The Effects of Environmental Pollutants and Exposures on Hair Follicle Pathophysiology DOI
Tara Samra, Rachel Lin, Andrea D. Maderal

et al.

Skin Appendage Disorders, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 11

Published: April 17, 2024

<b><i>Background:</i></b> Environmental exposures profoundly impact cutaneous physiology, with hair follicles (HFs) being particularly vulnerable due to their high levels of proliferation and perfusion. HFs are exposed directly contaminants that absorbed transcutaneously indirectly ingested inhaled pollutants via the bloodstream. <b><i>Summary:</i></b> Some pollutants, such as particulate matter, trigger inflammatory responses have been associated alopecia areata. Others, like tobacco smoke phthalates, exert endocrine effects unclear ramifications for HF function. Pesticides heavy metals both linked areata acute anagen effluvium, while polyaromatic hydrocarbons – ligands aryl hydrocarbon receptors androgenetic alopecia. Finally, UV exposure, which has increased anthropogenic ozone depletion, causes oxidative damage perifollicular mast cell degranulation. <b><i>Key Messages:</i></b> Pollutants far-reaching consequences pathology, remain incompletely characterized. The environmental on an active area research deserve further attention.

Language: Английский

Microplastics in dermatology: Potential effects on skin homeostasis DOI Creative Commons

Miguel Aristizabal,

Katherine V. Jiménez‐Orrego,

María Daniela Caicedo‐León

et al.

Journal of Cosmetic Dermatology, Journal Year: 2024, Volume and Issue: 23(3), P. 766 - 772

Published: Jan. 16, 2024

Abstract Background Microplastics (MPs) and nanoplastics (NPs) have become a growing concern in dermatology due to their widespread presence cosmetic formulations the environment. These minuscule synthetic polymer particles prompt an essential exploration of potential impact on dermatological homeostasis. Aims This study aims investigate effects MPs NPs integumentary system. Specifically, it seeks understand cutaneous alterations, inflammatory responses, disruptions skin's physiological functions caused by these particles. Patients/Methods The investigation involves comprehensive analysis emerging research NPs. includes environmental pervasiveness. delves into capacity breach barrier, raising concerns about implications prolonged exposure. Results Evidence suggests that may indeed incite provoke disturb homeostasis functions. Their small dimensions enhance capability further emphasizing apprehensions associated with Conclusions While precise understanding health remains ongoing scientific endeavor, this underscores significance findings emphasize need for proactive measures safeguard both individual well‐being preservation context health.

Language: Английский

Citations

24
Impact of climate change on immune responses and barrier defense DOI Creative Commons
Chrysanthi Skevaki, Kari C. Nadeau, Marc E. Rothenberg

et al.

Journal of Allergy and Clinical Immunology, Journal Year: 2024, Volume and Issue: 153(5), P. 1194 - 1205

Published: Feb. 2, 2024

Climate change is not just jeopardizing the health of our planet, but it increasingly impacting immune health.There an expanding body evidence that climaterelated exposures, such as air pollution, heat, wildfires, extreme weather events, and biodiversity loss significantly disrupt functioning human system.These exposures manifest in a broad range stimuli including antigens, allergens, heat stress, pollutants, microbiota changes, other toxic substances.Such pose direct indirect threat to body's primary line defense, epithelial barrier, affecting its physical integrity functional efficacy.Furthermore, these climate-related environmental stressors can hyper-stimulate innate system influence adaptive immunity, notably terms developing preserving tolerance.The or failure tolerance instigate wide spectrum non-communicable diseases autoimmune conditions, allergy, respiratory illnesses, metabolic diseases, obesity, others.As continues unravel, there need for additional research climate immunology covers diverse environments different global settings, employing modern biological epidemiological tools.

Language: Английский

Citations

24
Skin as the target for allergy prevention and treatment DOI Creative Commons
Andreina Marques‐Mejias, Irene Bartha, Christina E. Ciaccio

et al.

Annals of Allergy Asthma & Immunology, Journal Year: 2024, Volume and Issue: 133(2), P. 133 - 143

Published: Jan. 21, 2024

Language: Английский

Citations

19
Atopic dermatitis DOI
Emma Guttman‐Yassky, Yael Renert‐Yuval, Patrick M. Brunner

et al.

The Lancet, Journal Year: 2025, Volume and Issue: 405(10478), P. 583 - 596

Published: Feb. 1, 2025

Language: Английский

Citations

6
Environmental Air Pollutants Affecting Skin Functions with Systemic Implications DOI Open Access
Georgeta Bocheva, Radomir M. Slominski, Andrzej Słomiński

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(13), P. 10502 - 10502

Published: June 22, 2023

The increase in air pollution worldwide represents an environmental risk factor that has global implications for the health of humans worldwide. skin billions people is exposed to a mixture harmful pollutants, which can affect its physiology and are responsible cutaneous damage. Some polycyclic aromatic hydrocarbons photoreactive could be activated by ultraviolet radiation (UVR). Therefore, such UVR exposure would enhance their deleterious effects on skin. Air also affects vitamin D synthesis reducing UVB radiation, essential production D3, tachysterol, lumisterol derivatives. Ambient photopollution, blue-light pollution, cigarette smoke compromise structural integrity, interact with human microbiota, trigger or exacerbate range diseases through various mechanisms. Generally, elicits oxidative stress response activate inflammatory responses. aryl hydrocarbon receptor (AhR) act as sensor small molecules pollutants plays crucial role responses (photo)pollution. On other hand, targeting AhR/Nrf2 emerging novel treatment option induce diseases. AhR downstream regulatory pathways represent signaling system regulating phenotype Yin Yang fashion defined chemical nature activating cellular tissue context.

