Neurological mechanism-based analysis of the role and characteristics of physical activity in the improvement of depressive symptoms

Reviews in the Neurosciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Abstract Depression is a common mental disorder characterized by high prevalence and significant adverse effects, making the searching for effective interventions an urgent priority. In recent years, physical activity (PA) has increasingly been recognized as standard adjunctive treatment disorders owing to its low cost, easy application, efficiency. Epidemiological data shows positive preventive therapeutic effects of PA on illnesses such depression. This article systematically describes prophylactic depression biological basis. A comprehensive literature analysis reveals that significantly improves depressive symptoms upregulating expression “exerkines” irisin, adiponectin, BDNF positively impacting neuropsychiatric conditions. particular, lactate could also play critical role in ameliorating due findings about protein lactylation novel post-transcriptional modification. The suggests terms brain structure, may improve hippocampal volume, basal ganglia (neostriatum, caudate-crustal nucleus) PFC density patients with MDD. summary, this study elucidates multifaceted potential mechanisms particular emphasis roles various exerkines. Future research further investigate different types, intensities, durations depression, well how better integrate into existing strategies achieve optimal outcomes health interventions.

Language: Английский

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Peripheral to brain and hippocampus crosstalk induced by exercise mediates cognitive and structural hippocampal adaptations

Life Sciences, Journal Year: 2024, Volume and Issue: 352, P. 122799 - 122799

Published: June 7, 2024

Language: Английский

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Exercise intensity matters: A review on evaluating the effects of aerobic exercise intensity on muscle‐derived neuroprotective myokines

Alzheimer s & Dementia Translational Research & Clinical Interventions, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 1, 2025

Abstract Exercise as a medical intervention is effective to help prevent and manage many chronic complex diseases, including dementia. There evidence suggest that regular aerobic exercise protects against age‐related brain atrophy reduces the risk of cognitive decline. The mechanisms by which infers neuroprotective effect remain be established but may related maintenance volume neuronal survival, improved cerebrovascular density function, and/or increased synaptic plasticity. In addition, there growing beneficial effects on health function are, at least in part, mediated factors released skeletal muscle during contraction. fact responds suggests muscle‐derived peripheral factors, or “myokines,” play key role muscle–brain crosstalk neuroprotection. However, most “dose” promote changes these myokine pathways currently unknown. Specifically, date from studies have used moderate‐intensity exercise, research investigating merit high‐intensity scarce. Considering well‐established interval training protecting numerous conditions, more needed identify improve myokines. Highlights Neuroprotection through : Regular mitigates decline via multiple mechanisms, maintenance, Myokines mediators Muscle‐derived (myokines) crucial crosstalk, significantly contributing exercise. Intensity matters review underscores necessity define study intensity, revealing effective, if not more, promoting levels compared Future directions This emphasizes need for well‐controlled explore optimal dose enhancing their implications neurodegenerative disease prevention.

Language: Английский

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The Brain–Gut–Bone Axis in Neurodegenerative Diseases: Insights, Challenges, and Future Prospects

Advanced Science, Journal Year: 2024, Volume and Issue: 11(38)

Published: Aug. 9, 2024

Neurodegenerative diseases are global health challenges characterized by the progressive degeneration of nerve cells, leading to cognitive and motor impairments. The brain-gut-bone axis, a complex network that modulates multiple physiological systems, has gained increasing attention owing its profound effects on occurrence development neurodegenerative diseases. No comprehensive review been conducted clarify triangular relationship involving axis potential for innovative therapies disorders. In light this, new perspective is aimed propose interplay between brain, gut, bone highlighting their dynamic communication in diseases, as they modulate including nervous, immune, endocrine, metabolic systems. Therapeutic strategies maintaining balance brain regulation, intestinal microbiota improving skeletal health, also explored. intricate interactions within pose challenge effective treatments can comprehensively target this system. Furthermore, safety these requires further evaluation. This offers novel insights prevention treatment which have important implications clinical practice patient well-being.

