Expert consensus recommendations for improving and standardising the assessment of patients with generalised myasthenia gravis

European Journal of Neurology, Journal Year: 2024, Volume and Issue: 31(7)

Published: March 24, 2024

Regular and consistent disease assessment could provide a clearer picture of burden in generalised myasthenia gravis (gMG) improve patient care; however, the use tools practice lacks standardisation. This modified Delphi approach was taken to review current evidence on tool gMG develop expert-derived consensus recommendations for good practice.

Language: Английский

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Exercise and myasthenia gravis

International review of neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Exercise and myasthenia gravis

Rare Disease and Orphan Drugs Journal, Journal Year: 2025, Volume and Issue: 4(2)

Published: May 15, 2025

Myasthenia gravis (MG) is an autoimmune disease primarily affecting the neuromuscular junction. Its main clinical manifestations are fluctuating muscle weakness and easy fatigability, which currently believed to be caused by disease-specific autoantibodies. Pharmacological therapy first-line treatment for MG, regimens including glucocorticoids, immunosuppressants, pyridostigmine considered significantly improve patients’ manifestations, enabling patients achieve goal of minimal manifestation status (MMS). Supportive also equally important in practice. Traditionally, it was thought that exercise might exacerbate symptoms MG patients; however, with a deeper understanding publication relevant research findings, now moderate can benefit stable patients.

Language: Английский

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Perspectives of people with myasthenia gravis on physical activity and experience of physical activity advice from health professionals in the Australian context: a qualitative study

Disability and Rehabilitation, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 8

Published: April 13, 2024

Purpose Physical activity is an important modifiable determinant of health. There has been a historical aversion to movement in people with myasthenia gravis (MG) due the pathophysiology disease, however, research suggests engagement physical safe and does not exacerbate symptoms. are currently no studies investigating qualitative perspectives MG on activity. The aim this study was explore perceptions activity, barriers, enablers, participants' experiences advice from health professionals.

Language: Английский

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Personality factors in patients with myasthenia gravis: A prospective study

Brain and Behavior, Journal Year: 2023, Volume and Issue: 13(11)

Published: Aug. 22, 2023

In myasthenia gravis (MG), depression and anxiety have frequently been reported as comorbidities. However, little is known about personality characteristics in MG patients. We aimed to characterise traits correlate them with disease severity course.The Big Five Inventory data questionnaire was used investigate 44 patients 45 healthy controls similar age gender. 28 patients, a caregiver also available for patient assessments limit bias associated social desirability patients' responses. Patients were assessed regard premorbid (before manifestation of MG) present condition. addition, scales (Hospital Anxiety Depression Scale Beck Inventory) applied.Compared controls, showed significantly higher levels neuroticism, whereas openness extraversion lower. Agreeableness conscientiousness did not differ between groups. Neuroticism influenced by such generalization weakness, presence thymoma, bulbar involvement well duration. correlated level neuroticism but scores.A profile increased lower may contribute considerably the perception severity. It be related frequent comorbidities depression. Although increased, this characteristic increase during course disease. The indicate that muscle weakness accompanied or even complicated psychological aspects. Therefore, behavioral intervention addition specific pharmacological therapy might particular value.

Language: Английский

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Genetically predicted effects of physical activity and sedentary behavior on myasthenia gravis: evidence from mendelian randomization study

BMC Neurology, Journal Year: 2023, Volume and Issue: 23(1)

Published: Aug. 11, 2023

Abstract Background Myasthenia gravis (MG) is an autoimmune disorder affecting the neuromuscular junction. Despite potential benefits of higher physical activity and lower sedentary behavior in MG patients, evidence from observational studies for effect on risk limited inconclusive. Methods We employed linkage disequilibrium score (LDSC) regression, two-sample Mendelian randomization (MR), its multivariable extension analyses (MVMR) to assess relationship between leisure screen time (LST), moderate-to-vigorous intensity during (MVPA) using genome-wide association (GWAS) summary datasets. MR were performed inverse-variance-weighted (IVW), weighted-median, MR-Egger regression. Sensitivity further alternative instruments test robustness our findings. Results found genetic overlap LST (rg = 0.113, P 0.023) MG, as well MVPA (rg=-0.220, 0.0001) LDSC method. The results suggested liability increased (IVW OR 1.609, 95% CI 1.153 2.244; 0.005). This was particularly notable late-onset 1.698, 1.145 2.518; 0.008), but not early-onset MG. Consistent findings obtained MVMR analysis BMI covariate 1.593, 1.167 2.173, 0.003). However, does support a substantial causal Conclusion Our measured by indicating that lack exercise may play role development Longitudinal interventional this are warranted.

