Impacts of endocrine disrupting chemicals on reproduction in wildlife and humans

Environmental Research, Journal Year: 2021, Volume and Issue: 208, P. 112584 - 112584

Published: Dec. 21, 2021

Endocrine disrupting chemicals (EDCs) are ubiquitous in aquatic and terrestrial environments. The main objective of this review was to summarize the current knowledge impacts EDCs on reproductive success wildlife humans. examples selected often include a retrospective assessment over time discern how effects have changed last several decades. Collectively, evidence summarized here within reinforce concept that reproduction humans is negatively impacted by anthropogenic chemicals, with altering endocrine system function. These observations interfering different aspects axis particularly pronounced for species corroborated laboratory-based experiments (i.e. fish, amphibians, birds). Noteworthy, many these same indicators also observed epidemiological studies mammalian Given vast array strategies used animals, it perhaps not surprising no single disrupted target predictive effects. Nevertheless, there some general features control reproduction, particular, critical role steroid hormones play processes confer high degree susceptibility environmental chemicals. New research needed implications chemical exposures during development potential long-term Future emphasis field-based can form basis more deliberate, extensive, population level monitor contaminant effects, including adverse system, key addressing gaps.

Language: Английский

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Evaluating pollinator exposures to sulfoxaflor via bee-relevant matrices: a systems-level approach using semi-probabilistic methods for assessing hazards; sulfoxaflor environmental science review part IV

Journal of Toxicology and Environmental Health Part B, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 24

Published: March 25, 2025

Sulfoxaflor (SFX) is a newly registered IRAC Group 4C nAChR-receptor-agonist systemic insecticide that used to control sap-sucking insects in variety of crops. SFX has short half-life (< 2 days) agricultural soil and only as foliar-applied product. Pollinators such honey bees could be exposed directly spray if application occurs shortly before or during blooming flowers, or, systemic, via oral exposures nectar pollen collected by bees. Guided Weight-of-Evidence rubric, this paper critically assessed studies on the fate bee-relevant matrices submitted registrant several jurisdictions well few published open scientific literature. These provided data for residues and/or from 16 crops grown countries both hemispheres. transformation products were detected pollen. Transformation have low hazard honeybees, so focus was parent material, SFX, which observed dissipate rapidly after application. Dietary No-Observed-Adverse-Effect-Concentrations (NOAEC) derived results 10-day continuous feeding adult (0.50 mg kg-1 diet d-1) larval honeybees (1.69 precautionary toxicity benchmarks characterize hazards. In paper, we tiered process. The initial screening tier based greatest concentration measured matrix. For scenarios did not pass Tier-1, second time-weighted average (area under curve, AUC) matrix more realistic measure exposure. Of 90 use characterized, 36 benchmark ≥1concentration exceeding NOAEC. When AUC exposure estimated these scenarios, 3 benchmark. three anthers alfalfa California, strawberries France, peaches Michigan. two-tier procedure assessment lessened need further 97% reduced characterizing hazards field-level whole-hive tests conducted controlled conditions

Language: Английский

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Weight of evidence assessment of effects of sulfoxaflor on aquatic invertebrates: sulfoxaflor environmental science review part II

Journal of Toxicology and Environmental Health Part B, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 29

Published: March 25, 2025

Effects of sulfoxaflor (SFX) on aquatic invertebrates were assessed by comparing concentrations predicted to occur in or measured surface waters thresholds for adverse effects. Due the specific mode toxic action, fishes are relatively tolerant effects SFX. Daphnia magna with an LC50 378 mg SFX L-1 (SD = 19.13) was similarly SFX, while LOEC >110 L-1. A threshold insects, based chironomid midge, C. tentans, had LOAEL and NOAEL values 0.0455 0.0618 L-1, respectively. The acute-to-chronic ratio 18. Simulation models parameters selected a range applications crops environmental (EECs) from 2.2 7.7 µg Based these EECs, maximum hazard quotient (HQ) 0.11, which is less than US EPA level concern (LOC) 0.5, would normally be trigger regulatory action higher-tier assessments. risks posed organisms de minimis. Hazard quotients EEC standard, USEPA farm pond estimated use Pesticides Water Calculator (PWC version 1.52) scenarios application rates cotton insects similar those other insecticides including neonicotinoids organophosphorus compounds.

