Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(5), P. 1436 - 1436
Published: May 12, 2023
This
study
explores
the
therapeutic
efficacy
of
heparin-based
hydrogel
micropatches
containing
human
adipose-derived
stem
cells
(hASCs)
in
treating
neuropathic
pain
caused
by
nerve
damage.
Our
results
showed
that
hASCs
exhibited
neuroregenerative
and
pain-relieving
effects
when
used
with
animal
model.
The
use
this
combination
also
produced
enhanced
cell
viability
regeneration.
We
conducted
various
neurological
behavioral
tests,
dynamic
plantar
histological
examinations,
neuroelectrophysiological
examinations
to
confirm
effect.
findings
suggest
approach
could
maximize
improve
quality
life
for
patients
suffering
from
pain.
Polymers for Advanced Technologies,
Journal Year:
2024,
Volume and Issue:
35(7)
Published: July 1, 2024
Abstract
Water
contamination
from
industrial
dyes
poses
a
significant
threat
to
the
environment
and
human
health.
This
study
focuses
on
development
of
advanced
porous
cross‐linked
chitosan‐based
hydrogels
superparamagnetic
hydrogel
nanocomposites
for
efficient
removal
indigo
carmine
(IC)
dye
water.
The
were
using
benzophenonetetracarboxylic
dianhydride
(BTDA)
incorporated
functionalized
magnetic
iron
nanoparticles
(CP‐MNPs).
A
comparative
revealed
that
nanocomposite
exhibited
superior
performance
in
IC
adsorption.
Higher
efficiencies
observed
at
lower
amounts
cross‐linker,
pH,
adsorbent
dosage.
demonstrated
adsorption
compared
with
chitosan
hydrogel.
process
followed
pseudo‐second‐order
kinetic
model
Langmuir
isotherm
model.
Thermodynamic
data
indicated
onto
was
endothermic
spontaneous,
making
it
promising
material
environmental
applications.
Gels,
Journal Year:
2023,
Volume and Issue:
9(11), P. 907 - 907
Published: Nov. 16, 2023
Spinal
cord
injury
(SCI)
is
a
severe
neurological
caused
by
traffic
accidents,
trauma,
or
falls,
which
leads
to
significant
loss
of
sensory,
motor,
and
autonomous
functions
seriously
affects
the
patient's
life
quality.
Although
considerable
progress
has
been
made
in
mitigating
secondary
promoting
regeneration/repair
SCI,
therapeutic
effects
need
be
improved
due
drug
availability.
Given
their
good
biocompatibility,
biodegradability,
low
immunogenicity,
injectable
hydrogels
can
used
as
delivery
systems
achieve
controlled
release
drugs
other
substances
(cells
proteins,
etc.),
offering
new
hope
for
SCI
repair.
In
this
article,
we
summarized
types
hydrogels,
analyzed
application
further
discussed
mechanisms
treatment
such
anti-inflammatory,
antioxidant,
anti-apoptosis,
pro-neurogenesis.
Moreover,
highlighted
potential
benefits
combination
with
therapies,
including
recent
advances
achievements
these
promising
tools.
Our
review
may
offer
strategies
development
treatments
based
on
systems.
Biomimetics,
Journal Year:
2024,
Volume and Issue:
9(3), P. 140 - 140
Published: Feb. 25, 2024
Our
aim
was
to
investigate
axonal
outgrowth
from
different
tissue
models
on
soft
biomaterials
based
hyaluronic
acid
(HA).
We
hypothesized
that
HA-based
hydrogels
differentially
promote
neural
tissues.
Spinal
cord
sliced
cultures
(SCSCs)
and
dorsal
root
ganglion
(DRGCs)
were
maintained
a
collagen
gel,
physically
crosslinked
hydrogel
(Healon
5
Journal of Biomedical Materials Research Part B Applied Biomaterials,
Journal Year:
2025,
Volume and Issue:
113(2)
Published: Feb. 1, 2025
ABSTRACT
Traumatic
spinal
cord
injury
(SCI)
presents
a
significant
medical
challenge
due
to
its
intricate
nature
and
treatment
complexities.
SCI
can
cause
physical
impairments
by
affecting
neural
motor
functions
as
well
initiating
series
of
pathophysiological
events
exacerbating
the
initial
trauma.
