Injectable Hydrogels for Nervous Tissue Repair—A Brief Review

Gels, Journal Year: 2024, Volume and Issue: 10(3), P. 190 - 190

Published: March 9, 2024

The repair of nervous tissue is a critical research field in engineering because the degenerative process injured system. In this review, we summarize progress injectable hydrogels using vitro and vivo studies for regeneration tissue. Traditional treatments have not been favorable patients, as they are invasive inefficient; therefore, promising treatment damaged This review will contribute to better understanding potential scaffolds drug delivery system neural applications.

Language: Английский

---

Development of BDNF/NGF/IKVAV Peptide Modified and Gold Nanoparticle Conductive PCL/PLGA Nerve Guidance Conduit for Regeneration of the Rat Spinal Cord Injury

Macromolecular Bioscience, Journal Year: 2024, Volume and Issue: 24(5)

Published: Jan. 15, 2024

Abstract Spinal cord injuries are very common worldwide, leading to permanent nerve function loss with devastating effects in the affected patients. The challenges and inadequate results current clinical treatments scientists innovative neural regenerative research. Advances nanoscience tissue engineering have opened new avenues for spinal injury (SCI) treatment. In order designed guidance conduit (NGC) be functionally useful, it must ideal scaffold properties topographic features that promote linear orientation of damaged axons. this study, is aimed develop channeled polycaprolactone (PCL)/Poly‐D,L‐lactic‐co‐glycolic acid (PLGA) hybrid film scaffolds, modify their surfaces by IKVAV pentapeptide/gold nanoparticles (AuNPs) or polypyrrole (PPy) investigate behavior motor neurons on vitro under static/bioreactor conditions. Their potential regeneration after implantation into rat SCI shaping scaffolds modified factors a tubular form also examined. It shown groups decorated AuNPs highly neurite bioreactor conditions developed optimal NGC (PCL/PLGA G1‐IKVAV/BDNF/NGF‐AuNP 50 ) regenerates SCI. indicate can an candidate regeneration.

Language: Английский

---

Adipose-derived stem cell therapy for spinal cord injuries: Advances, challenges, and future directions

Regenerative Therapy, Journal Year: 2024, Volume and Issue: 26, P. 508 - 519

Published: June 1, 2024

Spinal cord injury (SCI) has limited treatment options for regaining function. Adipose-derived stem cells (ADSCs) show promise owing to their ability differentiate into multiple cell types, promote nerve survival, and modulate inflammation. This review explores ADSC therapy SCI, focusing on its potential improving function, preclinical early clinical trial progress, challenges, future directions. Preclinical studies have demonstrated transplantation's effectiveness in promoting functional recovery, reducing cavity formation, enhancing regrowth myelin repair. To improve efficacy, strategies including genetic modification combination with rehabilitation are being explored. Early trials shown safety feasibility, some suggesting motor sensory function improvements. Challenges remain translation, optimizing survival delivery, determining dosing, addressing tumor formation risks, establishing standardized protocols. Future research should focus overcoming these challenges exploring the combining other treatments, medication.

Language: Английский

---

Exploring the properties and potential of the neural extracellular matrix for next‐generation regenerative therapies

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(3)

Published: May 1, 2024

Abstract The extracellular matrix (ECM) is a dynamic and complex network of proteins molecules that surrounds cells tissues in the nervous system orchestrates myriad biological functions. This review carefully examines diverse interactions between ECM, as well transformative chemical physical changes ECM undergoes during neural development, aging, disease. These transformations play pivotal role shaping tissue morphogenesis activity, thereby influencing functionality central (CNS). In our comprehensive review, we describe behaviors CNS different physiological pathological scenarios explore unique properties make ECM‐based strategies attractive for repair regeneration. Addressing challenges scalability, variability, integration with host tissues, how advanced natural, synthetic, combinatorial approaches enhance biocompatibility, mechanical properties, functional recovery. Overall, this highlights potential decellularized powerful tool modeling regenerative purposes sets stage future research exciting field. article categorized under: Implantable Materials Surgical Technologies > Nanotechnology Tissue Repair Replacement Therapeutic Approaches Drug Discovery Nanomedicine Neurological Disease Nanomaterials Implants

Language: Английский

---

Therapeutic effects of erythropoietin-alginate/chitosan hydrogel on impaired male rat fertility after spinal cord injury

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: Jan. 18, 2025

Language: Английский

---

Biomaterials targeting the microenvironment for spinal cord injury repair: progression and perspectives

Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: May 9, 2024

Spinal cord injury (SCI) disrupts nerve pathways and affects sensory, motor, autonomic function. There is currently no effective treatment for SCI. SCI occurs within three temporal periods: acute, subacute, chronic. In each period there are different alterations in the cells, inflammatory factors, signaling spinal cord. Many biomaterials have been investigated of SCI, including hydrogels fiber scaffolds, some progress has made using multiple materials. However, limitations when individual treatment, these can be significantly improved by combining treatments with stem cells. order to better understand investigate new strategies its several combination therapies that include materials combined drugs, cytokines, etc. summarized current review.

