Centella asiatica Promotes Antioxidant Gene Expression and Mitochondrial Oxidative Respiration in Experimental Autoimmune Encephalomyelitis DOI Creative Commons

Payel Kundu,

Kanon Yasuhara,

Mikah S. Brandes

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(12), P. 1681 - 1681

Published: Dec. 13, 2024

Background/Objectives: Centella asiatica (L.) Urban (family Apiaceae) (C. asiatica) is a traditional botanical medicine used in aging and dementia. Water extracts of C. (CAW) have been to treat neuropsychiatric symptoms related animal models are associated with increases antioxidant response element (ARE) genes improvements mitochondrial respiratory function neuronal health. Because multiple sclerosis (MS) shares its neurogenerative pathology oxidative stress dysfunction dementia, MS may also benefit from asiatica. To determine whether CAW similarly benefits symptoms, ARE gene expression, respiration inflammatory MS, the effects on clinical disability inflammation, we tested using experimental autoimmune encephalomyelitis (EAE). Methods: C57BL/6J mice induced EAE were treated or placebo for 2 weeks. The outcomes disability, signs anxiety (open field test), respiration, inflammation demyelination. Results: At dosing schedule concentrations tested, CAW-treated demonstrated increased expression activity compared those placebo-treated EAE. was reduced infiltrates spinal cord, but differences between populations activated versus quiescent microglia equivocal. did not improve behavioral performance, motor Conclusions: In model demonstrates similar neuroprotective it exhibits dementia mouse models. These benefits, along anti-inflammatory CAW, support further investigation people MS.

Language: Английский

Optimisation of Ultrasound-Assisted Extraction of Total Phenolics and Flavonoids Content from Centella asiatica DOI Creative Commons

Vimolpa Hiranpradith,

Nantawan Therdthai, Aussama Soontrunnarudrungsri

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(2), P. 291 - 291

Published: Jan. 17, 2025

Centella asiatica (CA), known for its health-promoting properties, is rich in bioactive compounds. This study optimised ultrasound-assisted extraction (UAE) parameters to maximise total phenolic content (TPC) and flavonoid (TFC) using the response surface methodology (RSM). Ethanol concentration solvent volume significantly influenced TPC TFC yields (p < 0.0001), while ultrasonic power had nonsignificant effects 0.05). Time showed no significant effect on > 0.05) but due flavonoids’ sensitivity degradation Variable interactions were negligible The relationship between responses (TPC TFC) independent could be expressed as quadratic models fitted with a Predicted R2 of 0.8263 0.9006 TFC. Based RSM, optimal conditions—75% ethanol concentration, 87.5 W power, 30 min time, 20 mL volume—yielded values 52.29 ± 1.65 mg/g 43.71 1.92 mg/g, closely aligning model predictions at 95% confidence. Additionally, UAE condition provided asiaticoside 37.56 4.25 madecassoside 16.91 1.28 mg/g. offers valuable insights into factors influencing efficiency, sustainability, scalability recovering compounds, underscoring potential sustainable method developing functional food ingredients from CA.

Language: Английский

Citations

4
Decoding Ischemic Stroke: Perspectives on the Endoplasmic Reticulum, Mitochondria, and Their Crosstalk DOI Creative Commons
Chuxin Zhang, Xin Lan, Qingguo Wang

et al.

Redox Biology, Journal Year: 2025, Volume and Issue: unknown, P. 103622 - 103622

Published: March 1, 2025

Stroke is known for its high disability and mortality rates. Ischemic stroke (IS), the most prevalent form, imposes a considerable burden on affected individuals. Nevertheless, existing treatment modalities are hindered by limitations, including narrow therapeutic windows, substantial adverse effects, suboptimal neurological recovery. Clarifying pathological mechanism of IS prerequisite developing new strategies. In this context, functional disruption mitochondria, endoplasmic reticulum (ER), crosstalk mechanisms between them have garnered increasing attention their contributory roles in progression IS. Therefore, review provides comprehensive summary current pathomechanisms associated with involvement ER mitochondria IS, emphasising Ca2+ destabilization homeostasis, stress, oxidative disordered mitochondrial quality control, transfer. Additionally, article highlights interaction as well mitochondrial-ER contacts (MERCs) that structurally connect ER, aiming to provide ideas references research

Language: Английский

Citations

1
Could protein phosphatase 2A and glycogen synthase kinase-3 beta be targeted by natural compounds to ameliorate Alzheimer’s pathologies? DOI
Sushmitaa Dhevii Manoharan, Hafizah Abdul Hamid, Nur Fariesha Md Hashim

et al.