Leakage
from
ruptured
neurons
vessels
disrupt
ionic
balance
induces
excitotoxicity,
leading
progressive
cellular
degeneration.
Introducing
mitochondria
lesion
has
shown
potential
in
attenuating
secondary
injury.
Mitochondria
transplantation
improves
bioenergetics
reduces
concentration
reactive
oxygen
species
achieving
homeostasis
neuroprotection.
Nonetheless,
keeping
viable
outside
cell
environment
for
time
longer
than
few
minutes
proves
be
challenging.
Additionally,
localized
delivery
site
also
been
limited
other
factors
including
flow
rate
cerebrospinal
fluid
that
washes
away
mobilized
organelle
compromised
tissue
site.
Previously
we
showed
using
hyaluronic
acid‐methylcellulose
semi‐gels
(HAMC)
biocompatible,
erodible
thermogelling
vehicle
helped
overcome
some
these
challenges.
HAMC
allows
controlled
release
at
around
site,
utilizing
reverse
property
MC.
Sustained
slower
increase
their
uptake
tissue.
To
better
optimize
semi‐gel
requires
more
complete
understanding
physicochemical
properties
semi‐gels.
We
have
used
ultraviolet–visible
spectroscopy
measure
optical
density
different
HA
MC
ratios
examine
temperature
dependent
gelation
above
low
critical
solution
(LCST).
The
viscosity
degree
crystallinity
resulting
were
assessed.
Semi‐gel
erosion
mitochondrial
over
studied
fluorescence
microplate
reader.
Lastly,
seahorse
assay
was
study
released
respiration
viability
after
incubation
semi‐gel.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: June 27, 2024
Severe
spinal
cord
injuries
(SCI)
lead
to
loss
of
functional
activity
the
body
below
injury
site,
affect
a
person’s
ability
self-care
and
have
direct
impact
on
performance.
Due
structural
features
role
in
body,
consequences
SCI
cannot
be
completely
overcome
at
expense
endogenous
regenerative
potential
and,
developing
over
time,
severe
complications
years
after
injury.
Thus,
primary
task
this
type
treatment
is
create
artificial
conditions
for
growth
damaged
nerve
fibers
through
area
SCI.
Solving
problem
possible
using
tissue
neuroengineering
involving
technology
replacing
natural
environment
with
synthetic
matrices
(for
example,
hydrogels)
combination
stem
cells,
particular,
neural/progenitor
cells
(NSPCs).
This
approach
can
provide
maximum
stimulation
support
axons
neurons
their
myelination.
In
review,
we
consider
currently
available
options
improving
condition
(use
NSC
transplantation
or/and
replacement
matrix,
specifically
hydrogel).
We
emphasise
expediency
effectiveness
hydrogel
matrix
+
NSCs
complex
system
used
reconstruction
Since
such
(a
engineering
cell
therapy),
our
opinion,
allows
not
only
creation
supporting
regeneration
or
mechanical
cord,
but
also
strengthen
regeneration,
prevent
spread
inflammatory
process,
promote
restoration
lost
reflex,
motor
sensory
functions
injured
cord.
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
31, P. 101556 - 101556
Published: Feb. 4, 2025
Spinal
cord
injury
(SCI)
presents
a
formidable
challenge
in
clinical
settings,
resulting
sensory
and
motor
function
loss
imposing
significant
personal
societal
burdens.
However,
owning
to
the
adverse
microenvironment
limited
regenerative
capacity,
achieving
complete
functional
recovery
after
SCI
remains
elusive.
Additionally,
traditional
interventions
including
surgery
medication
have
series
of
limitations
that
restrict
effectiveness
treatment.
Recently,
tissue
engineering
(TE)
has
emerged
as
promising
approach
for
promoting
neural
regeneration
SCI,
which
can
effectively
delivery
drugs
into
site
cells
improve
survival
differential.
Here,
we
outline
main
pathophysiology
events
post
injury,
further
discuss
materials
common
assembly
strategies
used
scaffolds
treatment,
expound
on
latest
advancements
treatment
methods
based
drug
cell
detail,
propose
future
directions
repair
with
TE
highlight
potential
applications.
Bioengineering,
Journal Year:
2025,
Volume and Issue:
12(4), P. 347 - 347
Published: March 28, 2025
Objective:
Because
of
the
evolving
nature
tissue
engineering
scaffolds
in
treatment
spinal
cord
injury
(SCI),
current
study
was
carried
out
to
evaluate
research
productivity
SCI.
