Frontiers in Veterinary Science,
Journal Year:
2022,
Volume and Issue:
9
Published: April 1, 2022
Natural
and
experimental
SARS-CoV-2
infection
in
pets
has
been
widely
evidenced
since
the
beginning
of
COVID-19
pandemic.
Among
numerous
affected
animals,
cats
are
one
most
susceptible
species.
However,
little
is
known
about
viral
pathogenicity
transmissibility
case
variants
concern
(VOCs)
animal
hosts,
such
as
B.1.617.2
(Delta)
variant
first
detected
India.
Here,
we
have
identified
VOC
a
cat
living
with
positive
owner.
The
presented
mild
symptoms
(sneezing)
high
load
was
oropharyngeal
swab,
suggesting
that
an
active
occurring
upper
respiratory
tract
cat.
Transmission
from
owner
to
occurred
despite
human
being
fully
vaccinated
against
SARS-CoV-2.
This
study
documents
detection
B.1.165.2
Spain
emphasizes
importance
performing
surveillance
genomic
investigation
on
infected
animals.
Emerging infectious diseases,
Journal Year:
2021,
Volume and Issue:
27(9), P. 2450 - 2453
Published: Aug. 19, 2021
We
report
a
case
of
natural
infection
with
severe
acute
respiratory
syndrome
coronavirus
2
transmitted
from
an
owner
to
pet
ferret
in
the
same
household
Slovenia.
The
had
onset
gastroenteritis
dehydration.
Whole-genome
sequencing
viruses
isolated
and
revealed
2-nt
difference.
Organoids,
Journal Year:
2022,
Volume and Issue:
1(1), P. 2 - 27
Published: March 2, 2022
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
causes
disease
2019
(COVID-19),
which
was
classified
as
a
pandemic
in
March
2020.
As
of
22
January
2022,
globally
more
than
347
million
cases
COVID-19
have
been
diagnosed,
with
5.6
deaths,
making
it
the
deadliest
since
influenza
1918.
The
clinical
presentation
COVID-19-related
illness
spans
from
asymptomatic
to
mild
symptoms
akin
infection
symptoms,
including
pneumonia
necessitating
hospitalisation
and
admission
intensive
care
units.
starts
upper
tract
lungs
but
severe
can
also
involve
heart,
blood
vessels,
brain,
liver,
kidneys
intestine.
increasing
global
health
economic
burden
necessitates
an
urgent
response.
Understanding
functional
characteristics
cellular
tropism
SARS-CoV-2,
pathogenesis
that
leads
multi-organ
failure
death,
has
prompted
unprecedented
adoption
organoid
models.
Successful
drug
discovery
vaccine
development
rely
on
pre-clinical
models
faithfully
recapitulate
viral
life
cycle
host
cell
response
infection.
Human
stem
cell-derived
organoids
fulfill
these
criteria.
Here
we
highlight
role
study
SARS-CoV-2
modelling
pathogenesis.
Journal of General Virology,
Journal Year:
2025,
Volume and Issue:
106(4)
Published: April 4, 2025
Aminopeptidase
N
(APN)
is
a
transmembrane
protein
that
mediates
the
attachment
of
spike
several
clinically
important
coronaviruses
(CoVs)
responsible
for
respiratory
and
intestinal
diseases
in
animals
humans.
To
assess
potential
APN-mediated
viral
tropism,
we
characterized
APN
receptor
distribution
tissues
various
artiodactyls
(cervids,
bovids,
camelids
suids)
carnivores
(canids,
felids,
mustelids
phocids)
using
immunohistochemistry.
In
lungs,
expression
was
limited
to
artiodactyls,
with
strong
bronchiolar
epithelium
weaker
pneumocytes.
Nasal
turbinate
tracheal
samples,
where
available,
showed
stronger
over
carnivores.
consistently
detected
on
microvilli
enterocytes
small
intestine
across
multiple
taxa,
while
presence
colon
more
variable.
Of
examined,
pig
alpaca
expressed
most
abundant
upper
lower
tract.
silico
evaluation
orthologue
sequences
from
humans,
identified
distinct
evolutionary
relationships.
Further
binding
predictions
alphacoronavirus
human
coronavirus
229E
cognate
heterologous
revealed
substantial
overlapping
footprints
high
conservation
amino
acid
residues,
suggesting
an
divergence
subsequent
adaptation
229E-like
or
ancestral
virus
within
non-human
animal
host.
This
combined
anatomical
approach
enhances
understanding
host
susceptibility,
tissue
tropism
transmission
mechanisms
APN-dependent
CoVs
has
inform
future
strategies
disease
modelling,
surveillance
control.
Frontiers in Veterinary Science,
Journal Year:
2022,
Volume and Issue:
9
Published: April 1, 2022
Natural
and
experimental
SARS-CoV-2
infection
in
pets
has
been
widely
evidenced
since
the
beginning
of
COVID-19
pandemic.
Among
numerous
affected
animals,
cats
are
one
most
susceptible
species.
However,
little
is
known
about
viral
pathogenicity
transmissibility
case
variants
concern
(VOCs)
animal
hosts,
such
as
B.1.617.2
(Delta)
variant
first
detected
India.
Here,
we
have
identified
VOC
a
cat
living
with
positive
owner.
The
presented
mild
symptoms
(sneezing)
high
load
was
oropharyngeal
swab,
suggesting
that
an
active
occurring
upper
respiratory
tract
cat.
Transmission
from
owner
to
occurred
despite
human
being
fully
vaccinated
against
SARS-CoV-2.
This
study
documents
detection
B.1.165.2
Spain
emphasizes
importance
performing
surveillance
genomic
investigation
on
infected
animals.
