Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses

Neuron, Journal Year: 1994, Volume and Issue: 13(5), P. 1177 - 1185

Published: Nov. 1, 1994

Language: Английский

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The basic physiology and pathophysiology of melatonin

Sleep Medicine Reviews, Journal Year: 2004, Volume and Issue: 9(1), P. 11 - 24

Published: Dec. 16, 2004

Language: Английский

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Melatonin

FEBS Journal, Journal Year: 2006, Volume and Issue: 273(13), P. 2813 - 2838

Published: June 15, 2006

Melatonin is a ubiquitous molecule and widely distributed in nature, with functional activity occurring unicellular organisms, plants, fungi animals. In most vertebrates, including humans, melatonin synthesized primarily the pineal gland regulated by environmental light/dark cycle via suprachiasmatic nucleus. Pinealocytes function as 'neuroendocrine transducers' to secrete during dark phase of and, consequently, often called 'hormone darkness'. principally secreted at night centrally involved sleep regulation, well number other cyclical bodily activities. exclusively signaling 'time day' year' (hence considered help both clock calendar functions) all tissues thus be body's chronological pacemaker or 'Zeitgeber'. Synthesis also occurs areas body, retina, gastrointestinal tract, skin, bone marrow lymphocytes, from which it may influence physiological functions through paracrine signaling. has been extracted seeds leaves plants its concentration some this material several orders magnitude higher than night-time plasma value humans. participates diverse functions. addition timekeeping functions, an effective antioxidant scavenges free radicals up-regulates enzymes. It strong antiapoptotic function, effect exerts even ischemia. Melatonin's cytoprotective properties have practical implications treatment neurodegenerative diseases. immune-enhancing oncostatic properties. Its 'chronobiotic' shown treating various circadian rhythm disorders, such jet lag shift-work disorder. acting 'internal facilitator' promotes sleep, melatonin's sleep-facilitating found useful for insomnia symptoms elderly depressive patients. A recently introduced analog, agomelatine, efficient major disorder bipolar affective role 'photoperiodic molecule' seasonal reproduction established photoperiodic species, although regulatory humans remains under investigation. Taken together, evidence implicates broad range effects significant over many

Language: Английский

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Melatonin—A pleiotropic, orchestrating regulator molecule

Progress in Neurobiology, Journal Year: 2010, Volume and Issue: 93(3), P. 350 - 384

Published: Dec. 29, 2010

Language: Английский

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Physiological effects of melatonin: Role of melatonin receptors and signal transduction pathways

Progress in Neurobiology, Journal Year: 2008, Volume and Issue: 85(3), P. 335 - 353

Published: April 17, 2008

Language: Английский

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Adolescent Sleep Patterns, Circadian Timing, and Sleepiness at a Transition to Early School Days

SLEEP, Journal Year: 1998, Volume and Issue: 21(8), P. 871 - 881

Published: Dec. 1, 1998

Study Objectives:This study examined effects on adolescent sleep patterns, sleepiness, and circadian phase of a school transition requiring an earlier start.

Language: Английский

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Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters

Pharmacological Reviews, Journal Year: 2003, Volume and Issue: 55(2), P. 325 - 395

Published: May 28, 2003

Melatonin, the major hormone produced by pineal gland, displays characteristic daily and seasonal patterns of secretion. These robust predictable rhythms in circulating melatonin are strong synchronizers for expression numerous physiological processes photoperiodic species. In mammals, nighttime production is mainly driven circadian clock, situated suprachiasmatic nucleus hypothalamus, which controls release norepinephrine from dense sympathetic afferents. The pivotal role nocturnal stimulation synthesis has been extensively dissected at cellular molecular levels. Besides noradrenergic input, presence other transmitters originating various sources reported gland. Many these neuropeptides appear to contribute regulation modulating effects on biochemistry. aim this review firstly update our knowledge events underlying control synthesis; secondly gather together early recent data nonadrenergic modulation synthesis. This information reveals variety inputs that can be integrated gland; what elements crucial deliver very precise timing organism. also clarifies variation their subsequent function.

Language: Английский

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Molecular Dissection of Two Distinct Actions of Melatonin on the Suprachiasmatic Circadian Clock

Neuron, Journal Year: 1997, Volume and Issue: 19(1), P. 91 - 102

Published: July 1, 1997

Language: Английский

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Antioxidative Protection by Melatonin: Multiplicity of Mechanisms from Radical Detoxification to Radical Avoidance

Endocrine, Journal Year: 2005, Volume and Issue: 27(2), P. 119 - 130

Published: Jan. 1, 2005

Language: Английский

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Circadian Rhythm Sleep Disorders: Part I, Basic Principles, Shift Work and Jet Lag Disorders

SLEEP, Journal Year: 2007, Volume and Issue: 30(11), P. 1460 - 1483

Published: Nov. 1, 2007

This the first of two articles reviewing scientific literature on evaluation and treatment circadian rhythm sleep disorders (CRSDs), employing methodology evidence-based medicine. In this part paper, general principles biology that underlie clinical are reviewed. We then report accumulated evidence regarding shift work disorder (SWD) jet lag (JLD). A set specific questions relevant to practice were formulated, a systematic search was performed, abstracted graded. substantial body has provides rational basis SWD JLD. Physiological assessment involved determination phase using core temperature timing melatonin secretion. Behavioral logs, actigraphy Morningness-Eveningness Questionnaire (MEQ). Treatment interventions fall into three broad categories: 1) prescribed scheduling, 2) shifting ("resetting clock"), 3) symptomatic hypnotic stimulant medications. Circadian science also pointed way for JLD, these treatments have been introduced medicine with varying degrees success. More translational research is needed subjects who meet current diagnostic criteria.

Language: Английский

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