American Journal of Translational Research,
Journal Year:
2025,
Volume and Issue:
17(2), P. 736 - 747
Published: Jan. 1, 2025
Malignant
tumors
pose
a
significant
threat
to
human
health,
and
conventional
cancer
therapies
are
limited
by
inadequate
targeting,
leading
severe
side
effects.
Exosomes,
as
extracellular
vesicles
mediating
intercellular
communication,
exhibit
advantages
such
low
immunogenicity,
high
biocompatibility,
toxicity.
After
modification,
engineered
exosomes
can
be
employed
targeted
delivery
vehicles
in
tumor
therapy.
This
review
summarizes
the
cellular
origin,
production
methods,
engineering
strategies,
drug-loading
routes
of
exosomes,
discusses
their
applications
treatment,
delves
into
challenges
issues
translating
clinical
practice,
aiming
provide
insights
for
exosome
research.
Molecular Cancer,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: Jan. 13, 2025
This
review
highlights
recent
progress
in
exosome-based
drug
delivery
for
cancer
therapy,
covering
exosome
biogenesis,
cargo
selection
mechanisms,
and
their
application
across
multiple
types.
As
small
extracellular
vesicles,
exosomes
exhibit
high
biocompatibility
low
immunogenicity,
making
them
ideal
vehicles
capable
of
efficiently
targeting
cells,
minimizing
off-target
damage
side
effects.
aims
to
explore
the
potential
with
a
focus
on
applications
chemotherapy,
gene
immunomodulation.
Additionally,
challenges
related
production
standardization
are
analyzed,
highlighting
importance
addressing
these
issues
clinical
application.
In
conclusion,
systems
offer
promising
future
therapies.
Further
research
should
aim
enhance
efficiency
facilitate
translation,
paving
way
innovative
treatment
strategies.
Cancer Cell International,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Jan. 27, 2025
Theranostics
is
a
way
of
treating
illness
that
blends
medicine
with
testing.
Specific
characteristics
should
be
present
in
the
best
theranostic
agents
for
cancer:
(1)
drugs
safe
and
non-toxic;
(2)
they
able
to
treat
cancer
selectively;
(3)
build
up
only
cancerous
tissue.
Liposomes
(LPs)
are
one
most
efficient
drug
delivery
methods
based
on
nanotechnology.
Stealth
LPs
commercial
have
recently
had
an
impact
treatment.
Using
valuable
information
from
each
imaging
technique,
along
multimodality
functionality
liposomal
therapeutic
agents,
makes
them
very
appealing
personalized
monitoring
how
well
working
against
vivo
predicting
therapies
will
work.
On
other
hand,
their
use
as
nanoparticle
systems
currently
research
development
phase.
Nanoscale
system
innovation
has
made
LP-nanoparticle
hybrid
structures
useful
combining
methods.
LP-hybrid
nanoparticles
better
at
killing
cells
than
LP
counterparts,
making
excellent
options
vitro
applications.
Hybrid
liposomes
(HLs)
could
used
future
carriers
find
targets.
This
would
combine
features
synthetic
biological
systems.
Overarchingly,
this
article
provided
comprehensive
overview
many
types
detection,
therapy,
analysis.
An
evaluation
pros
cons
HLs
detection
treatment
also
been
conducted.
The
study
included
recent
significant
We
conclude
by
outlining
potential
benefits
drawbacks
approach
concurrent
different
malignancies,
its
prospects.
ACS Omega,
Journal Year:
2023,
Volume and Issue:
8(46), P. 43374 - 43387
Published: Nov. 9, 2023
Exosomes
are
nanoscale
vesicles
secreted
by
living
cells
that
have
similar
membrane
composition
to
parental
and
carry
a
variety
of
proteins,
lipids,
nucleic
acids.
Therefore,
exosomes
certain
biological
activities
play
an
important
role
in
intercellular
communication.
