach for microorganisms intended use in food or feed chains. QPS is based on an published data each taxonomic unit (TU), with respect its identity, the body relevant knowledge and concerns. Safety concerns identified TU are, where possible, confirmed at species/strain product level reflected by 'qualifications'. In period covered this Statement, no new information found that would change status previously recommended TUs. Of 71 notified EFSA between April September 2023 (30 as additives, 22 enzymes 7 novel foods 12 from plant protection products [PPP]), 61 were not evaluated because: 26 filamentous fungi, 1

Language: Английский

Citations

21

Update of the list of qualified presumption of safety (QPS) recommended microbiological agents intentionally added to food or feed as notified to EFSA 20: Suitability of taxonomic units notified to EFSA until March 2024 DOI Creative Commons
Konstantinos Koutsoumanis, Ana Allende, Avelino Álvarez‐Ordóñez

et al.

EFSA Journal, Journal Year: 2024, Volume and Issue: 22(7)

Published: July 1, 2024

Abstract The qualified presumption of safety (QPS) process was developed to provide a assessment approach for microorganisms intended use in food or feed chains. In the period covered by this statement, no new information found that would change status previously recommended QPS TUs. TUs list were updated based on verification, against their respective authoritative databases, correctness names and completeness synonyms. A procedure has been established ensure are kept up date relation recent taxonomical insights. Of 83 notified EFSA between October 2023 March 2024 (47 as additives, 25 enzymes 11 novel foods), 75 not evaluated because: 15 filamentous fungi, 1 Enterococcus faecium, 10 Escherichia coli, Streptomyces (all excluded from evaluation) 48 already have status. Two other eight notifications possible previous Panel Statement: Heyndrickxia faecalis (previously Weizmannia faecalis) Serratia marcescens. One at genus level so could be assessed five belonging Akkermansia muciniphila Actinomadura roseirufa still due concerns. Rhizobium radiobacter can with qualification production purposes. Microbacterium arborescens Burkholderia stagnalis cannot included lack body knowledge its chain B. also A. further assessment.

Language: Английский

Citations

12

The future is fermented: Microbial biodiversity of fermented foods is a critical resource for food innovation and human health DOI

Rodrigo Hernández-Velázquez,

Lena Flörl, Anton Lavrinienko

et al.

Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: 150, P. 104569 - 104569

Published: June 1, 2024

Language: Английский

Citations

9

Modification of the terms of authorisation of the feed additive consisting of canthaxanthin for chickens for fattening, minor poultry species for fattening, laying poultry and poultry reared for laying, ornamental fish and ornamental birds and ornamental breeder hens to include canthaxanthin produced with Yarrowia lipolytica CBS 146148 (DSM Nutritional Products Ltd.) DOI Creative Commons
Roberto Edoardo Villa,

Giovanna Azimonti,

Eleftherios Bonos

et al.

EFSA Journal, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 1, 2025

Abstract Following a request from the European Commission, Food Safety Authority was asked to deliver scientific opinion on proposed modification of terms authorisation canthaxanthin, regarding addition new production route, by yeast Yarrowia lipolytica CBS 146148. The additive is already authorised as sensory feed for use in chickens fattening, minor poultry species laying poultry, reared laying, ornamental fish, birds and breeder hens. Panel Additives Products or Substances used Animal Feed (FEEDAP) concludes that canthaxanthin produced with 146148 considered safe target species, consumer environment under current conditions use. Canthaxanthin not an irritant skin eyes it unlikely be sensitiser. No conclusion can reached respiratory sensitisation canthaxanthin. In absence data, no conclusions safety user any preparation fermentation Y. efficacious colouring agent fattening fish birds.

Language: Английский

Citations

1

Biosynthesis of Gamma-Aminobutyric Acid (GABA) by Lactiplantibacillus plantarum in Fermented Food Production DOI Creative Commons
Massimo Iorizzo, Gianluca Paventi, Catello Di Martino

et al.

Current Issues in Molecular Biology, Journal Year: 2023, Volume and Issue: 46(1), P. 200 - 220

Published: Dec. 26, 2023

In recent decades, given the important role of gamma-aminobutyric acid (GABA) in human health, scientists have paid great attention to enrichment this chemical compound food using various methods, including microbial fermentation. Moreover, GABA or GABA-rich products been successfully commercialized as additives functional dietary supplements. Several microorganisms can produce GABA, bacteria, fungi, and yeasts. Among GABA-producing microorganisms, lactic bacteria (LAB) are commonly used production many fermented foods. Lactiplantibacillus plantarum (formerly Lactobacillus plantarum) is a LAB species that has long history natural occurrence safe use wide variety foods beverages. Within species, some strains possess not only good pro-technological properties but also ability bioactive compounds, GABA. The present review aims, after preliminary excursus on function biosynthesis provide an overview current uses and, particular, L. with detailed focus results studies reported highlight selection new probiotic synthesize may offer concrete opportunities for design

Language: Английский

Citations

22

The quest for the perfect loaf of sourdough bread continues: Novel developments for selection of sourdough starter cultures DOI
Michael G. Gänzle, Nanzhen Qiao, Julia Bechtner

et al.