Methods:
Studies
published
from
2000
2025
were
retrieved
Web
Science
core
collection
with
topics
and
scaffolds.
The
data
analyzed
visualized
using
VOSviewer
network
analysis
software.
Results:
Among
1542
articles
analyzed,
annual
publications
surged
2019,
stabilizing
thereafter.
U.S.,
China,
Canada
led
productivity,
Northwestern
University
Biomaterials
journal
being
top
contributors.
Keyword
revealed
hotspots
such
as
functional
recovery,
axonal
regeneration,
stem
cells,
hydrogels.
Notably,
hydrogels
embedded
genetically
engineered
cells
emerged
a
pivotal
trend,
reflecting
shift
toward
biomimetic
combinatorial
therapies.
Collaboration
networks
highlighted
intensified
partnerships
between
Chinese
North
American
institutions,
signaling
global
interdisciplinary
efforts.
Conclusions:
This
provides
first
bibliometric
roadmap
for
SCI,
identifying
key
trends,
influential
entities,
underexplored
areas.
rise
international
collaborations
underscores
opportunities
targeted
research.
These
findings
guide
researchers
prioritizing
high-impact
journals,
fostering
partnerships,
advancing
novel
scaffold
designs
bridge
translational
gaps
SCI
treatment.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Nov. 5, 2024
Dealing
with
spinal
cord
injuries
presents
problematic
due
to
multiple
secondary
mechanisms.
Beyond
primary
concerns
like
paralysis
and
disability,
complications
including
urinary,
gastrointestinal,
cardiac,
respiratory
disorders,
along
substantial
economic
burdens
may
occur.
Limited
research
focuses
on
modeling
treating
contusion
compression
injuries.
Tissue
engineering
emerges
as
an
innovative
treatment,
targeting
lesion
pathophysiology.
This
study
was
evaluated
implanting
injectable
biomaterials
into
injury-induced
cavity
before
glial
scar
formation,
avoiding
tissue
incisions
minimizing
further
damage.
The
efficacy
of
alginate/thiolated
chitosan
hydrogel
investigated
for
acute
injury
induced
by
Vanický
method
in
Wistar
rats.
Three
days
post-injury,
administrated
through
microinjection
after
laminectomy.
After
60
days,
the
group
demonstrated
notable
motor
function
enhancement
compared
control
BBB
locomotor
test
(P
<
0.05).
However,
no
statistically
significant
differences
were
observed
MRI
assessment
concerning
severity.
Stereological
histopathological
evaluations
revealed
a
reduction
vacuole
volume
presence
axon
profiles
within
scaffold
0.05),
alongside
reduced
infiltration
inflammatory
Gitter
cells
group,
although
latter
not
control.
Thiolated
chitosan/
alginate
implantation
be
regarded
promising
treatment
enhance
restraining
destructive
processes
post-acute
injury.
Biomedicines,
Journal Year:
2022,
Volume and Issue:
10(10), P. 2563 - 2563
Published: Oct. 13, 2022
On
the
slow
path
to
improving
life
expectancy
and
quality
of
patients
post
spinal
cord
injury
(SCI),
recovery
remains
controversial.
The
potential
role
regenerative
capacity
nervous
system
has
led
numerous
attempts
stimulate
SCI
re-establish
interrupted
sensorimotor
loop
understand
its
in
process.
Numerous
resources
are
now
available,
from
pharmacological
biomolecular
approaches
neuromodulation
rehabilitation
interventions
based
on
use
various
neural
interfaces,
exoskeletons,
virtual
reality
applications.
integration
existing
seems
be
a
promising
field
research,
especially
perspective
living
conditions
short
medium
term.
Goals
such
as
reducing
chronic
forms
neuropathic
pain,
regaining
control
over
certain
physiological
activities,
enhancing
residual
abilities
often
more
urgent
than
complete
functional
recovery.
In
this
article,
we
provide
an
overview
latest
for
treatment
through
broad
phases
rehabilitation.
underlying
intention
work
is
introduce
neuroplasticity-based
multimodal
approach
promote
improve
after
SCI.
Nonetheless,
when
used
separately,
therapeutic
have
been
shown
modest
outcomes.
