Quadriceps Strength and Temporal Preparation in Elderly Adults: The Mediating Role of Beta Oscillation DOI Creative Commons

Ming‐Cho Ho,

Hao‐Lun Fu, Shih‐Chun Kao

et al.

European Journal of Neuroscience, Journal Year: 2025, Volume and Issue: 61(7)

Published: April 1, 2025

This study investigated the relationship between lower limb muscle strength and temporal preparation in older adults using an electroencephalogram to assess neural oscillations during cognitive processes. Forty were divided into higher (HSG, 70.40 ± 5.15 years) (LSG, 71.43 4.86 groups based on quadriceps estimated via a manual test. Functional mobility was assessed Timed Up Go (TUG) test, while evaluated choice response time (RT) task with randomly varying foreperiods (FPs) that required motor responses. The HSG outperformed LSG both TUG test (HSG: 6.07 1.14 vs. LSG: 6.79 0.88, p = 0.031) 462.97 51.06 ms 525.86 73.69 ms, 0.002), despite no clear FP effect either group. Additionally, demonstrated more pronounced modulation of oscillatory beta power late phase longer trials (qs < 0.05, FDR corrected), whereas significant observed shorter trials. Crucially, mediation analysis indicated significantly mediated RT [b -24.21; 95% CI (-53.51, -0.24)]. In summary, these findings suggest may influence development preparatory periods by modulating power, potentially serving as compensatory mechanism mitigate age-related declines processing speed preserve functional mobility.

Language: Английский

Delayed presentation of HIV among older individuals: a growing problem DOI Creative Commons
Amy C. Justice, Matthew Bidwell Goetz, Cameron Stewart

et al.

The Lancet HIV, Journal Year: 2022, Volume and Issue: 9(4), P. e269 - e280

Published: Feb. 23, 2022

Language: Английский

Citations

47
The multifactorial nature of healthy brain ageing: Brain changes, functional decline and protective factors DOI
Sonia Turrini, Bonnie Wong, Mark C. Eldaief

et al.

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 88, P. 101939 - 101939

Published: April 27, 2023

Language: Английский

Citations

37
Social connections as determinants of cognitive health and as targets for social interventions in persons with or at risk of Alzheimer’s disease and related disorders: a scoping review DOI Creative Commons
Pallavi Joshi,

Kyle Hendrie,

Dylan J. Jester

et al.

International Psychogeriatrics, Journal Year: 2023, Volume and Issue: 36(2), P. 92 - 118

Published: Nov. 23, 2023

ABSTRACT Background: Social connections have a significant impact on health across age groups, including older adults. Loneliness and social isolation are known risk factors for Alzheimer’s disease related dementias (ADRD). Yet, we did not find review focused meta-analyses systematic reviews of studies that had examined associations with cognitive decline trials technology-based other interventions to enhance in people ADRD. Study design: We conducted scoping 11 as possible determinants adults or at developing also eight persons results: The strongest evidence an association lower was engagement activities. There linking network size function decline, but it consistently significant. A number of, though all, reported marital status Surprisingly, showing support reduces the ADRD weak. To varying degrees, designed reduce loneliness improved activities well quality life no cognition. discuss strengths limitations included. Conclusions: seem be most consistent components improving among individuals Socially aid deserve more research.

Language: Английский

Citations

24
Successful cognitive aging is associated with thicker anterior cingulate cortex and lower tau deposition compared to typical aging DOI Creative Commons
Stefania Pezzoli, Joseph Giorgio, Adam Martersteck

et al.

Alzheimer s & Dementia, Journal Year: 2023, Volume and Issue: 20(1), P. 341 - 355

Published: Aug. 24, 2023

Abstract INTRODUCTION There is no consensus on either the definition of successful cognitive aging (SA) or underlying neural mechanisms. METHODS We examined agreement between new and existing definitions using: (1) a novel measure, age gap (SA‐CAG, cognitive‐predicted minus chronological age), (2) composite scores for episodic memory (SA‐EM), (3) non‐memory cognition (SA‐NM), (4) California Verbal Learning Test (SA‐CVLT). RESULTS Fair to moderate strength was found four definitions. Most SA groups showed greater cortical thickness compared typical (TA), especially in anterior cingulate midcingulate cortices medial temporal lobes. Greater hippocampal volume all except SA‐NM. Lower entorhinal 18 F‐Flortaucipir (FTP) uptake groups. DISCUSSION These findings suggest that feature SA, regardless its exact definition, resistance tau pathology preserved integrity, cortices. Highlights Different approaches have been used define (SA). Regardless different similar brain features. individuals volume. deposition, but not amyloid beta related SA. A combination integrity may be features

Language: Английский

Citations

23
Alcohol and stress exposure across the lifespan are key risk factors for Alzheimer's Disease and cognitive decline DOI Creative Commons
Laurel R. Seemiller, Julio Flores-Cuadra,

Keith R. Griffith

et al.

