A Mechanistic Understanding of Reactive Oxygen Species (ROS)‐Responsive Bio‐Polymeric Nanoparticles: Current State, Challenges and Future Toward Precision Therapeutics DOI
Vivek Pandey, Tejasvi Pandey

Biopolymers, Journal Year: 2025, Volume and Issue: 116(3)

Published: May 1, 2025

ABSTRACT Inflammation is a hallmark of various pathological conditions, including cancer, cardiovascular diseases, neurodegenerative disorders, and autoimmune diseases. Reactive oxygen species (ROS) are crucial mediators in the inflammatory microenvironment, playing pivotal role both normal cellular processes disease progression. Targeting ROS overproduction inflamed tissues has emerged as promising therapeutic strategy. Polymeric nanoparticles (NPs) responsive to levels have gained substantial attention precision drug delivery systems, capable ensuring controlled, site‐specific release. This review provides comprehensive mechanistic insight into ROS‐responsive polymeric nanoparticles, examining their structural design, functionalization strategies, release mechanisms, potential for targeted therapies conditions. Furthermore, we discuss recent advancements, challenges, future directions utilizing therapeutics, highlighting transformative clinical applications.

Language: Английский

Injectable biocompatible RAFT mediated nitroxide nanogels: A robust ROS-reduction antioxidant approach DOI
Suman Basak, Ishita Mukherjee, Tushar Kanti Das

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 236, P. 113790 - 113790

Published: Feb. 7, 2024

Language: Английский

Citations

31
Tumor microenvironment responsive nanozymes for multimodal imaging of tumors DOI Creative Commons
Heng Wang, Wenrui Ouyang, Hongxing Liu

et al.

Nano TransMed, Journal Year: 2024, Volume and Issue: 3, P. 100032 - 100032

Published: Jan. 29, 2024

Nanozymes exhibit immense potential and promising prospects in the realm of diagnostic imaging tumor therapy, owing to their inherent physicochemical properties enzymatic activities. With further development application nanotechnology, nanozymes are expected become an important tool field medicine, providing new solutions for disease diagnosis treatment. This review provides overview recent studies over past five years on capable responding microenvironment (TME) multimodal imaging, with a focus hypoxia, acid pH, excess GSH ROS. In addition, we present current status several common related contrast agents, such as MRI/CT, MRI/PET, MRI/SPECT, PET/CT. Moreover, some thoughts challenges, future development, clinical translation microenvironment-responsive shared. aims provide up-to-date theranostic nanomedicine reference those who fields, promote progress this interdisciplinary subject, accelerate translation.

Language: Английский

Citations

22
Reactive Oxygen Species: Role in Pathophysiology, and Mechanism of Endogenous and Dietary Antioxidants during Oxidative Stress DOI Open Access

Mohammad Mamun Sikder,

Xiaodong Li,

Steeve Akumwami

et al.

Chonnam Medical Journal, Journal Year: 2025, Volume and Issue: 61(1), P. 32 - 32

Published: Jan. 1, 2025

Redox imbalances, which result from excessive production of reactive oxygen species (ROS) or malfunctioning the antioxidant system, are source oxidative stress. ROS affects all structural and functional components cells, either directly indirectly. In addition to causing genetic abnormalities, also oxidatively modifies proteins by protein oxidation peroxidation alters lipid structure via advanced lipoxidation, decreasing function promoting damage cell death. On other hand, low levels constitute important redox-signaling molecules in various pathways that maintain cellular homeostasis regulate key transcription factors. As a result, can affect processes, such as apoptosis, migration, differentiation, proliferation. act signaling molecules, controlling normal physiological activities at level. Furthermore, there is an increasing body evidence indicating role clinical conditions. this review, we will summarize pathological processes action during

Language: Английский

Citations

3
Enhancing immunotherapy with tumour-responsive nanomaterials DOI
Stephen W. Linderman, Louis DeRidder, Lucía Sanjurjo

et al.

Nature Reviews Clinical Oncology, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

Language: Английский

Citations

3
ROS-responsive nanoparticles targeting inflamed colon for synergistic therapy of inflammatory bowel disease via barrier repair and anti-inflammation DOI
Ding Wang, Qi Jiang,

Ruoyu Shen

et al.

Nano Research, Journal Year: 2024, Volume and Issue: 17(6), P. 5409 - 5423

Published: Jan. 26, 2024

Language: Английский

Citations

15
Unlocking the Mitochondria for Nanomedicine-based Treatments: Overcoming Biological Barriers, Improving Designs, and Selecting Verification Techniques DOI Creative Commons
Camilla Pegoraro,

Inés Domingo-Ortí,

Inmaculada Conejos‐Sánchez

et al.

Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 207, P. 115195 - 115195

Published: Feb. 5, 2024

Enhanced targeting approaches will support the treatment of diseases associated with dysfunctional mitochondria, which play critical roles in energy generation and cell survival. Obstacles to mitochondria-specific include presence distinct biological barriers need pass through (or avoid) various internalization mechanisms. A range studies have reported design mitochondrially-targeted nanomedicines that navigate complex routes required influence mitochondrial function; nonetheless, a significant journey lies ahead before become suitable for clinical use. Moving swiftly forward require safety studies, vivo assays confirming effectiveness, methodologies validate mitochondria-targeted nanomedicines' subcellular location/activity. From nanomedicine standpoint, we describe involved (from administration arrival within mitochondria), features influencing rational design, techniques used identify/validate successful targeting. Overall, rationally-designed mitochondria-targeted-based hold great promise precise therapeutic delivery.

Language: Английский

Citations

11
Natural Compounds and Biomimetic Engineering to Influence Fibroblast Behavior in Wound Healing DOI Open Access
Charlotte E. Berry, Camille Brenac,

Caroline E. Gonzalez

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3274 - 3274

Published: March 14, 2024

Throughout history, natural products have played a significant role in wound healing. Fibroblasts, acting as primary cellular mediators skin healing, exhibit behavioral responses to compounds that can enhance the healing process. Identifying bioactive and understanding their impact on fibroblast behavior offers crucial translational opportunities realm of Modern scientific techniques enabled detailed how naturally derived modulate by influencing behavior. Specific known for properties been identified. Engineered biomimetic replicating microenvironment are designed facilitate normal Advanced delivery methods operating at micro- nano-scales developed effectively deliver these novel through stratum corneum. This review provides comprehensive summary efficacy promoting regeneration repair. Additionally, it explores engineering, where researchers draw inspiration from nature create materials devices mimicking physiological cues effective The concludes describing mechanisms aimed enhancing bioavailability compounds. Innovative future strategies involve exploring fibroblast-influencing pathways, responsive biomaterials, smart dressings with real-time monitoring, applications stem cells. However, translating findings clinical settings faces challenges such limited validation biomaterials large animal models logistical obstacles industrial production. integration ancient remedies modern approaches holds promise achieving scar-free

Language: Английский

Citations

10
Prolonged, staged, and self-regulated methotrexate release coupled with ROS scavenging in an injectable hydrogel for rheumatoid arthritis therapy DOI
Mingsheng Xu, Tingting Fu, Chenhui Zhang

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 375, P. 60 - 73

Published: Sept. 4, 2024

Language: Английский

Citations

10
Orally-administered nanomedicine systems targeting colon inflammation for the treatment of inflammatory bowel disease: latest advances DOI
Shumeng Hu, Runan Zhao, Yu Xu

et al.

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 12(1), P. 13 - 38

Published: Nov. 29, 2023

Inflammatory bowel disease (IBD) is a chronic and idiopathic condition that results in inflammation of the gastrointestinal tract, leading to conditions such as ulcerative colitis Crohn's disease.

Language: Английский

Citations

19
Tumor Microenvironment Responsive RNA Drug Delivery Systems: Intelligent Platforms for Sophisticated Release DOI
Guihua Wang,

Mengxia Zhang,

Weiwei Lai

et al.

Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: 21(9), P. 4217 - 4237

Published: July 26, 2024

Cancer is a significant health concern, increasingly showing insensitivity to traditional treatments, highlighting the urgent need for safer and more practical treatment options. Ribonucleic acid (RNA) gene therapy drugs have demonstrated promising potential in preclinical clinical trials antitumor by regulating tumor-related expression. However, RNA's poor membrane permeability stability restrict its effectiveness entering being utilized cells. An appropriate delivery system crucial achieving targeted tumor effects. The microenvironment (TME), characterized acidity, hypoxia, enzyme overexpression, elevated glutathione (GSH) concentration, excessive reactive oxygen species (ROS), essential survival. Furthermore, these distinctive features can also be harnessed develop intelligent drug systems. Various nanocarriers that respond TME been designed RNA delivery, advantages of targeting low toxicity. This Review discusses abnormal changes components TME, therapeutic RNAs' roles, underlying mechanisms, latest developments utilizing vectors microenvironments treating tumors. We hope it provides insight into creating optimizing improve their effectiveness.

Language: Английский

Citations

9