Language: Английский

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Physical activity, cathepsin B, and cognitive health

Trends in Molecular Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Brain‐derived neurotrophic factor drives muscle adaptation similar to aerobic training in mice

The FASEB Journal, Journal Year: 2025, Volume and Issue: 39(2)

Published: Jan. 24, 2025

Abstract This study, in vivo and vitro, investigated the role of brain‐derived neurotrophic factor (BDNF) skeletal muscle adaptations to aerobic exercise. BDNF is a contraction‐induced protein that may play involved repair, increased fat oxidation, mitochondrial biogenesis, all which are observed with training. The purpose this study was two‐pronged response (1) acute (2) chronic exercise male C57BL/6J mice. It also examined if treatment resulted similar In aim 1, mice underwent 2 hr. treadmill bout. 2, were assigned one four groups: control (CON); endurance training (ET; running 1 h/day, 5 days/wk); (3) (BDNF; 0.5 mg/kg·bw, (4) (ET + BDNF) for 8 weeks. Results demonstrated soleus (SOL) had higher content compared extensor digitorum longus (EDL) SOL After treatment, testing exhaustion main effect ET on increasing capacity. vitro contractile assessment EDL revealed increases max rate relaxation as ET. force‐frequency analysis showed produced force than CON BDNF, indicating an additive effect. proteins, COXIV, CS. These results demonstrate contributes

Language: Английский

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Exercise, Neuroprotective Exerkines, and Parkinson’s Disease: A Narrative Review

Biomolecules, Journal Year: 2024, Volume and Issue: 14(10), P. 1241 - 1241

Published: Sept. 30, 2024

Parkinson's disease (PD) is a prevalent neurodegenerative in which treatment often includes an exercise regimen. Exercise neuroprotective animal models of PD, and, more recently, human clinical studies have verified exercise's disease-modifying effect. Aerobic and resistance training improve many PD's motor non-motor symptoms, while neuromotor therapy stretching/flexibility exercises positively contribute to the quality life people with PD. Therefore, understanding role managing this complex disorder crucial. Exerkines are bioactive substances that synthesized released during been implicated several positive health outcomes, including neuroprotection. protect neuronal cells vitro rodent PD vivo. both increase exerkine levels blood, suggesting for exerkines theory. Many demonstrate potential protecting brain against pathological missteps caused by Every person (people) (PwP) needs comprehensive plan tailored their unique abilities. Here, we provide template help PwP understand importance treating describe barriers confronting attempt exercise, suggestions overcoming these barriers, explore In conclusion, together create powerful system should slowing chronic progression

Language: Английский

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Harnessing Passive Pulsatile Shear Stress for Alzheimer’s Disease Prevention and Intervention

Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: 98(2), P. 387 - 401

Published: Feb. 23, 2024

Alzheimer's disease (AD) affects more than 40 million people worldwide and is the leading cause of dementia. This a challenge for both patients caregivers puts significant strain on global healthcare system. To address this issue, Lancet Commission recommends focusing reducing modifiable lifestyle risk factors such as hypertension, diabetes, physical inactivity. Passive pulsatile shear stress (PPSS) interventions, which use devices like whole-body periodic acceleration, acceleration along Z-axis (pGz), Jogging Device, have shown systemic cellular effects in preclinical clinical models these risks factors. Based this, we propose that PPSS could be potential non-pharmacological non-invasive preventive or therapeutic strategy AD. We perform comprehensive review biological basis based all publications using demonstrate their various aspects draw from analysis to support our hypothesis. then delve into possible application an innovative intervention. discuss how holds promise ameliorating hypertension diabetes while mitigating inactivity, potentially offering holistic approach AD prevention management.

Language: Английский

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Higher Protein Intake does not Modulate Resistance Training–Induced Changes in Myokines and Cognitive Function in Middle-Aged Adults

Journal of Cognitive Enhancement, Journal Year: 2024, Volume and Issue: 8(1-2), P. 76 - 94

Published: Feb. 27, 2024

Language: Английский

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Soluble RAGE and skeletal muscle tissue RAGE expression profiles in lean and obese young adults across differential aerobic exercise intensities

Journal of Applied Physiology, Journal Year: 2023, Volume and Issue: 135(4), P. 849 - 862

Published: Sept. 7, 2023

This study is the first to investigate effects of aerobic exercise intensity on circulating sRAGE isoforms, muscle RAGE protein, and splicing. isoforms tended diminish with exercise, although this effect was attenuated increasing intensity. Muscle protein gene expression were unaffected by exercise. However, individuals obesity displayed nearly twofold higher expression, which positively correlated P65 subunit NF-κB.

Language: Английский

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