Brain Research, Journal Year: 2024, Volume and Issue: 1829, P. 148793 - 148793

Published: Feb. 1, 2024

Language: Английский

Citations

5
Peripheral Blood DNA Methylation Changes in Response to Centella asiatica Treatment in Aged Mice DOI Creative Commons
Olivia Monestime, Brett A. Davis,

Cora E. Layman

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(1), P. 52 - 52

Published: Jan. 10, 2025

Alterations in epigenetic modifications, like DNA methylation, peripheral blood could serve as a useful, minimally invasive biomarker of the effects anti-aging interventions. This study explores this potential with water extract botanical Centella asiatica (CAW). Eighteen-month-old mice were treated CAW their drinking for 5 weeks alongside vehicle-treated eighteen-month-old C57BL6 mice. Reduced representation bisulfite sequencing (RRBS) was used to identify genome-wide differential methylation CAW-treated aged compared Our results showed distinct enrichment differentially methylated regions (DMRs) nearby genes involved biological processes relevant aging (i.e., antioxidant response, metabolic regulation, cellular metabolism). A difference observed between males and females both number sites state methylation. Moreover, or overlapping DMRs found be enriched related previously described mouse brain calcium circadian rhythm). Together, our data suggest that signature readily accessible, CAW's aging.

Language: Английский

Citations

0
A comprehensive review of medicinal plants and their beneficial roles in alleviating bisphenol A–induced organ toxicity DOI Creative Commons

Shabnam Dolatabadi,

Sara Rahimzadeh Oskuei,

Soghra Mehri

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Language: Английский

Citations

0
Neuroprotective effects of Centella asiatica against LPS/amyloid beta-induced neurodegeneration through inhibition of neuroinflammation DOI

Saniya Ansari,

Vimal K. Maurya,

Swatantra Kumar

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Pro-Oxidants and Antioxidants Imbalance in Alzheimer’s Disease DOI Open Access
Pravat K. Mandal

Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: 99(s1), P. S1 - S4

Published: March 5, 2024

Alzheimer's disease (AD) is an irreversible progressive neurological disorder that manifested by gradual deterioration of cognitive reserve and impairment activities in daily living.There are 50 million AD patients globally this number will likely be doubled 2050 [1].Two dominant hypotheses, the amyloid-␤ (A␤) cascade [2] tau propagation [3], were considered causally linked to progression AD.However, a disease-modifying drug for not available, although significant clinical trials based on A␤ phosphorylation already being conducted [4,5].A recent report meta-analysis effect anti-A␤ drugs brain revealed ␤-secretase inhibitors like verubecestat accelerated hippocampal whole atrophy compared changes observed after placebo administration [6].Therapeutic development urgently required potential role oxidative stress (OS) as early causal process [7][8][9].OS identified

Language: Английский

Citations

3
Effects of Centella asiatica-isolated pectic polysaccharide on dextran sulfate sodium-induced colitis DOI
Hyun Young Shin,

Won Bi Jeong,

Mi Yeun Joung

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 285, P. 138237 - 138237

Published: Nov. 30, 2024

Language: Английский

Citations

3
Asiatic acid alleviates subarachnoid hemorrhage-induced brain injury in rats by inhibiting ferroptosis of neurons via targeting Acyl-coenzyme A Oxidase 1 DOI
Y. Hu, Jingyu Gu, Xin Jin

et al.

Neuropharmacology, Journal Year: 2024, Volume and Issue: 262, P. 110208 - 110208

Published: Nov. 3, 2024

Language: Английский

Citations

0
Centella asiatica Promotes Antioxidant Gene Expression and Mitochondrial Oxidative Respiration in Experimental Autoimmune Encephalomyelitis DOI Creative Commons

Payel Kundu,

Kanon Yasuhara,

Mikah S. Brandes

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(12), P. 1681 - 1681

Published: Dec. 13, 2024

Background/Objectives: Centella asiatica (L.) Urban (family Apiaceae) (C. asiatica) is a traditional botanical medicine used in aging and dementia. Water extracts of C. (CAW) have been to treat neuropsychiatric symptoms related animal models are associated with increases antioxidant response element (ARE) genes improvements mitochondrial respiratory function neuronal health. Because multiple sclerosis (MS) shares its neurogenerative pathology oxidative stress dysfunction dementia, MS may also benefit from asiatica. To determine whether CAW similarly benefits symptoms, ARE gene expression, respiration inflammatory MS, the effects on clinical disability inflammation, we tested using experimental autoimmune encephalomyelitis (EAE). Methods: C57BL/6J mice induced EAE were treated or placebo for 2 weeks. The outcomes disability, signs anxiety (open field test), respiration, inflammation demyelination. Results: At dosing schedule concentrations tested, CAW-treated demonstrated increased expression activity compared those placebo-treated EAE. was reduced infiltrates spinal cord, but differences between populations activated versus quiescent microglia equivocal. did not improve behavioral performance, motor Conclusions: In model demonstrates similar neuroprotective it exhibits dementia mouse models. These benefits, along anti-inflammatory CAW, support further investigation people MS.

Language: Английский

Citations

0