International Journal of Food Microbiology, Journal Year: 2023, Volume and Issue: 407, P. 110421 - 110421

Published: Oct. 4, 2023

Language: Английский

Citations

20

Safety and efficacy of a feed additive consisting of inactivated selenised yeast (Saccharomyces cerevisiae CCTCC M 2022402) for all animal species (Phytobiotics Futterzusatzstoffe GmbH) DOI Creative Commons
Vasileios Bampidis,

Giovanna Azimonti,

Maria de Lourdes Bastos

et al.

EFSA Journal, Journal Year: 2024, Volume and Issue: 22(4)

Published: April 1, 2024

Following a request from the European Commission, EFSA was asked to deliver scientific opinion on safety and efficacy of selenised yeast (inactivated)

Language: Английский

Citations

5

Update of the list of qualified presumption of safety (QPS) recommended microbiological agents intentionally added to food or feed as notified to EFSA 21: Suitability of taxonomic units notified to EFSA until September 2024 DOI Creative Commons
Ana Allende, Avelino Álvarez‐Ordóñez, Valeria Bortolaia

et al.

EFSA Journal, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 1, 2025

Abstract The qualified presumption of safety (QPS) process was developed to provide a assessment approach for microorganisms intended use in food or feed chains. In the period covered by this Statement, no new information found that would change status previously recommended QPS taxonomic units (TUs). TUs list were updated based on verification, against their respective authoritative databases, correctness names and completeness synonyms. Of 54 notified EFSA between April September 2024 (33 as additives, 17 enzymes 4 novel foods), 50 not evaluated because: 12 filamentous fungi, 1 Enterococcus faecium 8 Escherichia coli (all excluded from evaluation), 29 already have status. One notification (Ensifer adhaerens) previous Panel Statement. Another (Enterococcus lactis) 3‐year cycle reassessed within document. Two first time assessed possible status: Serratia plymuthica Lacticaseibacillus huelsenbergensis. Bacillus thuringiensis nakamurai been response internal requests. following concluded five TUs. L. huelsenbergensis can be granted its close relatedness several other species. E. lactis is due insufficient safety. S. B. are concerns. cannot lack body knowledge chain.

Language: Английский

Citations

0

Genomic insights into the beneficial potential of Bifidobacterium and Enterococcus strains isolated from Cameroonian infants DOI Creative Commons
Pierre Marie Kaktcham, Magdalena Kujawska, Edith Marius Foko Kouam

et al.

Microbial Genomics, Journal Year: 2025, Volume and Issue: 11(2)

Published: Feb. 19, 2025

A healthy early-life gut microbiota plays an important role in maintaining immediate and long-term health. Perturbations, particularly low- to middle-income communities, are associated with increased infection risk. Thus, a promising avenue for restoring infant is select key beneficial bacterial candidates from underexplored microbiomes developing new probiotic-based therapies. This study aimed recover bifidobacteria lactic acid bacteria the faeces of Cameroonian infants unravel genetic basis their properties. Faecal samples were collected 26 aged 0–5 months recruited Dschang (Cameroon). Recovered isolates subjected whole-genome sequencing silico analysis assess potential carbohydrate utilization, antimicrobial capacities, host-adaptation capabilities safety. From range infant-associated Bifidobacterium Enterococcus strains identified, species found harbour putative gene clusters implicated human milk oligosaccharide metabolism. Genes linked production peptides such as class IV lanthipeptides pseudocatenulatum , while those biosynthesis cytolysins, enterolysins, enterocins propeptins, among others, identified enterococci. Bifidobacterial did not contain genes virulence; however, we detected presence tetracycline resistance several belonging animalis subsp. lactis longum . Among enterococci, mundtii PM10 carry any or virulence. The latter, together all strains, also encoded adaptive stress-response-related genes, suggesting robust gastroinstestinal tract colonization potential. work provides first genomic characterization infants. Several showed confer Further phenotypic clinical investigations needed confirm suitability customized probiotics.

Language: Английский

Citations

0

Modulation of Antioxidant Capacity, Nutritional Composition, Probiotic Viability After Digestion and Sensory Attributes of Plant-Based Beverages Through Lactic Acid Fermentation DOI Creative Commons
M Vitali, Mónica Gandía, Guadalupe García‐Llatas

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(9), P. 1447 - 1447

Published: April 22, 2025

Fermented plant-based beverages are renowned due to their health benefits and sustainability. This study focuses on developing fermented local from rice, carob, tiger nuts. The fermentation process with four different commercial starters of lactic acid bacteria was optimized based pH drop colony counts at 37 °C the supplementation 7.5–15 g glucose/100 mL. Analyses antioxidant capacity, phytochemical profile, proximate composition sensory attributes were conducted, along studies gastrointestinal survival probiotics. Total polyphenols levels capacity followed order: carob > nut rice (159.8–218.9 34.1–127.9 7.2–17.5 mg GAE/L for total polyphenols; 4461.9–15,111.6 2916.8–7897.3 1845.7–6103.5 µM Trolox/L ORAC; 2057.7–4235.3 318.9–876.7 n.d.–239.7 TEAC, respectively). VEGE061 consortium showed best results majority parameters analyzed, influencing fat content fatty profiles increasing monounsaturated acids in nuts while promoting saturated beverages. Simulated vitro digestion significantly reduced probiotic nuts, and, a lesser extent, good attributes, floral notes, achieving balanced aroma profile VEGE061, displaying pleasant qualities VEGE033 consortia. Further research is needed explore optimal conditions scaling up strategies improve delivery, aiming increase post-digestion survival. approach could promote development healthy sustainable food alternatives.

Language: Английский

Citations

0