Language: Английский

---

Modern advances in spinal cord regeneration: hydrogel combined with neural stem cells

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: June 27, 2024

Severe spinal cord injuries (SCI) lead to loss of functional activity the body below injury site, affect a person’s ability self-care and have direct impact on performance. Due structural features role in body, consequences SCI cannot be completely overcome at expense endogenous regenerative potential and, developing over time, severe complications years after injury. Thus, primary task this type treatment is create artificial conditions for growth damaged nerve fibers through area SCI. Solving problem possible using tissue neuroengineering involving technology replacing natural environment with synthetic matrices (for example, hydrogels) combination stem cells, particular, neural/progenitor cells (NSPCs). This approach can provide maximum stimulation support axons neurons their myelination. In review, we consider currently available options improving condition (use NSC transplantation or/and replacement matrix, specifically hydrogel). We emphasise expediency effectiveness hydrogel matrix + NSCs complex system used reconstruction Since such (a engineering cell therapy), our opinion, allows not only creation supporting regeneration or mechanical cord, but also strengthen regeneration, prevent spread inflammatory process, promote restoration lost reflex, motor sensory functions injured cord.

Language: Английский

---

Multidimensional exploration of hydrogels as biological scaffolds for spinal cord regeneration: mechanisms and future perspectives

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: April 23, 2025

Spinal cord injury (SCI) is a severe condition that frequently leads to permanent disabilities and neurological dysfunction. Its progression driven by multifaceted pathophysiology, encompassing direct trauma, secondary cascades, intricate cellular molecular responses. While current therapies focus on alleviating symptoms restoring functionality, achieving effective neural regeneration in the spinal continues be significant challenge. Hydrogels, recognized for their exceptional biocompatibility, conductivity, injectability, have shown great potential as advanced scaffolds support neuronal axonal regeneration. Recently, these materials attracted interest field of SCI rehabilitation research. This review concludes recent progress hydrogel-based strategies rehabilitation, emphasizing distinct properties, underlying mechanisms, integration with bioactive molecules, stem cells, complementary biomaterials. Hydrogels foster providing tailored microenvironment, while features such self-repair, electrical controlled drug release significantly enhance therapeutic experimental models. explores hydrogel technologies applications, underscoring address challenges treatment paving way future clinical implementation.

Language: Английский

---

Spinal Cord Injury Management Based on Microglia-Targeting Therapies

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(10), P. 2773 - 2773

Published: May 8, 2024

Spinal cord injury is a complicated medical condition both from the clinician's point of view in terms management and patient's perspective unsatisfactory recovery. Depending on severity, this disorder can be devastating despite rapid appropriate use modern imaging techniques convenient surgical spinal decompression stabilization. In context, there mandatory need for novel adjunctive therapeutic approaches to classical treatments improve rehabilitation chances clinical outcomes. This review offers new original therapies targeting microglia, one most relevant immune cells implicated disorders. The first part manuscript reviews anatomical pathophysiological importance blood-spinal barrier components, including role microglia post-acute neuroinflammation. Subsequently, authors present emerging based modulation, such as cytokines modulators, stem cell, microRNA, nanoparticle-based that could positively impact management. Finally, future perspectives challenges are also highlighted ongoing trials related medications microglia.

Language: Английский

---

Enhancing neovascularization post-myocardial infarction through injectable hydrogel functionalized with endothelial-derived EVs

Biofabrication, Journal Year: 2024, Volume and Issue: 16(4), P. 045009 - 045009

Published: July 10, 2024

Abstract Over the past three decades, cell therapy development has fallen short of expectations, with many cellular sources demonstrating a ‘Janus effect’ and raising safety concerns. Extracellular vesicles (EVs), supported by advanced technologies, present promising avenue in regenerative medicine, offering benefits such as immune tolerance avoidance negative aspects associated transplants. Our previous research showcased enhanced organized subcutaneous vascularization using three-dimensional bioprinted patches containing HUVEC-derived EVs immunodeficient animal models. In this context, stress conditions on cells origin further boosted EVs’ neoangiogenic potential. Since neovascularization is first target requiring restoration, study aims to complement our work employing an injectable gelatin methacrylate (GelMA) hydrogel functionalized pathological condition acute myocardial infarction. This bioactive resulted reduced fibrosis, improved contractility, promoted angiogenesis, showing promise countering tissue deterioration addressing vascular deficits. Moreover, molecular characterization through miRNome proteomic analyses supports their potential bio-additives for functionalization. cell-free approach mitigates rejection oncogenic risks, innovative therapeutic advantages.

Language: Английский

---