Language: Английский

Citations

38
Global warming and implications for epithelial barrier disruption and respiratory and dermatologic allergic diseases DOI
Zeynep Çelebi Sözener,

Elsa R. Treffeisen,

Betül Özdel Öztürk

et al.

Journal of Allergy and Clinical Immunology, Journal Year: 2023, Volume and Issue: 152(5), P. 1033 - 1046

Published: Sept. 9, 2023

Language: Английский

Citations

26
Involvement and repair of epithelial barrier dysfunction in allergic diseases DOI Creative Commons
Hui-Fei Lu,

Yi-Chi Zhou,

Litao Yang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 1, 2024

The epithelial barrier serves as a critical defense mechanism separating the human body from external environment, fulfilling both physical and immune functions. This plays pivotal role in shielding environmental risk factors such allergens, pathogens, pollutants. However, since 19th century, escalating threats posed by pollution, global warming, heightened usage of industrial chemical products, alterations biodiversity have contributed to noteworthy surge allergic disease incidences. Notably, diseases frequently exhibit dysfunction barrier. proposed hypothesis introduces novel avenue for prevention treatment diseases. Despite increased attention development, numerous questions persist regarding mechanisms underlying disruption normal function. Consequently, this review aims provide comprehensive overview barrier’s diseases, encompassing influencing factors, assessment techniques, repair methodologies. By doing so, it seeks present innovative strategies

Language: Английский

Citations

17
Ethosomes for Curcumin and Piperine Cutaneous Delivery to Prevent Environmental-Stressor-Induced Skin Damage DOI Creative Commons
Francesca Ferrara,

Agnese Bondi,

Walter Pula

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(1), P. 91 - 91

Published: Jan. 11, 2024

Diesel particulate matter is one of the most dangerous environmental stressors affecting human health. Many plant-derived compounds with antioxidant and anti-inflammatory properties have been proposed to protect skin from pollution damage. Curcumin (CUR) has a plethora pharmacological activities, including anticancer, antimicrobial, antioxidant. However, it low bioavailability due its difficult absorption rapid metabolism elimination. CUR encapsulation in nanotechnological systems combination biopotentiators such as piperine (PIP) can improve pharmacokinetics, stability activity. In this study, ethosomes (ETs) were investigated for PIP delivery damage induced by diesel matter. ETs produced different strategies characterized their size distribution photon correlation spectroscopy, morphology transmission electron microscopy, drug efficiency high-performance liquid chromatography. Franz cells enabled us evaluate vitro diffusion ETs. The results highlighted that promote permeation curcumin. studies carried out on activity demonstrated an increase power using separately loaded ETs, suggesting possible application prevention exogenous stressors. Ex vivo explants shown suitability drug-loaded prevent structural engine exhaust exposure.

Language: Английский

Citations

13
Systemic barrier dysfunction in type 2 inflammation diseases: perspective in the skin, airways, and gastrointestinal tract DOI Creative Commons
Juan Meng, Hao Xiao, Feng Xu

et al.

Immunologic Research, Journal Year: 2025, Volume and Issue: 73(1)

Published: March 11, 2025

The epithelial barrier in different organs is the first line of defense against environmental insults and allergens, with type 2 immunity serving as a protective function. Genetic factors, biological chemical from surrounding environment altered regulate homeostasis through disruption tight junction proteins or dilated intercellular spaces. Recent studies suggest that dysfunction contributes to pathologic alteration diseases immune dysregulation including (but not limited to) atopic dermatitis, prurigo nodularis, asthma, chronic rhinosinusitis nasal polyps, eosinophilic esophagitis. In this review, we summarized current understanding its interaction inflammation across organs, discussed role pathogenesis inflammation. addition, recent progresses emerging restorative therapies are reviewed.

Language: Английский

Citations

1
An Overview on Microplastics Hazards to the Marine Ecosystem and Humans’ Health DOI Open Access
Asia Grattagliano,

Zaira Grattagliano,

Loredana Manfra

et al.

Water, Journal Year: 2025, Volume and Issue: 17(7), P. 916 - 916

Published: March 21, 2025

Microplastic contamination is rapidly becoming an increasingly worrying environmental problem and poses a real threat to marine ecosystems human health. The aim of this research was conduct traditional review the current state art regarding sources MPs in environment, including assessment their toxic effect on organisms transfer within food webs up humans. An extensive literature search (from 1 January 2024 15 February 2025) yielded total 1027 primary articles topic. This overview revealed that can be ingested by organisms, migrate through intestinal wall, spread other organs. They biomagnify along chain carriers chemicals pathogen agents. Exposure lead several risks, tissue damage, oxidative stress, changes immune-related gene expression, neurotoxicity, growth retardation, behavioural abnormalities. toxicity depends mainly particle size distribution composition/characteristics polymer. main routes exposure have been identified as ingestion (mainly seafood), inhalation, dermal exposure. There strong evidence seafood MPs, which pose potential risk study provides basis for assessing MPs’ health impacts.

Language: Английский

Citations

1