Language: Английский

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A review of the evidence for endocrine disrupting effects of current-use chemicals on wildlife populations

Critical Reviews in Toxicology, Journal Year: 2017, Volume and Issue: 48(3), P. 195 - 216

Published: Nov. 24, 2017

This review critically examines the data on claimed endocrine-mediated adverse effects of chemicals wildlife populations. It focuses current-use chemicals, and compares their apparent scale severity with those legacy which have been withdrawn from sale or use, although they may still be present in environment. The concludes that many endocrine activity are generally greater than caused by exception ethinylestradiol other estrogens found sewage effluents, causing widespread fish is considered current chemical testing regimes risk assessment procedures, at least to pesticides biocides subjected, part responsible for this improvement. noteworthy as most ecotoxicological regulatory purposes currently focused characterizing apical effect endpoints rather identifying mechanism(s) any observed effects. Furthermore, a suite internationally standardized ecotoxicity tests sensitive potential now place, under development, should ensure further characterization substances these properties so can adequately regulated.

Language: Английский

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Emerging contaminants in Brazilian rivers: Occurrence and effects on gene expression in zebrafish (Danio rerio) embryos

Chemosphere, Journal Year: 2018, Volume and Issue: 209, P. 696 - 704

Published: June 7, 2018

Emerging contaminants (ECs) are synthetic or naturally occurring chemicals that not commonly monitored despite having the potential of entering environment and causing adverse ecological and/or human health effects. This study aimed to determine whether ECs present in surface waters two rivers Mato Grosso do Sul State, Brazil, evaluate effects mixtures at environmentally relevant concentrations on zebrafish (Danio rerio) gene expression. were determined using solid-phase extraction liquid chromatography-mass spectrometry. The most frequently detected caffeine, imidacloprid, 2-hydroxy atrazine, tebuthiuron, bisphenol A. We used these data reconstruct reflecting environmental concentrations, codenamed T1, T2, T3. No observed, so increased. After a preliminary evaluation Observed Effect Concentration for each mixture, we analyzed changes expression target genes (cyp1a, hsp70, cat, sod1, tsh, cyp19a1a, cyp19a1b, cyp26b1, casp8, sox2, cyb561d2, thrb). cat was overrepresented T1 underrepresented other treatments. All induced which is marker (xeno-)estrogen exposure, them increased cyp1a, indicate presence dioxin-like compounds. studied had low EC there no indication any harmful zebrafish. However, intensive agricultural activity may result unsuspected peaks pollution, subsequent negative living organisms.

Language: Английский

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Prenatal phthalate exposure and reproductive function in young men

Environmental Research, Journal Year: 2015, Volume and Issue: 138, P. 264 - 270

Published: March 3, 2015

Language: Английский

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Embryotoxicity of atrazine and its degradation products to early life stages of zebrafish (Danio rerio)

Environmental Toxicology and Pharmacology, Journal Year: 2020, Volume and Issue: 77, P. 103370 - 103370

Published: March 3, 2020

Language: Английский

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Screening and prioritization of nano- and microplastic particle toxicity studies for evaluating human health risks – development and application of a toxicity study assessment tool

Microplastics and Nanoplastics, Journal Year: 2022, Volume and Issue: 2(1)

