Bioelectronic Medicine: a multidisciplinary roadmap from biophysics to precision therapies DOI Creative Commons
María Alejandra González‐González, Sílvia V. Conde, Ramón Latorre

et al.

Frontiers in Integrative Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Feb. 19, 2024

Bioelectronic Medicine stands as an emerging field that rapidly evolves and offers distinctive clinical benefits, alongside unique challenges. It consists of the modulation nervous system by precise delivery electrical current for treatment conditions, such post-stroke movement recovery or drug-resistant disorders. The unquestionable impact is underscored successful translation to humans in last decades, long list preclinical studies. Given emergency accelerating progress new neuromodulation treatments (i.e., hypertension, autoimmune degenerative diseases), collaboration between multiple fields imperative. This work intends foster multidisciplinary bring together different provide fundamental basis underlying Medicine. In this review we will go from biophysics cell membrane, which consider inner core neuromodulation, patient care. We discuss recently discovered mechanism neurotransmission switching how it design, update on neuronal glial health disease. advances biomedical technology have facilitated collection large amounts data, thereby introducing challenges data analysis. approaches high throughput analysis, encompassing big networks, artificial intelligence, internet things. Emphasis be placed understanding electrochemical properties neural interfaces, along with integration biocompatible reliable materials compliance regulations translational applications. Preclinical validation foundational process, critical aspects animal Finally, focus point-of-care ultimate goal bioelectronic medicine. a call scientists common endeavor: accelerate decoding era therapeutic possibilities.

Language: Английский

A Review of Recent Progress on Collagen‐Based Biomaterials DOI
Manhui Zheng, Xuechuan Wang, Yining Chen

et al.

Advanced Healthcare Materials, Journal Year: 2022, Volume and Issue: 12(16)

Published: Nov. 15, 2022

Abstract Since the 2010s, demand for healthcare models has exceeded prevailing resources available due to rapid increase in aging population China. However, a significant gap development of biomedical materials remains, especially between China and western developed countries. Collagen is major protein extracellular matrix (ECM) been extensively applied medical fields. Collagen‐based biomaterials (CBBs) are used prepare dressings dermal substitutes, surgical sutures, plasma tissue‐engineered scaffolds, drug delivery systems; this attributed their exceptional biocompatibility, biodegradability, hypoimmunogenicity, coordination collagen hosts tissues. This review provides thorough strides CBB structures, crosslinking forming technologies, real‐world applications. First, natural origin specific structures animal‐derived non‐animal‐derived introduced compared. Second, methods technologies CBBs across board discussed. Third, several examples considered demonstrate practical use highlight cautionary notes. Finally, underlying directions from an interdisciplinary perspective outlined. aims provide comprehensive mechanisms by which can be uniquely practically as advanced biomaterial, hence providing options augmenting its

Language: Английский

Citations

85
Ultra‐Thin Flexible Encapsulating Materials for Soft Bio‐Integrated Electronics DOI
Mingyu Sang, Kyubeen Kim, Jongwoon Shin

et al.

Advanced Science, Journal Year: 2022, Volume and Issue: 9(30)

Published: Aug. 28, 2022

Abstract Recently, bioelectronic devices extensively researched and developed through the convergence of flexible biocompatible materials electronics design that enables more precise diagnostics therapeutics in human health care opens up potential to expand into various fields, such as clinical medicine biomedical research. To establish an accurate stable bidirectional bio‐interface, protection against external environment high mechanical deformation is essential for wearable devices. In case implantable bioelectronics, special encapsulation optimized designs configurations provide electronic stability functionality are required accommodating organ properties, lifespans, functions biofluid environment. Here, this study introduces recent developments ultra‐thin encapsulations with novel can preserve or even improve electrical performance bio‐integrated by supporting safety from destruction contamination well optimizing use systems physiological environments. addition, a summary materials, methods, characteristics most widely used technologies introduced, thereby providing strategic selection appropriate choices recently bioelectronics.

Language: Английский

Citations

78
Solid implantable devices for sustained drug delivery DOI Creative Commons
Elizabeth Magill, Sara Demartis, Elisabetta Gavini

et al.

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 199, P. 114950 - 114950

Published: June 7, 2023

Implantable drug delivery systems (IDDS) are an attractive alternative to conventional administration routes. Oral and injectable the most common routes for providing peaks of concentrations in blood after followed by concentration decay a few hours. Therefore, constant is required keep levels within therapeutic window drug. Moreover, oral presents challenges due degradation gastrointestinal tract or first pass metabolism. IDDS can be used provide sustained prolonged periods time. The use this type especially interesting treatment chronic conditions where patient adherence treatments challenging. These normally systemic delivery. However, localised maximise amount delivered active site while reducing exposure. This review will cover current applications focusing on materials prepare main areas application.

Language: Английский

Citations

71
Advances in Wireless, Batteryless, Implantable Electronics for Real-Time, Continuous Physiological Monitoring DOI Creative Commons
Hyeonseok Kim, Bruno Rigo,

Gabriella Wong

et al.

Nano-Micro Letters, Journal Year: 2023, Volume and Issue: 16(1)

Published: Dec. 15, 2023

This review summarizes recent progress in developing wireless, batteryless, fully implantable biomedical devices for real-time continuous physiological signal monitoring, focusing on advancing human health care. Design considerations, such as biological constraints, energy sourcing, and wireless communication, are discussed achieving the desired performance of enhanced interface with tissues. In addition, we achievements materials used systems, emphasizing their importance multi-functionalities, biocompatibility, hemocompatibility. The batteryless offer minimally invasive device insertion to body, enabling portable monitoring advanced disease diagnosis. Lastly, summarize most practical applications care, highlighting potential immediate commercialization clinical uses.