Neurobiology of Stress, Journal Year: 2024, Volume and Issue: 29, P. 100605 - 100605

Published: Jan. 4, 2024

Alzheimer's Disease and related dementias (ADRD) are an increasing threat to global health initiatives. Efforts prevent the development of ADRD require understanding behaviors that increase decrease risk neurodegeneration cognitive decline, in addition uncovering underlying biological mechanisms behind these effects. Stress exposure alcohol consumption have both been associated with increased for human populations. However, our ability understand causal requires substantial preclinical research. In this review, we summarize existing animal research investigating connections between lifetime stress exposures ADRD.

Language: Английский

Citations

13
Association of Plasma Amyloid, P-Tau, GFAP, and NfL With CSF, Clinical, and Cognitive Features in Patients With Dementia With Lewy Bodies DOI
Katharina Bolsewig,

Annemartijn A. J. M. van Unnik,

Elena R. Blujdea

et al.

Neurology, Journal Year: 2024, Volume and Issue: 102(12)

Published: June 3, 2024

Plasma β-amyloid-1-42/1-40 (Aβ42/40), phosphorylated-tau (P-tau), glial fibrillary acidic protein (GFAP), and neurofilament light (NfL) have been widely examined in Alzheimer disease (AD), but little is known about their reflection of copathologies, clinical importance, predictive value dementia with Lewy bodies (DLB). We aimed to evaluate associations these biomarkers CSF amyloid, cognition, core features DLB.

Language: Английский

Citations

13
How Diet and Lifestyle Can Fine-Tune Gut Microbiomes for Healthy Aging DOI
María Tamayo, Maitane Olivares, Patricia Ruas‐Madiedo

et al.

Annual Review of Food Science and Technology, Journal Year: 2024, Volume and Issue: 15(1), P. 283 - 305

Published: June 28, 2024

Many physical, social, and psychological changes occur during aging that raise the risk of developing chronic diseases, frailty, dependency. These adversely affect gut microbiota, a phenomenon known as microbe-aging. Those microbiota alterations are, in turn, associated with development age-related diseases. The is highly responsive to lifestyle dietary changes, displaying flexibility also provides anactionable tool by which healthy can be promoted. This review covers, firstly, main socioeconomic factors modify composition function or unhealthy and, secondly, advances being made defining promoting aging, including microbiome-informed artificial intelligence tools, personalized patterns, food probiotic systems.

Language: Английский

Citations

9
Inflammatory markers in type 2 diabetes with vs. without cognitive impairment; a systematic review and meta-analysis DOI
Natasha Z. Anita, Julia Zebarth, Brian Chan

et al.

Brain Behavior and Immunity, Journal Year: 2021, Volume and Issue: 100, P. 55 - 69

Published: Nov. 20, 2021

Language: Английский

Citations

49
Novel Nutraceutical Compounds in Alzheimer Prevention DOI Creative Commons
Ricardo B. Maccioni, Camila Calfío, Andrea González

et al.

Biomolecules, Journal Year: 2022, Volume and Issue: 12(2), P. 249 - 249

Published: Feb. 3, 2022

Alzheimer’s disease (AD) incidence is increasing worldwide at an alarming rate. Considering this increase, prevention efforts, stemming from scientific research, health education, and public policies, are critical. Clinical studies evidenced that healthy lifestyles along with natural multitarget disease-modifying agents have a preventative impact on AD or mitigate symptoms in diagnosed patients. The pathological alterations of start 30 years before symptoms, it essential to develop the capacity detect those changes. In regard, molecular biomarkers early manifestations helpful. Based markers data, preventive interventions could reduce more than 40% cases. Protective actions include exercise, shown induce neurogenesis, cognitive stimulation, intellectual-social activity, nutrition among others. Mediterranean diet, preprobiotics, nutraceuticals containing bioactive molecules antioxidant anti-inflammatory properties relevant. Antiprotein aggregation whose mechanisms were described important. Anti-inflammatory anti-aggregation help control impairment, quercetin, biocurcumin, rosemarinic acid, Andean shilajit. Anthocyanidins, e.g., delphinidin, malvidin, flavonoids, also included. Quercetin hydroxy-tyrosol antiaging anti-AD properties. We emphasize relevance as main actor and/or dementia particularly AD.

Language: Английский

Citations

35
Using the Biopsychosocial Model to Guide Patient-Centered Neurological Treatments DOI
Aneeta Saxena, Sara Paredes-Echeverri, R. Michaelis

et al.

Seminars in Neurology, Journal Year: 2022, Volume and Issue: 42(02), P. 080 - 087

Published: Feb. 3, 2022

Abstract The biopsychosocial model was defined by George L. Engel to propose a holistic approach patient care. Through this model, physicians can understand patients in their context aid the development of tailored, individualized treatment plans that consider relevant biological, psychological, and social–cultural–spiritual factors impacting health longitudinal In article, we advocate for use neurology practice across outpatient inpatient clinical settings. To do so, first present history its relationships precision medicine deep phenotyping. Then, bring neurologist up-to-date information on components formulation, including predisposing, precipitating, perpetuating, protective factors. We conclude detailing illustrative neurological case examples using emphasizing importance considering psychological social delivery patient-centered care neurology.

Language: Английский

Citations

29