On
the
basis
its
potential
as
carrier
for
drug
delivery
systems,
been
engineered
compensate
shortage
natural
through
various
engineering
strategies
improving
efficiency,
enhancing
targeting
tissues
organs,
extending
circulating
half-life
exosomes.
This
review
focuses
on
loading
drugs
different
strategies,
discussions
exosome
surface
modification
summarizes
advantages
disadvantages
strategies.
In
addition,
this
provides
overview
recent
applications
number
refractory
relapsable
diseases.
has
provide
reference
further
research
development
Journal of Controlled Release,
Journal Year:
2023,
Volume and Issue:
358, P. 98 - 115
Published: April 29, 2023
Glioblastoma
(GBM)
is
an
adult's
most
aggressive
brain
tumor.
The
advances
in
molecular
pathology
and
cell
signaling
pathways
have
deepened
researchers'
understanding
of
intercellular
communication
mechanisms
that
can
induce
tumor
progression,
namely
the
release
extracellular
vesicles.
Exosomes
are
small
vesicles
various
biological
fluids
released
by
almost
all
cells,
thus
carrying
biomolecules
specific
to
their
parental
cell.
Several
pieces
evidence
indicate
exosomes
mediate
microenvironment
cross
blood-brain
barrier
(BBB),
valuable
tools
for
diagnostic
therapeutic
applications
under
scope
diseases
such
as
tumors.
This
review
aims
resume
several
characteristics
interplay
between
glioblastoma
exosomes,
describing
highlight
studies
demonstrate
role
GBM
potential
non-invasive
diagnoses
approaches,
namely,
nanocarriers
drug
or
gene
delivery
cancer
vaccines.
Nanomaterials,
Journal Year:
2024,
Volume and Issue:
14(7), P. 639 - 639
Published: April 6, 2024
Exosomes
are
spherical
extracellular
nanovesicles
with
an
endosomal
origin
and
unilamellar
lipid-bilayer
structure
sizes
ranging
from
30
to
100
nm.
They
contain
a
large
range
of
proteins,
lipids,
nucleic
acid
species,
depending
on
the
state
vesicle
(EV)-secreting
cell.
EVs’
function
is
encapsulate
part
EV-producing
cell
content,
transport
it
through
biological
fluids
targeted
recipient,
deliver
their
cargos
specifically
within
aimed
recipient
cells.
Therefore,
exosomes
considered
be
potential
drug-delivery
systems
that
can
stably
cargo
into
Various
cell-derived
produced
for
medical
issues,
but
use
therapeutic
purposes
still
faces
several
problems.
Some
these
difficulties
avoided
by
resorting
hemisynthetic
approaches.
We
highlight
here
uses
alternative
exosome-mimes
involving
cell-membrane
coatings
artificial
nanocarriers
or
hybridization
between
liposomes.
also
detail
drug-loading
strategies
deployed
make
them
drug-carrier
summarize
ongoing
clinical
trials
exosome-like
structures.
Finally,
we
open
questions
before
considering
disposals
confident
delivery.
Fundamental Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 1, 2024
Exosomes
are
natural
nano-size
particles
secreted
by
human
cells,
containing
numerous
bioactive
cargos.
Serving
as
crucial
mediators
of
intercellular
communication,
exosomes
involved
in
many
physiological
and
pathological
processes,
such
inflammation,
tissue
injury,
cardiovascular
diseases,
tumorigenesis
tumor
development.
have
exhibited
promising
results
the
diagnosis
treatment
cancer,
diseases
others.
They
a
rapidly
growing
class
drug
delivery
vehicles
with
advantages
over
conventional
synthetic
carriers.
used
therapeutic
applications
encounter
several
challenges,
lack
targeting
capabilities
short
residence
time.
In
this
review,
we
discuss
recent
advances
exosome
engineering
to
improve
describe
current
types
engineered
exosome-like
nanovesicles,
summarize
their
preclinical
diseases.
Further,
also
highlight
latest
strategies
developed
extend
retention
time
vivo
nanovesicles.