Language: Английский

Citations

50
Challenges and Opportunities of Implantable Neural Interfaces: From Material, Electrochemical and Biological Perspectives DOI
Qi Zeng, Zhaoling Huang

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(32)

Published: June 8, 2023

Abstract The desirable implantable neural interfaces can accurately record bioelectrical signals from neurons and regulate activities with high spatial/time resolution, facilitating the understanding of neuronal functions dynamics. However, electrochemical performance (impedance, charge storage/injection capacity) is limited miniaturization integration electrodes. “crosstalk” caused by uneven distribution elctric field leads to lower electrical stimulation/recording efficiency. mismatch between stiff electrodes soft tissues exacerbates inflammatory responses, thus weakening transmission signals. Though remarkable breakthroughs have been made through incorporation optimizing electrode design functionalized nanomaterials, chronic stability, long‐term activity in vivo still need further development. In this review, interface challenges mainly on electrochemistry biology are discussed, followed summarizing typical optimization technologies exploring recent advances application based traditional metallic materials, emerging 2D conducting polymer hydrogels, etc., for enhancing interfaces. strategies improving durability including enhanced adhesion minimized response, also summarized. promising directions finally presented provide enlightenment high‐performance future, which will promote profound progress neuroscience research.

Language: Английский

Citations

48
Neural modulation with photothermally active nanomaterials DOI
Yingqiao Wang, Raghav Garg, Devora Cohen-Karni

et al.

Nature Reviews Bioengineering, Journal Year: 2023, Volume and Issue: 1(3), P. 193 - 207

Published: Jan. 31, 2023

Language: Английский

Citations

43
High-density transparent graphene arrays for predicting cellular calcium activity at depth from surface potential recordings DOI
Mehrdad Ramezani, Jeong-Hoon Kim, Xin Liu

et al.

Nature Nanotechnology, Journal Year: 2024, Volume and Issue: 19(4), P. 504 - 513

Published: Jan. 11, 2024

Language: Английский

Citations

27
Injectable and Conductive Nanomicelle Hydrogel with α-Tocopherol Encapsulation for Enhanced Myocardial Infarction Repair DOI
Feng Zhang, Yike Zhang,

Si-chong Qian

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(14), P. 10216 - 10229

Published: March 4, 2024

Substantial advancements have been achieved in the realm of cardiac tissue repair utilizing functional hydrogel materials. Additionally, drug-loaded hydrogels emerged as a research hotspot for modulating adverse microenvironments and preventing left ventricular remodeling after myocardial infarction (MI), thereby fostering improved reparative outcomes. In this study, diacrylated Pluronic F127 micelles were used macro-cross-linkers hydrogel, hydrophobic drug α-tocopherol (α-TOH) was loaded. Through situ synthesis polydopamine (PDA) incorporation conductive components, an injectable highly compliant antioxidant/conductive composite FPDA constructed. The exhibited exceptional stretchability, high toughness, good conductivity, cell affinity, adhesion. rabbit model, material surgically implanted onto tissue, subsequent to ligation anterior descending coronary artery. Four weeks postimplantation, there discernible recovery, manifesting augmented fractional shortening ejection fraction, alongside reduced infarcted areas. findings investigation underscore substantial utility given their proactive capacity modulate post-MI infarct microenvironment enhance therapeutic outcomes infarction.

Language: Английский

Citations

22
Wireless Battery-free and Fully Implantable Organ Interfaces DOI
A. K. Bhatia, Jessica Hanna, Tucker Stuart

et al.

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(5), P. 2205 - 2280

Published: Feb. 21, 2024

Advances in soft materials, miniaturized electronics, sensors, stimulators, radios, and battery-free power supplies are resulting a new generation of fully implantable organ interfaces that leverage volumetric reduction mechanics by eliminating electrochemical storage. This device class offers the ability to provide high-fidelity readouts physiological processes, enables stimulation, allows control over organs realize therapeutic diagnostic paradigms. Driven seamless integration with connected infrastructure, these devices enable personalized digital medicine. Key advances carefully designed material, electrophysical, electrochemical, electromagnetic systems form implantables mechanical properties closely matched target deliver functionality supports sensors stimulators. The elimination operation, anywhere from acute, lifetimes matching subject physical dimensions imperceptible operation. review provides comprehensive overview basic building blocks related topics such as implantation, delivery, sterilization, user acceptance. State art examples categorized system an outlook interconnection advanced strategies for computation leveraging consistent influx elevate this current battery-powered is highlighted.

Language: Английский

Citations

19
Recent Advances in Two-Dimensional Nanomaterials for Healthcare Monitoring DOI

Arun Kumar Manoharan,

Mohamed Ismail Kamal Batcha,

Shanmugam Mahalingam

et al.

ACS Sensors, Journal Year: 2024, Volume and Issue: 9(4), P. 1706 - 1734

Published: April 2, 2024

The development of advanced technologies for the fabrication functional nanomaterials, nanostructures, and devices has facilitated biosensors analyses. Two-dimensional (2D) with unique hierarchical structures, a high surface area, ability to be functionalized target detection at surface, exhibit potential biosensing applications. electronic properties, mechanical flexibility, optical, electrochemical, physical properties 2D nanomaterials can easily modulated, enabling construction platforms various analytes targeted recognition, sensitivity, selectivity. This review provides an overview recent advances in nanostructures used biosensor wearable-sensor healthcare health-monitoring Finally, advantages 2D-nanomaterial-based several challenges their optimal operation have been discussed facilitate smart high-performance future.

Language: Английский

Citations

19