EFSA Journal,
Journal Year:
2024,
Volume and Issue:
22(11)
Published: Nov. 1, 2024
Abstract
Genetically
modified
Komagataella
phaffii
strain
MXY0541
was
developed
to
produce
soy
leghemoglobin
by
introducing
the
LGB2
coding
sequence
encoding
from
soybean
(Glycine
max).
The
molecular
characterisation
data
and
bioinformatic
analyses
do
not
raise
any
safety
concerns.
of
as
a
food
additive
has
already
been
assessed
EFSA
FAF
Panel
(EFSA‐Q‐2022‐00031).
GMO
does
identify
concerns
regarding
toxicity
allergenicity
protein
expressed
in
K.
phaffii,
finds
no
evidence
that
genetic
modification
would
change
its
overall
allergenicity.
concludes
LegH
Prep
derived
genetically
is
safe
for
human
consumption
with
regard
effects
modification.
No
environmental
impact
use
this
product
expected
recombinant
DNA
sequences
possibly
remaining
product.
respect
potential
on
health
environment
at
proposed
level
far
concerned.
conclusion
lead
issues.
EFSA Journal,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Jan. 1, 2024
The
qualified
presumption
of
safety
(QPS)
process
was
developed
to
provide
a
assessment
approach
for
microorganisms
intended
use
in
food
or
feed
chains.
QPS
is
based
on
an
published
data
each
taxonomic
unit
(TU),
with
respect
its
identity,
the
body
relevant
knowledge
and
concerns.
Safety
concerns
identified
TU
are,
where
possible,
confirmed
at
species/strain
product
level
reflected
by
'qualifications'.
In
period
covered
this
Statement,
no
new
information
found
that
would
change
status
previously
recommended
TUs.
Of
71
notified
EFSA
between
April
September
2023
(30
as
additives,
22
enzymes
7
novel
foods
12
from
plant
protection
products
[PPP]),
61
were
not
evaluated
because:
26
filamentous
fungi,
1
EFSA Journal,
Journal Year:
2024,
Volume and Issue:
22(7)
Published: July 1, 2024
Abstract
The
qualified
presumption
of
safety
(QPS)
process
was
developed
to
provide
a
assessment
approach
for
microorganisms
intended
use
in
food
or
feed
chains.
In
the
period
covered
by
this
statement,
no
new
information
found
that
would
change
status
previously
recommended
QPS
TUs.
TUs
list
were
updated
based
on
verification,
against
their
respective
authoritative
databases,
correctness
names
and
completeness
synonyms.
A
procedure
has
been
established
ensure
are
kept
up
date
relation
recent
taxonomical
insights.
Of
83
notified
EFSA
between
October
2023
March
2024
(47
as
additives,
25
enzymes
11
novel
foods),
75
not
evaluated
because:
15
filamentous
fungi,
1
Enterococcus
faecium,
10
Escherichia
coli,
Streptomyces
(all
excluded
from
evaluation)
48
already
have
status.
Two
other
eight
notifications
possible
previous
Panel
Statement:
Heyndrickxia
faecalis
(previously
Weizmannia
faecalis)
Serratia
marcescens.
One
at
genus
level
so
could
be
assessed
five
belonging
Akkermansia
muciniphila
Actinomadura
roseirufa
still
due
concerns.
Rhizobium
radiobacter
can
with
qualification
production
purposes.
Microbacterium
arborescens
Burkholderia
stagnalis
cannot
included
lack
body
knowledge
its
chain
B.
also
A.
further
assessment.
EFSA Journal,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Jan. 1, 2025
Abstract
Following
a
request
from
the
European
Commission,
Food
Safety
Authority
was
asked
to
deliver
scientific
opinion
on
proposed
modification
of
terms
authorisation
canthaxanthin,
regarding
addition
new
production
route,
by
yeast
Yarrowia
lipolytica
CBS
146148.
The
additive
is
already
authorised
as
sensory
feed
for
use
in
chickens
fattening,
minor
poultry
species
laying
poultry,
reared
laying,
ornamental
fish,
birds
and
breeder
hens.
Panel
Additives
Products
or
Substances
used
Animal
Feed
(FEEDAP)
concludes
that
canthaxanthin
produced
with
146148
considered
safe
target
species,
consumer
environment
under
current
conditions
use.
Canthaxanthin
not
an
irritant
skin
eyes
it
unlikely
be
sensitiser.
No
conclusion
can
reached
respiratory
sensitisation
canthaxanthin.
In
absence
data,
no
conclusions
safety
user
any
preparation
fermentation
Y.
efficacious
colouring
agent
fattening
fish
birds.
Current Issues in Molecular Biology,
Journal Year:
2023,
Volume and Issue:
46(1), P. 200 - 220
Published: Dec. 26, 2023
In
recent
decades,
given
the
important
role
of
gamma-aminobutyric
acid
(GABA)
in
human
health,
scientists
have
paid
great
attention
to
enrichment
this
chemical
compound
food
using
various
methods,
including
microbial
fermentation.
Moreover,
GABA
or
GABA-rich
products
been
successfully
commercialized
as
additives
functional
dietary
supplements.
Several
microorganisms
can
produce
GABA,
bacteria,
fungi,
and
yeasts.
Among
GABA-producing
microorganisms,
lactic
bacteria
(LAB)
are
commonly
used
production
many
fermented
foods.
Lactiplantibacillus
plantarum
(formerly
Lactobacillus
plantarum)
is
a
LAB
species
that
has
long
history
natural
occurrence
safe
use
wide
variety
foods
beverages.