Language: Английский

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Current state of research on exercise for the treatment of myasthenia gravis: A scoping review

Complementary Therapies in Medicine, Journal Year: 2024, Volume and Issue: 81, P. 103033 - 103033

Published: March 6, 2024

To provide a comprehensive overview of existing evidence, research gaps, and future priorities concerning the treatment myasthenia gravis (MG) using exercise therapies. Clinical studies on for MG were searched in nine databases to conduct scoping review. Two independent researchers screened literature comprehensively analyzed characteristics limitations included articles. A total 5725 retrieved, which 24 included. The conducted 16 different countries/regions 456 patients enrolled. Study designs both interventional observational studies. Exercise interventions aerobic exercise, resistance balance training, stretch are typically administered conjunction with medication, usual care, or some other interventions. intensity, frequency, duration varied hugely among Six-minute walk test, adverse events, muscle strength, quality life-15 scale, forced vital capacity, quantitative activities daily living scale most frequently used outcomes. All reported results favor efficacy safety MG, exercise-related events two This review provides an evidence MG. Key gaps include limited number participants, complex interventions, variability outcome selection, insufficient reporting publications. promotion still encounters several obstacles. larger population, rigorous study design conduction, standardized outcomes, essential.

Language: Английский

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Exploring impairments and allied health professional utilisation in people with myasthenia gravis: A cross-sectional study

Journal of Clinical Neuroscience, Journal Year: 2023, Volume and Issue: 114, P. 9 - 16

Published: June 3, 2023

Abstract

This study aimed to explore how people with myasthenia gravis experience impairments in vision, dizziness, hearing, and fatigue, these relate balance confidence, community participation, health-related quality of life. Additionally, this investigated the utilisation perception allied health role managing Australian context. Visual hearing impairments, along were found be correlated life participation varying degrees, while visual impairment dizziness confidence. Perception professionals was variable; common barriers better included participant clinicians having poor knowledge around gravis, previous experiences clinicians, uncertainty about clinicians' role, lack awareness that symptoms associated gravis. Further research exploring is recommended, education for disease appropriately access care.

Language: Английский

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Predictors to Health Promoting Behaviors among Patients with Myasthenia Gravis: Health Belief Model Approach

Journal of Population Therapeutics and Clinical Pharmacology, Journal Year: 2023, Volume and Issue: 30(5)

Published: Jan. 1, 2023

Myasthenia Gravis is a rare, chronic, acquired autoimmune neuromuscular disorder causing weakness in skeletal muscles.Patients with face many bio-psychosocial consequences that may require dramatic changes their lives.The aim of this study was to determine predictors health promoting behaviors among patients using Health Belief Model.A predictive correlational research design utilized fulfill the study.Consecutive sample convenience consisting 57 adult male and female admitted for 21 months at one Cairo University Hospitals, Egypt constituted sample.Data collected following tools:(a) Demographic Medical Background Data Form, (b) Glasgow Coma Scale conscious level potential participants, (c) The Adapted Health-Promoting Lifestyle Profile II tool assess health-promoting participants (d) Model disease variables were supposedly act as participants.Results showed majority (78.90%), married (66.70%), educated (96.50%) not working (91.20%), mean age 33.96 ±9.81.Most have no family history (96.50%), generalized (68.40%), onset between 20 40 years old (71.90%) initial signs symptoms are ptosis, limbs dysphagia (49.10 %, 40.40 % 35.10% respectively).Additionally, more than third achieved low total behaviors.Accordingly, only two belief model constructs, i.e., self-efficacy cues action shown be behaviors.The recommends self-management program should designed provide necessary tools improve enhance management skills.

Language: Английский

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Uključenost u fizioterapiju i tjelesne aktivnosti osoba s mijastenijom gravis

Journal of Applied Health Sciences, Journal Year: 2021, Volume and Issue: 7(1), P. 37 - 45

Published: Feb. 3, 2021

Mijastenija gravis jest autoimuna neuromuskularna bolest pri kojoj organizam stvara protutijela protiv receptora na mišićnim stanicama i tako sprječava prijenos podražaja sa živaca mišiće. Mišići se brzo umaraju javlja slabost mišića. Cilj istraživanja bio je provjeriti koliko su oboljeli od mijastenije uključeni u fizioterapijski program druge oblike tjelesne aktivnosti te ispitati stav oboljelih o ulozi njihovu postoji li razlika funkcioniranja svakodnevnom životu kod s obzirom poteškoće povezane inkontinencijom, operaciju timusa spol. U istraživanju sudjelovalo 211 ispitanika dijagnosticiranom mijastenijom gravis, 181 žena (85,8%) 30 muškaraca (14,2%), prosječne dobi 39 godina. Rezultati ovog pokazuju da većina smatra kako planirana tjelesna aktivnost pogoršava njihovo zdravstveno stanje, nema utjecaja ili nisu upoznati učincima manje tjelesno aktivne većinski uključene proces fizioterapije ni neki drugi vid aktivnosti. Statistički značajna nađena osoba koje operirale timus (p<0,00) imaju problema inkontinencijom (p<0,00). Neupitno mijastenija dovodi do smanjenja edukacija važnosti terapijskog vježbanja donosi benefite smislu boljeg za oboljele gravis.

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