Published: Jan. 14, 2022

Abstract Concern regarding the human health implications that exposure to nano- and microplastic particles (NMPs) potentially represents is increasing. While there have been several years of research reporting on ecotoxicological effects NMPs, toxicology studies only recently emerged. The available hazard data are thus limited, with potential concern relevance reliability for understanding implications. In this study we develop apply a NMP toxicity screening assessment tool (NMP-TSAT) evaluating against suite quality assurance control (QA/QC) criteria both in vivo vitro studies. A total 74 representing either inhalation or oral pathways were identified evaluated. Assessment categories include particle characterization, experimental design, applicability risk assessment; critical non-critical organized allow prioritization. It observed majority evaluated using NMP-TSAT performed monodisperse particles, predominately spheres (≈60%), consisting polystyrene (≈46%). tested < 5 μm, minimal size 10 nm maximum about 200 μm. score (TAS) possible 52, whereas it 46, which based receiving 2 26 23 criteria, respectively. TAS ranged from between 12 44 16–34, studies, Given challenges associated prioritizing ranking them according their propose Tiered approach, whereby initially screened how they various defined assessing hazards risks health. instance, minimum ‘1’ each regardless rank TAS, prioritized as part Tier 1 prioritization phase, would then be followed by an expert evaluation, level assessment. Using approach identify ingestion at least all criteria. Lastly, key observations strengthening future identified, these need generation access standard reference materials representative NMPs use test systems and/or improved characterization verification characteristics, adoption design guidance, such recommended OECD, when conducting tests.

Language: Английский

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A quantitative weight-of-evidence review of preclinical studies examining the potential developmental neurotoxicity of acetaminophen

Critical Reviews in Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 55

Published: Feb. 21, 2025

Acetaminophen [paracetamol; N-acetyl-para-aminophenol (APAP)] is an antipyretic/analgesic commonly used in the treatment of fever and mild to moderate pain, headache, myalgia, dysmenorrhea. Recent literature has questioned safety acetaminophen use during pregnancy, with emphasis on whether exposure developing nervous system results behavioral changes consistent autism spectrum disorder (ASD), attention-deficit/hyperactivity (ADHD), and/or other cognitive deficits offspring. No previous review a fully detailed, quantitative weight-of-evidence (QWoE) approach critically examine preclinical data regards potential developmental neurotoxicity (DNT). Following regulatory guidance, QWoE framework using prespecified scoring criteria was developed approaches characterize adverse DNT outcomes considerations for biological relevance response (outcome score) strength methods study design (methods score). Considerations score included (1) experimental design, (2) details/reliability measurement(s), (3) transparency, (4) translational/methodological relevance. outcome response-related statistical significance, dose-response, relevance/reliability/magnitude, plausibility, (5) translational relevance, including consideration systemic toxicity/hepatotoxicity therapeutic non-systemically toxic doses durations use. Application this 34 vivo studies identified that assess resulted 188 entries documented across 11 endpoints: social behavior, stereotypic rigidity, attention/impulsivity, hyperactivity, anxiety-like sensorimotor function, spatial learning/memory, nonspatial neuroanatomy, neurotransmission. For each endpoint, mean were calculated total segregated by sex assist determining quality adversity. Informed all entries, analysis demonstrated showing no evidence male female rodents following at nonsystemically doses. Although some endpoints (behavioral neurotransmission) generally displayed more limited dataset relatively lower quality, similar conclusions drawn based indicating lack reliability reported effects. Overall, demonstrates effects structure function system, neuroanatomical, neurotransmission, endpoints.

Language: Английский

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Properties, mode of insecticidal action, environmental exposure pathways, and uses of the insecticide sulfoxaflor; sulfoxaflor environmental science review part I

Journal of Toxicology and Environmental Health Part B, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 24

Published: March 25, 2025

Sulfoxaflor (SFX, CAS# 946578-00-3) is marketed by Corteva Agrisciences Inc. as Isoclast®. SFX a Group 4C, nicotinic acetylcholine receptor agonist and systemic insecticide that most active against sucking insects. This paper critically reviews characterizes the physical chemical properties of to facilitate development conceptual models identify environmental compartments with greatest potential concentrations organisms likely be exposed. These were assessed in Weight Evidence (WoE) framework scenarios at risk. The solubility water approximately 550 mg L- 1 POW 0.8, so it will not bioconcentrate or undergo trophic transfer. It has move soils, but this unlikely because short half-life (hours 2-5 days) agricultural soils where bacteria mediate dissipation. Some transformation products have longer half-lives (months) soil are more mobile less toxic concern for adverse effects. does significant photolysis hydrolysis water, lead risk aquatic systems approved over-water use label recommends buffer zones protect sensitive areas. Overall, under good practices result biologically relevant exposures non-target species areas environment.

Language: Английский

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