Multiomics Reveals Biological Mechanisms Linking Macroscale Structural Covariance Network Dysfunction With Neuropsychiatric Symptoms Across the Alzheimer’s Disease Continuum DOI Creative Commons
Jiwei Jiang, Kun Zhao, Wenyi Li

et al.

Biological Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Exploring the Genetic Landscape of Mild Behavioral Impairment as an Early Marker of Cognitive Decline: An Updated Review Focusing on Alzheimer’s Disease DOI Open Access
Efthalia Angelopoulou, Christos Koros, Alexandros Hatzimanolis

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2645 - 2645

Published: Feb. 24, 2024

The clinical features and pathophysiology of neuropsychiatric symptoms (NPSs) in dementia have been extensively studied. However, the genetic architecture underlying neurobiological mechanisms NPSs at preclinical stages cognitive decline Alzheimer's disease (AD) remain largely unknown. Mild behavioral impairment (MBI) represents an at-risk state for incident is defined by emergence persistent among non-demented individuals later life. These include affective dysregulation, decreased motivation, impulse dyscontrol, abnormal perception thought content, social inappropriateness. Accumulating evidence has recently begun to shed more light on background MBI, focusing its potential association with factors related AD. Apolipoprotein E (APOE) genotype MS4A locus associated ZCWPW1 inappropriateness psychosis, BIN1 EPHA1 NME8 apathy. between MBI polygenic risk scores (PRSs) terms AD also explored. Potential implicated neuroinflammation, synaptic dysfunction, epigenetic modifications, oxidative stress responses, proteosomal impairment, immune responses. In this review, we summarize critically discuss available emphasis AD, aiming gain insights into mechanisms, which till now unexplored. addition, propose future areas research emerging field, aim better understand molecular links decline.

Language: Английский

Citations

9
Choroid plexus volume as a novel candidate neuroimaging marker of the Alzheimer’s continuum DOI Creative Commons
Jiwei Jiang,

Zhizheng Zhuo,

Anxin Wang

et al.

Alzheimer s Research & Therapy, Journal Year: 2024, Volume and Issue: 16(1)

Published: July 3, 2024

Enlarged choroid plexus (ChP) volume has been reported in patients with Alzheimer's disease (AD) and inversely correlated cognitive performance. However, its clinical diagnostic predictive value, mechanisms by which ChP impacts the AD continuum remain unclear.

Language: Английский

Citations

9
Malnutrition exacerbating neuropsychiatric symptoms on the Alzheimer's continuum is relevant to the cAMP signaling pathway: Human and mouse studies DOI Creative Commons
Jiwei Jiang, Tianlin Jiang,

Xiaohong Wang

et al.

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Abstract INTRODUCTION Malnutrition correlates with neuropsychiatric symptoms (NPSs) in Alzheimer's disease (AD); however, the potential mechanism underlying this association remains unclear. METHODS Baseline and longitudinal associations of nutritional status NPSs were analyzed 374 patients on AD continuum 61 healthy controls. Serum biomarkers, behavioral tests, cerebral neurotransmitters, differentially gene expression evaluated standard malnourished diet–fed transgenic APPswe/PSEN1dE9 (APP/PS1) mice. RESULTS Poor increased blood flow midbrain striatum associated severe general subtypes, especially depression, anxiety, apathy. APP/PS1 mice fed a diet showed poor status, depression‐ anxiety‐like behaviors, altered neurotransmitter levels, downregulated c‐Fos striatum; these suppressed cyclic adenosine monophosphate (cAMP) signaling pathway. DISCUSSION exacerbating is relevant to cAMP pathway striatum, suggesting for targeted interventions mitigate continuum. Highlights linked specific symptom (NPS) deterioration. affects NPSs, usually involving striatum. Malnourished induces behaviors exacerbates

Language: Английский

Citations

0
High-dimensional mediation analysis reveals the mediating role of physical activity patterns in genetic pathways leading to AD-like brain atrophy DOI Creative Commons

Hanxiang Xu,

Shizhuo Mu,

Jingxuan Bao

et al.

BioData Mining, Journal Year: 2025, Volume and Issue: 18(1)

Published: March 24, 2025

Alzheimer's disease (AD) is a complex disorder that affects multiple biological systems including cognition, behavior and physical health. Unfortunately, the pathogenic mechanisms behind AD are not yet clear treatment options still limited. Despite increasing number of studies examining pairwise relationships between genetic factors, activity (PA), AD, few have successfully integrated all three domains data, which may help reveal impact these genomic phenomic factors on AD. We use high-dimensional mediation analysis as an integrative framework to study among PA AD-like brain atrophy quantified by spatial patterns atrophy. integrate data from genetics, neuroimaging measures collected 13,425 UK Biobank samples unveil relationship risk signatures in contexts aging Specifically, we used composite imaging marker, Spatial Pattern Abnormality for Recognition Early (SPARE-AD) characterizes atrophy, outcome variable represent risk. Through GWAS, identified single nucleotide polymorphisms (SNPs) significantly associated with SPARE-AD exposure variables. employed conventional summary statistics functional principal component extract mediators. After constructing variables, utilized method, Bayesian Mediation Analysis (BAMA), estimate potential mediating pathways SNPs, multivariate SPARE-AD. BAMA incorporates continuous shrinkage prior select active mediators large pool candidates. total 22 pathways, indicating how variants can influence altering activity. By comparing results those obtained using univariate analysis, demonstrate advantages methods over analysis. multi-omics several These findings contribute better understanding Moreover, our research demonstrates method revealing disease.

Language: Английский

Citations

0
Mapping the Neuropsychiatric Symptoms in Alzheimer’s Disease Using Biomarkers, Cognitive Abilities, and Personality Traits: A Systematic Review DOI Creative Commons
Athanasios Chatzikostopoulos, Despina Μoraitou, Vasileios Papaliagkas

et al.

Diagnostics, Journal Year: 2025, Volume and Issue: 15(9), P. 1082 - 1082

Published: April 24, 2025

Background/Objectives: Symptoms (NPS) in Alzheimer’s disease (AD) have multiple effects daily living, not only for the patients but their caregivers too. The present systematic review was performed order to identify if biomarkers, cognitive functions, and personality traits can be considered as important factors development maintenance of these symptoms. Methods: To achieve that, existing literature spanning period from 2018 2024 critically analyzed. included review, a study had investigate any mentioned above. In total, 182 articles were assessed eligibility, 50 met inclusion criteria. Results: Most studies focused on role biomarkers found that amyloid β, tau phospho-tau protein are closely related incidence severity NPS. fewer studies, function also associated with Conclusions: conclusion, NPS, underlying mechanisms, still, mostly remain unknown.

Language: Английский

Citations

0
Multiomics Reveals Biological Mechanisms Linking Macroscale Structural Covariance Network Dysfunction With Neuropsychiatric Symptoms Across the Alzheimer’s Disease Continuum DOI Creative Commons
Jiwei Jiang, Kun Zhao, Wenyi Li

et al.

Biological Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

1