The emerging role of the gut microbiota and its application in inflammatory bowel disease

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 179, P. 117302 - 117302

Published: Aug. 19, 2024

Inflammatory bowel disease (IBD), including Crohn's and ulcerative colitis, is a complex disorder with an unknown cause. However, the dysbiosis of gut microbiome has been found to play role in IBD etiology, exacerbated immune responses defective intestinal barrier integrity. The can also be potential biomarker for several diseases, IBD. Currently, conventional treatments targeting pro-inflammatory cytokines pathways IBD-associated do not yield effective results. Other therapies that directly target dysbiotic outcomes are emerging. We review health its as diagnostic, prognostic, therapeutic This explores emerging advancements microbiome-associated alterations IBD, such nanoparticle or encapsulation delivery, fecal microbiota transplantation, nutritional therapies, microbiome/probiotic engineering, phage therapy, mesenchymal stem cells (MSCs), proteins, herbal formulas.

Language: Английский

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Machine Learning‐Assisted High‐Throughput Screening of Nanozymes for Ulcerative Colitis

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 12, 2025

Ulcerative colitis (UC) is a chronic gastrointestinal inflammatory disorder with rising prevalence. Due to the recurrent and difficult-to-treat nature of UC symptoms, current pharmacological treatments fail meet patients' expectations. This study presents machine learning-assisted high-throughput screening strategy expedite discovery efficient nanozymes for treatment. Therapeutic requirements, including antioxidant property, acid stability, zeta potential, are quantified predicted by using learning model. Non-quantifiable attributes, intestinal barrier repair efficacy biosafety, assessed via screening. Feature significance analysis, sure independence screening, sparsifying operator symbolic regression reveal high-dimensional structure-activity relationships between material features therapeutic needs. SrDy

Language: Английский

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Sustained release of 5-aminosalicylic acid from azoreductase-responsive polymeric prodrugs for prolonged colon-targeted colitis therapy

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Aug. 6, 2024

Ulcerative colitis (UC) is a challenging inflammatory gastrointestinal disorder, whose therapies encounter limitations in overcoming insufficient colonic retention and rapid systemic clearance. In this study, we report an innovative polymeric prodrug nanoformulation for targeted UC treatment through sustained 5-aminosalicylic acid (5-ASA) delivery. Amphiphilic polymer-based 13.5 nm micelles were engineered to incorporate azo-linked 5-ASA motifs, enabling cleavage via azoreductases. vitro, exhibited excellent stability under gastric/intestinal conditions while demonstrating controlled release over 24 h fluids. Orally administered revealed prolonged 24-h high accumulation within inflamed murine tissue. At approximately 60% dose reduction from those most advanced recent studies, the platform halted DSS progression outperformed standard therapy 77–97% suppression of markers. Histological analysis confirmed intact colon morphology restored barrier protein expression. This integrated addresses colon-targeted localized bioactivation tailored pharmacokinetics, suggesting potential nanotechnology-guided precision delivery transform disease management.

Language: Английский

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Artemisia argyi Polyphenols Attenuates DSS-induced Colitis in Mice by Regulating the Structural Composition of Gut Microbiota

Phytomedicine, Journal Year: 2024, Volume and Issue: 132, P. 155897 - 155897

Published: July 16, 2024

Language: Английский

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Effect of microenvironmental viscosity on the emergence of colon cancer cell resistance to doxorubicin

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Microenvironmental viscosity enhanced doxorubicin resistance of colon cancer cells.

Language: Английский

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Analysis of nanomedicine applications for inflammatory bowel disease: structural and temporal dynamics, research hotspots, and emerging trends

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 8, 2025

The application of nanomedicine in inflammatory bowel disease (IBD) has gained significant attention the recent years. As field rapidly evolves, analyzing research trends and identifying hotpots are essential for guiding future advancements, a comprehensive bibliometric can provide valuable insights. current focused on publications from 2001 to 2024, was sourced Web Science Core Collection (WoSCC). CiteSpace VOSviewer were employed visualize authors, institutions, countries, co-cited references, keywords, thereby mapping intellectual structure emerging field. analysis covered 1,518 literature across 447 journals, authored by 9,334 researchers 5,459 institutions 287 countries/regions. global publication numbers exhibited an upward trend, particularly last decade, with China leading as top publishing country Chinese Academy Sciences foremost institution. Dr. Xiao Bo is prominent figure advanced drug delivery systems. This interdisciplinary field, which spans materials science, pharmacy, medicine, seen influential mainly concentrated targeted nanoparticles treatment IBD. Keyword revealed that hotspots include delivery, immune cell regulation, antioxidant damage, intestinal microbiota homeostasis, nanovesicles. study offers overview landscape, emphasizing rapid growth increasing complexity this It identifies key trends, including efforts enhance precision, efficacy, safety applications. Emerging directions highlighted crucial further progress evolving area.

Language: Английский

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Pathophysiology of IBD as a Key Strategy for Polymeric Nanoparticle Development

Advanced Therapeutics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Abstract Inflammatory bowel disease (IBD) is a complex chronic inflammatory disorder of the gastrointestinal (GI) tract with an uncertain etiology. Currently, IBD therapy relies on induction clinical remission followed by maintenance using anti‐inflammatory drugs and immunosuppressants; however, definite cure still out scope. Established approaches are characterized adverse drug‐related side effects that can even be potentially life‐threatening. In contrast, increased interest remarkable scientific progress in targeted drug delivery systems offer promising approach to reduce systemic events, delivering therapeutic substances only inflamed tissue. All alteration barrier integrity, especially disturbed epithelial barrier, unique pattern receptors cell surface and/or oxidative stress milieu areas used as effective for controlled delivery. Hence, this review focuses pathophysiology GI potential strategy polymeric nanoparticles treatment. Interdisciplinary efforts between chemistry gastroenterology/immunology promise create novel synergies improve development nanoparticle significant impact. regard, current challenges translation nanomedicine also discussed.

Language: Английский

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Nanotechnology-based drug delivery system for targeted therapy of Ulcerative colitis from traditional chinese medicine: A review

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 673, P. 125375 - 125375

Published: Feb. 16, 2025

Language: Английский

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Oral delivery of ultra-small zwitterionic nanoparticles to overcome mucus and epithelial barriers for macrophage modulation and colitis therapy

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Application of aggregation-induced emission materials in gastrointestinal diseases

World Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: 31(16)

Published: April 25, 2025

Aggregation-induced emission (AIE) is a phenomenon characterized by certain fluorescent molecules that exhibit weak or no luminescence in solution but demonstrate significantly enhanced upon aggregation. Accordingly, AIE materials have successfully addressed the limitations associated with aggregation-caused quenching effects and made significant progress application of various fields medicine recent years. At present, gastrointestinal (GI) diseases mainly GI imaging, diagnosis treatment. In this review, we summarize applications pathogens diseases, including inflammatory bowel disease tumors, outline combined treatment methods tumor therapy.

Language: Английский

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