Within
species,
some
strains
possess
not
only
good
pro-technological
properties
but
also
ability
bioactive
compounds,
GABA.
The
present
review
aims,
after
preliminary
excursus
on
function
biosynthesis
provide
an
overview
current
uses
and,
particular,
L.
with
detailed
focus
results
studies
reported
highlight
selection
new
probiotic
synthesize
may
offer
concrete
opportunities
for
design
EFSA Journal,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Jan. 1, 2025
Abstract
The
qualified
presumption
of
safety
(QPS)
process
was
developed
to
provide
a
assessment
approach
for
microorganisms
intended
use
in
food
or
feed
chains.
In
the
period
covered
by
this
Statement,
no
new
information
found
that
would
change
status
previously
recommended
QPS
taxonomic
units
(TUs).
TUs
list
were
updated
based
on
verification,
against
their
respective
authoritative
databases,
correctness
names
and
completeness
synonyms.
Of
54
notified
EFSA
between
April
September
2024
(33
as
additives,
17
enzymes
4
novel
foods),
50
not
evaluated
because:
12
filamentous
fungi,
1
Enterococcus
faecium
8
Escherichia
coli
(all
excluded
from
evaluation),
29
already
have
status.
One
notification
(Ensifer
adhaerens)
previous
Panel
Statement.
Another
(Enterococcus
lactis)
3‐year
cycle
reassessed
within
document.
Two
first
time
assessed
possible
status:
Serratia
plymuthica
Lacticaseibacillus
huelsenbergensis.
Bacillus
thuringiensis
nakamurai
been
response
internal
requests.
following
concluded
five
TUs.
L.
huelsenbergensis
can
be
granted
its
close
relatedness
several
other
species.
E.
lactis
is
due
insufficient
safety.
S.
B.
are
concerns.
cannot
lack
body
knowledge
chain.
Microbial Genomics,
Journal Year:
2025,
Volume and Issue:
11(2)
Published: Feb. 19, 2025
A
healthy
early-life
gut
microbiota
plays
an
important
role
in
maintaining
immediate
and
long-term
health.
Perturbations,
particularly
low-
to
middle-income
communities,
are
associated
with
increased
infection
risk.
Thus,
a
promising
avenue
for
restoring
infant
is
select
key
beneficial
bacterial
candidates
from
underexplored
microbiomes
developing
new
probiotic-based
therapies.
This
study
aimed
recover
bifidobacteria
lactic
acid
bacteria
the
faeces
of
Cameroonian
infants
unravel
genetic
basis
their
properties.
Faecal
samples
were
collected
26
aged
0–5
months
recruited
Dschang
(Cameroon).
Recovered
isolates
subjected
whole-genome
sequencing
silico
analysis
assess
potential
carbohydrate
utilization,
antimicrobial
capacities,
host-adaptation
capabilities
safety.
From
range
infant-associated
Bifidobacterium
Enterococcus
strains
identified,
species
found
harbour
putative
gene
clusters
implicated
human
milk
oligosaccharide
metabolism.
Genes
linked
production
peptides
such
as
class
IV
lanthipeptides
pseudocatenulatum
,
while
those
biosynthesis
cytolysins,
enterolysins,
enterocins
propeptins,
among
others,
identified
enterococci.
Bifidobacterial
did
not
contain
genes
virulence;
however,
we
detected
presence
tetracycline
resistance
several
belonging
animalis
subsp.
lactis
longum
.
Among
enterococci,
mundtii
PM10
carry
any
or
virulence.
The
latter,
together
all
strains,
also
encoded
adaptive
stress-response-related
genes,
suggesting
robust
gastroinstestinal
tract
colonization
potential.
work
provides
first
genomic
characterization
infants.
Several
showed
confer
Further
phenotypic
clinical
investigations
needed
confirm
suitability
customized
probiotics.
Foods,
Journal Year:
2025,
Volume and Issue:
14(9), P. 1447 - 1447
Published: April 22, 2025
Fermented
plant-based
beverages
are
renowned
due
to
their
health
benefits
and
sustainability.
This
study
focuses
on
developing
fermented
local
from
rice,
carob,
tiger
nuts.
The
fermentation
process
with
four
different
commercial
starters
of
lactic
acid
bacteria
was
optimized
based
pH
drop
colony
counts
at
37
°C
the
supplementation
7.5–15
g
glucose/100
mL.
Analyses
antioxidant
capacity,
phytochemical
profile,
proximate
composition
sensory
attributes
were
conducted,
along
studies
gastrointestinal
survival
probiotics.
Total
polyphenols
levels
capacity
followed
order:
carob
>
nut
rice
(159.8–218.9
34.1–127.9
7.2–17.5
mg
GAE/L
for
total
polyphenols;
4461.9–15,111.6
2916.8–7897.3
1845.7–6103.5
µM
Trolox/L
ORAC;
2057.7–4235.3
318.9–876.7
n.d.–239.7
TEAC,
respectively).
VEGE061
consortium
showed
best
results
majority
parameters
analyzed,
influencing
fat
content
fatty
profiles
increasing
monounsaturated
acids
in
nuts
while
promoting
saturated
beverages.
Simulated
vitro
digestion
significantly
reduced
probiotic
nuts,
and,
a
lesser
extent,
good
attributes,
floral
notes,
achieving
balanced
aroma
profile
VEGE061,
displaying
pleasant
qualities
VEGE033
consortia.
Further
research
is
needed
explore
optimal
conditions
scaling
up
strategies
improve
delivery,
aiming
increase
post-digestion
survival.
approach
could
promote
development
healthy
sustainable
food
alternatives.